Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation

American Journal of Pathology

Volumn 159, Issue 5, 2001, Pages 1597-1602

  Chen, Qi ^a   Yoshida, Hirotaka ^a   Schubert, David ^a   Maher, Pamela ^b   Mallory, Margaret ^c   Masliah, Eliezer ^c  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PRESENILIN BINDING PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NEUROFIBRILLARY TANGLE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

EID: 0035155597     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63005-2     Document Type: Article

References (42)

1. Neurotransmitter enzyme abnormalities in senile dementia: CAT and GAD activities in necropsy tissue
2. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
3. The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type
4. Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex
5. Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?
6. Quantitative synaptic alterations in the human neocortex during normal aging
7. Presenilin structure, function, and role in Alzheimer's disease
8. Binding partners of Alzheimer's disease proteins: Are they physiologically relevant?
9. Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
10. Isolation and characterization of a novel presenilin binding protein
11. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
12. Changes in phosphorylation of tau during ischemia and reperfusion in the rabbit spinal cord
13. The distribution of tau in the mammalian central nervous system J Cell Biol
14. Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal
15. The fine structure of neurofibrillary tangles in Alzheimer's disease
16. Ultrastructural studies in Alzheimer's presenile dementia
17. The ultrastructure of the neurofibrillary tangle and the senile plaque
18. Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer's disease
19. Occurrence of neuropil threads in the senile brain and in Alzheimer's disease: A third location of paired helical filaments outside the neurofibrillary tangles and neuritic plaques
20. Neuropil threads occur in dendrites of tangle-bearing nerve cells
21. Re-evaluation of the structural organization of neuritic plaques in Alzheimer's disease
22. Altered Tau and neurofilament proteins in neurodegenerative diseases: Diagnostic implications for Alzheimer's disease and Lewy body dementias
23. Abnormal phosphorylation of the microtubule associated protein tau in Alzheimer cytoskeletal pathology
24. Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease
25. Immunological determinants of tau proteins are present in neurofibrillary tangles of Alzheimer's disease
26. Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
27. Tau in Alzheimer's disease
28. A68: A major subunit of paired helical filaments and derivatized forms of normal Tau
29. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
30. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
31. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17
32. Mutation in the tau gene in familiar multiple system tauopathy with presenile dementia
33. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
34. Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
35. FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10
36. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta
37. Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding
38. Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig
39. Amyloid-beta injection in rat amygdala alters tau protein but not mRNA expression
40. Aging renders the brain vulnerable to amyloid C-protein neurotoxicity
41. Role of Crk oncogene product in physiologic signaling
42. Tau protein isoforms, phosphorylation, and role in neurodegenerative disorders