High-throughput screening-based selection and scale-up of aqueous two-phase systems for pDNA purification

Journal of Separation Science

Volumn 35, Issue 22, 2012, Pages 3197-3207

  Wiendahl, Matthias ^b   Oelmeier, Stefan A ^a   Dismer, Florian ^a   Hubbuch, Jürgen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Aqueous two phase partitioning; Genetic algorithm; High throughput process development; Pharmaceutical downstream processing; Plasmid DNA purification

Indexed keywords

AQUEOUS TWO PHASE; AQUEOUS TWO PHASE SYSTEM; AQUEOUS TWO-PHASE EXTRACTION; AUTOMATED OPTIMIZATION; COMPLEX OPTIMIZATION; DOWNSTREAM-PROCESSING; GENE DELIVERY; HIGH CAPACITY; HIGH-THROUGHPUT; LARGE-SCALE PRODUCTION; OPTIMIZATION STRATEGY; PHARMACEUTICAL APPLICATIONS; PLASMID DNA; PLASMID DNA (PDNA); PROCESS DEVELOPMENT; PROCESS STEPS; RESPONSE SURFACE METHODOLOGY; SCALE-UP; SCREENING SYSTEM;

BIOMOLECULES; CHROMATOGRAPHY; GENE TRANSFER; GENETIC ALGORITHMS; OPTIMIZATION; RNA; SEPARATION; SOLVENT EXTRACTION;

PURIFICATION;

NUCLEIC ACID; PLASMID DNA;

AQUEOUS TWO PHASE EXTRACTION; ARTICLE; CHROMATOGRAPHY; DNA PURIFICATION; DOWNSTREAM PROCESSING; GENE DELIVERY SYSTEM; GENETIC ALGORITHM; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL;

CHEMICAL FRACTIONATION; DNA; DNA CONTAMINATION; HIGH-THROUGHPUT SCREENING ASSAYS; PLASMIDS;

EID: 84870035438     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201200310     Document Type: Article

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