Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration

Progress in Retinal and Eye Research

Volumn 43, Issue , 2014, Pages 1-16

  Namekata, Kazuhiko ^a   Kimura, Atsuko ^a   Kawamura, Kazuto ^a   Harada, Chikako ^a   Harada, Takayuki ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Axon regeneration; Dock3; Glaucoma; Guanine exchange factors; Neuroprotection; Optic nerve; Retinal ganglion cells

Indexed keywords

DEDICATOR OF CYTOKINESIS PROTEIN; DOCK1 PROTEIN; DOCK10 PROTEIN; DOCK11 PROTEIN; DOCK2 PRTOEIN; DOCK3 PROTEIN; DOCK4 PROTEIN; DOCK5 PROTEIN; DOCK6 PROTEIN; DOCK7 PROTEIN; DOCK8 PROTEIN; DOCK9 PROTEIN; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NEUROPROTECTIVE AGENT;

ACTIN FILAMENT; ALZHEIMER DISEASE; CELL DEATH; CELL MOTILITY; ELMO; EXCITOTOXICITY; GLAUCOMA; HUMAN; MICROTUBULE ASSEMBLY; NERVE FIBER REGENERATION; NEUROPROTECTION; NONHUMAN; OPTIC NERVE; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN STRUCTURE; RETINA GANGLION CELL; REVIEW; ANIMAL; DISEASE MODEL; METABOLISM; MOUSE; NERVE FIBER; NERVE REGENERATION; NEURODEGENERATIVE DISEASES; PHYSIOLOGY;

ANIMALS; AXONS; DISEASE MODELS, ANIMAL; GLAUCOMA; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICE; NERVE REGENERATION; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; RETINAL GANGLION CELLS;

EID: 84908054377     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2014.06.005     Document Type: Review

References (188)

1. Alexander M.S., Casar J.C., Motohashi N., Vieira N.M., Eisenberg I., Marshall J.L., Gasperini M.J., Lek A., Myers J.A., Estrella E.A., Kang P.B., Shapiro F., Rahimov F., Kawahara G., Widrick J.J., Kunkel L.M. MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. J.Clin. Invest. 2014, 124:2651-2667.
2. Alkelai A., Lupoli S., Greenbaum L., Kohn Y., Kanyas-Sarner K., Ben-Asher E., Lancet D., Macciardi F., Lerer B. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. Int. J. Neuropsychopharmacol. 2012, 15:459-469.
3. Amadoro G., Ciotti M.T., Costanzi M., Cestari V., Calissano P., Canu N. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:2892-2897.
4. Anderson M.G., Libby R.T., Mao M., Cosma I.M., Wilson L.A., Smith R.S., John S.W. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol. 2006, 4:20.
5. Atorf J., Scholz M., Garreis F., Lehmann J., Bräuer L., Kremers J. Functional protective effects of long-term memantine treatment in the DBA/2J mouse. Doc. Ophthalmol. 2013, 126:221-232.
6. Bai N., Aida T., Yanagisawa M., Katou S., Sakimura K., Mishina M., Tanaka K. NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina. Mol. Brain 2013, 6:34.
7. Bai N., Hayashi H., Aida T., Namekata K., Harada T., Mishina M., Tanaka K. Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity. Mol. Brain 2013, 6:22.
8. Bertrand J., Winton M.J., Rodriguez-Hernandez N., Campenot R.B., McKerracher L. Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J.Neurosci. 2005, 25:1113-1121.
9. Biersmith B., Liu Z.C., Bauman K., Geisbrecht E.R. The DOCK protein sponge binds to ELMO and functions in Drosophila embryonic CNS development. PLoS One 2011, 6:e16120.
10. Blasius A.L., Brandl K., Crozat K., Xia Y., Khovananth K., Krebs P., Smart N.G., Zampolli A., Ruggeri Z.M., Beutler B.A. Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2706-2711.
11. Bonomi L., Marchini G., Marraffa M., Bernardi P., De Franco I., Perfetti S., Varotto A., Tenna V. Prevalence of glaucoma and intraocular pressure distribution in a defined population. The Egna-Neumarkt Study. Ophthalmology 1998, 105:209-215.
12. Bourne H.R., Sanders D.A., McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature 1990, 348:125-132.
13. Chen Q., Kimura H., Schubert D. Anovel mechanism for the regulation of amyloid precursor protein metabolism. J.Cell. Biol. 2002, 158:79-89.
14. Chen Q., Peto C.A., Shelton G.D., Mizisin A., Sawchenko P.E., Schubert D. Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration. J.Neurosci. 2009, 29:118-130.
15. Chen Q., Yoshida H., Schubert D., Maher P., Mallory M., Masliah E. Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation. Am. J. Pathol. 2001, 159:1597-1602.
16. Cimino P.J., Sokal I., Leverenz J., Fukui Y., Montine T.J. DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain. Am. J. Pathol. 2009, 175:1622-1630.
17. Cimino P.J., Yang Y., Li X., Hemingway J.F., Cherne M.K., Khademi S.B., Fukui Y., Montine K.S., Montine T.J., Keene C.D. Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease. Exp. Mol. Pathol. 2013, 94:366-371.
