High throughput screening based selection of phases for aqueous two-phase system-centrifugal partitioning chromatography of monoclonal antibodies

Journal of Chromatography A

Volumn 1252, Issue , 2012, Pages 104-114

  Oelmeier, Stefan A ^a   Ladd Effio, Christopher ^a   Hubbuch, Jürgen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Centrifugal partitioning chromatography; High throughput screening; Host cell protein; Monoclonal antibody; Process development

Indexed keywords

AQUEOUS TWO PHASE; AQUEOUS TWO PHASE SYSTEM; BATCH EXTRACTION; CHROMATOGRAPHIC SEPARATIONS; DESCRIPTORS; HIGH THROUGHPUT SCREENING; HIGH THROUGHPUT SCREENING METHODS; HOST CELL PROTEIN; OPERATION CONDITIONS; PHASE SELECTION; PRECIPITATION DATA; PRIOR KNOWLEDGE; PROCESS DEVELOPMENT; PROCESS DEVELOPMENT TIME; PROTEIN CONCENTRATIONS; SCREENING APPROACHES; TARGET MOLECULE; TARGET PROTEINS; TIE-LINE;

CENTRIFUGATION; EXPERIMENTS; LIQUID CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; PURIFICATION; SURFACE PLASMON RESONANCE;

PROTEINS;

MONOCLONAL ANTIBODY;

AQUEOUS TWO PHASE SYSTEM-CENTRIFUGAL PARTITIONING CHROMATOGRAPHY; ARTICLE; CENTRIFUGATION; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; PARTITION CHROMATOGRAPHY; PHASE PARTITIONING; PHASE SEPARATION; PRECIPITATION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PURIFICATION; QUALITATIVE ANALYSIS; SCREENING TEST;

ANIMALS; ANTIBODIES, MONOCLONAL; CENTRIFUGATION; CHEMICAL PRECIPITATION; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; HIGH-THROUGHPUT SCREENING ASSAYS; LIQUID-LIQUID EXTRACTION; SOLUBILITY;

EID: 84864550319     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.06.075     Document Type: Article

References (28)

1. Azevedo A.M., Rosa P.A.J., Ferreira I.F., Aires-Barros M.R. Trends Biotechnol. 2009, 27:240.
2. Sasakawa S., Walter H. Biochemistry 1972, 11:2760.
3. Johansson G., Sarnesto A., Huge-Jensen E., Szabo-Lin I., Guthenberg C., Mannervik B. Acta Chem. Scand. 1974, 28b:873.
4. Berggren K., Wolf A., Asenjo J.A., Andrews B.A., Tjerneld F. Biochim. Biophys. Acta 2002, 1596:253.
5. Asenjo J.A., Schmidt A.S., Hachem F., Andrews B.A. J. Chromatogr. A 1994, 668:47.
6. Andrews B.A., Schmidt A.S., Asenjo J.A. Biotechnol. Bioeng. 2005, 90:380.
7. Rosa P.A.J. J. Chromatogr. A 2007, 1141:50.
8. Oelmeier S.A., Dismer F., Hubbuch J. Biotechnol. Bioeng. 2011, 108:69.
9. Armstrong D.W. J. Liq. Chromatogr. Relat. Technol. 1988, 11:2433.
10. Sutherland I.A., Audo G., Bourton E., Couillard F., Fisher D., Garrard I., Hewitson P., Intes O. J. Chromatogr. A 2008, 1190:57.
11. Berthod A., Hassoun M., Ruiz-Angel M.J. Anal. Bioanal. Chem. 2005, 383:327.
12. Merchuk J.C., Andrews B.A., Asenjo J.A. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 1998, 711:285.
13. Foucault A. Centrifugal Partition Chromatography, Chromatographic Science 1995, M. Dekker.
14. Atha D.H., Ingham K.C. J. Biol. Chem. 1981, 256:12108.
15. Shih Y.C., Prausnitz J.M., Blanch H.W. Biotechnol. Bioeng. 1992, 40:1155.
16. Iyer H.V., Przybycien T.M. AIChE J. 1994, 40:349.
17. Ahamed T., Esteban B.N.A., Ottens M., Dedem G.W.K.v., Wielen L.A.M.v.d., Bisschops M.A.T., Lee A., Pham C., Thommes J. Biophys. J. 2007, 93:610.
18. Kumar A., Galaev I., Mattiasson B. Precipitation of Proteins: Nonspecific and Specific 2003, CRC Press, (Chapter 7).
19. Perosa F., Carbone R., Ferrone S., Dammacco F. J. Immunol. Methods 1990, 128:9.
20. Persson J., Lester P. Biotechnol. Bioeng. 2004, 87:424.
21. Rito-Palomares M. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2004, 807:3.
22. Benavides J., Rito-Palomares M. J. Chem. Technol. Biotechnol. 2008, 83:133.
23. Hachem F. Enzyme Microb. Technol. 1996, 19:507.
24. Przybycien T.M., Bailey J.E. AIChE J. 1989, 35:1779.
25. Sutherland I.A. J. Chromatogr. A 2007, 1151:6.
26. Bérot S., Le Goff E., Foucault A., Quillien L. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2007, 845:205.
27. Sutherland I.A., de Folter J., Wood P. J. Liq. Chromatogr. Relat. Technol. 2003, 26:1449.
28. Folter J.D., Sutherland I.A. J. Chromatogr. A 2009, 1216:4218.