-
1
-
-
33845729059
-
The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton
-
Takenawa, T. & Suetsugu, S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nature Rev. Mol. Cell Biol. 8, 37-48 (2007).
-
(2007)
Nature Rev. Mol. Cell Biol.
, vol.8
, pp. 37-48
-
-
Takenawa, T.1
Suetsugu, S.2
-
2
-
-
70349566487
-
The WASP and WAVE family proteins
-
Kurisu, S. & Takenawa, T. The WASP and WAVE family proteins. Genome Biol. 10, 226 (2009).
-
(2009)
Genome Biol.
, vol.10
, pp. 226
-
-
Kurisu, S.1
Takenawa, T.2
-
3
-
-
0030006284
-
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
-
Symons, M. et al. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84, 723-734 (1996).
-
(1996)
Cell
, vol.84
, pp. 723-734
-
-
Symons, M.1
-
4
-
-
0033574722
-
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
-
Rohatgi, R. et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97, 221-231 (1999).
-
(1999)
Cell
, vol.97
, pp. 221-231
-
-
Rohatgi, R.1
-
5
-
-
0032585538
-
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
-
Machesky, L. M. & Insall, R. H. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Curr. Biol. 8, 1347-1356 (1998).
-
(1998)
Curr. Biol.
, vol.8
, pp. 1347-1356
-
-
MacHesky, L.M.1
Insall, R.H.2
-
6
-
-
0032481290
-
Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization
-
Miki, H. & Takenawa, T. Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization. Biochem. Biophys. Res. Commun. 243, 73-78 (1998).
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.243
, pp. 73-78
-
-
Miki, H.1
Takenawa, T.2
-
7
-
-
0034720293
-
Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins
-
Blanchoin, L. et al. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins. Nature 404, 1007-1011 (2000).
-
(2000)
Nature
, vol.404
, pp. 1007-1011
-
-
Blanchoin, L.1
-
8
-
-
14044276352
-
The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-κB (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement
-
Huang, W., Ochs, H. D., Dupont, B. & Vyas, Y. M. The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-κB (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement. J. Immunol. 174, 2602-2611 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 2602-2611
-
-
Huang, W.1
Ochs, H.D.2
Dupont, B.3
Vyas, Y.M.4
-
9
-
-
0035877803
-
A role for Wiskott-Aldrich syndrome protein in T-cell receptor-mediated transcriptional activation independent of actin polymerization
-
Silvin, C. Belisle, B. & Abo, A. A role for Wiskott-Aldrich syndrome protein in T-cell receptor-mediated transcriptional activation independent of actin polymerization. J. Biol. Chem. 276, 21450-21457 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21450-21457
-
-
Silvin, C.1
Belisle, B.2
Abo, A.3
-
10
-
-
37749037456
-
Human subtelomeric WASH genes encode a new subclass of the WASP family
-
Linardopoulou, E. V. et al. Human subtelomeric WASH genes encode a new subclass of the WASP family. PLoS Genet. 3, 2477-2485 (2007).
-
(2007)
PLoS Genet.
, vol.3
, pp. 2477-2485
-
-
Linardopoulou, E.V.1
-
11
-
-
46149096223
-
WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport
-
Campellone, K. G., Webb, N. J., Znameroski, E. A. & Welch, M. D. WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. Cell 134, 148-161 (2008).
-
(2008)
Cell
, vol.134
, pp. 148-161
-
-
Campellone, K.G.1
Webb, N.J.2
Znameroski, E.A.3
Welch, M.D.4
-
12
-
-
0028116532
-
A multiinstitutional survey of the Wiskott-Aldrich syndrome
-
Sullivan, K. E., Mullen, C. A., Blaese, R. M. & Winkelstein, J. A. A multiinstitutional survey of the Wiskott-Aldrich syndrome. J. Pediatr. 125, 876-885 (1994).
-
(1994)
J. Pediatr.
, vol.125
, pp. 876-885
-
-
Sullivan, K.E.1
Mullen, C.A.2
Blaese, R.M.3
Winkelstein, J.A.4
-
13
-
-
0037736679
-
Autoimmunity in Wiskott-Aldrich syndrome: Risk factors, clinical features, and outcome in a single-center cohort of 55 patients
-
Dupuis-Girod, S. et al. Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. Pediatrics 111, e622-e627 (2003).