18. Cole A.R. Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia. FEBS J. 2013, 280:5213-5227.
19. Cook D.R., Rossman K.L., Der C.J. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene 2013, 16:1-15.
20. Côté J.F., Motoyama A.B., Bush J.A., Vuori K. Anovel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat. Cell. Biol. 2005, 7:797-807.
21. Côté J.F., Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell. Biol. 2007, 17:383-393.
22. Cox A.D., Der C.J. Ras history: the saga continues. Small GTPases 2010, 1:2-27.
23. Crawford G., Enders A., Gileadi U., Stankovic S., Zhang Q., Lambe T., Crockford T.L., Lockstone H.E., Freeman A., Arkwright P.D., Smart J.M., Ma C.S., Tangye S.G., Goodnow C.C., Cerundolo V., Godfrey D.I., Su H.C., Randall K.L., Cornall R.J. DOCK8 is critical for the survival and function of NKT cells. Blood 2013, 122:2052-2061.
24. Czugala M., Karolak J.A., Nowak D.M., Polakowski P., Pitarque J., Molinari A., Rydzanicz M., Bejjani B.A., Yue B.Y., Szaflik J.P., Gajecka M. Novel mutation and three other sequence variants segregating with phenotype at keratoconus 13q32 susceptibility locus. Eur. J. Hum. Genet. 2012, 20:389-397.
25. Dancescu M., Rubio-Trujillo M., Biron G., Bron D., Delespesse G., Sarfati M. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. J.Exp. Med. 1992, 176:1319-1326.
26. de Lima S., Koriyama Y., Kurimoto T., Oliveira J.T., Yin Y., Li Y., Gilbert H.Y., Fagiolini M., Martinez A.M., Benowitz L. Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:9149-9154.
27. DeRosse P., Lencz T., Burdick K.E., Siris S.G., Kane J.M., Malhotra A.K. The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. Schizophr. Bull. 2008, 34:1047-1053.
28. de Silva M.G., Elliott K., Dahl H.H., Fitzpatrick E., Wilcox S., Delatycki M., Williamson R., Efron D., Lynch M., Forrest S. Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. J.Med. Genet. 2003, 40:733-740.
29. De Strooper B., Iwatsubo T., Wolfe M.S. Presenilins and gamma-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harb. Perspect. Med. 2012, 2:a006304.
30. Detera-Wadleigh S.D., Liu C.Y., Maheshwari M., Cardona I., Corona W., Akula N., Steele C.J., Badner J.A., Kundu M., Kassem L., Potash J.B., Gibbs R., Gershon E.S., McMahon F.J. Sequence variation in DOCK9 and heterogeneity in bipolar disorder. Psychiatr. Genet. 2007, 17:274-286. Consortium, N.G.I.f.B.D.
31. Dong L.D., Chen J., Li F., Gao F., Wu J., Miao Y., Wang Z. Enhanced expression of NR2B subunits of NMDA receptors in the inherited glaucomatous DBA/2J mouse retina. Neural Plast. 2013, 2013:670254.
32. Dulak A.M., Stojanov P., Peng S., Lawrence M.S., Fox C., Stewart C., Bandla S., Imamura Y., Schumacher S.E., Shefler E., McKenna A., Carter S.L., Cibulskis K., Sivachenko A., Saksena G., Voet D., Ramos A.H., Auclair D., Thompson K., Sougnez C., Onofrio R.C., Guiducci C., Beroukhim R., Zhou Z., Lin L., Lin J., Reddy R., Chang A., Landrenau R., Pennathur A., Ogino S., Luketich J.D., Golub T.R., Gabriel S.B., Lander E.S., Beer D.G., Godfrey T.E., Getz G., Bass A.J. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat. Genet. 2013, 45:478-486.
33. Eguchi K., Yoshioka Y., Yoshida H., Morishita K., Miyata S., Hiai H., Yamaguchi M. The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells. Exp. Cell. Res. 2013, 319:2179-2195.
34. Eickholt B.J., Walsh F.S., Doherty P. An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J.Cell. Biol. 2002, 157:211-217.
35. Engelhardt K.R., McGhee S., Winkler S., Sassi A., Woellner C., Lopez-Herrera G., Chen A., Kim H.S., Lloret M.G., Schulze I., Ehl S., Thiel J., Pfeifer D., Veelken H., Niehues T., Siepermann K., Weinspach S., Reisli I., Keles S., Genel F., Kutukculer N., Camcioglu Y., Somer A., Karakoc-Aydiner E., Barlan I., Gennery A., Metin A., Degerliyurt A., Pietrogrande M.C., Yeganeh M., Baz Z., Al-Tamemi S., Klein C., Puck J.M., Holland S.M., McCabe E.R., Grimbacher B., Chatila T.A. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J.Allergy Clin. Immunol. 2009, 124:1289-1302. e1284.
36. Feng H., Hu B., Jarzynka M.J., Li Y., Keezer S., Johns T.G., Tang C.K., Hamilton R.L., Vuori K., Nishikawa R., Sarkaria J.N., Fenton T., Cheng T., Furnari F.B., Cavenee W.K., Cheng S.Y. Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:3018-3023.
37. Feng H., Hu B., Liu K.W., Li Y., Lu X., Cheng T., Yiin J.J., Lu S., Keezer S., Fenton T., Furnari F.B., Hamilton R.L., Vuori K., Sarkaria J.N., Nagane M., Nishikawa R., Cavenee W.K., Cheng S.Y. Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRalpha-stimulated glioma tumorigenesis in mice and humans. J.Clin. Invest. 2011, 121:4670-4684.
