Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons

Science Signaling

Volumn 6, Issue 265, 2013, Pages

  Miyamoto, Yuki ^a,b   Torii, Tomohiro ^a   Yamamori, Natsuki ^a,c   Ogata, Toru ^d   Tanoue, Akito ^a   Yamauchi, Junji ^a,b,c  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b Japan Human Sciences Foundation   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^d NATIONAL REHABILITATION CENTER FOR PERSONS WITH DISABILITIES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR DOCK6; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; PROTEIN PHOSPHATASE PP2A; PROTEIN TYROSINE KINASE A; SERINE; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; MOUSE; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALS; AXONS; BASE SEQUENCE; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCKDOWN TECHNIQUES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MICE, TRANSGENIC; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; SENSORY RECEPTOR CELLS; SERINE;

EID: 84875142237     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003661     Document Type: Article

References (48)

1. R. P. Bunge, Expanding roles for the Schwann cell: Ensheathment, myelination, trophism and regeneration. Curr. Opin. Neurobiol. 3, 805-809 (1993). (Pubitemid 23303389)
2. S. Krispin, E. Nitzan, C. Kalcheim, The dorsal neural tube: A dynamic setting for cell fate decisions. Dev. Neurobiol. 70, 796-812 (2010).
3. A. Hall, Rho GTPases and the actin cytoskeleton. Science 279, 509-514 (1998). (Pubitemid 28067271)
4. K. Kaibuchi, S. Kuroda, M. Amano, Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu. Rev. Biochem. 68, 459-486 (1999). (Pubitemid 29449200)
5. D. Bar-Sagi, A. Hall, Ras and Rho GTPases: A family reunion. Cell 103, 227-238 (2000).
6. Y. Takai, T. Sasaki, T. Matozaki, Small GTP-binding proteins. Physiol. Rev. 81, 153-208 (2001). (Pubitemid 32098004)
7. A. Schmidt, A. Hall, Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch. Genes Dev. 16, 1587-1609 (2002). (Pubitemid 34743321)
8. K. L. Rossman, C. J. Der, J. Sondek, GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6, 167-180 (2005). (Pubitemid 40215811)
9. M. Matsuda, T. Kurata, Emerging components of the Crk oncogene product: The first identified adaptor protein. Cell. Signal. 8, 335-340 (1996). (Pubitemid 26366410)
10. J. F. Côté, K. Vuori, Identification of an evolutionally conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell Sci. 115, 4901-4913 (2002). (Pubitemid 36054642)
11. N. Meller, S. Merlot, C. Guda, CZH proteins: A new family of Rho-GEFs. J. Cell Sci. 118, 4937-4946 (2005). (Pubitemid 41672426)
12. J. F. Côté, K. Vuori, GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol. 17, 383-393 (2007). (Pubitemid 47375099)
13. Y. Miyamoto, J. Yamauchi, Cellular signaling of Dock family proteins in neural function. Cell. Signal. 22, 175-182 (2010).
14. T. Nagase, R. Kikuno, K. I. Ishikawa, M. Hirosawa, O. Ohara, Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7, 65-73 (2000).
15. Y. Miyamoto, J. Yamauchi, A. Sanbe, A. Tanoue, Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Exp. Cell Res. 313, 791-804 (2007). (Pubitemid 46198823)
16. J. Yamauchi, Y. Miyamoto, J. R. Chan, A. Tanoue. ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J. Cell Biol. 181, 351-365 (2008). (Pubitemid 351574558)
17. S. Peng, J. P. York, P. Zhang, A transgenic approach for RNA interference-based genetic screening in mice. Proc. Natl. Acad. Sci. U.S.A. 103, 2252-2256 (2006). (Pubitemid 43271656)
18. J. Yamauchi, Y. Miyamoto, H. Hamasaki, A. Sanbe, S. Kusakawa, A. Nakamura, H. Tsumura, M. Maeda, N. Nemoto, K. Kawahara, T. Torii, A. Tanoue, The atypical guanine-nucleotide exchange factor, dock7, negatively regulates Schwann cell differentiation and myelination. J. Neurosci. 31, 12579-12592 (2011).
19. S. Parrinello, I. Napoli, S. Ribeiro, P. W. Digby, M. Fedorova, D. B. Parkinson, R. D. S. Doddrell, M. Nakayama, R. H. Adams, A. C. Lloyd, EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell 143, 145-155 (2010).
20. Y. Miyamoto, J. Yamauchi, A. Tanoue, C. Wu, W. C. Mobley, TrkB binds and tyrosinephosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc. Natl. Acad. Sci. U.S.A. 103, 10444-10449 (2006). (Pubitemid 44051186)
21. B. McCright, A. M. Rivers, S. Audlin, D. M. Virshup, The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation- induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J. Biol. Chem. 271, 22081-22089 (1996). (Pubitemid 26303837)
