Oxygen transfer characteristics of miniaturized bioreactor systems

Biotechnology and Bioengineering

Volumn 110, Issue 4, 2013, Pages 1005-1019

  Kirk, Timothy V ^a   Szita, Nicolas ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Microbioreactors; Minibioreactors; Oxygen monitoring; Oxygen transfer

Indexed keywords

BIOREACTOR SYSTEM; E. COLI; FLUID HANDLING SYSTEMS; FLUORESCENCE LIFETIMES; HIGH RATE; HIGH THROUGHPUT SCREENING; MATHEMATICAL RELATIONSHIP; MICRO BIOREACTOR; MINIBIOREACTORS; OXYGEN MONITORING; OXYGEN TRANSFER; OXYGEN TRANSFER CHARACTERISTICS; OXYGEN UPTAKE RATES; PRODUCTION SYSTEM; REACTOR PERFORMANCE; REAL TIME MEASUREMENTS; TRANSFER PERFORMANCE;

ESCHERICHIA COLI; OXYGEN;

BIOREACTORS;

DISSOLVED OXYGEN;

BIOREACTOR; BIOSENSOR; CONCENTRATION (PARAMETERS); ELECTRONICS; ESCHERICHIA COLI; GAS FLOW; HIGH THROUGHPUT SCREENING; INSTRUMENTATION; NONBIOLOGICAL MODEL; OXYGEN CONSUMPTION; REVIEW;

BIOREACTORS; MINIATURIZATION; OXYGEN;

EID: 84874212237     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24824     Document Type: Review

References (82)