38. Fournier A.E., Takizawa B.T., Strittmatter S.M. Rho kinase inhibition enhances axonal regeneration in the injured CNS. J.Neurosci. 2003, 23:1416-1423.
39. Fukui Y., Hashimoto O., Sanui T., Oono T., Koga H., Abe M., Inayoshi A., Noda M., Oike M., Shirai T., Sasazuki T. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 2001, 412:826-831.
40. Gadea G., Sanz-Moreno V., Self A., Godi A., Marshall C.J. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr. Biol. 2008, 18:1456-1465.
41. Gao C., Hölscher C., Liu Y., Li L. GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease. Rev. Neurosci. 2011, 23:1-11.
42. Geraldo S., Gordon-Weeks P.R. Cytoskeletal dynamics in growth-cone steering. J.Cell. Sci. 2009, 122:3595-3604.
43. Gherghel D., Mroczkowska S., Qin L. Reduction in blood glutathione levels occurs similarly in patients with primary-open angle or normal tension glaucoma. Invest. Ophthalmol. Vis. Sci. 2013, 54:3333-3339.
44. Griggs B.L., Ladd S., Saul R.A., DuPont B.R., Srivastava A.K. Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. Genomics 2008, 91:195-202.
45. Grimsley C.M., Kinchen J.M., Tosello-Trampont A.C., Brugnera E., Haney L.B., Lu M., Chen Q., Klingele D., Hengartner M.O., Ravichandran K.S. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J.Biol. Chem. 2004, 279:6087-6097.
46. Gumienny T.L., Brugnera E., Tosello-Trampont A.C., Kinchen J.M., Haney L.B., Nishiwaki K., Walk S.F., Nemergut M.E., Macara I.G., Francis R., Schedl T., Qin Y., Van Aelst L., Hengartner M.O., Ravichandran K.S. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 2001, 107:27-41.
47. Hall A. Rho GTPases and the actin cytoskeleton. Science 1998, 279:509-514.
48. Hall A., Lalli G. Rho and Ras GTPases in axon growth, guidance, and branching. Cold Spring Harb. Perspect. Biol. 2010, 2:a001818.
49. Ham H., Guerrier S., Kim J., Schoon R.A., Anderson E.L., Hamann M.J., Lou Z., Billadeau D.D. Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J.Immunol. 2013, 190:3661-3669.
50. Hammarlund M., Nix P., Hauth L., Jorgensen E.M., Bastiani M. Axon regeneration requires a conserved MAP kinase pathway. Science 2009, 323:802-806.
51. Hamoud N., Tran V., Croteau L.P., Kania A., Côté J.F. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:3745-3750.
52. Hanawa-Suetsugu K., Kukimoto-Niino M., Mishima-Tsumagari C., Akasaka R., Ohsawa N., Sekine S., Ito T., Tochio N., Koshiba S., Kigawa T., Terada T., Shirouzu M., Nishikimi A., Uruno T., Katakai T., Kinashi T., Kohda D., Fukui Y., Yokoyama S. Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:3305-3310.
53. Harada C., Nakamura K., Namekata K., Okumura A., Mitamura Y., Iizuka Y., Kashiwagi K., Yoshida K., Ohno S., Matsuzawa A., Tanaka K., Ichijo H., Harada T. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis invivo. Am. J. Pathol. 2006, 168:261-269.
54. Harada C., Namekata K., Guo X., Yoshida H., Mitamura Y., Matsumoto Y., Tanaka K., Ichijo H., Harada T. ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma. Cell. Death Differ. 2010, 17:1751-1759.
55. Harada T., Harada C., Nakamura K., Quah H.M., Okumura A., Namekata K., Saeki T., Aihara M., Yoshida H., Mitani A., Tanaka K. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J.Clin. Invest. 2007, 117:1763-1770.
56. Harada T., Harada C., Watanabe M., Inoue Y., Sakagawa T., Nakayama N., Sasaki S., Okuyama S., Watase K., Wada K., Tanaka K. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:4663-4666.
57. Harada Y., Tanaka Y., Terasawa M., Pieczyk M., Habiro K., Katakai T., Hanawa-Suetsugu K., Kukimoto-Niino M., Nishizaki T., Shirouzu M., Duan X., Uruno T., Nishikimi A., Sanematsu F., Yokoyama S., Stein J.V., Kinashi T., Fukui Y. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood 2012, 119:4451-4461.
58. Hardingham G.E., Bading H. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat. Rev. Neurosci. 2010, 11:682-696.
59. Hasegawa H., Kiyokawa E., Tanaka S., Nagashima K., Gotoh N., Shibuya M., Kurata T., Matsuda M. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol. Cell. Biol. 1996, 16:1770-1776.
60. Heasman S.J., Ridley A.J. Mammalian Rho GTPases: new insights into their functions from invivo studies. Nat. Rev. Mol. Cell. Biol. 2008, 9:690-701.
61. Hellal F., Hurtado A., Ruschel J., Flynn K.C., Laskowski C.J., Umlauf M., Kapitein L.C., Strikis D., Lemmon V., Bixby J., Hoogenraad C.C., Bradke F. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science 2011, 331:928-931.
62. Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J.Cell. Biol. 2010, 190:461-477.
