메뉴 건너뛰기




Volumn 61, Issue 9, 2006, Pages 2939-2949

Fluid mixing in shaken bioreactors: Implications for scale-up predictions from microlitre-scale microbial and mammalian cell cultures

Author keywords

Automated microscale processing; Biocatalysis; Cell culture; Fermentation; Scale up

Indexed keywords

ANTIBODIES; BIOCATALYSTS; BIOCONVERSION; BIOMASS; CELL CULTURE; COMPOSITION; DRUG PRODUCTS PLANTS; FERMENTATION; MASS TRANSFER; MIXING; REACTION KINETICS; SUSPENSIONS (FLUIDS);

EID: 33244488506     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2005.11.028     Document Type: Article
Times cited : (116)

References (37)
  • 1
    • 33244494742 scopus 로고    scopus 로고
    • Engineering characterisation of hybridoma cells in shaken microwell plates: Application to high-throughput process development
    • submitted for publication
    • Barrett, T.A., Zhang, H., Levy, M.S., Lye, G.J., 2005. Engineering characterisation of hybridoma cells in shaken microwell plates: application to high-throughput process development. Biotechnology Bioengineering, submitted for publication.
    • (2005) Biotechnology Bioengineering
    • Barrett, T.A.1    Zhang, H.2    Levy, M.S.3    Lye, G.J.4
  • 2
    • 0342265153 scopus 로고    scopus 로고
    • Power consumption in shaking flasks on rotary shaking machines: I. Power consumption measurement in unbaffled flasks at low liquid viscosity
    • J. Büchs, U. Maier, C. Milbradt, and B. Zoels Power consumption in shaking flasks on rotary shaking machines I. Power consumption measurement in unbaffled flasks at low liquid viscosity Biotechnology Bioengineering 68 2000 589 593
    • (2000) Biotechnology Bioengineering , vol.68 , pp. 589-593
    • Büchs, J.1    Maier, U.2    Milbradt, C.3    Zoels, B.4
  • 3
    • 0035105527 scopus 로고    scopus 로고
    • Out-of-phase conditions, a hitherto unknown phenomenon in shaking bioreactors
    • J. Büchs, S. Lotter, and C. Milbradt Out-of-phase conditions, a hitherto unknown phenomenon in shaking bioreactors Biochemical Engineering Journal 7 2001 135 141
    • (2001) Biochemical Engineering Journal , vol.7 , pp. 135-141
    • Büchs, J.1    Lotter, S.2    Milbradt, C.3
  • 4
    • 0027527774 scopus 로고
    • Animal cell culture in stirred bioreactors: Observations on scale-up
    • Y. Chisti Animal cell culture in stirred bioreactors observations on scale-up Bioprocess Engineering 9 1993 191 196
    • (1993) Bioprocess Engineering , vol.9 , pp. 191-196
    • Chisti, Y.1
  • 5
    • 23844547597 scopus 로고    scopus 로고
    • Engineering mammalian cell factories for improved recombinant monoclonal antibody production: Lessons from nature?
    • D.M. Dinnis, and D.C. James Engineering mammalian cell factories for improved recombinant monoclonal antibody production lessons from nature? Biotechnology Bioengineering 91 2005 180 189
    • (2005) Biotechnology Bioengineering , vol.91 , pp. 180-189
    • Dinnis, D.M.1    James, D.C.2
  • 6
    • 0037026964 scopus 로고    scopus 로고
    • The use of microscale processing technologies for quantification of biocatalytic Baeyer-Villiger oxidation kinetics
    • S.D. Doig, S.C.R. Pickering, G.J. Lye, and J.M. Woodley The use of microscale processing technologies for quantification of biocatalytic Baeyer-Villiger oxidation kinetics Biotechnology Bioengineering 80 2002 42 49
    • (2002) Biotechnology Bioengineering , vol.80 , pp. 42-49
    • Doig, S.D.1    Pickering, S.C.R.2    Lye, G.J.3    Woodley, J.M.4
  • 7
    • 15344339338 scopus 로고    scopus 로고
    • Modelling surface aeration rates in shaken microtitre plates using dimensionless groups
    • S.D. Doig, S.C.R. Pickering, G.J. Lye, and F. Baganz Modelling surface aeration rates in shaken microtitre plates using dimensionless groups Chemical Engineering Science 60 2005 2741 2750
    • (2005) Chemical Engineering Science , vol.60 , pp. 2741-2750
    • Doig, S.D.1    Pickering, S.C.R.2    Lye, G.J.3    Baganz, F.4
  • 8
    • 0035101279 scopus 로고    scopus 로고
    • Effectiveness of orbital shaking for the aeration of suspended cultures in square-deepwell microtiter plates
    • W.A. Duetz, and B. Witholt Effectiveness of orbital shaking for the aeration of suspended cultures in square-deepwell microtiter plates Biochemical Engineering Journal 7 2001 113 115
