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Volumn 18, Issue 20, 2011, Pages 3028-3034

The potential role of glycogen synthase kinase 3 inhibitors as Amyotrophic lateral sclerosis pharmacological therapy

Author keywords

Amyotrophic lateral sclerosis (ALS); GSK 3 inhibitors; Motor neurons; Neurodegenerative diseases

Indexed keywords

AR A 014418; ARIMOCLOMOL; BRX 345; CEFTRIAXONE; CK 2017357; EPIGALLOCATECHIN GALLATE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; KNS 760704; LITHIUM; LITHIUM CARBONATE; NORPHENAZONE; NP 001; OLESOXIME; PIOGLITAZONE; PRAMIPEXOLE; PYRIMETHAMINE; RASAGILINE; RETINOIC ACID; RILUZOLE; TIDEGLUSIB; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 79959948402     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711796391697     Document Type: Review
Times cited : (25)

References (86)
  • 3
    • 41149141053 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis from bench to bedside
    • DOI 10.1055/s-2008-1062265
    • Lomen-Hoerth, C. Amyotrophic lateral sclerosis from bench to bedside. Semin. Neurol., 2008, 28, 205-211 (Pubitemid 351438981)
    • (2008) Seminars in Neurology , vol.28 , Issue.2 , pp. 205-211
    • Lomen-Hoerth, C.1
  • 4
    • 78649816445 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Pathophysiology, diagnosis and management
    • Gordon, P. H. Amyotrophic lateral sclerosis: pathophysiology, diagnosis and management. CNS Drugs, 2011, 25, 1-15
    • (2011) CNS Drugs , vol.25 , pp. 1-15
    • Gordon, P.H.1
  • 5
    • 0020388782 scopus 로고
    • Epidemiology of amyotrophic lateral sclerosis
    • Kurtzke, J. F. Epidemiology of amyotrophic lateral sclerosis. Adv. Neurol., 1982, 36, 281-302
    • (1982) Adv. Neurol. , vol.36 , pp. 281-302
    • Kurtzke, J.F.1
  • 9
    • 79959994298 scopus 로고    scopus 로고
    • ALS pathogenesis: Recent insights from genetics and mouse models
    • doi:10.1016/j.pnpbp. 2010.1008.1006
    • Swarup, V.; Julien, J.-P. ALS pathogenesis: Recent insights from genetics and mouse models. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2010, doi:10.1016/j.pnpbp. 2010.1008.1006
    • (2010) Prog. Neuropsychopharmacol. Biol. Psychiatry
    • Swarup, V.1    Julien, J.-P.2
  • 10
    • 78649277728 scopus 로고    scopus 로고
    • Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets
    • Bosco, D. A.; Landers, J. E. Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets. CNS Neurol. Disord. Drug Targets, 2010, 9, 779-790
    • (2010) CNS Neurol. Disord. Drug Targets , vol.9 , pp. 779-790
    • Bosco, D.A.1    Landers, J.E.2
  • 12
    • 78349241067 scopus 로고    scopus 로고
    • Pathogenic TARDBP mutations in amyotrophic lateral sclerosis and frontotemporal dementia: Diseaseassociated pathways
    • Barmada, S. J.; Finkbeiner, S. Pathogenic TARDBP mutations in amyotrophic lateral sclerosis and frontotemporal dementia: diseaseassociated pathways. Rev. Neurosci., 2010, 21, 251-272
    • (2010) Rev. Neurosci. , vol.21 , pp. 251-272
    • Barmada, S.J.1    Finkbeiner, S.2
  • 13
  • 14
    • 77956850818 scopus 로고    scopus 로고
    • TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
    • Mackenzie, I. R.; Rademakers, R.; Neumann, M. TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol., 2010, 9, 995-1007
    • (2010) Lancet Neurol. , vol.9 , pp. 995-1007
    • Mackenzie, I.R.1    Rademakers, R.2    Neumann, M.3
  • 15
    • 33745223900 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis (motor neuron disease): Proposed mechanisms and pathways to treatment