63. Hirata E., Yukinaga H., Kamioka Y., Arakawa Y., Miyamoto S., Okada T., Sahai E., Matsuda M. Invivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. J.Cell. Sci. 2012, 125:858-868.
64. Hochreiter-Hufford A.E., Lee C.S., Kinchen J.M., Sokolowski J.D., Arandjelovic S., Call J.A., Klibanov A.L., Yan Z., Mandell J.W., Ravichandran K.S. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature 2013, 497:263-267.
65. Hur E.M., Zhou F.Q. GSK3 signalling in neural development. Nat. Rev. Neurosci. 2010, 11:539-551.
66. Iida F., Matsushima Y., Hiai H., Uga S., Honda Y. Rupture of lens cataract: a novel hereditary recessive cataract model in the mouse. Exp. Eye Res. 1997, 64:107-113.
67. Ittner L.M., Ke Y.D., Delerue F., Bi M., Gladbach A., van Eersel J., Wolfing H., Chieng B.C., Christie M.J., Napier I.A., Eckert A., Staufenbiel M., Hardeman E., Gotz J. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 2010, 142:387-397.
68. Inoue T., Tanihara H. Rho-associated kinase inhibitors: a novel glaucoma therapy. Prog. Retin. Eye Res. 2013, 37:1-12.
69. Iwase A., Suzuki Y., Araie M., Yamamoto T., Abe H., Shirato S., Kuwayama Y., Mishima H.K., Shimizu H., Tomita G., Inoue Y., Kitazawa Y. The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmology 2004, 111:1641-1648.
70. Jabara H.H., McDonald D.R., Janssen E., Massaad M.J., Ramesh N., Borzutzky A., Rauter I., Benson H., Schneider L., Baxi S., Recher M., Notarangelo L.D., Wakim R., Dbaibo G., Dasouki M., Al-Herz W., Barlan I., Baris S., Kutukculer N., Ochs H.D., Plebani A., Kanariou M., Lefranc G., Reisli I., Fitzgerald K.A., Golenbock D., Manis J., Keles S., Ceja R., Chatila T.A., Geha R.S. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat. Immunol. 2012, 13:612-620.
71. Jungmichel S., Sylvestersen K.B., Choudhary C., Nguyen S., Mann M., Nielsen M.L. Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry. Cell. Rep. 2014, 6:578-591.
72. Ju W.K., Kim K.Y., Angert M., Duong-Polk K.X., Lindsey J.D., Ellisman M.H., Weinreb R.N. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest. Ophthalmol. Vis. Sci. 2009, 50:707-716.
73. Karnoub A.E., Weinberg R.A. Ras oncogenes: split personalities. Nat. Rev. Mol. Cell. Biol. 2008, 9:517-531.
74. Kashiwa A., Yoshida H., Lee S., Paladino T., Liu Y., Chen Q., Dargusch R., Schubert D., Kimura H. Isolation and characterization of novel presenilin binding protein. J.Neurochem. 2000, 75:109-116.
75. Katoh H., Negishi M. RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature 2003, 424:461-464.
76. Katome T., Namekata K., Guo X., Semba K., Kittaka D., Kawamura K., Kimura A., Harada C., Ichijo H., Mitamura Y., Harada T. Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury. Cell. Death Differ. 2013, 20:270-280.
77. Kitamura Y., Shibagaki K., Takata K., Tsuchiya D., Taniguchi T., Gebicke-Haerter P.J., Miki H., Takenawa T., Shimohama S. Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta (1-42) in rat microglia. J.Pharmacol. Sci. 2003, 92:115-123.
78. Klein B.E., Klein R., Sponsel W.E., Franke T., Cantor L.B., Martone J., Menage M.J. Prevalence of glaucoma. The Beaver Dam eye study. Ophthalmology 1992, 99:1499-1504.
79. Koester M.P., Muller O., Pollerberg G.E. Adenomatous polyposis coli is differentially distributed in growth cones and modulates their steering. J.Neurosci. 2007, 27:12590-12600.
80. Komander D., Patel M., Laurin M., Fradet N., Pelletier A., Barford D., Côté J.F. An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol. Biol. Cell. 2008, 19:4837-4851.
81. Kozma R., Sarner S., Ahmed S., Lim L. Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol. Cell. Biol. 1997, 17:1201-1211.
82. Kubo T., Hata K., Yamaguchi A., Yamashita T. Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. Curr. Pharm. Des. 2007, 13:2493-2499.
83. Kulkarni K., Yang J., Zhang Z., Barford D. Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors. J.Biol. Chem. 2011, 286:25341-25351.
84. Kuramoto K., Negishi M., Katoh H. Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons. J.Neurosci. Res. 2009, 87:1794-1805.
85. Kurimoto T., Yin Y., Omura K., Gilbert H.Y., Kim D., Cen L.P., Moko L., Kugler S., Benowitz L.I. Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. J.Neurosci. 2010, 30:15654-15663.
86. Laurin M., Côté J.F. Insights into the biological functions of Dock family guanine nucleotide exchange factors. Genes. Dev. 2014, 28:533-547.
87. Laurin M., Fradet N., Blangy A., Hall A., Vuori K., Côté J.F. The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion invivo. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:15446-15451.
