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Volumn 6, Issue , 2014, Pages 25-32

High throughput process development in biomanufacturing

Author keywords

[No Author keywords available]

Indexed keywords

MANUFACTURE;

EID: 84907538797     PISSN: None     EISSN: 22113398     Source Type: Journal    
DOI: 10.1016/j.coche.2014.08.004     Document Type: Review
Times cited : (30)

References (53)
  • 1
    • 84885497662 scopus 로고    scopus 로고
    • Bright future outlook and huge challenges to overcome: An attempt to write the short story of the biopharma industry with current status, selected issues, and potential solutions in discovery, R&D, and manufacturing
    • Wiley-VCH Verlag GmbH & Co. KGaA
    • G. Jagschies Bright future outlook and huge challenges to overcome: an attempt to write the short story of the biopharma industry with current status, selected issues, and potential solutions in discovery, R&D, and manufacturing Modern Biopharmaceuticals 2013 Wiley-VCH Verlag GmbH & Co. KGaA 487 526
    • (2013) Modern Biopharmaceuticals , pp. 487-526
    • Jagschies, G.1
  • 2
    • 84896549713 scopus 로고    scopus 로고
    • Purifying biopharmaceuticals: Knowledge-based chromatographic process development
    • A.T. Hanke, and M. Ottens Purifying biopharmaceuticals: knowledge-based chromatographic process development Trends Biotechnol 32 2014 210 220
    • (2014) Trends Biotechnol , vol.32 , pp. 210-220
    • Hanke, A.T.1    Ottens, M.2
  • 3
    • 84867220763 scopus 로고    scopus 로고
    • Model-based high-throughput process development for chromatographic whey proteins separation
    • B.K. Nfor, J. Ripić, A. van der Padt, M. Jacobs, and M. Ottens Model-based high-throughput process development for chromatographic whey proteins separation Biotechnol J 7 2012 1221 1232
    • (2012) Biotechnol J , vol.7 , pp. 1221-1232
    • Nfor, B.K.1    Ripić, J.2    Van Der Padt, A.3    Jacobs, M.4    Ottens, M.5
  • 4
    • 84867205078 scopus 로고    scopus 로고
    • Editorial: High-throughput process development
    • J. Hubbuch Editorial: high-throughput process development Biotechnol J 7 2012 1185
    • (2012) Biotechnol J , vol.7 , pp. 1185
    • Hubbuch, J.1
  • 5
    • 84867214455 scopus 로고    scopus 로고
    • Meeting report: High-throughput process development - HTPD 2012
    • S.K. Hansen, and S.A. Oelmeier Meeting report: high-throughput process development - HTPD 2012 Biotechnol J 7 2012 1189 1191
    • (2012) Biotechnol J , vol.7 , pp. 1189-1191
    • Hansen, S.K.1    Oelmeier, S.A.2
  • 6
    • 79951674715 scopus 로고    scopus 로고
    • High-throughput process development for biopharmaceutical drug substances
    • R. Bhambure, K. Kumar, and A.S. Rathore High-throughput process development for biopharmaceutical drug substances Trends Biotechnol 29 2011 127 135
    • (2011) Trends Biotechnol , vol.29 , pp. 127-135
    • Bhambure, R.1    Kumar, K.2    Rathore, A.S.3
  • 7
    • 79851490029 scopus 로고    scopus 로고
    • A review of advanced small-scale parallel bioreactor technology for accelerated process development: Current state and future need
    • R. Bareither, and D. Pollard A review of advanced small-scale parallel bioreactor technology for accelerated process development: Current state and future need Biotechnol Progr 27 2011 2 14
    • (2011) Biotechnol Progr , vol.27 , pp. 2-14
    • Bareither, R.1    Pollard, D.2
  • 8
    • 84923007754 scopus 로고    scopus 로고