    • DOI 10.1111/j.1467-9639.2006.00001.x, PII S1462399406010854
    • Goodall, E. F.; Morrison, K. E. Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment. Expert Rev. Mol. Med., 2006, 8, 1-22 (Pubitemid 43904876)
    • (2006) Expert Reviews in Molecular Medicine , vol.8 , Issue.11 , pp. 1-22
    • Goodall, E.F.1    Morrison, K.E.2
  • 16
    • 60849093466 scopus 로고    scopus 로고
    • Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
    • Rothstein, J. D. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann. Neurol., 2009, 65, S3-S9
    • (2009) Ann. Neurol. , vol.65
    • Rothstein, J.D.1
  • 17
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • DOI 10.1146/annurev.neuro.27.070203.144244
    • Bruijn, L. I.; Miller, T. M.; Cleveland, D. W. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Ann. Rev. Neurosci., 2004, 27, 723-749 (Pubitemid 39050419)
    • (2004) Annual Review of Neuroscience , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 18
    • 77953503937 scopus 로고    scopus 로고
    • Riluzole, neuroprotection and amyotrophic lateral sclerosis
    • Cheah, B. C.; Vucic, S.; Krishnan, A. V.; Kiernan, M. C. Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr. Med. Chem., 2010, 17, 1942-1199
    • (2010) Curr. Med. Chem. , vol.17 , pp. 1942-1199
    • Cheah, B.C.1    Vucic, S.2    Krishnan, A.V.3    Kiernan, M.C.4
  • 19
  • 20
    • 79551512488 scopus 로고    scopus 로고
    • Research advances in amyotrophic lateral sclerosis, 2009 to 2010
    • Traub, R.; Mitsumoto, H.; Rowland, L. P. Research advances in amyotrophic lateral sclerosis, 2009 to 2010. Curr. Neurol. Neurosci. Rep., 2011, 11, 67-77
    • (2011) Curr. Neurol. Neurosci. Rep. , vol.11 , pp. 67-77
    • Traub, R.1    Mitsumoto, H.2    Rowland, L.P.3
  • 22
    • 0032728304 scopus 로고    scopus 로고
    • Experimental models of amyotrophic lateral sclerosis
    • DOI 10.1006/nbdi.1999.0266
    • Elliott, J. L. Experimental models of amyotrophic lateral sclerosis. Neurobiol. Dis., 1999, 6, 310-320 (Pubitemid 29496211)
    • (1999) Neurobiology of Disease , vol.6 , Issue.5 , pp. 310-320
    • Elliott, J.L.1
  • 23
    • 79951674097 scopus 로고    scopus 로고
    • Transgenic animal models of neurodegeneration based on human genetic studies
    • Harvey, B. K.; Richie, C. T.; Hoffer, B. J.; Airavaara, M. Transgenic animal models of neurodegeneration based on human genetic studies. J. Neural. Transm., 2011, 118, 27-45
    • (2011) J. Neural. Transm. , vol.118 , pp. 27-45
    • Harvey, B.K.1    Richie, C.T.2    Hoffer, B.J.3    Airavaara, M.4
  • 24
    • 36949019768 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis models and human neuropathology: Similarities and differences
    • DOI 10.1007/s00401-007-0308-4
    • Kato, S. Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences. Acta Neuropathol., 2008, 115, 97-114 (Pubitemid 50003823)
    • (2008) Acta Neuropathologica , vol.115 , Issue.1 , pp. 97-114
    • Kato, S.1
  • 25
    • 79951754463 scopus 로고    scopus 로고
    • Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: A window of opportunity in the search for genetic modifiers
    • doi: 10.3109/17482968.17482010.17550626
    • Heiman-Patterson, T. D.; Sher, R. B.; Blankenhorn, E. A.; Alexander, G.; Deitch, J. S.; Kunst, C. B.; Maragakis, N.; Cox, G. Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: A window of opportunity in the search for genetic modifiers. Amyotroph. Lateral Scler., 2011, doi: 10.3109/17482968.17482010.17550626
    • (2011) Amyotroph. Lateral Scler.
