메뉴 건너뛰기




Volumn 1, Issue 4, 2013, Pages 301-311

Matrix-Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation

Author keywords

Capillary rarefaction; Chronic kidney disease; Interstitium; Matrix producing cells; Myofibroblast; Pericyte

Indexed keywords


EID: 84907044310     PISSN: None     EISSN: 2167485X     Source Type: Journal    
DOI: 10.1007/s40139-013-0026-7     Document Type: Review
Times cited : (49)

References (113)
  • 1
    • 77951587507 scopus 로고    scopus 로고
    • Acute kidney injury: a springboard for progression in chronic kidney disease
    • PID: 20200097, COI: 1:CAS:528:DC%2BC3cXmt1Kltro%3D
    • Venkatachalam MA, Griffin KA, Lan R et al (2010) Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 298(5):F1078–F1094
    • (2010) Am J Physiol Renal Physiol , vol.298 , Issue.5 , pp. F1078-F1094
    • Venkatachalam, M.A.1    Griffin, K.A.2    Lan, R.3
  • 2
    • 58149485462 scopus 로고    scopus 로고
    • Acute kidney injury increases risk of ESRD among elderly
    • PID: 19020007
    • Ishani A, Xue JL, Himmelfarb J et al (2009) Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 20(1):223–228
    • (2009) J Am Soc Nephrol , vol.20 , Issue.1 , pp. 223-228
    • Ishani, A.1    Xue, J.L.2    Himmelfarb, J.3
  • 3
    • 58149505555 scopus 로고    scopus 로고
    • Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis
    • PID: 19346042
    • Coca SG, Yusuf B, Shlipak MG et al (2009) Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 53(6):961–973
    • (2009) Am J Kidney Dis , vol.53 , Issue.6 , pp. 961-973
    • Coca, S.G.1    Yusuf, B.2    Shlipak, M.G.3
  • 4
    • 84878231896 scopus 로고    scopus 로고
    • Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis
    • PID: 23325411
    • Campanholle G, Ligresti G, Gharib SA, Duffield JS (2013) Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis. Am J Physiol Cell Physiol 304(7):C591–C603
    • (2013) Am J Physiol Cell Physiol , vol.304 , Issue.7 , pp. C591-C603
    • Campanholle, G.1    Ligresti, G.2    Gharib, S.A.3    Duffield, J.S.4
  • 5
    • 82355190219 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of renal fibrosis
    • PID: 22009250, COI: 1:CAS:528:DC%2BC3MXhsFeisLjP
    • Liu Y (2011) Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol 7(12):684–696
    • (2011) Nat Rev Nephrol , vol.7 , Issue.12 , pp. 684-696
    • Liu, Y.1
  • 6
    • 31644441212 scopus 로고    scopus 로고
    • The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 2—tumours and tumour-like lesions
    • PID: 16612972, COI: 1:STN:280:DC%2BD283gs1Kjuw%3D%3D
    • Eyden B (2005) The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 2—tumours and tumour-like lesions. J Submicrosc Cytol Pathol 37(3–4):231–296
    • (2005) J Submicrosc Cytol Pathol , vol.37 , Issue.3-4 , pp. 231-296
    • Eyden, B.1
  • 7
    • 77955056291 scopus 로고    scopus 로고
    • Regulation of myofibroblast activities: calcium pulls some strings behind the scene
    • PID: 20451515, COI: 1:CAS:528:DC%2BC3cXptlCkurY%3D
    • Follonier Castella L, Gabbiani G, McCulloch CA, Hinz B (2010) Regulation of myofibroblast activities: calcium pulls some strings behind the scene. Exp Cell Res 316(15):2390–2401
    • (2010) Exp Cell Res , vol.316 , Issue.15 , pp. 2390-2401
    • Follonier Castella, L.1    Gabbiani, G.2    McCulloch, C.A.3    Hinz, B.4
  • 8
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • PID: 19487818, COI: 1:CAS:528:DC%2BD1MXntVCjtr0%3D
    • Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119(6):1420–1428
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 9
    • 84864962631 scopus 로고    scopus 로고
    • The role of the myofibroblast in tumor stroma remodeling
    • PID: 22568985
    • Otranto M, Sarrazy V, Bonte F et al (2012) The role of the myofibroblast in tumor stroma remodeling. Cell Adh Migr 6(3):203–219