1. Alderman J, Hynes J, Floyd SM, Krüger J, O'Connor R, Papkovsky DB. 2004. A low-volume platform for cell-respirometric screening based on quenched-luminescence oxygen sensing. Biosens Bioelectron 19(11):1529-1535.
2. Andersen KB, von Meyenburg K. 1980. Are growth rates of Escherichia coli in batch cultures limited by respiration? J Bacteriol 144(1):114-123.
3. Armstrong L, Feneuille S. 1975. Theoretical analysis of the phase shift measurement of lifetimes using monochromatic light. J Phys B 8(4):546-551.
4. Bacon JR, Demas JN. 1987. Determination of oxygen concentrations by luminescence quenching of a polymer-immobilized transition-metal complex. Anal Chem 59(23):2780-2785.
5. Bambot SB, Holavanahali R, Lakowicz JR, Carter GM, Rao G. 1994. Phase fluorometric sterilizable optical oxygen sensor. Biotechnol Bioeng 43(11):1139-1145.
6. Betts J, Baganz F. 2006. Miniature bioreactors: Current practices and future opportunities. Microbial Cell Factories 5(1):21-21.
7. Biń AK. 1984. Mass transfer to the free interface in stirred vessels. Chemical Engineering Communications 31(1):155-155.
8. Boccazzi P, Zanzotto A, Szita N, Bhattacharya S, Jensen KF, Sinskey AJ. 2005. Gene expression analysis of Escherichia coli grown in miniaturized bioreactor platforms for high-throughput analysis of growth and genomic data. Applied Microbiology and Biotechnology 68(4):518-532.
9. Boccazzi P, Zhang Z, Kurosawa K, Szita N, Bhattacharya S, Jensen KF, Sinskey AJ. 2006. Differential gene expression profiles and real-time measurements of growth parameters in Saccharomyces cerevisiae grown in microliter-scale bioreactors equipped with internal stirring. Biotechnol Prog 22(3):710-717.
10. Brett CMA, Brett AMO. 1993. Electrochemistry: Principles, methods, and applications. USA: Oxford University Press.
11. Buchenauer A, Hofmann MC, Funke M, Büchs J, Mokwa W, Schnakenberg U. 2009. Micro-bioreactors for fed-batch fermentations with integrated online monitoring and microfluidic devices. Biosens Bioelectron 24(5):1411-1416.
12. Büchs J, Maier U, Milbradt C, Zoels B. 2000a. Power consumption in shaking flasks on rotary shaking machines: I. Power consumption measurement in unbaffled flasks at low liquid viscosity. Biotechnol Bioeng 68(6):589-593.
13. Büchs J, Maier U, Milbradt C, Zoels B. 2000b. Power consumption in shaking flasks on rotary shaking machines: II. Nondimensional description of specific power consumption and flow regimes in unbaffled flasks at elevated liquid viscosity. Biotechnol Bioeng 68(6):594-601.
14. Büchs J, Lotter S, Milbradt C. 2001. Out-of-phase operating conditions, a hitherto unknown phenomenon in shaking bioreactors. Biochem Eng J 7(2):135-141.
15. Charles M, Wilson J. 2002. Fermenter design. Encyclopedia of bioprocess technology. Hoboken, New Jersey: John Wiley & Sons, Inc.
16. Chen A, Chitta R, Chang D, Amanullah A. 2009. Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development. Biotechnol Bioeng 102(1):148-160.
17. Demas JN, DeGraff BA. 1991. Design and applications of highly luminescent transition metal complexes. Anal Chem 63(17):829A-837A.
18. Deshpande RR, Heinzle E. 2004. On-line oxygen uptake rate and culture viability measurement of animal cell culture using microplates with integrated oxygen sensors. Biotechnol Lett 26(9):763-767.
19. Deshpande R, Wittmann C, Heinzle E. 2004. Microplates with integrated oxygen sensing for medium optimization in animal cell culture. Cytotechnology 46(1):1-8.
20. Doig SD, Pickering SCR, Lye GJ, Baganz F. 2005. Modelling surface aeration rates in shaken microtitre plates using dimensionless groups. Chem Eng Sci 60(10):2741-2750.
21. Ducommun P, Ruffieux P-A, Furter M-P, Marison I, von Stockar U. 2000. A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures. J Biotechnol 78(2):139-147.
22. Duetz WA. 2007. Microtiter plates as mini-bioreactors: Miniaturization of fermentation methods. Trends Microbiol 15(10):469-475.
23. Duetz WA, Witholt B. 2004. Oxygen transfer by orbital shaking of square vessels and deepwell microtiter plates of various dimensions. Biochem Eng J 17(3):181-185.
24. Dumsday GJ, Ocal G, Bridger JS, Zachariou M. 2009. The use of oxygen uptake rate to monitor discovery of microbial and enzymatic biocatalysts. Biotechnol Bioeng 102(3):673-683.
25. Duschinsky F. 1933. Der zeitliche Intensitätsverlauf von intermittierend angeregter Resonanzstrahlung. Z Phys A 81(1-2):7-22.
26. Funke M, Diederichs S, Kensy F, Müller C, Büchs J. 2009. The baffled microtiter plate: Increased oxygen transfer and improved online monitoring in small scale fermentations. Biotechnol Bioeng 103(6):1118-1128.
