Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 8, 2012, Pages 3018-3023

  Feng, Haizhong ^a,b   Hu, Bo ^a,b   Jarzynka, Michael J ^a,b,k   Li, Yanxin ^b   Keezer, Susan ^c   Johns, Terrance G ^d   Tang, Careen K ^e   Hamilton, Ronald L ^b   Vuori, Kristiina ^f   Nishikawa, Ryo ^g   Sarkaria, Jann N ^h   Fenton, Tim ^i,l   Cheng, Tao ^b,j   Furnari, Frank B ⁱ   Cavenee, Webster K ⁱ   Cheng, Shi Yuan ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CELL SIGNALING TECHNOLOGY   (United States)

^d HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e GEORGETOWN UNIVERSITY   (United States)

^f BURNHAM INSTITUTE   (United States)

^g SAITAMA MEDICAL UNIVERSITY   (Japan)

^h MAYO CLINIC   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^k UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^l UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

Akt; Invasion

Indexed keywords

DEDICATOR OF CYTOKINESIS 1; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR DELTA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; RAC1 PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INVASION; CARCINOGENESIS; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL SURVIVAL; GLIOBLASTOMA; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR GROWTH;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOTYROSINE; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-FYN; RAC GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN; RECEPTOR, EPIDERMAL GROWTH FACTOR; SRC-FAMILY KINASES;

EID: 84863147746     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121457109     Document Type: Article

References (20)

1. Van Meir EG, et al. (2010) Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma. CA Cancer J Clin 60:166-193.
2. Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068.
3. Furnari FB, et al. (2007) Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes Dev 21:2683-2710. (Pubitemid 350070717)
4. Huang PH, Xu AM, White FM (2009) Oncogenic EGFR signaling networks in glioma. Sci Signal 2:re6.
5. Nishikawa R, et al. (1994) A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA 91:7727-7731. (Pubitemid 24238258)
6. Cai XM, et al. (2005) Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression. Int J Cancer 117:905-912.
7. Rossman KL, Der CJ, Sondek J (2005) GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6:167-180. (Pubitemid 40215811)
8. Côté JF, Vuori K (2007) GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol 17:383-393.
9. Schiller MR (2006) Coupling receptor tyrosine kinases to Rho GTPases-GEFs what's the link. Cell Signal 18:1834-1843.
10. Duchek P, Somogyi K, Jékely G, Beccari S, Rørth P (2001) Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Cell 107:17-26. (Pubitemid 32972034)
11. Jarzynka MJ, et al. (2007) ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Cancer Res 67:7203-7211. (Pubitemid 47206548)
12. Hu B, et al. (2009)ADP-ribosylation factor 6 regulates glioma cell invasion through the IQdomain GTPase-activating protein 1-Rac1-mediated pathway. Cancer Res 69:794-801.
13. Stettner MR, et al. (2005) Lyn kinase activity is the predominant cellular Src kinase activity in glioblastoma tumor cells. Cancer Res 65:5535-5543. (Pubitemid 40911153)
14. Lu KV, et al. (2009) Fyn and Src are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res 69:6889-6898.
15. Giannini C, et al. (2005) Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme. Neuro-oncol 7:164-176. (Pubitemid 40590516)
16. Jungbluth AA, et al. (2003) A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor. Proc Natl Acad Sci USA 100:639-644. (Pubitemid 36126105)
17. Burridge K, Wennerberg K (2004) Rho and Rac take center stage. Cell 116:167-179. (Pubitemid 38167310)
18. Inda MM, et al. (2010) Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev 24:1731-1745.
19. Feng H, et al. (2011) Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest 121:4670-4684.
20. Premkumar L, et al. (2010) Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J Biol Chem 285:13211-13222.