    • High-throughput miniaturized bioreactors for cell culture process development: Reproducibility, scalability, and control
    • S. Rameez, S.S. Mostafa, C. Miller, and A.A. Shukla High-throughput miniaturized bioreactors for cell culture process development: reproducibility, scalability, and control Biotechnol Progr 2014
    • (2014) Biotechnol Progr
    • Rameez, S.1    Mostafa, S.S.2    Miller, C.3    Shukla, A.A.4
  • 9
    • 84868259526 scopus 로고    scopus 로고
    • An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform
    • P. Rohe, D. Venkanna, B. Kleine, R. Freudl, and M. Oldiges An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform Microb Cell Factories 11 2012 144
    • (2012) Microb Cell Factories , vol.11 , pp. 144
    • Rohe, P.1    Venkanna, D.2    Kleine, B.3    Freudl, R.4    Oldiges, M.5
  • 10
    • 84862689354 scopus 로고    scopus 로고
    • Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process
    • D.M. Bower, K.S. Lee, R.J. Ram, and K.L.J. Prather Fed-batch microbioreactor platform for scale down and analysis of a plasmid DNA production process Biotechnol Bioeng 109 2012 1976 1986
    • (2012) Biotechnol Bioeng , vol.109 , pp. 1976-1986
    • Bower, D.M.1    Lee, K.S.2    Ram, R.J.3    Prather, K.L.J.4
  • 11
    • 77951570798 scopus 로고    scopus 로고
    • Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures
    • A. Amanullah, J.M. Otero, M. Mikola, A. Hsu, J. Zhang, J. Aunins, H.B. Schreyer, J.A. Hope, and A.P. Russo Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures Biotechnol Bioeng 106 2010 57 67
    • (2010) Biotechnol Bioeng , vol.106 , pp. 57-67
    • Amanullah, A.1    Otero, J.M.2    Mikola, M.3    Hsu, A.4    Zhang, J.5    Aunins, J.6    Schreyer, H.B.7    Hope, J.A.8    Russo, A.P.9
  • 12
    • 70349617005 scopus 로고    scopus 로고
    • Application of microbioreactors in fermentation process development: A review
    • D. Schäpper, M. Alam, N. Szita, A. Eliasson Lantz, and K. Gernaey Application of microbioreactors in fermentation process development: a review Anal Bioanal Chem 395 2009 679 695
    • (2009) Anal Bioanal Chem , vol.395 , pp. 679-695
    • Schäpper, D.1    Alam, M.2    Szita, N.3    Eliasson Lantz, A.4    Gernaey, K.5
  • 13
    • 33747873393 scopus 로고    scopus 로고
    • Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control
    • H.L.T. Lee, P. Boccazzi, R.J. Ram, and A.J. Sinskey Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control Lab Chip 6 2006 1229 1235
    • (2006) Lab Chip , vol.6 , pp. 1229-1235
    • Lee, H.L.T.1    Boccazzi, P.2    Ram, R.J.3    Sinskey, A.J.4
  • 15
    • 84874212237 scopus 로고    scopus 로고
    • Oxygen transfer characteristics of miniaturized bioreactor systems
    • T.V. Kirk, and N. Szita Oxygen transfer characteristics of miniaturized bioreactor systems Biotechnol Bioeng 110 2013 1005 1019
    • (2013) Biotechnol Bioeng , vol.110 , pp. 1005-1019
    • Kirk, T.V.1    Szita, N.2
  • 16
    • 33244488506 scopus 로고    scopus 로고
    • Fluid mixing in shaken bioreactors: Implications for scale-up predictions from microlitre-scale microbial and mammalian cell cultures
    • M. Micheletti, T. Barrett, S.D. Doig, F. Baganz, M.S. Levy, J.M. Woodley, and G.J. Lye Fluid mixing in shaken bioreactors: implications for scale-up predictions from microlitre-scale microbial and mammalian cell cultures Chem Eng Sci 61 2006 2939 2949
    • (2006) Chem Eng Sci , vol.61 , pp. 2939-2949