    • (2001) Biochemical Engineering Journal , vol.7 , pp. 113-115
    • Duetz, W.A.1    Witholt, B.2
  • 10
    • 0142026352 scopus 로고    scopus 로고
    • PH control in microwell fermentations of S. erythraea CA340: Influence on biomass growth kinetics and erythromycin biosynthesis
    • I. Elmahdi, F. Baganz, K. Dixon, T. Harrop, D. Sugden, and G.J. Lye pH control in microwell fermentations of S. erythraea CA340 influence on biomass growth kinetics and erythromycin biosynthesis Biochemical Engineering Journal 16 2003 299 310
    • (2003) Biochemical Engineering Journal , vol.16 , pp. 299-310
    • Elmahdi, I.1    Baganz, F.2    Dixon, K.3    Harrop, T.4    Sugden, D.5    Lye, G.J.6
  • 11
    • 28644450879 scopus 로고    scopus 로고
    • Microscale process evaluation of recombinant biocatalyst libraries: Application to Bayer-Villiger monooxygenase catalysed lactone synthesis
    • C. Ferreira-Torres, M. Micheletti, and G.J. Lye Microscale process evaluation of recombinant biocatalyst libraries application to Bayer-Villiger monooxygenase catalysed lactone synthesis Biosystems Bioengineering 28 2005 83 93
    • (2005) Biosystems Bioengineering , vol.28 , pp. 83-93
    • Ferreira-Torres, C.1    Micheletti, M.2    Lye, G.J.3
  • 12
    • 33244497005 scopus 로고    scopus 로고
    • Design and instrumentation of a novel miniature bioreactor system for high throughput fermentation optimisation
    • submitted for publication
    • Gill, N.K., Appleton, M., Baganz, F., Peacock, M., Lye, G.J., 2005. Design and instrumentation of a novel miniature bioreactor system for high throughput fermentation optimisation. Biochemical Engineering Journal, submitted for publication.
    • (2005) Biochemical Engineering Journal
    • Gill, N.K.1    Appleton, M.2    Baganz, F.3    Peacock, M.4    Lye, G.J.5
  • 13
  • 14
    • 33244483740 scopus 로고    scopus 로고
    • Cell culture scale-down model development through impeller agitation rate optimization
    • Harrison Hot Spring, BC, Canada, 10-14 July 2005
    • Hashimura, Y., Li, F., Lee, B., 2005. Cell culture scale-down model development through impeller agitation rate optimization. Biochemical Engineering XIV. Harrison Hot Spring, BC, Canada, 10-14 July 2005.
    • (2005) Biochemical Engineering XIV
    • Hashimura, Y.1    Li, F.2    Lee, B.3
  • 15
    • 0037454635 scopus 로고    scopus 로고
    • Characterization of gas-liquid mass transfer phenomena in microtiter plates
    • R. Hermann, M. Lehmann, and J. Büchs Characterization of gas-liquid mass transfer phenomena in microtiter plates Biotechnology Bioengineering 81 2003 178 186
    • (2003) Biotechnology Bioengineering , vol.81 , pp. 178-186
    • Hermann, R.1    Lehmann, M.2    Büchs, J.3
  • 17
    • 0343182984 scopus 로고    scopus 로고
    • Enzyme-catalysed carbon-carbon bond formation: Large-scale production of Escherichia coli transketolase
    • G.R. Hobbs, R.K. Mitra, R.P. Chauhan, J.M. Woodley, and M.D. Lilly Enzyme-catalysed carbon-carbon bond formation large-scale production of Escherichia coli transketolase Journal of Biotechnology 45 1996 173 179
    • (1996) Journal of Biotechnology , vol.45 , pp. 173-179
    • Hobbs, G.R.1    Mitra, R.K.2    Chauhan, R.P.3    Woodley, J.M.4    Lilly, M.D.5
  • 18
    • 0035916872 scopus 로고    scopus 로고
    • Quantitative screening method for hydrolases in microplates using pH indicators: Determination of kinetic parameters by dynamic pH monitoring
    • G.T. John, and E. Heinzle Quantitative screening method for hydrolases in microplates using pH indicators determination of kinetic parameters by dynamic pH monitoring Biotechnology Bioengineering 72 2001 620 627
    • (2001) Biotechnology Bioengineering , vol.72 , pp. 620-627
    • John, G.T.1    Heinzle, E.2
  • 20
    • 0037294298 scopus 로고    scopus 로고
    • Design of a prototype miniature bioreactor for high throughput automated bioprocessing
    • S.R. Lamping, H. Zhang, B. Allen, and P.A. Shamlou Design of a prototype miniature bioreactor for high throughput automated bioprocessing Chemical Engineering Science 58 2003 747 758
    • (2003) Chemical Engineering Science , vol.58 , pp. 747-758
    • Lamping, S.R.1    Zhang, H.2    Allen, B.3    Shamlou, P.A.4
  • 22
    • 4644370842 scopus 로고    scopus 로고
