High-throughput process development methods for chromatography and precipitation of proteins: Advantages and precautions

Engineering in Life Sciences

Volumn 13, Issue 5, 2013, Pages 446-455

  Yoshimoto, Noriko ^a   Minakuchi, Kazunobu ^a   Itoh, Daisuke ^a   Isakari, Yu ^a   Yamamoto, Shuichi ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

96 Well microplate; High throughput process development; Monolith chromatography; Protein A chromatography; Protein precipitation

Indexed keywords

BATCH ADSORPTION EXPERIMENTS; DYNAMIC BINDING CAPACITY; LINEAR GRADIENT ELUTION; MICROPLATES; PRECIPITATION PROCESS; PROCESS DEVELOPMENT; PROTEIN A CHROMATOGRAPHY; PROTEIN PRECIPITATION;

ANTIBODIES; CHROMATOGRAPHY; EXPERIMENTS; ION EXCHANGE; PRECIPITATION (CHEMICAL); SOLUBILITY;

ION EXCHANGE MEMBRANES;

PROTEIN A;

ADSORPTION; BREAKTHROUGH CURVE; MICROPLATE; PROTEIN; PURIFICATION; SOLUBILITY;

ADSORPTION; ARTICLE; COLUMN CHROMATOGRAPHY; DESORPTION; DIFFUSION; GEL CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; PRECIPITATION; PROCESS DEVELOPMENT; PURIFICATION; SCREENING; SOLUBILITY;

EID: 84884134118     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.201200121     Document Type: Article

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