Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis

Nature Communications

Volumn 4, Issue , 2013, Pages

  Li, Hongyan ^a,b   Yang, Lei ^a   Fu, Hui ^a   Yan, Jianshe ^b   Wang, Ying ^c   Guo, Hua ^a   Hao, Xishan ^a   Xu, Xuehua ^b   Jin, Tian ^b   Zhang, Ning ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Beichen Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ELMO1 PROTEIN; GALPHAI2 PROTEIN; RAC1 PROTEIN; RAC2 PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

BIOLOGICAL INVASION; CANCER; CELL ORGANELLE; GENE EXPRESSION; POLYMERIZATION; PROTEIN; SIGNALING; TRANSLOCATION;

ARTICLE; BREAST CANCER; CHEMOTAXIS; CONTROLLED STUDY; CYTOSKELETON; DISTANT METASTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE METASTASIS; METASTASIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR INVASION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BREAST NEOPLASMS; CHEMOKINE CXCL12; CHEMOTAXIS; ENZYME ACTIVATION; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; RAC GTP-BINDING PROTEINS; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

EID: 84877734357     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2680     Document Type: Article

References (32)

1. Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001). (Pubitemid 32225831)
2. Zlotnik, A. Involvement of chemokine receptors in organ-specific metastasis. Contrib. Microbiol. 13, 191-199 (2006).
3. Nicolson, G. L. Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis. Cancer Metastasis Rev. 12, 325-343 (1993). (Pubitemid 23293288)
4. Jin, T., Xu, X. & Hereld, D. Chemotaxis, chemokine receptors and human disease. Cytokine 44, 1-8 (2008).
5. Hernandez, L., Magalhaes, M. A., Coniglio, S. J., Condeelis, J. S. & Segall, J. E. Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res. 13, R128 (2011).
6. Cote, J. F. & Vuori, K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol. 17, 383-393 (2007). (Pubitemid 47375099)
7. Dong, X. et al. P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr. Biol. 15, 1874-1879 (2005). (Pubitemid 41501524)
8. Isik, N., Brzostowski, J. A. & Jin, T. An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis. Dev. Cell 15, 590-602 (2008).
9. Li, Z. et al. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell 114, 215-227 (2003). (Pubitemid 36936915)
10. Van Haastert, P. J. & Devreotes, P. N. Chemotaxis: signalling the way forward. Nat. Rev. Mol. Cell Biol. 5, 626-634 (2004). (Pubitemid 39025063)
11. Sun, C. X., Magalhaes, M. A. & Glogauer, M. Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor. J. Cell Biol. 179, 239-245 (2007). (Pubitemid 350004888)
12. Insall, R. H. & Machesky, L. M. Actin dynamics at the leading edge: from simple machinery to complex networks. Dev. Cell 17, 310-322 (2009).
13. Pollard, T. D. & Borisy, G. G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112, 453-465 (2003). (Pubitemid 36263079)
14. Reddien, P. W. & Horvitz, H. R. The engulfment process of programmed cell death in Caenorhabditis elegans. Annu. Rev. Cell Dev. Biol. 20, 193-221 (2004). (Pubitemid 39488637)
15. Cote, J. F., Motoyama, A. B., Bush, J. A. & Vuori, K. A novel and evolutionarily conserved PtdIns(3, 4, 5)P3-binding domain is necessary for DOCK180 signalling. Nat. Cell Biol. 7, 797-807 (2005). (Pubitemid 41079052)
16. Yan, J. et al. A Gbetagamma effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis. Dev. Cell 22, 92-103 (2012).
17. Grimsley, C. M. et al. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J. Biol. Chem. 279, 6087-6097 (2004). (Pubitemid 38220641)
18. Brugnera, E. et al. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat. Cell Biol. 4, 574-582 (2002).
19. Katoh, H. & Negishi, M. RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature 424, 461-464 (2003). (Pubitemid 36917498)
20. deBakker, C. D. et al. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr. Biol. 14, 2208-2216 (2004).
21. Jarzynka, M. J. et al. ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Cancer Res. 67, 7203-7211 (2007). (Pubitemid 47206548)
22. Moepps, B., Frodl, R., Rodewald, H. R., Baggiolini, M. & Gierschik, P. Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo. Eur. J. Immunol. 27, 2102-2112 (1997). (Pubitemid 27346030)
23. Kremer, K. N., Kumar, A. & Hedin, K. E. G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. J. Immunol. 187, 3177-3185 (2011).
24. Liu, Y. et al. Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Mol. Cancer Res. 7, 944-954 (2009).
25. Chung, S. et al. N-cadherin regulates mammary tumor cell migration through Akt3 suppression. Oncogene 32, 422-430 (2012).
26. Rajah, T. T., Peine, K. J., Du, N., Serret, C. A. & Drews, N. R. Physiological concentrations of genistein and 17beta-estradiol inhibit MDA-MB-231 breast cancer cell growth by increasing BAX/BCL-2 and reducing pERK1/2. Anticancer Res. 32, 1181-1191 (2012).
27. Zhang, F. et al. mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis. Cancer Res. 70, 9360-9370 (2010).
28. Sun, R. et al. Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells. Cancer Res. 65, 1433-1441 (2005). (Pubitemid 40270172)
29. Park, J. W., Choi, Y. J., Suh, S. I. & Kwon, T. K. Involvement of ERK and protein tyrosine phosphatase signaling pathways in EGCG-induced cyclooxygenase-2 expression in Raw 264.7 cells. Biochem. Biophys. Res. Commun. 286, 721-725 (2001). (Pubitemid 32912947)
30. Wang, W. et al. Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer Res. 67, 3505-3511 (2007). (Pubitemid 46762128)
31. Walker, L. C. et al. Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Res. 12, R102 (2010).
32. Tsuboi, S. A complex of Wiskott-Aldrich syndrome protein with mammalian verprolins plays an important role in monocyte chemotaxis. J. Immunol. 176, 6576-6585 (2006). (Pubitemid 43787840)