A sub-two minutes method for monoclonal antibody-aggregate quantification using parallel interlaced size exclusion high performance liquid chromatography

Journal of Chromatography A

Volumn 1218, Issue 50, 2011, Pages 9010-9018

  Diederich, Patrick ^a   Hansen, Sigrid K ^a   Oelmeier, Stefan A ^a   Stolzenberger, Bianca ^a   Hubbuch, Jürgen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Aggregates; High throughput analytics; Interlaced injection; Monoclonal antibody; PI SEC; Size exclusion chromatography

Indexed keywords

AVERAGE THROUGHPUT; COEFFICIENT OF VARIATION; COMMERCIAL PRODUCTIONS; HIGH PRECISION; HIGH RESOLUTION; HIGH THROUGHPUT; IN-PROCESS; LAG TIME; MONOCLONAL ANTIBODIES (MAB); PARALLELIZATIONS; PI-SEC; PROCESS DEVELOPMENT; PURIFICATION PROCESS; REPRODUCIBILITIES; SAMPLE INJECTION; SHORT COLUMN; SIZE EXCLUSION;

AGGREGATES; COLUMN CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; PROCESS CONTROL; PROCESS MONITORING; THROUGHPUT;

SIZE EXCLUSION CHROMATOGRAPHY;

MONOCLONAL ANTIBODY;

ACCURACY; ARTICLE; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOASSAY; INTERMETHOD COMPARISON; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS MONITORING; QUANTITATIVE ANALYSIS; REPRODUCIBILITY;

ANTIBODIES, MONOCLONAL; BIOCHEMICAL PROCESSES; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, CHEMICAL; PARTICLE SIZE; POROSITY;

EID: 81855164598     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.09.086     Document Type: Article

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