Quantitative high throughput analytics to support polysaccharide production process development

Vaccine

Volumn 32, Issue 24, 2014, Pages 2819-2828

  Noyes, Aaron ^a,b   Godavarti, Ranga ^b   Titchener Hooker, Nigel ^a   Coffman, Jonathan ^b   Mukhopadhyay, Tarit ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Capsular polysaccharides; Carbohydrates; Endotoxin assays; High throughput process development; Phenol sulphuric acid assay; Sugar quantification

Indexed keywords

ENDOTOXIN; HYALURONIC ACID; N ACETYLNEURAMINIC ACID; POLYSACCHARIDE; POLYSACCHARIDE VACCINE; SULFURIC ACID; TRISACCHARIDE;

ARTICLE; BACTERIAL MEMBRANE; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; DOWNSTREAM PROCESSING; HIGH THROUGHPUT SCREENING; INCUBATION TEMPERATURE; LIMIT OF QUANTITATION; MEASUREMENT ACCURACY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN DETERMINATION; PURIFICATION; ROOM TEMPERATURE;

CAPSULAR POLYSACCHARIDES; CARBOHYDRATES; ENDOTOXIN ASSAYS; HIGH THROUGHPUT PROCESS DEVELOPMENT; PHENOL SULPHURIC ACID ASSAY; SUGAR QUANTIFICATION;

HIGH-THROUGHPUT SCREENING ASSAYS; POLYSACCHARIDES; TECHNOLOGY, PHARMACEUTICAL; VACCINES;

EID: 84899947204     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2014.02.034     Document Type: Article

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