22. W. T. Arthur, S. M. Ellerbroek, C. J. Der, K. Burridge, K. Wennerberg, XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J. Biol. Chem. 277, 42964-42972 (2002). (Pubitemid 35285675)
23. H. Y. Liu, J. I. MacDonald, T. Hryciw, C. Li, S. O. Meakin, Human tumorous imaginal disc 1 (TID1) associates with Trk receptor tyrosine kinases and regulates neurite outgrowth in nnr5-TrkA cells. J. Biol. Chem. 280, 19461-19471 (2005). (Pubitemid 41379466)
24. R. J. Smeyne, R. Klein, A. Schnapp, L. K. Long, S. Bryant, A. Lewin, S. A. Lira, M. Barbacid, Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368, 246-249 (1994). (Pubitemid 24108841)
25. I. Silos-Santiago, D. C. Molliver, S. Ozaki, R. J. Smeyne, A. M. Fagan, M. Barbacid, W. D. Snider, Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice. J. Neurosci. 15, 5929-5942 (1995).
26. L. Luo, Rho GTPases in neuronal morphogenesis. Nat. Rev. Neurosci. 1, 173-180 (2000).
27. D. J. Montell, The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development. Development 126, 3035-3046 (1999). (Pubitemid 29378169)
28. J. Bateman, H. Shu, D. Van Vactor, The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron 26, 93-106 (2000).
29. R. Steven, T. J. Kubiseski, H. Zheng, S. Kulkarni, J.Mancillas, A. Ruiz Morales, C. W. Hogue, T. Pawson, J. Culotti, UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92, 785-795 (1998). (Pubitemid 28155317)
30. S. P. O'Brien, K. Seipel, Q. G. Medley, R. Bronson, R. Segal, M. Streuli, Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos. Proc. Natl. Acad. Sci. U.S.A. 97, 12074-12078 (2000).
31. P. Penzes, R. C. Johnson, V. Kambampati, R. E. Mains, B. A. Eipper, Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology. J. Neurosci. 21, 8426-8434 (2001). (Pubitemid 33051441)
32. E. A. Lundquist, P. W. Reddien, E. Hartwieg, H. R. Horvitz, C. I. Bargmann, Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128, 4475-4488 (2001). (Pubitemid 33130428)
33. Y. C. Wu, T. W. Cheng, M. C. Lee, N. Y. Weng, Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth. Dev. Biol. 250, 145-155 (2002).
34. D. Liu, H.-Y. Zheng, Z.-Z. Luo, Q. Wang, L.-Q. Zhu, Effect of PP-2A on neurite outgrowth in neuronal cells. In Vitro Cell. Dev. Biol. Anim. 46, 702-707 (2010).
35. J. Zheng, W. H. Shen, T. J. Lu, Y. Zhou, Q. Chen, Z. Wang, T. Xiang, Y. C. Zhu, C. Zhang, S. Duan, Z. Q. Xiong, Clathrin-dependent endocytosis is required for TrkB-dependent Aktmediated neuronal protection and dendritic growth. J. Biol. Chem. 283, 13280-13288 (2008).
36. A. Markus, J. Zhong, W. D. Snider, Raf and Akt mediate distinct aspects of sensory axon growth. Neuron 35, 65-76 (2002). (Pubitemid 34804323)
37. X. Li, X. Gao, G. Liu, W. Xiong, J. Wu, Y. Rao, Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Nat. Neurosci. 11, 28-35 (2008).
38. N. J. Xu, M. Henkemeyer, Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning. Nat. Neurosci. 12, 268-276 (2009).
39. H. Katoh, M. Negishi, RhoG activates Rac1 by direct interaction with the Dock180- binding protein Elmo. Nature 424, 461-464 (2003). (Pubitemid 36917498)
40. S. Ueda, S. Fujimoto, K. Hiramoto, M. Negishi, H. Katoh, Dock4 regulates dendritic development in hippocampal neurons. J. Neurosci. Res. 86, 3052-3061 (2008).
41. K. Namekata, C. Harada, C. Taya, X. Guo, H. Kimura, L. F. Parada, T. Harada, Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc. Natl. Acad. Sci. U.S.A. 107, 7586-7591 (2010).
42. M. Watabe-Uchida, K. A. John, J. A. Janas, S. E. Newey, L. Van Aelst, The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron 51, 727-739 (2006). (Pubitemid 44374902)
43. K. Kuramoto, M. Negishi, H. Katoh, Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons. J. Neurosci. Res. 87, 1794-1805 (2009).
44. Y. Miyamoto, J. Yamauchi, H. Itoh, Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK. J. Biol. Chem. 278, 29890-29900 (2003). (Pubitemid 36962377)
45. T. Toyofuku, J. Yoshida, T. Sugimoto, H. Zhang, A. Kumanogoh, M. Hori, H. Kikutani, FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat. Neurosci. 8, 1712-1719 (2005). (Pubitemid 41683199)
46. J. R. Chan, T. A.Watkins, J. M. Cosgaya, C. Zhang, L. Chen, L. F. Reichardt, E. M. Shooter, B. A. Barres, NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron 43, 183-191 (2004). (Pubitemid 38942959)
47. Y. Miyamoto, J. Yamauchi, J. R. Chan, A. Okada, Y. Tomooka, S. Hisanaga, A. Tanoue, Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. J. Cell Sci. 120, 4355-4366 (2007).
48. Y. Miyamoto, J. Yamauchi, A. Tanoue, Cdk5 phosphorylation ofWAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. J. Neurosci. 28, 8326-8337 (2008).