    • Heiman-Patterson, T.D.1    Sher, R.B.2    Blankenhorn, E.A.3    Alexander, G.4    Deitch, J.S.5    Kunst, C.B.6    Maragakis, N.7    Cox, G.8
  • 27
    • 33947323759 scopus 로고    scopus 로고
    • Lost in translation: Treatment trials in the SOD1 mouse and in human ALS
    • DOI 10.1016/j.nbd.2006.12.015, PII S0969996106003287
    • Benatar, M. Lost in translation: treatment trials in the SOD1 mouse and in human ALS. Neurobiol. Dis., 2007, 26, 1-13 (Pubitemid 46437445)
    • (2007) Neurobiology of Disease , vol.26 , Issue.1 , pp. 1-13
    • Benatar, M.1
  • 29
    • 79955812764 scopus 로고    scopus 로고
    • TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology
    • doi: 10.1159/000321547
    • Wegorzewska, I.; Baloh, R. H. TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology. Neurodegener. Dis., 2011, doi: 10.1159/000321547
    • (2011) Neurodegener. Dis.
    • Wegorzewska, I.1    Baloh, R.H.2
  • 30
    • 73249152831 scopus 로고    scopus 로고
    • TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
    • Wegorzewska, I.; Bell, S.; Cairns, N. J.; Miller, T. M.; Baloh, R. H. TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc. Natl. Acad. Sci. USA, 2009, 106, 18809-18814
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 18809-18814
    • Wegorzewska, I.1    Bell, S.2    Cairns, N.J.3    Miller, T.M.4    Baloh, R.H.5
  • 33
    • 77955395385 scopus 로고    scopus 로고
    • Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U
    • Tsai, K. J.; Yang, C. H.; Fang, Y. H.; Cho, K. H.; Chien, W. L.; Wang, W. T.; Wu, T. W.; Lin, C. P.; Fu, W. M.; Shen, C. K. Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. J. Exp. Med., 2010, 207, 1661-1673
    • (2010) J. Exp. Med. , vol.207 , pp. 1661-1673
    • Tsai, K.J.1    Yang, C.H.2    Fang, Y.H.3    Cho, K.H.4    Chien, W.L.5    Wang, W.T.6    Wu, T.W.7    Lin, C.P.8    Fu, W.M.9    Shen, C.K.10
  • 35
    • 77958022745 scopus 로고    scopus 로고
    • Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
    • Shan, X.; Chiang, P. M.; Price, D. L.; Wong, P. C. Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. Proc. Natl. Acad. Sci. USA, 2010, 107, 16325-16330
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 16325-16330
    • Shan, X.1    Chiang, P.M.2    Price, D.L.3    Wong, P.C.4
  • 38
    • 77951236534 scopus 로고    scopus 로고
    • Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS)
    • Hanson, K. A.; Kim, S. H.; Wassarman, D. A.; Tibbetts, R. S. Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS). J. Biol. Chem., 2010, 285, 11068-11072
    • (2010) J. Biol. Chem. , vol.285 , pp. 11068-11072
    • Hanson, K.A.1    Kim, S.H.2    Wassarman, D.A.3    Tibbetts, R.S.4
  • 40
    • 4644350389 scopus 로고    scopus 로고
    • Occurrence of β-methylamino-L-alanine (BMAA) in. ALS/PDC patients from Guam
    • DOI 10.1111/j.1600-0404.2004.00320.x
    • Murch, S. J.; Cox, P. A.; Banack, S. A.; Steele, J. C.; Sacks, O. W. Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam. Acta Neurol. Scand., 2004, 110, 267-269 (Pubitemid 39274063)
    • (2004) Acta Neurologica Scandinavica , vol.110 , Issue.4 , pp. 267-269
    • Murch, S.J.1    Cox, P.A.2    Banack, S.A.3    Steele, J.C.4    Sacks, O.W.5
  • 41
    • 74549160247 scopus 로고    scopus 로고
    • Cyanobacteria and BMAA exposure from desert dust: A possible link to sporadic ALS among Gulf War veterans
    • Cox, P. A.; Richer, R.; Metcalf, J. S.; Banack, S. A.; Codd, G. A.; Bradley, W. G. Cyanobacteria and BMAA exposure from desert dust: a possible link to sporadic ALS among Gulf War veterans. Amyotroph. Lateral Scler., 2009, 10 Suppl 2, 109-117
    • (2009) Amyotroph. Lateral Scler. , vol.10 , Issue.2 SUPPL. , pp. 109-117