88. Laurin M., Huber J., Pelletier A., Houalla T., Park M., Fukui Y., Haibe-Kains B., Muller W.J., Côté J.F. Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:7434-7439.
89. Le Floc'h A., Tanaka Y., Bantilan N.S., Voisinne G., Altan-Bonnet G., Fukui Y., Huse M. Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. J.Exp. Med. 2013, 210:2721-2737.
90. Li D.W., Liu Z.Q., Chen W., Yao M., Li G.R. Association of glycogen synthase kinase-3β with Parkinson's disease (review). Mol. Med. Rep. 2014, 9:2043-2050.
91. Li J.B., Lu Z.G., Xu L., Wang Q., Zhang Z.H., Fang J.H. Neuroprotective effects of bis(7)-tacrine in a rat model of pressure-induced retinal ischemia. Cell. Biochem. Biophys. 2014, 68:275-282.
92. Li H., Yang L., Fu H., Yan J., Wang Y., Guo H., Hao X., Xu X., Jin T., Zhang N. Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis. Nat. Commun. 2013, 4:1706.
93. Li X., Gao X., Liu G., Xiong W., Wu J., Rao Y. Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Nat. Neurosci. 2008, 11:28-35.
94. Liang X., Wang Q., Hand T., Wu L., Breyer R.M., Montine T.J., Andreasson K. Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J.Neurosci. 2005, 25:10180-10187.
95. Lin Q., Yang W., Baird D., Feng Q., Cerione R.A. Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. J.Biol. Chem. 2006, 281:35253-35262.
96. Lu M., Kinchen J.M., Rossman K.L., Grimsley C., Hall M., Sondek J., Hengartner M.O., Yajnik V., Ravichandran K.S. ASteric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Curr. Biol. 2005, 15:371-377.
97. Maes M., Fišar Z., Medina M., Scapagnini G., Nowak G., Berk M. New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates-Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology 2012, 20:127-150.
98. Makino Y., Tsuda M., Ichihara S., Watanabe T., Sakai M., Sawa H., Nagashima K., Hatakeyama S., Tanaka S. Elmo1 inhibits ubiquitylation of Dock180. J.Cell. Sci. 2006, 119:923-932.
99. McCubrey J.A., Steelman L.S., Bertrand F.E., Davis N.M., Sokolosky M., Abrams S.L., Montalto G., D'Assoro A.B., Libra M., Nicoletti F., Maestro R., Basecke J., Rakus D., Gizak A., Demidenko Z.N., Cocco L., Martelli A.M., Cervello M. GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget 2014, 5:881-911.
100. Medina M., Avila J. New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease. Expert Opin. Ther. Targets 2014, 18:69-77.
101. Meller N., Irani-Tehrani M., Kiosses W.B., Del Pozo M.A., Schwartz M.A. Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. Nat. Cell. Biol. 2002, 4:639-647.
102. Meller N., Irani-Tehrani M., Ratnikov B.I., Paschal B.M., Schwartz M.A. The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain. J.Biol. Chem. 2004, 279:37470-37476.
103. Meller N., Merlot S., Guda C. CZH proteins: a new family of Rho-GEFs. J.Cell. Sci. 2005, 118:4937-4946.
104. Miletic A.V., Sakata-Sogawa K., Hiroshima M., Hamann M.J., Gomez T.S., Ota N., Kloeppel T., Kanagawa O., Tokunaga M., Billadeau D.D., Swat W. Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. J.Biol. Chem. 2006, 281:38257-38265.
105. Miyamoto Y., Torii T., Yamamori N., Ogata T., Tanoue A., Yamauchi J. Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons. Sci. Signal. 2013, 6:ra15.
106. Miyamoto Y., Yamauchi J., Sanbe A., Tanoue A. Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Exp. Cell. Res. 2007, 313:791-804.
107. Mony L., Kew J.N., Gunthorpe M.J., Paoletti P. Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. Br. J. Pharmacol. 2009, 157:1301-1317.
108. Mou F., Praskova M., Xia F., Van Buren D., Hock H., Avruch J., Zhou D. The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J.Exp. Med. 2012, 209:741-759.
109. Namekata K., Enokido Y., Iwasawa K., Kimura H. MOCA induces membrane spreading by activating Rac1. J.Biol. Chem. 2004, 279:14331-14337.
110. Namekata K., Harada C., Guo X., Kimura A., Kittaka D., Watanabe H., Harada T. Dock3 stimulates axonal outgrowth via GSK-3beta-mediated microtubule assembly. J.Neurosci. 2012, 32:264-274.
111. Namekata K., Harada C., Taya C., Guo X., Kimura H., Parada L.F., Harada T. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:7586-7591.
112. Namekata K., Kimura A., Kawamura K., Guo X., Harada C., Tanaka K., Harada T. Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma. Cell. Death Differ. 2013, 20:1250-1256.
113. Namekata K., Watanabe H., Guo X., Kittaka D., Kawamura K., Kimura A., Harada C., Harada T. Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG. Genes. Cells 2012, 17:688-697.
114. Nava C., Keren B., Mignot C., Rastetter A., Chantot-Bastaraud S., Faudet A., Fonteneau E., Amiet C., Laurent C., Jacquette A., Whalen S., Afenjar A., Perisse D., Doummar D., Dorison N., Leboyer M., Siffroi J.P., Cohen D., Brice A., Heron D., Depienne C. Prospective diagnostic analysis of copy number variants using SNP microarrays in individuals with autism spectrum disorders. Eur. J. Hum. Genet. 2014, 22:71-78.
