A tool for increasing the lifetime of chromatography resins

mAbs

Volumn 3, Issue 2, 2011, Pages 192-202

  Grönberg, Anna ^a   Eriksson, Malin ^a   Ersoy, Maria ^a   Johansson, Hans J ^a  

^a GE Healthcare Bio Sciences AB   (Sweden)

Author keywords

Bioprocess; Chromatography; Cleaning in place; High throughput; Monoclonal antibody; Process development; Protein A; Screening

Indexed keywords

RESIN; ION EXCHANGE RESIN; MONOCLONAL ANTIBODY; SODIUM HYDROXIDE;

ARTICLE; BIOFOULING; BIOPROCESS; CENTRIFUGATION; CHROMATOGRAPHY; CLEANING; CONTAMINATION; HIGH THROUGHPUT SCREENING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROCESS DEVELOPMENT; REPRODUCIBILITY; AFFINITY CHROMATOGRAPHY; ANIMAL; AUTOMATION; CHEMISTRY; CHO CELL; CRICETULUS; CULTURE MEDIUM; EVALUATION; FILTRATION; HAMSTER; INSTRUMENTATION; ION EXCHANGE CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METHODOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOMATION; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, ION EXCHANGE; CRICETINAE; CRICETULUS; CULTURE MEDIA, CONDITIONED; FILTRATION; HIGH-THROUGHPUT SCREENING ASSAYS; ION EXCHANGE RESINS; REPRODUCIBILITY OF RESULTS; SODIUM HYDROXIDE;

EID: 79952733443     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.3.2.14874     Document Type: Article

References (11)

1. Hagel L, Jagschies G, Sofer G. Cleaning and Sanitization. In: Handbook of Process Chromatography - Development, Manufacturing, Validation and Economics. Second edition. London, UK: Academic Press 2008; 147-59.
2. Björkman T, Blackwell J, Castillo F, Ecker D, Fulton SP, Jagschies G, et al. High Throughput Methods for Process Development. In: Levine L, Jagshies G eds. The Development of Therapeutic Monoclonal Antibody Products - A Comprehensive Guide to CMC Activities form Clone to Clinic. Acton, MA Bioprocess Technology consultants Inc 2010; 190-7.
3. Handbook: High-throughput Process Development with PreDictorTM Plates, Principles and Methods 28-9403-58 AA, GE Healthcare 12/2009.
4. Grönberg A, Tengliden H, Johansson HJ. Rapid development of CIP protocols for affinity media. Poster presented at the SPICA conference. Sept 29-Oct 01, 2008.
5. Eriksson M. Development of a High Throughput Method for Screening of Cleaning-in-Place Protocols for Chromatography Media. Degree project in Biotechnology and Genomics Engineering. Institute of Technology, Umeå University 2009.
6. High-throughput process development for design of cleaning-in-place protocols. Application note 28-9845-64 AA. GE Healthcare 2010.
7. Grönberg A, Ersoy M, Johansson HJ, Solamo F. Highthroughput development of cleaning-in-place protocols for chromatography resins. Oral presentation at ACS conference. BIOT program, Washington DC 2009.
8. Grönberg A, Johansson HJ, Eriksson KO, Carredano E. High-throughput process development technology for design of cleaning-in-place (CIP) protocols for chromatography media. Oral presentation at Miniaturisation - Micro Scale Bioprocess Development conference, UK 2010.
9. Grönberg A, Johansson HJ, Eriksson KO, Carredano E. Automated HTPD Technology for design of CIP protocols for Chromatography resins. Poster presented at High-throughput Process Development meeting. Krakow Poland 2010.
10. PreDictor plates instructions, 28-9258-34 AD, GE Healthcare.
11. HT Protein LabChip Kit User Guide, Caliper Life Sciences 2007.