Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse

Experimental Eye Research

Volumn 86, Issue 5, 2008, Pages 828-834

  Omi, Natsue ^a,b,c   Kiyokawa, Etsuko ^a   Matsuda, Michiyuki ^a   Kinoshita, Kazuo ^b   Yamada, Shuichi ^d   Yamada, Kazumi ^d   Matsushima, Yoshibumi ^e   Wang, Yun ^a   Kawai, Jun ^c   Suzuki, Masanori ^c   Hayashizaki, Yoshihide ^c   Hiai, Hiroshi ^a,b  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Shiga Medical Center Research Institute   (Japan)

^c RIKEN   (Japan)

^d AKITA UNIVERSITY   (Japan)

^e SAITAMA CANCER CENTER   (Japan)

Author keywords

cataract; Dock5; mouse; mutation; rupture of lens

Indexed keywords

DEDICATOR OF CYTOKINESIS 180 PROTEIN; DEDICATOR OF CYTOKINESIS 5 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAC1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CONTROLLED STUDY; EXON; GENE DELETION; GENE LOCUS; GENE MAPPING; GENE MUTATION; LENS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

ANIMALS; CATARACT; CHROMOSOME MAPPING; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; EYE PROTEINS; GENES, RECESSIVE; GENETIC PREDISPOSITION TO DISEASE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HAPLOTYPES; LENS, CRYSTALLINE; MALE; MICE; MICE, INBRED BALB C; MUTATION; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RUPTURE, SPONTANEOUS; SIGNAL TRANSDUCTION;

EID: 42749085832     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.02.011     Document Type: Article

References (25)

1. Brazier H., Stephens S., Ory S., Fort P., Morrison N., and Blangy A. Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts. J. Bone Miner. Res. 21 (2006) 1387-1398
2. Côté J.F., and Vuori K. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell Sci. 115 (2002) 4901-4913
3. Côté J.F., Motoyama A.B., Bush J.A., and Vuori K. A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signaling. Nat. Cell Biol. 7 (2005) 797-807
4. Erickson M.R., Galletta B.J., and Abmayr S.M. Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. J. Cell Biol. 138 (1997) 589-603
5. Fukui Y., Hashimoto O., Sanui T., Oono T., Koga H., Abe M., Inayoshi A., Noda M., Oike M., Shirai S., and Sasazuki T. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412 (2001) 826-831
6. Gilmour D.T., Lyon G.J., Carlton M.B., Sanes J.R., Cunningham J.M., Anderson J.R., Hogan B.L., Evans M.J., and Colledge W.H. Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 17 (1998) 1860-1870
7. Graw J. Congenital hereditary cataracts. Int. J. Dev. Biol. 48 (2004) 1031-1044
8. Hasegawa H., Kiyokawa E., Tanaka S., Nagashima K., Gotoh N., Shibuya M., Kurata T., and Matsuda M. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol. Cell. Biol. 16 (1996) 1770-1776
9. Iida F., Matsushima Y., Hiai H., Uga S., and Honda Y. Rupture of lens cataract: a novel hereditary recessive cataract model in the mouse. Exp. Eye Res. 64 (1997) 107-111
10. Itoh R.E., Kurokawa K., Ohba Y., Yoshizaki H., Mochizuki N., and Matsuda M. Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single molecule probes in the membrane of living cells. Mol. Cell. Biol. 22 (2002) 6582-6591
11. Kim E., Ree S.D., Bae Y., Okumoto M., Yoon J.B., Song C.W., and Yoon S.D. Genomic organization of the region spanning D14Mit262 and D14Mit86 on mouse chromosome 14 and exclusion of Adam28 and Adamdec 1 as the cataract-causing gene. Cytogenet. Genome Res. 116 (2007) 12-17
12. Kiyokawa E., Hashimoto Y., Kobayashi S., Sugimura H., Kurata T., and Matsuda M. Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 12 (1998) 3331-3336
13. Kiyokawa E., Hashimoto Y., Kurata T., Sugimura H., and Matsuda M. Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex. J. Biol. Chem. 273 (1998) 24479-24484
14. Maddala R., Deng P.F., Costello J.M., Wawrousek E.F., Zigler J.S., and Rao P.V. Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. Lab. Invest. 84 (2004) 679-692
15. Matsushima Y., Kamoto T., Iida F., Abujiang P., Honda Y., and Hiai H. Mapping of rupture of lens cataract (rlc) on mouse chromosome 14. Genomics 36 (1996) 553-554
16. Moore C.A., Parkin C.A., Bidet Y., and Ingham P.W. A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion. Development 134 (2007) 3145-3153
17. Norose K., Lo W.K., Clark J.I., Sage E.H., and Howe C.C. Lenses of SPARC-null mice exhibit an abnormal cell surface basement membrane interface. Exp. Eye Res. 71 (2000) 295-307
18. Rao P.V., Robison Jr. W.G., Bettelheim F., Lin L.R., and Ziegler Jr. J.S. Role of small GTP-binding proteins in lovastatin-induced cataracts. Invest. Ophthalmol. Vis. Sci. 38 (1997) 2313-2321
19. Rao V., Wawrousek E., Tamm E.R., and Zigler Jr. J.S. Rho GTPase inactivation impairs lens growth and integrity. Lab. Invest. 82 (2002) 231-239
20. Rushton E., Drysdal R., Abmay S.M., Michelso A.M., and Bate M. Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development. Development 121 (1995) 1979-1988
21. Song C.W., Okumoto M., Mori N., Yamate J., Sakuma S., Kim S.S., Hilgers J., and Esaki K. A new hereditary cataract mouse with lens rupture. Lab. Anim. 31 (1997) 248-253
22. Terai K., and Matsuda M. The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. Embo J. 25l (2006) 3556-3564
23. Teramoto Y., Uga S., Matsushim Y., Shimizu K., Morita T., and Shirakawa S. Morphological study on rupture of posterior capsule in RLC mouse lens. Graefes Arch. Clin. Exp. Ophthalmol. 238 (2000) 970-978
24. Toda Y., Kono K., Abiru H., Kokuryo K., Endo M., Yaegashi H., and Fukumoto M. Application of tyramide signal amplification system to immunohistochemistry: a potent method to localize antigens that are not detectable by ordinary method. Pathol. Intern. 49 (1999) 479-483
25. Yajnik V., Paulding C., Sordella R., McClatchey A.I., Saito M., Wahrer D.C., Reynolds P., Bell D.W., Lake R., van den Heuvel S., Settleman J., and Haber D.A. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell 112 (2003) 673-684