Examination of a genetic algorithm for the application in high-throughput downstream process development

Biotechnology Journal

Volumn 7, Issue 10, 2012, Pages 1203-1215

  Treier, Katrin ^a,b   Berg, Annette ^a,c   Diederich, Patrick ^a   Lang, Katharina ^a   Osberghaus, Anna ^a   Dismer, Florian ^a   Hubbuch, Jürgen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b BASF SE   (Germany)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Downstream processing; Genetic algorithms; High throughput screening; Inclusion body refolding; Optimization

Indexed keywords

DOWNSTREAM PROCESS; DOWNSTREAM-PROCESSING; GA OPTIMIZATION; GLOBAL OPTIMUM; HIGH NOISE LEVELS; HIGH THROUGHPUT EXPERIMENTS; HIGH-THROUGHPUT; HIGH-THROUGHPUT SCREENING; IN-SILICO; MATHEMATICAL FUNCTIONS; MULTIDIMENSIONAL OPTIMIZATION; OBJECTIVE FUNCTIONS; OPTIMAL PARAMETER SETTINGS; OPTIMIZATION APPROACH; OPTIMIZATION METHOD; POPULATION SIZES; PREMATURE CONVERGENCE; REFOLDING; RESPONSE SURFACE ANALYSIS; SELECTION PRESSURES; SIGNIFICANT IMPACTS; SIMPLE SYSTEM;

DESIGN OF EXPERIMENTS; FUNCTIONS; OPTIMIZATION; POPULATION STATISTICS; SURFACE ANALYSIS; THROUGHPUT;

GENETIC ALGORITHMS;

LYSOZYME;

ARTICLE; COMPUTER MODEL; GENETIC ALGORITHM; HIGH THROUGHPUT SCREENING; MATHEMATICAL ANALYSIS; PARAMETERS; POPULATION SIZE; PRESSURE; PRIORITY JOURNAL; PROCESS DEVELOPMENT;

ALGORITHMS; BUFFERS; COMPUTER SIMULATION; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN-ION CONCENTRATION; MODELS, GENETIC; MODELS, THEORETICAL; MURAMIDASE; PROTEIN FOLDING; RESEARCH DESIGN;

EID: 84867195750     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200145     Document Type: Article

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