    • Cox, P.A.1    Richer, R.2    Metcalf, J.S.3    Banack, S.A.4    Codd, G.A.5    Bradley, W.G.6
  • 42
    • 38349089902 scopus 로고    scopus 로고
    • Animal models of BMAA neurotoxicity: A critical review
    • Karamyan, V. T.; Speth, R. C. Animal models of BMAA neurotoxicity: a critical review. Life Sci., 2008, 82, 233-246
    • (2008) Life Sci. , vol.82 , pp. 233-246
    • Karamyan, V.T.1    Speth, R.C.2
  • 44
    • 33751560981 scopus 로고    scopus 로고
    • A nonprotein amino acid and neurodegeneration
    • Cox, P. A.; Banack, S. A. A nonprotein amino acid and neurodegeneration. Science, 2006, 314, 1242
    • (2006) Science , vol.314 , pp. 1242
    • Cox, P.A.1    Banack, S.A.2
  • 45
    • 0034730573 scopus 로고    scopus 로고
    • Motor neuron disease in vitro: The use of cultured motor neurons to study amyotrophic lateral sclerosis
    • Bär, P. R. Motor neuron disease in vitro: the use of cultured motor neurons to study amyotrophic lateral sclerosis. Eur. J. Pharmacol., 2000, 405, 285-295
    • (2000) Eur. J. Pharmacol. , vol.405 , pp. 285-295
    • Bär, P.R.1
  • 49
    • 79959951540 scopus 로고    scopus 로고
    • http://www.knoppneurosciences.com
  • 50
    • 77955358107 scopus 로고    scopus 로고
    • Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis
    • Martin, L. J. Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. IDrugs, 2010, 13, 568-580
    • (2010) IDrugs , vol.13 , pp. 568-580
    • Martin, L.J.1
  • 51
    • 77954106884 scopus 로고    scopus 로고
    • Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis
    • Phukan, J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs, 2010, 13, 482-496
    • (2010) IDrugs , vol.13 , pp. 482-496
    • Phukan, J.1
  • 52
    • 79959991547 scopus 로고    scopus 로고
    • Clinical trial NCT00561366
    • www.clinicaltrials.gov (Clinical trial NCT00561366)
  • 53
    • 79959939733 scopus 로고    scopus 로고
    • Clinical trial NCT01083667
    • www.clinicaltrials.gov (Clinical trial NCT01083667)
  • 55
    • 39849110726 scopus 로고    scopus 로고
    • The GSK3 hypothesis of Alzheimer's disease
    • DOI 10.1111/j.1471-4159.2007.05194.x
    • Hooper, C.; Killick, R.; Lovestone, S. The GSK3 hypothesis of Alzheimer's disease. J. Neurochem., 2008, 104, 1433-1439 (Pubitemid 351316776)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.6 , pp. 1433-1439
    • Hooper, C.1    Killick, R.2    Lovestone, S.3
  • 56
    • 50249112166 scopus 로고    scopus 로고
    • Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs
    • Martinez, A. Preclinical efficacy on GSK-3 inhibitors: towards a future generation of powerful drugs. Med. Res. Rev., 2008, 28, 773-796
    • (2008) Med. Res. Rev. , vol.28 , pp. 773-796
    • Martinez, A.1
  • 57
    • 54249140068 scopus 로고    scopus 로고
    • GSK-3 inhibitors: A ray of hope for the treatment of Alzheimer's disease?
    • Martinez, A.; Perez, D. I. GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease? J. Alzheimers Dis., 2008, 15, 181-191
    • (2008) J. Alzheimers Dis. , vol.15 , pp. 181-191
    • Martinez, A.1    Perez, D.I.2
  • 58
    • 63849147445 scopus 로고    scopus 로고
    • GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics
    • Wada, A. GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics. Front. Biosci., 2009, 14, 1558-1570
    • (2009) Front. Biosci. , vol.14 , pp. 1558-1570
    • Wada, A.1
  • 59
    • 50249188313 scopus 로고    scopus 로고
    • Martinez, A., Castro, A. and Medina, M. Eds., Ed.; John Wiley & Sons: Hoboken, New Jersey
    • Jope, R. S. In: Glycogen synthase kinase 3 (GSK-3) and its inhibitors. Martinez, A., Castro, A. and Medina, M. Eds., Ed.; John Wiley & Sons: Hoboken, New Jersey, 2006, pp. 223-242.