27. Funke M, Buchenauer A, Mokwa W, Kluge S, Hein L, Muller C, Kensy F, Buchs J. 2010a. Bioprocess control in microscale: Scalable fermentations in disposable and user-friendly microfluidic systems. Microb Cell Fact 9(1):86-98.
28. Funke M, Buchenauer A, Schnakenberg U, Mokwa W, Diederichs S, Mertens A, Müller C, Kensy F, Büchs J. 2010b. Microfluidic biolector-Microfluidic bioprocess control in microtiter plates. Biotechnol Bioeng 107(3):497-505.
29. Ge X, Hanson M, Shen H, Kostov Y, Brorson KA, Frey DD, Moreira AR, Rao G. 2006. Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture. J Biotechnol 122(3):293-306.
30. Gill NK, Appleton M, Baganz F, Lye GJ. 2008. Design and characterisation of a miniature stirred bioreactor system for parallel microbial fermentations. Biochem Eng J 39(1):164-176.
31. Hanson MA, Ge X, Kostov Y, Brorson KA, Moreira AR, Rao G. 2007. Comparisons of optical pH and dissolved oxygen sensors with traditional electrochemical probes during mammalian cell culture. Biotechnol Bioeng 97(4):833-841.
32. Hanson M, Brorson K, Moreira A, Rao G. 2009. Comparisons of optically monitored small-scale stirred tank vessels to optically controlled disposable bag bioreactors. Microb Cell Fact 8(1):44-50.
33. Harms P, Kostov Y, Rao G. 2002. Bioprocess monitoring. Curr Opin Biotechnol 13(2):124-127.
34. Harms P, Kostov Y, French JA, Soliman M, Anjanappa M, Ram A, Rao G. 2006. Design and performance of a 24-station high throughput microbioreactor. Biotechnol Bioeng 93(1):6-13.
35. Hessel V, Löwe H, Schönfeld F. 2005. Micromixers-A review on passive and active mixing principles. Chem Eng Sci 60(8-9):2479-2501.
36. Hodkinson JR. 1966. The optical measurement of aerosols. In: Davies CN, editor. Aerosol science. London: Academic Press. p 287-357.
37. Hortsch R, Stratmann A, Weuster-Botz D. 2010. New milliliter-scale stirred tank bioreactors for the cultivation of mycelium forming microorganisms. Biotechnol Bioeng 106(3):443-451.
38. Isett K, George H, Herber W, Amanullah A. 2007. Twenty-four-well plate miniature bioreactor high-throughput system: Assessment for microbial cultivations. Biotechnol Bioeng 98(5):1017-1028.
39. La. Biotechnol Bioeng 99(5):1128-1139.
40. Junker BH. 2004. Scale-up methodologies for Escherichia coli and yeast fermentation processes. J Biosci Bioeng 97(6):347-364.
41. Klein T, Schneider K, Heinzle E. 2012. A system of miniaturized stirred bioreactors for parallel continuous cultivation of yeast with online measurement of dissolved oxygen and off-gas. Biotechnol Bioeng 110(2):535-542.
42. Kondragunta B, Drew JL, Brorson KA, Moreira AR, Rao G. 2010. Advances in clone selection using high-throughput bioreactors. Biotechnol Prog 26(4):1095-1103.
43. Konstantinov K, Chuppa S, Sajan E, Tsai Y, Yoon S, Golini F. 1994. Real-time biomass-concentration monitoring in animal-cell cultures. Trends Biotechnol 12(8):324-333.
44. Kostov Y, Harms P, Randers-Eichhorn L, Rao G. 2001. Low-cost microbioreactor for high-throughput bioprocessing. Biotechnol Bioeng 72(3):346-352.
45. Krasnopolskaya TS, Meleshko VV, Peters GWM, Meijer HEH. 1999. Mixing in Stokes flow in an annular wedge cavity. Eur J Mech B/Fluids 18(5):793-822.
46. Krommenhoek EE. 2007. Integrated sensor array for on-line monitoring micro bioreactors. Enschede, Netherlands: University of Twente.
47. Krommenhoek EE, Gardeniers JGE, Bomer JG, Li X, Ottens M, van Dedem GWK, Van Leeuwen M, van Gulik WM, van der Wielen LAM, Heijnen JJ, van den Berg A. 2007. Integrated electrochemical sensor array for on-line monitoring of yeast fermentations. Anal Chem 79(15):5567-5573.
48. Krommenhoek EE, van Leeuwen M, Gardeniers H, van Gulik WM, van den Berg A, Li X, Ottens M, van der Wielen LAM, Heijnen JJ. 2008. Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration. Biotechnol Bioeng 99(4):884-892.
49. Kumar S, Wittmann C, Heinzle E. 2004. Review: Minibioreactors. Biotechnol Lett 26(1):1-10.
50. Kyung Y-S, Peshwa MV, Gryte DM, Hu W-S. 1994. High density culture of mammalian cells with dynamic perfusion based on on-line oxygen uptake rate measurements. Cytotechnology 14(3):183-190.
51. Lamping SR, Zhang H, Allen B, Ayazi Shamlou P. 2003. Design of a prototype miniature bioreactor for high throughput automated bioprocessing. Chem Eng Sci 58(3-6):747-758.
52. Lee Y, Tsao G. 1979. Dissolved oxygen electrodes. In: Ghose T, Blakebrough N, Fiechter A, editors. Advances in biochemical engineering, Vol. 13. Berlin/Heidelberg: Springer. p 35-86.
53. Lee HLT, Boccazzi P, Ram RJ, Sinskey AJ. 2006. Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control. Lab Chip 6(9):1229-1235.