-
(2003)
Pediatrics
, vol.111
-
-
Dupuis-Girod, S.1
-
14
-
-
9144241005
-
Clinical course of patients with WASP gene mutations
-
Imai, K. et al. Clinical course of patients with WASP gene mutations. Blood 103, 456-464 (2004).
-
(2004)
Blood
, vol.103
, pp. 456-464
-
-
Imai, K.1
-
15
-
-
0035093787
-
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia
-
Devriendt, K. et al. Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia. Nature Genet. 27, 313-317 (2001).
-
(2001)
Nature Genet.
, vol.27
, pp. 313-317
-
-
Devriendt, K.1
-
16
-
-
33749343053
-
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia
-
Ancliff, P. J. et al. Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood 108, 2182-2189 (2006).
-
(2006)
Blood
, vol.108
, pp. 2182-2189
-
-
Ancliff, P.J.1
-
17
-
-
57449089754
-
A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene
-
Beel, K. et al. A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene. Br. J. Haematol. 144, 120-126 (2009).
-
(2009)
Br. J. Haematol.
, vol.144
, pp. 120-126
-
-
Beel, K.1
-
18
-
-
0034624753
-
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
-
Kim, A. S., Kakalis, L. T., Abdul-Manan, N., Liu, G. A. & Rosen, M. K. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404, 151-158 (2000).
-
(2000)
Nature
, vol.404
, pp. 151-158
-
-
Kim, A.S.1
Kakalis, L.T.2
Abdul-Manan, N.3
Liu, G.A.4
Rosen, M.K.5
-
19
-
-
0033609388
-
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein
-
Abdul-Manan, N. et al. Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature 399, 379-383 (1999).
-
(1999)
Nature
, vol.399
, pp. 379-383
-
-
Abdul-Manan, N.1
-
20
-
-
33947382640
-
Differential regulation of WASP and N-WASP by Cdc42 Rac1, Nck, and PI(4,5)P2
-
Tomasevic, N. et al. Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2. Biochemistry 46, 3494-3502 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 3494-3502
-
-
Tomasevic, N.1
-
21
-
-
0347915637
-
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation
-
Badour, K. et al. Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. J. Exp. Med. 199, 99-112 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 99-112
-
-
Badour, K.1
-
22
-
-
0035809163
-
A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42
-
Fukuoka, M. et al. A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. J. Cell Biol. 152, 471-482 (2001).
-
(2001)
J. Cell Biol.
, vol.152
, pp. 471-482
-
-
Fukuoka, M.1
-
23
-
-
0035854732
-
Nck and phosphatidylinositol 4, 5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway
-
Rohatgi R., Nollau, P., Ho, H. Y., Kirschner, M. W. & Mayer, B. J. Nck and phosphatidylinositol 4, 5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J. Biol. Chem. 276, 26448-26452 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26448-26452
-
-
Rohatgi, R.1
Nollau, P.2
Ho, H.Y.3
Kirschner, M.W.4
Mayer, B.J.5
-
25
-
-
3242671847
-
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex
-
Ho, H. Y. et al. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell 11 8, 203-216 (2004).
-
(2004)
Cell
, vol.11
, Issue.8
, pp. 203-216
-
-
Ho, H.Y.1
-
26
-
-
55049090663
-
Hierarchical regulation of WASP/ WAVE proteins
-
Padrick, S. B. et al. Hierarchical regulation of WASP/ WAVE proteins. Mol. Cell 32, 426-438 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 426-438
-
-
Padrick, S.B.1
-
27
-
-
0037160142
-
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein
-
Cory, G. O., Garg, R., Cramer, R. & Ridley, A. J. Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. J. Biol. Chem. 277, 45115-45121 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45115-45121
-
-
Cory, G.O.1
Garg, R.2
Cramer, R.3
Ridley, A.J.4
-
28
-
-
73949143369
-
Cdc42 regulates Fcγ receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich Syndrome protein (WASP) and neural-WASP
-
Park, H. & Cox, D. Cdc42 regulates Fcγ receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich Syndrome protein (WASP) and neural-WASP. Mol. Biol. Cell 20, 4500-11508 (2009).
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 4500-11508
-
-
Park, H.1
Cox, D.2
-
29
-
-
70450236976
-
Regulation of podosome dynamics by WASp phosphorylation: Implication in matrix degradation and chemotaxis in macrophages
-
Dovas, A. et al. Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages. J. Cell Sci. 122, 3873-3882 (2009).