    • Micheletti, M.1    Barrett, T.2    Doig, S.D.3    Baganz, F.4    Levy, M.S.5    Woodley, J.M.6    Lye, G.J.7
  • 17
    • 84863022497 scopus 로고    scopus 로고
    • Fluorinert, an oxygen carrier, improves cell culture performance in deep square 96-well plates by facilitating oxygen transfer
    • A. Meyer, R.G.G. Condon, G. Keil, N. Jhaveri, Z. Liu, and Y.-S. Tsao Fluorinert, an oxygen carrier, improves cell culture performance in deep square 96-well plates by facilitating oxygen transfer Biotechnol Progr 28 2012 171 178
    • (2012) Biotechnol Progr , vol.28 , pp. 171-178
    • Meyer, A.1    Condon, R.G.G.2    Keil, G.3    Jhaveri, N.4    Liu, Z.5    Tsao, Y.-S.6
  • 18
    • 84886241053 scopus 로고    scopus 로고
    • Automated disposable small scale reactor for high throughput bioprocess development: A proof of concept study
    • R. Bareither, N. Bargh, R. Oakeshott, K. Watts, and D. Pollard Automated disposable small scale reactor for high throughput bioprocess development: A proof of concept study Biotechnol Bioeng 110 2013 3126 3138
    • (2013) Biotechnol Bioeng , vol.110 , pp. 3126-3138
    • Bareither, R.1    Bargh, N.2    Oakeshott, R.3    Watts, K.4    Pollard, D.5
  • 19
    • 46249092863 scopus 로고    scopus 로고
    • High-throughput screening of chromatographic separations: I. Method development and column modeling
    • L. Jonathan, J.F.K. Coffman, D. Brian, and Kelley High-throughput screening of chromatographic separations: I. Method development and column modeling Biotechnol Bioeng 100 2008 605 618
    • (2008) Biotechnol Bioeng , vol.100 , pp. 605-618
    • Jonathan, L.1    Coffman, J.F.K.2    Brian, D.3    Kelley4
  • 20
    • 46249099122 scopus 로고    scopus 로고
    • High-throughput screening of chromatographic separations: II. Hydrophobic interaction
    • F. Jack, B.D.K. Kramarczyk, and L. Coffman Jonathan High-throughput screening of chromatographic separations: II. Hydrophobic interaction Biotechnol Bioeng 100 2008 707 720
    • (2008) Biotechnol Bioeng , vol.100 , pp. 707-720
    • Jack, F.1    Kramarczyk, B.D.K.2    Jonathan, L.C.3
  • 22
    • 46249100489 scopus 로고    scopus 로고
    • High-throughput screening of chromatographic separations: IV. Ion-exchange
    • D. Brian, M.S. Kelley, Patrick Bastek, F. Kramarczyk Jack, Kathleen Molnar, Tianning Yu, and Jon Coffman High-throughput screening of chromatographic separations: IV. Ion-exchange Biotechnol Bioeng 100 2008 950 963
    • (2008) Biotechnol Bioeng , vol.100 , pp. 950-963
    • Brian, D.1    Kelley, M.S.2    Bastek, P.3    Jack, F.K.4    Molnar, K.5    Yu, T.6    Coffman, J.7
  • 23
    • 84867227740 scopus 로고    scopus 로고
    • High-throughput process development of chromatography steps: Advantages and limitations of different formats used
    • K.M. Łącki High-throughput process development of chromatography steps: advantages and limitations of different formats used Biotechnol J 7 2012 1192 1202
    • (2012) Biotechnol J , vol.7 , pp. 1192-1202
    • Łącki, K.M.1
  • 24
    • 45149083380 scopus 로고    scopus 로고
    • High-throughput process development: Determination of dynamic binding capacity using microtiter filter plates filled with chromatography resin
    • T. Bergander, K. Nilsson-Välimaa, K. Åberg, and K.M. Lacki High-throughput process development: determination of dynamic binding capacity using microtiter filter plates filled with chromatography resin Biotechnol Progr 24 2008 632 639
    • (2008) Biotechnol Progr , vol.24 , pp. 632-639