    • (2006) Glycogen Synthase Kinase 3 (GSK-3) and its Inhibitors , pp. 223-242
    • Jope, R.S.1
  • 60
    • 1642286981 scopus 로고    scopus 로고
    • GSK-3 inhibitors: Discoveries and developments
    • DOI 10.2174/0929867043455738
    • Alonso, M.; Martinez, A. GSK-3 inhibitors: discoveries and developments. Curr. Med. Chem., 2004, 11, 755-763 (Pubitemid 38380049)
    • (2004) Current Medicinal Chemistry , vol.11 , Issue.6 , pp. 755-763
    • Alonso, M.1    Martinez, A.2
  • 62
    • 79951673475 scopus 로고    scopus 로고
    • Martinez, A., Castro, A. and Medina, M. Eds., Ed.; John Wiley & Sons: Hoboken, New Jersey
    • Alonso, D.; Martinez, A. In: Glycogen synthase kinase 3 (GSK-3) and its inhibitors. Martinez, A., Castro, A. and Medina, M. Eds., Ed.; John Wiley & Sons: Hoboken, New Jersey, 2006, pp. 307-331.
    • (2006) Glycogen Synthase Kinase 3 (GSK-3) and its Inhibitors , pp. 307-331
    • Alonso, D.1    Martinez, A.2
  • 63
    • 33845302976 scopus 로고    scopus 로고
    • Peptides targeting protein kinases: Strategies and implications
    • DOI 10.1152/physiol.00022.2006
    • Kaidanovich-Beilin, O.; Eldar-Finkelman, H. Peptides targeting protein kinases: strategies and implications. Physiology, 2006, 21, 411-418 (Pubitemid 44879250)
    • (2006) Physiology , vol.21 , Issue.6 , pp. 411-418
    • Kaidanovich-Beilin, O.1    Eldar-Finkelman, H.2
  • 66
    • 79959476224 scopus 로고    scopus 로고
    • Switching reversibility to irreversibility in GSK-3 inhibitors: Clues for specific design of new compounds
    • doi. 10.1021/jm1016279
    • Pérez, D. I.; Palomo, V.; Pérez, C.; Gil, C.; Dans, P.; Luque, F. J.; Conde, S.; Martinez, A. Switching reversibility to irreversibility in GSK-3 inhibitors: clues for specific design of new compounds. J. Med. Chem., 2011, doi. 10.1021/jm1016279
    • (2011) J. Med. Chem.
    • Pérez, D.I.1    Palomo, V.2    Pérez, C.3    Gil, C.4    Dans, P.5    Luque, F.J.6    Conde, S.7    Martinez, A.8
  • 67
    • 0345184327 scopus 로고    scopus 로고
    • Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord
    • Hu, J. H.; Zhang, H.; Wagey, R.; Krieger, C.; Pelech, S. L. Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord. J. Neurochem., 2003, 85, 432-442 (Pubitemid 36438338)
    • (2003) Journal of Neurochemistry , vol.85 , Issue.2 , pp. 432-442
    • Hu, J.-H.1    Zhang, H.2    Wagey, R.3    Krieger, C.4    Pelech, S.L.5
  • 68
    • 39149141844 scopus 로고    scopus 로고
    • Upregulation of GSK3beta expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci)
    • Yang, W.; Leystra-Lantz, C.; Strong, M. J. Upregulation of GSK3beta expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci). Brain Res., 2008, 1196, 131-139
    • (2008) Brain Res. , vol.1196 , pp. 131-139
    • Yang, W.1    Leystra-Lantz, C.2    Strong, M.J.3
  • 69
    • 70349309705 scopus 로고    scopus 로고
    • Immunohistochemical expression of IGF-I and GSK in the spinal cord of Kii and Guamanian ALS patients
    • Kihira, T.; Suzuki, A.; Kondo, T.; Wakayama, I.; Yoshida, S.; Hasegawa, K.; Garruto, R. M. Immunohistochemical expression of IGF-I and GSK in the spinal cord of Kii and Guamanian ALS patients. Neuropathology, 2009, 29, 548-558