-
(2009)
J. Cell Sci.
, vol.122
, pp. 3873-3882
-
-
Dovas, A.1
-
30
-
-
69949155572
-
The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: A role for phosphatidylinositol 3-kinase and Cdc42
-
Cammer, M. et al. The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42. J. Biol. Chem. 284, 23302-23311 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 23302-23311
-
-
Cammer, M.1
-
31
-
-
77649104423
-
Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid
-
Ma, T., Samanna, V. & Chellaiah, M. A. Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid. J. Mol. Signal. 3, 4 (2008).
-
(2008)
J. Mol. Signal.
, vol.3
, pp. 4
-
-
Ma, T.1
Samanna, V.2
Chellaiah, M.A.3
-
32
-
-
70349466839
-
Phosphorylation of WASp is a key regulator of activity and stability in vivo
-
Blundell, M. P. et al. Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc. Natl Acad. Sci. USA 106, 15738-15743 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 15738-15743
-
-
Blundell, M.P.1
-
33
-
-
0038392871
-
Contingent phosphorylation/ dephosphorylation provides a mechanism of molecular memory in WASP
-
Torres, E. & Rosen, M. K. Contingent phosphorylation/ dephosphorylation provides a mechanism of molecular memory in WASP. Mol. Cell 11, 1215-1227 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 1215-1227
-
-
Torres, E.1
Rosen, M.K.2
-
34
-
-
0038392873
-
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP
-
Cory, G. O., Cramer, R., Blanchoin, L. & Ridley, A. J. Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol. Cell 11, 1229-1239 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 1229-1239
-
-
Cory, G.O.1
Cramer, R.2
Blanchoin, L.3
Ridley, A.J.4
-
35
-
-
33751432818
-
WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells
-
Chou, H. C. et al. WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells. Curr. Biol. 16, 2337-2344 (2006).
-
(2006)
Curr. Biol.
, vol.16
, pp. 2337-2344
-
-
Chou, H.C.1
-
36
-
-
0942276831
-
Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T-and B-cell lineages
-
Konno, A. et al. Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T-and B-cell lineages. Blood 103, 676-678 (2004).
-
(2004)
Blood
, vol.103
, pp. 676-678
-
-
Konno, A.1
-
37
-
-
33846526209
-
WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP)
-
de la Fuente, M. A. et al. WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). Proc. Natl Acad. Sci. USA 104, 926-931 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 926-931
-
-
De La Fuente, M.A.1
-
38
-
-
0031446340
-
WIP a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells
-
Ramesh, N., Anton, I. M., Hartwig, J. H. & Geha, R. S. WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc. Natl Acad. Sci. USA 94, 14671-14676 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 14671-14676
-
-
Ramesh, N.1
Anton, I.M.2
Hartwig, J.H.3
Geha, R.S.4
-
39
-
-
0037112347
-
Structure of the N-WASP EVH1 domain-WIP complex: Insight into the molecular basis of Wiskott-Aldrich Syndrome
-
Volkman, B. F., Prehoda, K. E., Scott, J. A., Peterson, F. C. & Lim, W. A. Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell 111, 565-576 (2002).
-
(2002)
Cell
, vol.111
, pp. 565-576
-
-
Volkman, B.F.1
Prehoda, K.E.2
Scott, J.A.3
Peterson, F.C.4
Lim, W.A.5
-
40
-
-
34247179024
-
Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP
-
Peterson, F. C. et al. Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. J. Biol. Chem. 282, 8446-8453 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 8446-8453
-
-
Peterson, F.C.1
-
41
-
-
0036928182
-
Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation
-
Sasahara, Y. et al. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol. Cell 10, 1269-1281 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 1269-1281
-
-
Sasahara, Y.1
-
42
-
-
34548562065
-
Analysis of conformational changes in WASP using a split YFP
-
Lim, R. P., Misra, A., Wu, Z. & Thanabalu, T. Analysis of conformational changes in WASP using a split YFP. Biochem. Biophys. Res. Commun. 362, 1085-1089 (2007).
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.362
, pp. 1085-1089
-
-
Lim, R.P.1
Misra, A.2
Wu, Z.3
Thanabalu, T.4
-
43
-
-
2942717809
-
WASP (Wiskott-Aldrich syndrome protein) gene mutations and phenotype
-
Imai, K., Nonoyama, S. & Ochs, H. D. WASP (Wiskott-Aldrich syndrome protein) gene mutations and phenotype. Curr. Opin. Allergy Clin. Immunol. 3, 427-436 (2003).