115. Neubrand V.E., Thomas C., Schmidt S., Debant A., Schiavo G. Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio. J.Cell. Sci. 2010, 123:2111-2123.
116. Nishikimi A., Meller N., Uekawa N., Isobe K., Schwartz M.A., Maruyama M. Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett. 2005, 579:1039-1046.
117. Nobes C.D., Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62.
118. Nutt J.G., Gunzler S.A., Kirchhoff T., Hogarth P., Weaver J.L., Krams M., Jamerson B., Menniti F.S., Landen J.W. Effects of a NR2B selective NMDA glutamate antagonist, CP-101, 606, on dyskinesia and Parkinsonism. Mov. Disord. 2008, 13:1860-1866.
119. Ogawa K., Tanaka Y., Uruno T., Duan X., Harada Y., Sanematsu F., Yamamura K., Terasawa M., Nishikimi A., Côté J.F., Fukui Y. DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation. J.Exp. Med. 2014, pii: jem.20131926.
120. Omi N., Kiyokawa E., Matsuda M., Kinoshita K., Yamada S., Yamada K., Matsushima Y., Wang Y., Kawai J., Suzuki M., Hayashizaki Y., Hiai H. Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp. Eye Res. 2008, 86:828-834.
121. Orlic-Milacic M., Kaufman L., Mikhailov A., Cheung A.Y., Mahmood H., Ellis J., Gianakopoulos P.J., Minassian B.A., Vincent J.B. Over-expression of either MECP2_e1 or MECP2_e2 in neuronally differentiated cells results in different patterns of gene expression. PLoS One 2014, 9:e91742.
122. Osborne N.N. Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned. Acta. Ophthalmol. 2009, 87:450-454.
123. Pagnamenta A.T., Bacchelli E., de Jonge M.V., Mirza G., Scerri T.S., Minopoli F., Chiocchetti A., Ludwig K.U., Hoffmann P., Paracchini S., Lowy E., Harold D.H., Chapman J.A., Klauck S.M., Poustka F., Houben R.H., Staal W.G., Ophoff R.A., O'Donovan M.C., Williams J., Nothen M.M., Schulte-Korne G., Deloukas P., Ragoussis J., Bailey A.J., Maestrini E., Monaco A.P. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biol. Psychiatry 2010, 68:320-328. International Molecular Genetic Study Of Autism, C.
124. Palomo V., Perez D.I., Gil C., Martinez A. The potential role of glycogen synthase kinase 3 inhibitors as amyotrophic lateral sclerosis pharmacological therapy. Curr. Med. Chem. 2011, 18:3028-3034.
125. Pankratz N., Beecham G.W., DeStefano A.L., Dawson T.M., Doheny K.F., Factor S.A., Hamza T.H., Hung A.Y., Hyman B.T., Ivinson A.J., Krainc D., Latourelle J.C., Clark L.N., Marder K., Martin E.R., Mayeux R., Ross O.A., Scherzer C.R., Simon D.K., Tanner C., Vance J.M., Wszolek Z.K., Zabetian C.P., Myers R.H., Payami H., Scott W.K., Foroud T. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann. Neurol. 2012, 71:370-384. Consortium, P.G.
126. Paoletti P., Bellone C., Zhou Q. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat. Rev. Neurosci. 2013, 14:383-400.
127. Park D., Tosello-Trampont A.C., Elliott M.R., Lu M., Haney L.B., Ma Z., Klibanov A.L., Mandell J.W., Ravichandran K.S. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 2007, 450:430-434.
128. Park K.K., Liu K., Hu Y., Smith P.D., Wang C., Cai B., Xu B., Connolly L., Kramvis I., Sahin M., He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 2008, 322:963-966.
129. Patel M., Margaron Y., Fradet N., Yang Q., Wilkes B., Bouvier M., Hofmann K., Côté J.F. An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling. Curr. Biol. 2010, 20:2021-2027.
130. Patel M., Pelletier A., Côté J.F. Opening up on ELMO regulation: new insights into the control of Rac signaling by the DOCK180/ELMO complex. Small GTPases 2011, 2:268-275.
131. Pertz O.C., Wang Y., Yang F., Wang W., Gay L.J., Gristenko M.A., Clauss T.R., Anderson D.J., Liu T., Auberry K.J., Camp D.G., Smith R.D., Klemke R.L. Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:1931-1936.
132. Picard M., Petrie R.J., Antoine-Bertrand J., Saint-Cyr-Proulx E., Villemure J.F., Lamarche-Vane N. Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth. Cell. Signal 2009, 21:1961-1973.
133. Pochwat B., Pałucha-Poniewiera A., Szewczyk B., Pilc A., Nowak G. NMDA antagonists under investigation for the treatment of major depressive disorder. Expert Opin. Investig. Drugs 2014, 12:1-12.
134. Premkumar L., Bobkov A.A., Patel M., Jaroszewski L., Bankston L.A., Stec B., Vuori K., Côté J.F., Liddington R.C. Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J.Biol. Chem. 2010, 285:13211-13222.
135. Purro S.A., Ciani L., Hoyos-Flight M., Stamatakou E., Siomou E., Salinas P.C. Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J.Neurosci. 2008, 28:8644-8654.
