Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

Science

Volumn 325, Issue 5946, 2009, Pages 1398-1402

  Yang, Jing ^a   Zhang, Ziguo ^a   Mark Roe, S ^a   Marshall, Christopher J ^a   Barford, David ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; MAGNESIUM; NUCLEOTIDE; PROTEIN CDC42; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; VALINE;

BIOCHEMISTRY; CATALYSIS; ENZYME ACTIVITY; MAGNESIUM; NUCLEIC ACID; PHOSPHATE (ORGANIC);

ALPHA HELIX; ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME RELEASE; MOLECULAR SENSOR; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; REGULATORY MECHANISM; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CDC42 GTP-BINDING PROTEIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 70249105718     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1174468     Document Type: Article

References (30)

1. A. B. Jaffe, A. Hall, Annu. Rev. Cell Dev. Biol. 21, 247 (2005).
2. S. J. Heasman, A. J. Ridley, Nat. Rev. Mol. Cell Biol. 9, 690 (2008).
3. I. R. Vetter, A. Wittinghofer, Science 294, 1299 (2001).
4. J. L. Bos, H. Rehmann, A. Wittinghofer, Cell 129, 865 (2007).
5. K. L. Rossman, C. J. Der, J. Sondek, Nat. Rev. Mol. Cell Biol. 6, 167 (2005).
6. N. Meller, S. Merlot, C. Guda, J. Cell Sei. 118, 4937 (2005).
7. J. F. Cote, K. Vuori, Trends Cell Biol. 17, 383 (2007).
8. V. Sanz-Moreno et al., Cell 135, 510 (2008).
9. G. Gadea, V. Sanz-Moreno, A. Self, A. Godi, C. J. Marshall, Curr. Biol. 18, 1456 (2008).
10. E. Brugnera et al., Nat. Cell Biol. 4, 574 (2002).
11. J. F. Cote, K. Vuori, J. Cell Sei. 115, 4901 (2002).
12. N. Meller, M. Irani-Tehrani, W. B. Kiosses, M. A. Del Pozo, M. A. Schwartz, Nat. Cell Biol. 4, 639 (2002).
13. Y. Miyamoto, J. Yamauchi, A. Sanbe, A. Tanoue, Exp. Cell Res. 313, 791 (2007).
14. J. F. Cote, A. B. Motoyama, J. A. Bush, K. Vuori, Nat. Cell Biol. 7, 797 (2005).
15. S. Kobayashi et al., Biochem. J. 354, 73 (2001).
16. H. Hasegawa et al., Mol. Cell. Biol. 16, 1770 (1996).
17. T. L. Gumienny et al., Cell 107, 27 (2001).
18. D. Komander et al., Mol. Biol Cell 19, 4837 (2008).
19. Materials and methods are available as supporting material on Science Online.
20. N. Meller, M. Irani-Tehrani, B. I. Ratnikov, B. M. Paschal, M. A. Schwartz, J. Biol. Chem. 279, 37470 (2004).
21. N. Nassar, G. R. Hoffman, D. Manor, J. C. Clardy, R. A. Cerione, Nat Struct. Biol. 5, 1047 (1998).
22. M. G. Rudolph, A. Wittinghofer, I. R. Vetter, Protein Sei. 8, 778 (1999).
23. M. J. Phillips, G. Calero, B. Chan, S. Ramachandran, R. A. Cerione, J. Biol. Chem. 283, 14153 (2008).
24. J. Reinstein, I. Schlichting, M. Freeh, R. S. Goody, A. Wittinghofer, J. Biol. Chem. 266, 17700 (1991).
25. P. A. Boriack-Sjodin, S. M. Margarit, D. Bar-Sagi, J. Kuriyan, Nature 394, 337 (1998).
26. D. K. Worthylake, K. L. Rossman, J. Sondek, Nature 408, 682 (2000).
27. G. Buchwald et al., EMBO J. 21, 3286 (2002).
28. C. Thomas, I. Fricke, A. Scrima, A. Berken, A. Wittinghofer, Mol. Cell 25, 141 (2007).
29. K. L. Rossman et al, J. Biol. Chem. 277, 50893 (2002).
30. DHR2-Cdc42 complex and -GDP and -GTP complexes, respectively.