-
(2003)
Curr. Opin. Allergy Clin. Immunol.
, vol.3
, pp. 427-436
-
-
Imai, K.1
Nonoyama, S.2
Ochs, H.D.3
-
44
-
-
0037383561
-
Macrophages of patients with X-linked thrombocytopenia display an attenuated Wiskott-Aldrich syndrome phenotype
-
Linder, S. et al. Macrophages of patients with X-linked thrombocytopenia display an attenuated Wiskott-Aldrich syndrome phenotype. Immunol. Cell Biol. 81, 130-136 (2003).
-
(2003)
Immunol. Cell Biol.
, vol.81
, pp. 130-136
-
-
Linder, S.1
-
45
-
-
33644939588
-
WIP: A multifunctional protein involved in actin cytoskeleton regulation
-
Anton, I. M. & Jones, G. E. WIP: A multifunctional protein involved in actin cytoskeleton regulation. Eur. J. Cell Biol. 85, 295-304 (2006).
-
(2006)
Eur. J. Cell Biol.
, vol.85
, pp. 295-304
-
-
Anton, I.M.1
Jones, G.E.2
-
46
-
-
0036198683
-
WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation
-
Anton, I. M. et al. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity 16, 193-204 (2002).
-
(2002)
Immunity
, vol.16
, pp. 193-204
-
-
Anton, I.M.1
-
47
-
-
0030612470
-
Expression of Wiskott-Aldrich syndrome protein (WASP) gene during haematopoietic differentiation
-
Parolini, O. et al. Expression of Wiskott-Aldrich syndrome protein (WASP) gene during haematopoietic differentiation. Blood 90, 70-75 (1997).
-
(1997)
Blood
, vol.90
, pp. 70-75
-
-
Parolini, O.1
-
48
-
-
0028932527
-
Nonrandom inactivation of the X chromosome in early lineage haematopoietic cells in carriers of Wiskott-Aldrich syndrome
-
Wengler, G., Gorlin, J. B., Williamson, J. M., Rosen, F. S. & Bing, D. H. Nonrandom inactivation of the X chromosome in early lineage haematopoietic cells in carriers of Wiskott-Aldrich syndrome. Blood 85, 2471-2477 (1995).
-
(1995)
Blood
, vol.85
, pp. 2471-2477
-
-
Wengler, G.1
Gorlin, J.B.2
Williamson, J.M.3
Rosen, F.S.4
Bing, D.H.5
-
49
-
-
0043240225
-
A defect in haematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome
-
Lacout, C. et al. A defect in haematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome. Blood 102, 1282-1289 (2003).
-
(2003)
Blood
, vol.102
, pp. 1282-1289
-
-
Lacout, C.1
-
50
-
-
0032118427
-
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
-
Snapper, S. B. et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 9, 81-91 (1998).
-
(1998)
Immunity
, vol.9
, pp. 81-91
-
-
Snapper, S.B.1
-
51
-
-
0033230229
-
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes
-
Zhang, J. et al. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J. Exp. Med. 190, 1329-1342 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1329-1342
-
-
Zhang, J.1
-
52
-
-
61849088892
-
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
-
Meyer-Bahlburg, A. et al. Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis. Blood 11 2, 4158-4169 (2008).
-
(2008)
Blood
, vol.11
, Issue.2
, pp. 4158-4169
-
-
Meyer-Bahlburg, A.1
-
53
-
-
34848899850
-
Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development
-
Cotta-de-Almeida, V. et al. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc. Natl Acad. Sci. USA 104, 15424-15429 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 15424-15429
-
-
Cotta-De-Almeida, V.1
-
54
-
-
61449190767
-
WASP confers selective advantage for specific haematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function
-
Westerberg, L. S. et al. WASP confers selective advantage for specific haematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. Blood 11 2, 4139-4147 (2008).
-
(2008)
Blood
, vol.11
, Issue.2
, pp. 4139-4147
-
-
Westerberg, L.S.1
-
55
-
-
46749091756
-
Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome
-
Davis, B. R. et al. Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome. Blood 111, 5064-5067 (2008).
