Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

Nature Cell Biology

Volumn 4, Issue 9, 2002, Pages 639-647

  Meller, Nahum ^a   Irani Tehrani, Mohammad ^a   Kiosses, William B ^a   Del Pozo, Miguel A ^a   Schwartz, Martin A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG; ZIZZIMIN1;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CELL GROWTH; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; RAT; REGULATORY MECHANISM;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CDC42 GTP-BINDING PROTEIN; CLONING, MOLECULAR; ENZYME ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RHO GTP-BINDING PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0036713381     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb835     Document Type: Article

References (29)

1. Rho GTPases and their effector proteins
2. Effectors for the Rho GTPases
3. GEFs: Structural basis for their activation of small GTP-binding proteins
4. The Dbl family of oncogenes
5. Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
6. C. Elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
7. Activation of Rac1 by a Crk SH3-binding protein, DOCK180
8. Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins
9. Evidence that DOCK180 upregulates signals from the CrkII-p13O(Cas) complex
10. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
11. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
12. Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes
13. Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
14. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
15. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells
16. The Pfam protein families database
17. Predicting coiled coils by use of pairwise residue correlations
18. Prediction and analysis of coiled-coil structures
19. Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling
20. A modulator of the Rho family G proteins, RhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
21. S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
22. Biochemical analysis of SopE from Salmonella typhimurium, a highly efficient guanosine nucleotide exchange factor for RhoGTPases
23. Ced- 12/elmo, a novel member of the crkII/dockl8O/rac pathway, is required for phagocytosis and cell migration
24. Plant GTPases: The Rhos in bloom
25. Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras
26. A role for p21-activated kinase in endothelial cell migration
27. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
28. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes
29. Multiple sequence alignment with hierarchical clustering