    • Bergander, T.1    Nilsson-Välimaa, K.2    Åberg, K.3    Lacki, K.M.4
  • 25
    • 34249873258 scopus 로고    scopus 로고
    • An automated microscale chromatographic purification of virus-like particles as a strategy for process development 10.1042/BA20060240
    • M.D. Wenger, P. Dephillips, C.E. Price, and D.G. Bracewell An automated microscale chromatographic purification of virus-like particles as a strategy for process development 10.1042/BA20060240 Biotechnol Appl Biochem 047 2007 131 139
    • (2007) Biotechnol Appl Biochem , vol.47 , pp. 131-139
    • Wenger, M.D.1    Dephillips, P.2    Price, C.E.3    Bracewell, D.G.4
  • 26
    • 84867200460 scopus 로고    scopus 로고
    • Predicting protein dynamic binding capacity from batch adsorption tests
    • G. Carta Predicting protein dynamic binding capacity from batch adsorption tests Biotechnol J 7 2012 1216 1220
    • (2012) Biotechnol J , vol.7 , pp. 1216-1220
    • Carta, G.1
  • 27
    • 84923011054 scopus 로고    scopus 로고
    • A practical strategy for using miniature chromatography columns in a standardized high-throughput workflow for purification development of monoclonal antibodies
    • J.P. Welsh, M.G. Petroff, P. Rowicki, H. Bao, T. Linden, D.J. Roush, and J.M. Pollard A practical strategy for using miniature chromatography columns in a standardized high-throughput workflow for purification development of monoclonal antibodies Biotechnol Progr 2014
    • (2014) Biotechnol Progr
    • Welsh, J.P.1    Petroff, M.G.2    Rowicki, P.3    Bao, H.4    Linden, T.5    Roush, D.J.6    Pollard, J.M.7
  • 28
    • 84862223168 scopus 로고    scopus 로고
    • High-throughput methods for miniaturization and automation of monoclonal antibody purification processes
    • K. Treier, S. Hansen, C. Richter, P. Diederich, J. Hubbuch, and P. Lester High-throughput methods for miniaturization and automation of monoclonal antibody purification processes Biotechnol Progr 28 2012 723 732
    • (2012) Biotechnol Progr , vol.28 , pp. 723-732
    • Treier, K.1    Hansen, S.2    Richter, C.3    Diederich, P.4    Hubbuch, J.5    Lester, P.6
  • 29
    • 33644908243 scopus 로고    scopus 로고
    • High-throughput process development for recombinant protein purification
    • K. Rege, M. Pepsin, B. Falcon, L. Steele, and M. Heng High-throughput process development for recombinant protein purification Biotechnol Bioeng 93 2006 618 630
    • (2006) Biotechnol Bioeng , vol.93 , pp. 618-630
    • Rege, K.1    Pepsin, M.2    Falcon, B.3    Steele, L.4    Heng, M.5
  • 31
    • 84867215894 scopus 로고    scopus 로고
    • Applying high-throughput methods to develop a purification process for a highly glycosylated protein
    • N. Sanaie, D. Cecchini, and J. Pieracci Applying high-throughput methods to develop a purification process for a highly glycosylated protein Biotechnol J 7 2012 1242 1255
    • (2012) Biotechnol J , vol.7 , pp. 1242-1255
    • Sanaie, N.1    Cecchini, D.2    Pieracci, J.3
  • 32
    • 84877354795 scopus 로고    scopus 로고
    • High-throughput chromatography screenings for modulating charge-related isoform patterns
    • A. Gerster, F. Rudolph, and M. Dieterle High-throughput chromatography screenings for modulating charge-related isoform patterns BioProcess Int 11 2013 46 53
    • (2013) BioProcess Int , vol.11 , pp. 46-53
    • Gerster, A.1    Rudolph, F.2    Dieterle, M.3
  • 33
    • 84878394704 scopus 로고    scopus 로고