-
(2008)
Blood
, vol.111
, pp. 5064-5067
-
-
Davis, B.R.1
-
56
-
-
69849106030
-
Revertant somatic mosaicism in the Wiskott-Aldrich syndrome
-
Davis, B. R. & Candotti, F. Revertant somatic mosaicism in the Wiskott-Aldrich syndrome. Immunol. Res. 44, 127-131 (2009).
-
(2009)
Immunol. Res.
, vol.44
, pp. 127-131
-
-
Davis, B.R.1
Candotti, F.2
-
57
-
-
0035871629
-
Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome
-
Ariga, T. et al. Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome. J. Immunol. 166, 5245-5249 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 5245-5249
-
-
Ariga, T.1
-
58
-
-
0035902552
-
Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism
-
Wada, T. et al. Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism. Proc. Natl Acad. Sci. USA 98, 8697-8702 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 8697-8702
-
-
Wada, T.1
-
59
-
-
0037108290
-
Wiskott-Aldrich syndrome in a female
-
Lutskiy, M. I., Sasahara, Y., Kenney, D. M., Rosen, F. S. & Remold-O'Donnell, E. Wiskott-Aldrich syndrome in a female. Blood 100, 2763-2768 (2002).
-
(2002)
Blood
, vol.100
, pp. 2763-2768
-
-
Lutskiy, M.I.1
Sasahara, Y.2
Kenney, D.M.3
Rosen, F.S.4
Remold-O'Donnell, E.5
-
60
-
-
0038665327
-
Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings
-
Wada, T. et al. Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings. J. Clin. Invest. 111, 1389-1397 (2003).
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1389-1397
-
-
Wada, T.1
-
61
-
-
34548447079
-
Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia
-
Moulding, D. A. et al. Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. J. Exp. Med. 204, 2213-2224 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2213-2224
-
-
Moulding, D.A.1
-
62
-
-
1842559666
-
Early deficit of lymphocytes in Wiskott-Aldrich syndrome: Possible role of WASP in human lymphocyte maturation
-
Park, J. Y. et al. Early deficit of lymphocytes in Wiskott-Aldrich syndrome: possible role of WASP in human lymphocyte maturation. Clin. Exp. Immunol. 136, 104-110 (2004).
-
(2004)
Clin. Exp. Immunol.
, vol.136
, pp. 104-110
-
-
Park, J.Y.1
-
63
-
-
28444459536
-
Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome
-
Wada, T., Schurman, S. H., Garabedian, E. K., Yachie, A. & Candotti, F. Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome. Blood 106, 3895-3897 (2005).
-
(2005)
Blood
, vol.106
, pp. 3895-3897
-
-
Wada, T.1
Schurman, S.H.2
Garabedian, E.K.3
Yachie, A.4
Candotti, F.5
-
64
-
-
0030816363
-
Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation
-
Gallego, M. D., Santamaria, M., Pena, J. & Molina, I. J. Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation. Blood 90, 3089-3097 (1997).
-
(1997)
Blood
, vol.90
, pp. 3089-3097
-
-
Gallego, M.D.1
Santamaria, M.2
Pena, J.3
Molina, I.J.4
-
65
-
-
31544454208
-
WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1α
-
Gallego, M. D. et al. WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1α. Int. Immunol. 18, 221-232 (2005).
-
(2005)
Int. Immunol.
, vol.18
, pp. 221-232
-
-
Gallego, M.D.1
-
66
-
-
4444310711
-
Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology
-
Majstoravich, S. et al. Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology. Blood 104, 1396-1403 (2004).
-
(2004)
Blood
, vol.104
, pp. 1396-1403
-
-
Majstoravich, S.1
-
67
-
-
0037241232
-
The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse
-
Badour, K. et al. The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. Immunity 18, 141-154 (2003).
-
(2003)
Immunity
, vol.18
, pp. 141-154
-
-
Badour, K.1
-
68
-
-
0036669692
-
Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation
-
Dupre, L. et al. Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation. Immunity 17, 157-166 (2002).
-
(2002)
Immunity
, vol.17
, pp. 157-166
-
-
Dupre, L.1
-
69
-
-
3242762840
-
Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production
-
Cannon, J. L. & Burkhardt, J. K. Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production. J. Immunol. 173, 1658-1662 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 1658-1662
-
-
Cannon, J.L.1
Burkhardt, J.K.2
-
71
-
-
33750806210
-
+ T cells from Wiskott-Aldrich syndrome patients
-
+ T cells from Wiskott-Aldrich syndrome patients. J. Immunol. 177, 7451-7461 (2006).
