High-throughput methods for miniaturization and automation of monoclonal antibody purification processes

Biotechnology Progress

Volumn 28, Issue 3, 2012, Pages 723-732

  Treier, Katrin ^a,c   Hansen, Sigrid ^a   Richter, Carolin ^a   Diederich, Patrick ^a   Hubbuch, Jürgen ^a   Lester, Philip ^b  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b GENENTECH INC   (United States)

^c BASF SE   (Germany)

Author keywords

Downstream process development; High throughput screening; Miniaturization; Monoclonal antibodies; Packed bed chromatography

Indexed keywords

96-WELL MICROTITER PLATE; ABSORPTION MEASUREMENTS; BIOPHARMACEUTICAL INDUSTRY; CHROMATOGRAPHIC COLUMN; CHROMATOGRAPHIC METHODS; DOWNSTREAM PROCESS; HIGH-THROUGHPUT; HIGH-THROUGHPUT METHOD; HIGH-THROUGHPUT SCREENING; LIQUID HANDLING; MASS BALANCE; MINIATURIZATION; MONOCLONAL ANTIBODY PURIFICATION; PACKED BED CHROMATOGRAPHY; PROCESS DEVELOPMENT; PURIFICATION METHOD; SCALE-DOWN;

CHROMATOGRAPHIC ANALYSIS; LIQUID CHROMATOGRAPHY; MINIATURE INSTRUMENTS; MONOCLONAL ANTIBODIES; PACKED BEDS; PURIFICATION;

LIQUIDS;

ANION EXCHANGE RESIN; CATION EXCHANGE RESIN; MONOCLONAL ANTIBODY;

ABSORPTION; ARTICLE; AUTOMATION; ELECTRONICS; ION EXCHANGE CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METHODOLOGY;

ABSORPTION; ANION EXCHANGE RESINS; ANTIBODIES, MONOCLONAL; AUTOMATION; CATION EXCHANGE RESINS; CHROMATOGRAPHY, ION EXCHANGE; MINIATURIZATION;

EID: 84862223168     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1533     Document Type: Article

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