    • Using high throughput screening to define virus clearance by chromatography resins
    • L. Connell-Crowley, E.A. Larimore, and R. Gillespie Using high throughput screening to define virus clearance by chromatography resins Biotechnol Bioeng 110 2013 1984 1994
    • (2013) Biotechnol Bioeng , vol.110 , pp. 1984-1994
    • Connell-Crowley, L.1    Larimore, E.A.2    Gillespie, R.3
  • 34
    • 79952733443 scopus 로고    scopus 로고
    • A tool for increasing the lifetime of chromatography resins
    • A. Grönberg, M. Eriksson, M. Ersoy, and H.J. Johansson A tool for increasing the lifetime of chromatography resins mAbs 3 2011 192 202
    • (2011) MAbs , vol.3 , pp. 192-202
    • Grönberg, A.1    Eriksson, M.2    Ersoy, M.3    Johansson, H.J.4
  • 35
    • 84856215254 scopus 로고    scopus 로고
    • Effects of resin ligand density on yield and impurity clearance in preparative cation exchange chromatography. II. Process characterization
    • J. Fogle, and J. Persson Effects of resin ligand density on yield and impurity clearance in preparative cation exchange chromatography. II. Process characterization J Chromatogr A 1225 2012 70 78
    • (2012) J Chromatogr A , vol.1225 , pp. 70-78
    • Fogle, J.1    Persson, J.2
  • 36
    • 84875944817 scopus 로고    scopus 로고
    • Chromatography process development in the quality by design paradigm. I: Establishing a high-throughput process development platform as a tool for estimating "characterization space" for an ion exchange chromatography step
    • R. Bhambure, and A.S. Rathore Chromatography process development in the quality by design paradigm. I: Establishing a high-throughput process development platform as a tool for estimating "characterization space" for an ion exchange chromatography step Biotechnol Progr 29 2013 403 414
    • (2013) Biotechnol Progr , vol.29 , pp. 403-414
    • Bhambure, R.1    Rathore, A.S.2
  • 37
    • 84870035438 scopus 로고    scopus 로고
    • High-throughput screening-based selection and scale-up of aqueous two-phase systems for pDNA purification
    • M. Wiendahl, S.A. Oelmeier, F. Dismer, and J. Hubbuch High-throughput screening-based selection and scale-up of aqueous two-phase systems for pDNA purification J Sep Sci 35 2012 3197 3207
    • (2012) J Sep Sci , vol.35 , pp. 3197-3207
    • Wiendahl, M.1    Oelmeier, S.A.2    Dismer, F.3    Hubbuch, J.4
  • 38
    • 84864550319 scopus 로고    scopus 로고
    • High throughput screening based selection of phases for aqueous two-phase system-centrifugal partitioning chromatography of monoclonal antibodies
    • S.A. Oelmeier, C. Ladd Effio, and J. Hubbuch High throughput screening based selection of phases for aqueous two-phase system-centrifugal partitioning chromatography of monoclonal antibodies J Chromatogr A 1252 2012 104 114
    • (2012) J Chromatogr A , vol.1252 , pp. 104-114
    • Oelmeier, S.A.1    Ladd Effio, C.2    Hubbuch, J.3
  • 39
    • 84867195750 scopus 로고    scopus 로고
    • Examination of a genetic algorithm for the application in high-throughput downstream process development
    • K. Treier, A. Berg, P. Diederich, K. Lang, A. Osberghaus, F. Dismer, and J. Hubbuch Examination of a genetic algorithm for the application in high-throughput downstream process development Biotechnol J 7 2012 1203 1215
    • (2012) Biotechnol J , vol.7 , pp. 1203-1215
    • Treier, K.1    Berg, A.2    Diederich, P.3    Lang, K.4    Osberghaus, A.5    Dismer, F.6    Hubbuch, J.7
  • 40