-
(2006)
J. Immunol.
, vol.177
, pp. 7451-7461
-
-
Trifari, S.1
-
72
-
-
77951709767
-
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
-
23 Dec doi:10.1182/blood-2009-07-235754
-
Morales-Tirado, V. et al. Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood 23 Dec 2009 (doi:10.1182/blood-2009-07-235754).
-
(2009)
Blood
-
-
Morales-Tirado, V.1
-
73
-
-
70949098060
-
Combined immunodeficiency associated with DOCK8 mutations
-
Zhang, Q. et al. Combined immunodeficiency associated with DOCK8 mutations. N. Engl. J. Med. 361, 2046-2055 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2046-2055
-
-
Zhang, Q.1
-
74
-
-
71149115670
-
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
-
Engelhardt, K. R. et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J. Allergy Clin. Immunol. 124, 1289-1302 (2009).
-
(2009)
J. Allergy Clin. Immunol.
, vol.124
, pp. 1289-1302
-
-
Engelhardt, K.R.1
-
75
-
-
70449718702
-
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
-
Randall, K. L. et al. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nature Immunol. 10, 1283-1291 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 1283-1291
-
-
Randall, K.L.1
-
76
-
-
12844254921
-
Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response
-
Westerberg, L. et al. Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response. Blood 105, 1144-1152 (2005).
-
(2005)
Blood
, vol.105
, pp. 1144-1152
-
-
Westerberg, L.1
-
77
-
-
68149163481
-
Innate-like recognition of microbes by invariant natural killer T cells
-
Kronenberg, M. & Kinjo, Y. Innate-like recognition of microbes by invariant natural killer T cells. Curr. Opin. Immunol. 21, 391-396 (2009).
-
(2009)
Curr. Opin. Immunol.
, vol.21
, pp. 391-396
-
-
Kronenberg, M.1
Kinjo, Y.2
-
78
-
-
70350546309
-
The contrasting roles of NKT cells in tumour immunity
-
Berzofsky, J. A. & Terabe, M. The contrasting roles of NKT cells in tumour immunity. Curr. Mol. Med. 9, 667-672 (2009).
-
(2009)
Curr. Mol. Med.
, vol.9
, pp. 667-672
-
-
Berzofsky, J.A.1
Terabe, M.2
-
79
-
-
67649216135
-
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells
-
Astrakhan, A., Ochs, H. D. & Rawlings, D. J. Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells. J. Immunol. 182, 7370-7380 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 7370-7380
-
-
Astrakhan, A.1
Ochs, H.D.2
Rawlings, D.J.3
-
80
-
-
65549150035
-
The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function
-
Locci, M. et al. The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function. J. Exp. Med. 206, 735-742 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 735-742
-
-
Locci, M.1
-
81
-
-
0034192223
-
Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis
-
Lorenzi, R., Brickell, P. M., Katz, D. R., Kinnon, C. & Thrasher, A. J. Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis. Blood 95, 2943-2946 (2000).
-
(2000)
Blood
, vol.95
, pp. 2943-2946
-
-
Lorenzi, R.1
Brickell, P.M.2
Katz, D.R.3
Kinnon, C.4
Thrasher, A.J.5
-
82
-
-
0035871703
-
Cutting edge: The Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells
-
Leverrier, Y. et al. Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells. J. Immunol. 166, 4831-4834 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 4831-4834
-
-
Leverrier, Y.1
-
83
-
-
36348952157
-
Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages
-
Tsuboi, S. & Meerloo, J. Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages. J. Biol. Chem. 282, 34194-34203 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 34194-34203
-
-
Tsuboi, S.1
Meerloo, J.2
-
84
-
-
0035883040
-
Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation
-
Burns, S., Thrasher, A. J., Blundell, M. P., Machesky, L. & Jones, G. E. Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation. Blood 98, 1142-1149 (2001).
-
(2001)
Blood
, vol.98
, pp. 1142-1149
-
-
Burns, S.1
Thrasher, A.J.2
Blundell, M.P.3
MacHesky, L.4
Jones, G.E.5
-
85
-
-
0033578374
-
Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages
-
Linder, S., Nelson, D., Weiss, M. & Aepfelbacher, M. Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages. Proc. Natl Acad. Sci. USA 96, 9648-9653 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 9648-9653
-
-
Linder, S.1
Nelson, D.2
Weiss, M.3
Aepfelbacher, M.4
-
86
-
-
0031831252
-
Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome
-
Zicha, D. et al. Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome. Br. J. Haematol. 101, 659-665 (1998).