136. Randall K.L., Chan S.S., Ma C.S., Fung I., Mei Y., Yabas M., Tan A., Arkwright P.D., Al Suwairi W., Lugo Reyes S.O., Yamazaki-Nakashimada M.A., Garcia-Cruz Mde L., Smart J.M., Picard C., Okada S., Jouanguy E., Casanova J.L., Lambe T., Cornall R.J., Russell S., Oliaro J., Tangye S.G., Bertram E.M., Goodnow C.C. DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J.Exp. Med. 2011, 208:2305-2320.
137. Randall K.L., Lambe T., Johnson A.L., Treanor B., Kucharska E., Domaschenz H., Whittle B., Tze L.E., Enders A., Crockford T.L., Bouriez-Jones T., Alston D., Cyster J.G., Lenardo M.J., Mackay F., Deenick E.K., Tangye S.G., Chan T.D., Camidge T., Brink R., Vinuesa C.G., Batista F.D., Cornall R.J., Goodnow C.C. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat. Immunol. 2009, 10:1283-1291.
138. Ren M., Senatorov V.V., Chen R.W., Chuang D.M. Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:6210-6215.
139. Roche K.W., Standley S., McCallum J., Dune Ly C., Ehlers M.D., Wenthold R.J. Molecular determinants of NMDA receptor internalization. Nat. Neurosci. 2001, 4:794-802.
140. Rossman K.L., Der C.J., Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell. Biol. 2005, 6:167-180.
141. Sakabe I., Asai A., Iijima J., Maruyama M. Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells. Immun. Ageing 2012, 9:2.
142. Sakai Y., Tanaka Y., Yanagihara T., Watanabe M., Duan X., Terasawa M., Nishikimi A., Sanematsu F., Fukui Y. The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation. Blood 2013, 122:386-393.
143. Sakthivel K.M., Prabhu V.V., Guruvayoorappan C. WAVEs: a novel and promising weapon in the cancer therapy tool box. Asian Pac. J. Cancer Prev. 2012, 13:1719-1722.
144. Sanal O., Jing H., Ozgur T., Ayvaz D., Strauss-Albee D.M., Ersoy-Evans S., Tezcan I., Turkkani G., Matthews H.F., Haliloglu G., Yuce A., Yalcin B., Gokoz O., Oguz K.K., Su H.C. Additional diverse findings expand the clinical presentation of DOCK8 deficiency. J.Clin. Immunol. 2012, 32:698-708.
145. Sanui T., Inayoshi A., Noda M., Iwata E., Oike M., Sasazuki T., Fukui Y. DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells. Immunity 2003, 19:119-129.
146. Savio T., Schwab M.E. Lesioned corticospinal tract axons regenerate in myelin-free rat spinal cord. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:4130-4133.
147. Schwechter B., Rosenmund C., Tolias K.F. RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:14462-14467.
148. Semba K., Namekata K., Guo X., Harada C., Harada T., Mitamura Y. Renin-angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma. Cell. Death Dis. 2014, 5:e1333.
149. Semba K., Namekata K., Kimura A., Harada C., Mitamura Y., Harada T. Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma. Cell. Death Dis. 2014, 5:e1341.
150. Sengottuvel V., Fischer D. Facilitating axon regeneration in the injured CNS by microtubules stabilization. Commun. Integr. Biol. 2011, 4:391-393.
151. Sengottuvel V., Leibinger M., Pfreimer M., Andreadaki A., Fischer D. Taxolfacilitates axon regeneration in the mature CNS. J.Neurosci. 2011, 31:2688-2699.
152. Shaheen R., Faqeih E., Sunker A., Morsy H., Al-Sheddi T., Shamseldin H.E., Adly N., Hashem M., Alkuraya F.S. Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. Am. J. Hum. Genet. 2011, 89:328-333.
153. Shankar G.M., Bloodgood B.L., Townsend M., Walsh D.M., Selkoe D.J., Sabatini B.L. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J.Neurosci. 2007, 27:2866-2875.
154. Sobczyk A., Scheuss V., Svoboda K. NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines. J.Neurosci. 2005, 25:6037-6046.
155. Soleman S., Filippov M.A., Dityatev A., Fawcett J.W. Targeting the neural extracellular matrix in neurological disorders. Neuroscience 2013, 253:194-213.
156. Stevenson C., de la Rosa G., Anderson C.S., Murphy P.S., Capece T., Kim M., Elliott M.R. Essential role of elmo1 in dock2-dependent lymphocyte migration. J.Immunol. 2014, 192:6062-6070.
157. Sun F., Park K.K., Belin S., Wang D., Lu T., Chen G., Zhang K., Yeung C., Feng G., Yankner B.A., He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature 2011, 480:372-375.
158. Tachi N., Hashimoto Y., Matsuoka M. MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid beta precursor protein and presenilins. Biochem. J. 2012, 442:413-422.
159. Takenawa T., Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat. Rev. Mol. Cell. Biol. 2007, 8:37-48.
160. Tanihara H., Inoue T., Yamamoto T., Kuwayama Y., Abe H., Araie M., K-115 Clinical Study Group Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension. Am. J. Ophthalmol. 2013, 156:731-736.
161. Terasawa M., Uruno T., Mori S., Kukimoto-Niino M., Nishikimi A., Sanematsu F., Tanaka Y., Yokoyama S., Fukui Y. Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration. PLoS One 2012, 7:e46277.