    • 60849096390 scopus 로고    scopus 로고
    • High throughput screening for the design and optimization of chromatographic processes: Automated optimization of chromatographic phase systems
    • A.K.T. Susanto, E. Knieps-Grünhagen, E. von Lieres, and J. Hubbuch High throughput screening for the design and optimization of chromatographic processes: automated optimization of chromatographic phase systems Chem Eng Technol 32 2009 140 154
    • (2009) Chem Eng Technol , vol.32 , pp. 140-154
    • Susanto, A.K.T.1    Knieps-Grünhagen, E.2    Von Lieres, E.3    Hubbuch, J.4
  • 41
    • 84884134118 scopus 로고    scopus 로고
    • High-throughput process development methods for chromatography and precipitation of proteins: Advantages and precautions
    • N. Yoshimoto, K. Minakuchi, D. Itoh, Y. Isakari, and S. Yamamoto High-throughput process development methods for chromatography and precipitation of proteins: advantages and precautions Eng Life Sci 13 2013 446 455
    • (2013) Eng Life Sci , vol.13 , pp. 446-455
    • Yoshimoto, N.1    Minakuchi, K.2    Itoh, D.3    Isakari, Y.4    Yamamoto, S.5
  • 42
    • 84896413109 scopus 로고    scopus 로고
    • High-throughput screening for the development of a monoclonal antibody affinity precipitation step using ELP-z stimuli responsive biopolymers
    • R.D. Sheth, B. Madan, W. Chen, and S.M. Cramer High-throughput screening for the development of a monoclonal antibody affinity precipitation step using ELP-z stimuli responsive biopolymers Biotechnol Bioeng 110 2013 2664 2676
    • (2013) Biotechnol Bioeng , vol.110 , pp. 2664-2676
    • Sheth, R.D.1    Madan, B.2    Chen, W.3    Cramer, S.M.4
  • 43
    • 84870013094 scopus 로고    scopus 로고
    • Development and characterization of an automated high throughput screening method for optimization of protein refolding processes
    • A. Berg, S.A. Oelmeier, J. Kittelmann, F. Dismer, and J. Hubbuch Development and characterization of an automated high throughput screening method for optimization of protein refolding processes J Sep Sci 35 2012 3149 3159
    • (2012) J Sep Sci , vol.35 , pp. 3149-3159
    • Berg, A.1    Oelmeier, S.A.2    Kittelmann, J.3    Dismer, F.4    Hubbuch, J.5
  • 44
    • 84859648485 scopus 로고    scopus 로고
    • A generic hierarchical screening method for the analysis of microscale refolds using an automated robotic platform
    • G.C. Ordidge, G. Mannall, J. Liddell, P.A. Dalby, and M. Micheletti A generic hierarchical screening method for the analysis of microscale refolds using an automated robotic platform Biotechnol Progr 28 2012 435 444
    • (2012) Biotechnol Progr , vol.28 , pp. 435-444
    • Ordidge, G.C.1    Mannall, G.2    Liddell, J.3    Dalby, P.A.4    Micheletti, M.5
  • 45
    • 84888028322 scopus 로고    scopus 로고
    • Optimization of random PEGylation reactions by means of high throughput screening
    • B. Maiser, F. Dismer, and J. Hubbuch Optimization of random PEGylation reactions by means of high throughput screening Biotechnol Bioeng 111 2014 104 114
    • (2014) Biotechnol Bioeng , vol.111 , pp. 104-114
    • Maiser, B.1    Dismer, F.2    Hubbuch, J.3
  • 46
    • 84878414775 scopus 로고    scopus 로고
    • High throughput process development (HTPD) platform for membrane chromatography
    • S. Muthukumar, and A.S. Rathore High throughput process development (HTPD) platform for membrane chromatography J Membr Sci 442 2013 245 253
    • (2013) J Membr Sci , vol.442 , pp. 245-253