-
(1998)
Br. J. Haematol.
, vol.101
, pp. 659-665
-
-
Zicha, D.1
-
87
-
-
0032528414
-
Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine
-
Badolato, R. et al. Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine. J. Immunol. 161, 1026-1033 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 1026-1033
-
-
Badolato, R.1
-
88
-
-
13544267428
-
Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein
-
de Noronha, S. et al. Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. Blood 105, 1590-1597 (2005).
-
(2005)
Blood
, vol.105
, pp. 1590-1597
-
-
De Noronha, S.1
-
89
-
-
39649094147
-
Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells
-
Bouma, G., Burns, S. & Thrasher, A. J. Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood 11 0, 4278-4284 (2007).
-
(2007)
Blood
, vol.11
, Issue.0
, pp. 4278-4284
-
-
Bouma, G.1
Burns, S.2
Thrasher, A.J.3
-
90
-
-
49049103195
-
+ T cells
-
+ T cells. J. Immunol. 181, 1135-1142 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 1135-1142
-
-
Pulecio, J.1
-
92
-
-
1642539127
-
Maturation of DC is associated with changes in motile characteristics and adherence
-
Burns, S. et al. Maturation of DC is associated with changes in motile characteristics and adherence. Cell. Motil. Cytoskeleton 57, 118-132 (2004).
-
(2004)
Cell. Motil. Cytoskeleton
, vol.57
, pp. 118-132
-
-
Burns, S.1
-
93
-
-
33747149898
-
Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils
-
Zhang, H. et al. Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity 25, 285-295 (2006).
-
(2006)
Immunity
, vol.25
, pp. 285-295
-
-
Zhang, H.1
-
94
-
-
0037143734
-
Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and co-localizes with actin to NK cell-activating immunologic synapses
-
Orange, J. S. et al. Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and co-localizes with actin to NK cell-activating immunologic synapses. Proc. Natl Acad. Sci. USA 99, 11351-11356 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 11351-11356
-
-
Orange, J.S.1
-
95
-
-
3142585003
-
Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: Ability of IL-2 to correct NK cell functional defect
-
Gismondi, A. et al. Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect. Blood 104, 436-443 (2004).
-
(2004)
Blood
, vol.104
, pp. 436-443
-
-
Gismondi, A.1
-
96
-
-
8644281284
-
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs
-
Borg, C. et al. NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood 104, 3267-3275 (2004).
-
(2004)
Blood
, vol.104
, pp. 3267-3275
-
-
Borg, C.1
-
97
-
-
33847161301
-
+ regulatory T cells
-
+ regulatory T cells. J. Exp. Med. 204, 381-391 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 381-391
-
-
Maillard, M.H.1
-
98
-
-
33846850600
-
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis
-
Humblet-Baron, S. et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J. Clin. Invest. 11 7, 407-418 (2007).
-
(2007)
J. Clin. Invest.
, vol.11
, Issue.7
, pp. 407-418
-
-
Humblet-Baron, S.1
-
99
-
-
33847168188
-
+ natural regulatory T cells
-
+ natural regulatory T cells. J. Exp. Med. 204, 369-380 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 369-380
-
-
Marangoni, F.1
-
100
-
-
34250687456
-
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome
-
Adriani, M. et al. Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin. Immunol. 124, 41-48 (2007).
-
(2007)
Clin. Immunol.
, vol.124
, pp. 41-48
-
-
Adriani, M.1
-
101
-
-
38049139182
-
Long-term outcome following haematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: Collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation
-
Ozsahin, H. et al. Long-term outcome following haematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation. Blood 111, 439-445 (2008).
-
(2008)
Blood
, vol.111
, pp. 439-445
-
-
Ozsahin, H.1
-
102
-
-
70349816649
-
- mice correlate with evidence of increased in vivo platelet consumption
-
- mice correlate with evidence of increased in vivo platelet consumption. Exp. Haematol. 37, 1353-1363 (2009).
-
(2009)
Exp. Haematol.
, vol.37
, pp. 1353-1363
-
-
Marathe, B.M.1
|