    • (2009) Neuropathology , vol.29 , pp. 548-558
    • Kihira, T.1    Suzuki, A.2    Kondo, T.3    Wakayama, I.4    Yoshida, S.5    Hasegawa, K.6    Garruto, R.M.7
  • 70
    • 4444356826 scopus 로고    scopus 로고
    • Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals
    • DOI 10.1016/j.tox.2004.05.008, PII S0300483X04002963
    • Koh, S. H.; Kwon, H.; Kim, K. S.; Kim, J.; Kim, M. H.; Yu, H. J.; Kim, M.; Lee, K. W.; Do, B. R.; Jung, H. K.; Yang, K. W.; Appel, S. H.; Kim, S. H. Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals. Toxicology, 2004, 202, 213-225 (Pubitemid 39165396)
    • (2004) Toxicology , vol.202 , Issue.3 , pp. 213-225
    • Koh, S.-H.1    Kwon, H.2    Kim, K.S.3    Kim, J.4    Kim, M.-H.5    Yu, H.-J.6    Kim, M.7    Lee, K.-W.8    Do, B.R.9    Jung, H.K.10    Yang, K.-W.11    Appel, S.H.12    Kim, S.H.13
  • 71
    • 23244436178 scopus 로고    scopus 로고
    • Role of GSK-3β activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene
    • DOI 10.1111/j.1460-9568.2005.04191.x
    • Koh, S. H.; Lee, Y. B.; Kim, K. S.; Kim, H. J.; Kim, M.; Lee, Y. J.; Kim, J.; Lee, K. W.; Kim, S. H. Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene. Eur. J. Neurosci., 2005, 22, 301-309 (Pubitemid 41097603)
    • (2005) European Journal of Neuroscience , vol.22 , Issue.2 , pp. 301-309
    • Koh, S.-H.1    Lee, Y.-B.2    Kim, K.S.3    Kim, H.-J.4    Kim, M.5    Lee, Y.J.6    Kim, J.7    Lee, K.W.8    Kim, S.H.9
  • 72
    • 57349106488 scopus 로고    scopus 로고
    • Immunohistochemical study on the distribution of glycogen synthase kinase 3alpha in the central nervous system of SOD1 (G93A) transgenic mice
    • Chung, Y. H.; Joo, K. M.; Kim, D. J.; Kim, S. S.; Kim, K. Y.; Lee, W. B.; Cha, C. I. Immunohistochemical study on the distribution of glycogen synthase kinase 3alpha in the central nervous system of SOD1 (G93A) transgenic mice. Neurol. Res., 2008, 30, 926-931
    • (2008) Neurol. Res. , vol.30 , pp. 926-931
    • Chung, Y.H.1    Joo, K.M.2    Kim, D.J.3    Kim, S.S.4    Kim, K.Y.5    Lee, W.B.6    Cha, C.I.7
  • 73
    • 34548012115 scopus 로고    scopus 로고
    • GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder
    • DOI 10.1016/j.neubiorev.2007.03.002, PII S0149763407000243
    • Rowe, M. K.; Wiest, C.; Chuang, D. M. GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder. Neurosci. Biobehav. Rev., 2007, 31, 920-931 (Pubitemid 47285347)
    • (2007) Neuroscience and Biobehavioral Reviews , vol.31 , Issue.6 , pp. 920-931
    • Rowe, M.K.1    Wiest, C.2    Chuang, D.-M.3
  • 74
    • 0030449964 scopus 로고    scopus 로고
    • Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    • Stambolic, V.; Ruel, L.; Woodgett, J. R. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr. Biol., 1996, 6, 1664-1668 (Pubitemid 27050234)
    • (1996) Current Biology , vol.6 , Issue.12 , pp. 1664-1668
    • Stambolic, V.1    Ruel, L.2    Woodgett, J.R.3
  • 76
    • 0036909443 scopus 로고    scopus 로고
    • Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium
    • DOI 10.1016/S0028-3908(02)00215-0