    • Gas-liquid mass transfer coefficient in stirred tanks interpreted through models of idealized eddy structure of turbulence in the bubble vicinity
    • V. Linek, M. Kordac, M. Fujasová, and T. Moucha Gas-liquid mass transfer coefficient in stirred tanks interpreted through models of idealized eddy structure of turbulence in the bubble vicinity Chemical Engineering and Processing 43 2004 1511 1517
    • (2004) Chemical Engineering and Processing , vol.43 , pp. 1511-1517
    • Linek, V.1    Kordac, M.2    Fujasová, M.3    Moucha, T.4
  • 23
    • 4043119663 scopus 로고    scopus 로고
    • Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures
    • M. Losen, B. Frölich, M. Pohl, and J. Büchs Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures Biotechnology Progress 20 2004 1062 1068
    • (2004) Biotechnology Progress , vol.20 , pp. 1062-1068
    • Losen, M.1    Frölich, B.2    Pohl, M.3    Büchs, J.4
  • 24
    • 0037212099 scopus 로고    scopus 로고
    • Accelerated design of bioconversion processes using automated microscale processing techniques
    • G.J. Lye, P.A. Shamlou, F. Baganz, P.A. Dalby, and J.M. Woodley Accelerated design of bioconversion processes using automated microscale processing techniques Trends in Biotechnology 21 2003 29 37
    • (2003) Trends in Biotechnology , vol.21 , pp. 29-37
    • Lye, G.J.1    Shamlou, P.A.2    Baganz, F.3    Dalby, P.A.4    Woodley, J.M.5
  • 26
    • 0031973750 scopus 로고    scopus 로고
    • Escherichia coli transketolase-catalyzed carbon-carbon bond formation: Biotransformation characterization for reactor evaluation and selection
    • R.K. Mitra, J.M. Woodley, and M.D. Lilly Escherichia coli transketolase-catalyzed carbon-carbon bond formation biotransformation characterization for reactor evaluation and selection Enzyme and Microbiol Technology 22 1998 64 70
    • (1998) Enzyme and Microbiol Technology , vol.22 , pp. 64-70
    • Mitra, R.K.1    Woodley, J.M.2    Lilly, M.D.3
  • 29
    • 0000748242 scopus 로고
    • Comparison of measured and calculated oxygen solubilities in fermentation media
    • G. Quicker, A. Schumpe, B. König, and W.-D. Deckwer Comparison of measured and calculated oxygen solubilities in fermentation media Biotechnology Bioengineering 23 1981 635 650
    • (1981) Biotechnology Bioengineering , vol.23 , pp. 635-650
    • Quicker, G.1    Schumpe, A.2    König, B.3    Deckwer, W.-D.4
  • 30
    • 0031006049 scopus 로고    scopus 로고
    • Influence of hyperosmolar basal media on hybridoma cell growth and antibody production
    • J.S. Ryu, and M.S. Lee Influence of hyperosmolar basal media on hybridoma cell growth and antibody production Bioprocess Engineering 16 1997 105 310
    • (1997) Bioprocess Engineering , vol.16 , pp. 105-310
    • Ryu, J.S.1    Lee, M.S.2
  • 32
    • 0026416508 scopus 로고
    • The influence of temperature on a mouse-mouse hybridoma growth and monoclonal antibody production
    • G.K. Sureshkumar, and R. Muthanaransan The influence of temperature on a mouse-mouse hybridoma growth and monoclonal antibody production Biotechnology Bioengineering 37 1990 292 295
    • (1990) Biotechnology Bioengineering , vol.37 , pp. 292-295
    • Sureshkumar, G.K.1    Muthanaransan, R.2
  • 33
    • 0034044645 scopus 로고    scopus 로고
    • Modeling oxygen solubility in water and electrolyte solutions
    • D. Tromans Modeling oxygen solubility in water and electrolyte solutions Industrial Engineering Chemistry Research 39 2000 805 812
    • (2000) Industrial Engineering Chemistry Research , vol.39 , pp. 805-812
    • Tromans, D.1
  • 34
    • 0018491753 scopus 로고
    • Review of measuring methods and results in nonviscous gas-liquid mass transfer in stirred vessels
    • K. van't Riet Review of measuring methods and results in nonviscous gas-liquid mass transfer in stirred vessels Industrial Engineering Process Design and Development 18 1979 357 364
    • (1979) Industrial Engineering Process Design and Development , vol.18 , pp. 357-364
    • Van't Riet, K.1
  • 35
    • 0032949506 scopus 로고    scopus 로고
    • Reactor design for large scale suspension animal cell culture
    • J. Varley, and J. Birch Reactor design for large scale suspension animal cell culture Cytotechnology 29 1999 177 205
    • (1999) Cytotechnology , vol.29 , pp. 177-205
    • Varley, J.1    Birch, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.