Activation of Rac1 by Src-dependent phosphorylation of Dock180 Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Journal of Clinical Investigation

Volumn 121, Issue 12, 2011, Pages 4670-4684

  Feng, Haizhong ^a,b   Hu, Bo ^a,b   Liu, Kun Wei ^a,b,g   Li, Yanxin ^b   Lu, Xinghua ^b   Cheng, Tao ^b,c   Yiin, Jia Jean ^d   Lu, Songjian ^b   Keezer, Susan ^e   Fenton, Tim ^f,k   Furnari, Frank B ^f   Hamilton, Ronald L ^b   Vuori, Kristiina ^g   Sarkaria, Jann N ^h   Nagane, Motoo ⁱ   Nishikawa, Ryo ^j   Cavenee, Webster K ^f   Cheng, Shi Yuan ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d Veteran General Hospital   (Taiwan)

^e CELL SIGNALING TECHNOLOGY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g BURNHAM INSTITUTE   (United States)

^h MAYO CLINIC   (United States)

ⁱ KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^j SAITAMA MEDICAL UNIVERSITY   (Japan)

^k UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DOCK180 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN P130; RAC1 PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER PATIENT; CANCER SURVIVAL; CARCINOGENESIS; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL MOTILITY; GENE SILENCING; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; ENZYME ACTIVATION; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GLIOBLASTOMA; HUMANS; MICE; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PHOSPHORYLATION; PROGNOSIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-CRK; RAC GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SRC-FAMILY KINASES; TRANSPLANTATION, HETEROLOGOUS;

EID: 84055191095     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI58559     Document Type: Article

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