    • De Sarno, P.; Li, X.; Jope, R. S. Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. Neuropharmacology, 2002, 43, 1158-1164 (Pubitemid 36009369)
    • (2002) Neuropharmacology , vol.43 , Issue.7 , pp. 1158-1164
    • De Sarno, P.1    Li, X.2    Jope, R.S.3
  • 78
    • 33947363215 scopus 로고    scopus 로고
    • Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis
    • Shin, J. H.; Cho, S. I.; Lim, H. R.; Lee, J. K.; Lee, Y. A.; Noh, J. S.; Joo, I. S.; Kim, K. W.; Gwag, B. J. Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis. Mol. Pharmacol., 2007, 71, 965-975
    • (2007) Mol. Pharmacol. , vol.71 , pp. 965-975
    • Shin, J.H.1    Cho, S.I.2    Lim, H.R.3    Lee, J.K.4    Lee, Y.A.5    Noh, J.S.6    Joo, I.S.7    Kim, K.W.8    Gwag, B.J.9
  • 79
    • 74149092630 scopus 로고    scopus 로고
    • Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord
    • Calderó, J.; Brunet, N.; Tarabal, O.; Piedrafita, L.; Hereu, M.; Ayala, V.; Esquerda, J. E. Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord. Neuroscience, 2010, 165, 1353-1369
    • (2010) Neuroscience , vol.165 , pp. 1353-1369
    • Calderó, J.1    Brunet, N.2    Tarabal, O.3    Piedrafita, L.4    Hereu, M.5    Ayala, V.6    Esquerda, J.E.7
  • 80
    • 49249136687 scopus 로고    scopus 로고
    • Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
    • Feng, H. L.; Leng, Y.; Ma, C. H.; Zhang, J.; Ren, M.; Chuang, D. M. Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model. Neuroscience, 2008, 155, 567-572
    • (2008) Neuroscience , vol.155 , pp. 567-572
    • Feng, H.L.1    Leng, Y.2    Ma, C.H.3    Zhang, J.4    Ren, M.5    Chuang, D.M.6
  • 81
    • 40449135649 scopus 로고    scopus 로고
    • Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: Roles of glycogen synthase kinase-3 inhibition
    • DOI 10.1523/JNEUROSCI.5467-07.2008
    • Leng, Y.; Liang, M. H.; Ren, M.; Marinova, Z.; Leeds, P.; Chuang, D. M. Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition. J. Neurosci., 2008, 28, 2576-2588 (Pubitemid 351348211)
    • (2008) Journal of Neuroscience , vol.28 , Issue.10 , pp. 2576-2588
    • Leng, Y.1    Liang, M.-H.2    Ren, M.3    Marinova, Z.4    Leeds, P.5    Chuang, D.-M.6
  • 83
    • 0037013685 scopus 로고    scopus 로고
    • Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors
    • DOI 10.1016/S0960-894X(02)00169-5, PII S0960894X02001695
    • Naerum, L.; Norskov-Lauritsen, L.; Olesen, P. H. Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. Bioorg. Med. Chem. Lett., 2002, 12, 1525-1528 (Pubitemid 34521927)
    • (2002) Bioorganic and Medicinal Chemistry Letters , vol.12 , Issue.11 , pp. 1525-1528
    • Narum, L.1    Norskov-Lauritsen, L.2    Olesen, P.H.3
  • 84
    • 34248596671 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS
    • DOI 10.1016/j.expneurol.2007.03.004, PII S0014488607000945
    • Koh, S. H.; Kim, Y.; Kim, H. Y.; Hwang, S.; Lee, C. H.; Kim, S. H. Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. Exp. Neurol., 2007, 205, 336-346 (Pubitemid 46755762)
    • (2007) Experimental Neurology , vol.205 , Issue.2 , pp. 336-346
    • Koh, S.-H.1    Kim, Y.2    Kim, H.Y.3    Hwang, S.4    Lee, C.H.5    Kim, S.H.6


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