162. Thrasher A.J., Burns S.O. WASP: a key immunological multitasker. Nat. Rev. Immunol. 2010, 10:182-192.
163. Tolias K.F., Bikoff J.B., Burette A., Paradis S., Harrar D., Tavazoie S., Weinberg R.J., Greenberg M.E. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron 2005, 45:525-538.
164. Ueda S., Negishi M., Katoh H. Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation. Mol. Biol. Cell. 2013, 24:1602-1613.
165. Upadhyay G., Goessling W., North T.E., Xavier R., Zon L.I., Yajnik V. Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling. Oncogene 2008, 27:5845-5855.
166. Valvezan A.J., Klein P.S. GSK-3 and wnt signaling in neurogenesis and bipolar disorder. Front. Mol. Neurosci. 2012, 5:1.
167. Vives V., Laurin M., Cres G., Larrousse P., Morichaud Z., Noel D., Côté J.F., Blangy A. The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts. J.Bone Min. Res. 2011, 26:1099-1110.
168. Wahl A.S., Schwab M.E. Finding an optimal rehabilitation paradigm after stroke: enhancing fiber growth and training of the brain at the right moment. Front. Hum. Neurosci. 2014, 7:911.
169. Wang S.K., Chang R.T. An emerging treatment option for glaucoma: rho kinase inhibitors. Clin. Ophthalmol. 2014, 8:883-890.
170. Watabe-Uchida M., John K.A., Janas J.A., Newey S.E., Van Aelst L. The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron 2006, 51:727-739.
171. Waters J.E., Astle M.V., Ooms L.M., Balamatsias D., Gurung R., Mitchell C.A. P-Rex1-a multidomain protein that regulates neurite differentiation. J.Cell. Sci. 2008, 121:2892-2903.
172. Watkins T.A., Wang B., Huntwork-Rodriguez S., Yang J., Jiang Z., Eastham-Anderson J., Modrusan Z., Kaminker J.S., Tessier-Lavigne M., Lewcock J.W. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:4039-4044.
173. Wu X., Ramachandran S., Lin M.C., Cerione R.A., Erickson J.W. Aminimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180. Biochemistry 2011, 50:1070-1080.
174. Xiao Y., Peng Y., Wan J., Tang G., Chen Y., Tang J., Ye W.C., Ip N.Y., Shi L. The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics. J.Biol. Chem. 2013, 288:20034-20045.
175. Yajnik V., Paulding C., Sordella R., McClatchey A.I., Saito M., Wahrer D.C., Reynolds P., Bell D.W., Lake R., van den Heuvel S., Settleman J., Haber D.A. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell 2003, 112:673-684.
176. Yamauchi J., Miyamoto Y., Chan J.R., Tanoue A. ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J.Cell. Biol. 2008, 181:351-365.
177. Yang J., Zhang Z., Roe S.M., Marshall C.J., Barford D. Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science 2009, 325:1398-1402.
178. Yang Y.T., Wang C.L., Van Aelst L. DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat. Neurosci. 2012, 15:1201-1210.
179. Yashiro K., Philpot B.D. Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity. Neuropharmacology 2008, 55:1081-1094.
180. Yelo E., Bernardo M.V., Gimeno L., Alcaraz-García M.J., Majado M.J., Parrado A. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. Mol. Immunol. 2008, 45:3411-3418.
181. Yin Y., Henzl M.T., Lorber B., Nakazawa T., Thomas T.T., Jiang F., Langer R., Benowitz L.I. Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat. Neurosci. 2006, 9:843-852.
182. Yokota Y., Kim W.Y., Chen Y., Wang X., Stanco A., Komuro Y., Snider W., Anton E.S. The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex. Neuron 2009, 61:42-56.
183. Yoshimura T., Kawano Y., Arimura N., Kawabata S., Kikuchi A., Kaibuchi K. GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 2005, 120:137-149.
184. Yurkewicz L., Weaver J., Bullock M.R., Marshall L.F. The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury. J.Neurotrauma 2005, 22:1428-1443.
185. Zeron M.M., Hansson O., Chen N., Wellington C.L., Leavitt B.R., Brundin P., Hayden M.R., Raymond L.A. Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron 2002, 33:849-860.
186. Zhang Q., Davis J.C., Lamborn I.T., Freeman A.F., Jing H., Favreau A.J., Matthews H.F., Davis J., Turner M.L., Uzel G., Holland S.M., Su H.C. Combined immunodeficiency associated with DOCK8 mutations. N.Engl. J. Med. 2009, 361:2046-2055.
187. Zhou F.Q., Zhou J., Dedhar S., Wu Y.H., Snider W.D. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 2004, 42:897-912.
188. Zhou L., Opalinska J., Sohal D., Yu Y., Mo Y., Bhagat T., Abdel-Wahab O., Fazzari M., Figueroa M., Alencar C., Zhang J., Kambhampati S., Parmar S., Nischal S., Hueck C., Suzuki M., Freidman E., Pellagatti A., Boultwood J., Steidl U., Sauthararajah Y., Yajnik V., McMahon C., Gore S.D., Platanias L.C., Levine R., Melnick A., Wickrema A., Greally J.M., Verma A. Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. J.Biol. Chem. 2011, 286:25211-25223.