Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 25211-25223

  Zhou, Li ^a   Opalinska, Joanna ^a   Sohal, Davendra ^a   Yu, Yiting ^a   Mo, Yongkai ^a   Bhagat, Tushar ^a   Abdel Wahab, Omar ^b   Fazzari, Melissa ^a   Figueroa, Maria ^c   Alencar, Cristina ^a   Zhang, Jinghang ^a   Kambhampati, Suman ^d   Parmar, Simrit ^e   Nischal, Sangeeta ^a   Hueck, Christoph ^a   Suzuki, Masako ^a   Freidman, Ellen ^a   Pellagatti, Andrea ^f   Boultwood, Jacqueline ^f   Steidl, Ulrich ^a   Sauthararajah, Yogen ^g   Yajnik, Vijay ^h   Mcmahon, Christine ^a   Gore, Steven D ⁱ   Platanias, Leonidas C ^j   Levine, Ross ^b   Melnick, Ari ^c   Wickrema, Amittha ^k   Greally, John M ^a   Vermaa, Amit ^a   more..

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^g UNIVERSITY OF CHICAGO   (United States)

^h LERNER RESEARCH INSTITUTE   (United States)

ⁱ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^j JOHNS HOPKINS UNIVERSITY   (United States)

^k NORTHWESTERN UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AGE-MATCHED CONTROLS; BONE MARROW; BONE MARROW STEM CELLS; CHROMOSOMAL REGIONS; COLONY FORMATION; COMPARATIVE GENOMIC HYBRIDIZATIONS; CPG ISLANDS; DATA SETS; EPIGENETIC ALTERATIONS; HYPERMETHYLATION; INTEGRATIVE ANALYSIS; PERIPHERAL BLOOD;

BLOOD; BONE; CELL DEATH; STEM CELLS;

GENES;

CD34 ANTIGEN; GENOMIC DNA; GUANOSINE TRIPHOSPHATASE; PROTEIN DOCK4; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BONE MARROW BIOPSY; BONE MARROW DEPRESSION; CD34 SELECTION; CHROMOSOME 7Q; CLINICAL ARTICLE; COLONY FORMATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOCK4 GENE; EPIGENETICS; ERYTHROID CELL; GENE; GENE AMPLIFICATION; GENE DELETION; GENE LOCATION; GENE SILENCING; GENOME ANALYSIS; HELP ASSAY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE; MICROARRAY ANALYSIS; MYELODYSPLASTIC SYNDROME; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; BONE MARROW CELLS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 7; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENETIC MARKERS; GTPASE-ACTIVATING PROTEINS; HUMANS; LEUKOCYTES; MALE; MYELODYSPLASTIC SYNDROMES; STEM CELLS;

EID: 79960149493     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.235028     Document Type: Article

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