    • Muthukumar, S.1    Rathore, A.S.2
  • 48
    • 84878989389 scopus 로고    scopus 로고
    • Host cell protein analysis in therapeutic protein bioprocessing - Methods and applications
    • A.L. Tscheliessnig, J. Konrath, R. Bates, and A. Jungbauer Host cell protein analysis in therapeutic protein bioprocessing - methods and applications Biotechnol J 8 2013 655 670
    • (2013) Biotechnol J , vol.8 , pp. 655-670
    • Tscheliessnig, A.L.1    Konrath, J.2    Bates, R.3    Jungbauer, A.4
  • 49
    • 84866264970 scopus 로고    scopus 로고
    • Full automation and validation of a flexible ELISA platform for host cell protein and protein A impurity detection in biopharmaceuticals
    • G. Rey, and M.W. Wendeler Full automation and validation of a flexible ELISA platform for host cell protein and protein A impurity detection in biopharmaceuticals J Pharm Biomed Anal 70 2012 580 586
    • (2012) J Pharm Biomed Anal , vol.70 , pp. 580-586
    • Rey, G.1    Wendeler, M.W.2
  • 50
    • 84899947204 scopus 로고    scopus 로고
    • Quantitative high throughput analytics to support polysaccharide production process development
    • A. Noyes, R. Godavarti, N. Titchener-Hooker, J. Coffman, and T. Mukhopadhyay Quantitative high throughput analytics to support polysaccharide production process development Vaccine 32 2014 2819 2828
    • (2014) Vaccine , vol.32 , pp. 2819-2828
    • Noyes, A.1    Godavarti, R.2    Titchener-Hooker, N.3    Coffman, J.4    Mukhopadhyay, T.5
  • 51
    • 81855164598 scopus 로고    scopus 로고
    • A sub-two minutes method for monoclonal antibody-aggregate quantification using parallel interlaced size exclusion high performance liquid chromatography
    • P. Diederich, S.K. Hansen, S.A. Oelmeier, B. Stolzenberger, and J. Hubbuch A sub-two minutes method for monoclonal antibody-aggregate quantification using parallel interlaced size exclusion high performance liquid chromatography J Chromatogr A 1218 2011 9010 9018
    • (2011) J Chromatogr A , vol.1218 , pp. 9010-9018
    • Diederich, P.1    Hansen, S.K.2    Oelmeier, S.A.3    Stolzenberger, B.4    Hubbuch, J.5
  • 52
    • 84867216317 scopus 로고    scopus 로고
    • Strategic Assay Selection for analytics in high-throughput process development: Case studies for downstream processing of monoclonal antibodies
    • S. Konstantinidis, S. Kong, S. Chhatre, A. Velayudhan, E. Heldin, and N. Titchener-Hooker Strategic Assay Selection for analytics in high-throughput process development: case studies for downstream processing of monoclonal antibodies Biotechnol J 7 2012 1256 1268
    • (2012) Biotechnol J , vol.7 , pp. 1256-1268
    • Konstantinidis, S.1    Kong, S.2    Chhatre, S.3    Velayudhan, A.4    Heldin, E.5    Titchener-Hooker, N.6
  • 53
    • 84867400118 scopus 로고    scopus 로고
    • Strategic assay deployment as a method for countering analytical bottlenecks in high throughput process development: Case studies in ion exchange chromatography
    • S. Konstantinidis, E. Heldin, S. Chhatre, A. Velayudhan, and N. Titchener-Hooker Strategic assay deployment as a method for countering analytical bottlenecks in high throughput process development: case studies in ion exchange chromatography Biotechnol Progr 28 2012 1292 1302
    • (2012) Biotechnol Progr , vol.28 , pp. 1292-1302
    • Konstantinidis, S.1    Heldin, E.2    Chhatre, S.3    Velayudhan, A.4    Titchener-Hooker, N.5


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