Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG

Genes to Cells

Volumn 17, Issue 8, 2012, Pages 688-697

  Namekata, Kazuhiko ^a   Watanabe, Hayaki ^a   Guo, Xiaoli ^a   Kittaka, Daiji ^a   Kawamura, Kazuto ^a   Kimura, Atsuko ^a   Harada, Chikako ^a   Harada, Takayuki ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DOCK3 PROTEIN; ELMO PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAC1 PROTEIN; RHOG PROTEIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL TISSUE; ARTICLE; CELL STRAIN; CELLULAR DISTRIBUTION; IN VITRO STUDY; MOUSE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARRIER PROTEINS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURITES; NEUROPEPTIDES; PC12 CELLS; PHOSPHORYLATION; PROTEIN INTERACTION MAPPING; PROTEIN TRANSPORT; RAC GTP-BINDING PROTEINS; RATS; RECEPTOR, TRKB; SIGNAL TRANSDUCTION; TERNARY COMPLEX FACTORS; TRANSFECTION;

EID: 84864291394     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2012.01616.x     Document Type: Article

References (34)

1. - co-transporter KCC2. Development 130, 1267-1280.
2. Cerione, R.A. & Zheng, Y. (1996) The Dbl family of oncogenes. Curr. Opin. Cell Biol. 8, 216-222.
3. Clarke, S. (1992) Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu. Rev. Biochem. 61, 355-386.
4. Cote, J.F. & Vuori, K. (2007) GEF what? Dock180 and related proteins help Rac to polarize cells in new ways Trends Cell Biol. 17, 383-393.
5. Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B. & Weinberger, D.R. (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269.
6. Friedel, S., Horro, F.F., Wermter, A.K., et al. (2005) Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 132B, 96-99.
7. Grimsley, C.M., Kinchen, J.M., Tosello-Trampont, A.C., Brugnera, E., Haney, L.B., Lu, M., Chen, Q., Klingele, D., Hengartner, M.O. & Ravichandran, K.S. (2004) Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J. Biol. Chem. 279, 6087-6097.
8. Gumienny, T.L., Brugnera, E., Tosello-Trampont, A.C., et al. (2001) CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 107, 27-41.
9. Handa, Y., Suzuki, M., Ohya, K., Iwai, H., Ishijima, N., Koleske, A.J., Fukui, Y. & Sasakawa, C. (2007) Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery. Nat. Cell Biol. 9, 121-128.
10. Harada, C., Guo, X., Namekata, K., Kimura, A., Nakamura, K., Tanaka, K., Parada, L.F. & Harada, T. (2011) Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration. Nat. Commun. 2, 189.
11. Hayashi, M.L., Choi, S.Y., Rao, B.S., Jung, H.Y., Lee, H.K., Zhang, D., Chattarji, S., Kirkwood, A. & Tonegawa, S. (2003) Altered cortical synaptic morphology and impaired memory consolidation in forebrain-specific dominant-negative PAK transgenic mice. Neuron 42, 773-787.
12. Hing, H., Xiao, J., Harden, N., Lim, L. & Zipursky, S.L. (1999) Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97, 853-863.
13. Hiramoto, K., Negishi, M. & Katoh, H. (2006) Dock4 is regulated by RhoG and promotes Rac-dependent cell migration. Exp. Cell Res. 312, 4205-4216.
14. Hollis, E.R., Jamshidia, P., Löw, K., Blescha, A. & Tuszynski, M.H. (2009) Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc. Natl Acad. Sci. USA 106, 7215-7220.
15. Katoh, H. & Negishi, M. (2003) RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature 424, 461-464.
16. Kaufmann, N., Wills, Z.P. & Van Vactor, D. (1998) Drosophila Rac1 controls motor axon guidance. Development 125, 453-461.
17. Kent, L., Green, E., Hawi, Z., et al. (2005) Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Mol. Psychiatry 10, 939-943.
18. Komander, D., Patel, M., Laurin, M., Fradet, N., Pelletier, A., Barford, D. & Cote, J.F. (2008) An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol. Biol. Cell 19(483), 7-4851.
19. Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H. & Bonhoeffer, T. (1995) Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. Natl Acad. Sci. USA 92, 8856-8860.
20. Kumar, R., Gururaj, A.E. & Barnes, C.J. (2006) p21-activated kinases in cancer. Nat. Rev. Cancer 6, 459-471.
21. Lemmon, M.A. & Ferguson, K.M. (2000) Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem. J. 350(Pt 1), 1-18.
22. Luikart, B.W., Nef, S., Virmani, T., Lush, M.E., Liu, Y., Kavalali, E.T. & Parada, L.F. (2005) TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J. Neurosci. 25, 3774-3786.
23. Meller, N., Merlot, S. & Guda, C. (2005) CZH proteins: a new family of Rho-GEFs. J. Cell Sci. 118, 4937-4946.
24. Nakayama, A.Y., Harms, M.B. & Luo, L. (2000) Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons. J. Neurosci. 20, 5329-5338.
25. Namekata, K., Harada, C., Guo, X., Kimura, A., Kittaka, D., Watanabe, H. & Harada, T. (2012) Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly. J. Neurosci. 32, 264-274.
26. Namekata, K., Harada, C., Taya, C., Guo, X., Kimura, H., Parada, L.F. & Harada, T. (2010) Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc. Natl Acad. Sci. USA 107, 7586-7591.
27. Patterson, S.L., Abel, T., Deuel, T.A., Martin, K.C., Rose, J.C. & Kandel, E.R. (1996) Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16, 1137-1145.
28. Santy, L.C., Ravichandran, K.S. & Casanova, J.E. (2005) The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Curr. Biol. 15, 1749-1754.
29. Schmidt, A. & Hall, A. (2002) Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 16, 1587-1609.
30. de Silva, M.G., Elliott, K., Dahl, H.H., Fitzpatrick, E., Wilcox, S., Delatycki, M., Williamson, R., Efron, D., Lynch, M. & Forrest, S. (2003) Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. J. Med. Genet. 40, 733-740.
31. Takenawa, T. & Suetsugu, S. (2007) The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat. Rev. Mol. Cell Biol. 8, 37-48.
32. Tashiro, A. & Yuste, R. (2004) Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: evidence for two forms of spine motility. Mol. Cell. Neurosci. 26, 429-440.
33. Wu, Y.I., Frey, D., Lungu, O.I., Jaehrig, A., Schlichting, I., Kuhlman, B. & Hahn, K.M. (2009) A genetically encoded photoactivatable Rac controls the motility of living cells. Nature 461, 104-108.
34. Zipkin, I.D., Kindt, R.M. & Kenyon, C.J. (1997) Role of a new Rho family member in cell migration and axon guidance in C. elegans Cell 90, 883-894.