54. Lee KS, Lee HLT, Ram RJ. 2007. Polymer waveguide backplanes for optical sensor interfaces in microfluidics. Lab Chip 7(11):1539-1545.
55. Lee KS, Boccazzi P, Sinskey AJ, Ram RJ. 2011. Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture. Lab Chip 11(10):1730-1739.
56. Lübbert A, Bay Jørgensen S. 2001. Bioreactor performance: A more scientific approach for practice. J Biotechnol 85(2):187-212.
57. Maier U, Büchs J. 2001. Characterisation of the gas-liquid mass transfer in shaking bioreactors. Biochem Eng J 7(2):99-106.
58. Maier U, Losen M, Büchs J. 2004. Advances in understanding and modeling the gas-liquid mass transfer in shake flasks. Biochem Eng J 17(3):155-167.
59. Micheletti M, Lye GJ. 2006. Microscale bioprocess optimisation. Curr Opin Biotechnol 17(6):611-618.
60. Nanchen A, Schicker A, Sauer U. 2006. Nonlinear dependency of intracellular fluxes on growth rate in miniaturized continuous cultures of Escherichia coli. Appl Environ Microbiol 72(2):1164-1172.
61. Nielsen J, Villadsen J, Lidén G. 2003. Bioreaction engineering principles. New York, New York: Kluwer Academic/Plenum Publishers.
62. Nienow AW. 2006. Reactor engineering in large scale animal cell culture. Cytotechnology 50(1-3):9-33.
63. Özbek B, Gayik S. 2001. The studies on the oxygen mass transfer coefficient in a bioreactor. Process Biochem 36(8-9):729-741.
64. Ozturk SS, Palsson BO. 1991. Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 2. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor. Biotechnol Prog 7(6):481-494.
65. Puskeiler R, Kaufmann K, Weuster-Botz D. 2005. Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD). Biotechnol Bioeng 89(5):512-523.
66. Santos VE, Galdeano C, Gomez E, Alcon A, Garcia-Ochoa F. 2006. Oxygen uptake rate measurements both by the dynamic method and during the process growth of Rhodococcus erythropolis IGTS8: Modelling and difference in results. Biochem Eng J 32(3):198-204.
67. Schäpper D, Stocks SM, Szita N, Lantz AE, Gernaey KV. 2010. Development of a single-use microbioreactor for cultivation of microorganisms. Chem Eng J 160(3):891-898.
68. Schneider K, Schütz V, John G, Heinzle E. 2010. Optical device for parallel online measurement of dissolved oxygen and pH in shake flask cultures. Bioprocess Biosyst Eng 33(5):541-547.
69. Shives E, Xu Y, Jiang H. 2002. Fluorescence lifetime tomography of turbid media based on an oxygen-sensitive dye. Opt Express 10(26):1557-1562.
70. Sonnleitner B, Käppeli O. 1986. Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: Formulation and verification of a hypothesis. Biotechnol Bioeng 28(6):927-937.
71. Swanson NL, Billard BD, Gennaro TL. 1999. Limits of optical transmission measurements with application to particle sizing techniques. Appl Opt 38(27):5887-5893.
72. Szita N, Boccazzi P, Zhang Z, Boyle P, Sinskey AJ, Jensen KF. 2005. Development of a multiplexed microbioreactor system for high-throughput bioprocessing. Lab Chip 5(8):819-826.
73. Tang YJ, Laidlaw D, Gani K, Keasling JD. 2006. Evaluation of the effects of various culture conditions on Cr(VI) reduction by Shewanella oneidensis MR-1 in a novel high-throughput mini-bioreactor. Biotechnol Bioeng 95(1):176-184.
74. Vallejos JR, Kostov Y, Ram A, French JA, Marten MR, Rao G. 2006. Optical analysis of liquid mixing in a minibioreactor. Biotechnol Bioeng 93(5):906-911.
75. Weiss S, John GT, Klimant I, Heinzle E. 2002. Modeling of mixing in 96-well microplates observed with fluorescence indicators. Biotechnol Prog 18(4):821-830.
76. Weuster-Botz D, Puskeiler R, Kusterer A, Kaufmann K, John GT, Arnold M. 2005. Methods and milliliter scale devices for high-throughput bioprocess design. Bioprocess Biosyst Eng 28(2):109-119.
77. Wolfbeis OS. 1991. Fiber optic chemical sensors and biosensors, Vol. II. Boca Raton, Florida: CRC Press.
78. Zanzotto A, Szita N, Boccazzi P, Lessard P, Sinskey AJ, Jensen KF. 2004. Membrane-aerated microbioreactor for high-throughput bioprocessing. Biotechnol Bioeng 87(2):243-254.
79. Zanzotto A, Boccazzi P, Gorret N, Van Dyk TK, Sinskey AJ, Jensen KF. 2006. In situ measurement of bioluminescence and fluorescence in an integrated microbioreactor. Biotechnol Bioeng 93(1):40-47.
80. Zhang Z, Boccazzi P, Choi H-G, Perozziello G, Sinskey AJ, Jensen KF. 2006a. Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor. Lab Chip 6(7):906-913.
81. Zhang Z, Szita N, Boccazzi P, Sinskey AJ, Jensen KF. 2006b. A well-mixed, polymer-based microbioreactor with integrated optical measurements. Biotechnol Bioeng 93(2):286-296.
82. 3 scale. Bioresour Technol 100(3):1406-1412.