    • (2012) Cell Adh Migr , vol.6 , Issue.3 , pp. 203-219
    • Otranto, M.1    Sarrazy, V.2    Bonte, F.3
  • 11
    • 84863306899 scopus 로고    scopus 로고
    • Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis
    • This work demonstrates that injury of tubular epithelial cells promotes fibrosis
    • ∙ Grgic I, Campanholle G, Bijol V et al (2012) Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int 82(2):172–83. This work demonstrates that injury of tubular epithelial cells promotes fibrosis
    • (2012) Kidney Int , vol.82 , Issue.2 , pp. 172-183
    • Grgic, I.1    Campanholle, G.2    Bijol, V.3
  • 12
    • 0036318317 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies
    • PID: 12081572
    • Rastaldi MP, Ferrario F, Giardino L et al (2002) Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 62(1):137–146
    • (2002) Kidney Int , vol.62 , Issue.1 , pp. 137-146
    • Rastaldi, M.P.1    Ferrario, F.2    Giardino, L.3
  • 13
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • PID: 12808448, COI: 1:CAS:528:DC%2BD3sXkvFOjs7Y%3D
    • Zeisberg M, Hanai J, Sugimoto H et al (2003) BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9(7):964–968
    • (2003) Nat Med , vol.9 , Issue.7 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3
  • 14
    • 0036322007 scopus 로고    scopus 로고
    • Evidence that fibroblasts derive from epithelium during tissue fibrosis
    • PID: 12163453, COI: 1:CAS:528:DC%2BD38XlvFKhtLY%3D
    • Iwano M, Plieth D, Danoff TM et al (2002) Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Investig 110(3):341–350
    • (2002) J Clin Investig , vol.110 , Issue.3 , pp. 341-350
    • Iwano, M.1    Plieth, D.2    Danoff, T.M.3
  • 15
    • 84875053173 scopus 로고    scopus 로고
    • Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins
    • PID: 23224993, COI: 1:CAS:528:DC%2BC3sXktFShs7Y%3D
    • Phua YL, Martel N, Pennisi DJ et al (2013) Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins. J Pathol 229(5):685–696
    • (2013) J Pathol , vol.229 , Issue.5 , pp. 685-696
    • Phua, Y.L.1    Martel, N.2    Pennisi, D.J.3
  • 16
    • 79551521517 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
    • PID: 21370523, COI: 1:CAS:528:DC%2BC3MXhsl2rtbg%3D
    • Kriz W, Kaissling B, Le Hir M (2011) Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest 121(2):468–474
    • (2011) J Clin Invest , vol.121 , Issue.2 , pp. 468-474
    • Kriz, W.1    Kaissling, B.2    Le Hir, M.3
  • 17
    • 73949096744 scopus 로고    scopus 로고
    • Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    • These data reveal using genetic lineage tracing that FoxD1+ resident pericytes, perivascular fibroblasts, and interstitial fibroblasts give rise to myofibroblasts in renal fibrogenesis after unilateral ureteral obstruction
    • ∙ Humphreys BD, Lin SL, Kobayashi A et al (2010) Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176(1):85–97. These data reveal using genetic lineage tracing that FoxD1+ resident pericytes, perivascular fibroblasts, and interstitial fibroblasts give rise to myofibroblasts in renal fibrogenesis after unilateral ureteral obstruction
    • (2010) Am J Pathol , vol.176 , Issue.1 , pp. 85-97
    • Humphreys, B.D.1    Lin, S.L.2    Kobayashi, A.3
  • 18
    • 33645460730 scopus 로고    scopus 로고
    • Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis
    • PID: 16467445, COI: 1:CAS:528:DC%2BD28XislCqs7c%3D
    • Roufosse C, Bou-Gharios G, Prodromidi E et al (2006) Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis. J Am Soc Nephrol 17(3):775–782
    • (2006) J Am Soc Nephrol , vol.17 , Issue.3 , pp. 775-782
    • Roufosse, C.1    Bou-Gharios, G.2    Prodromidi, E.3
  • 19
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • PID: 19008372, COI: 1:CAS:528:DC%2BD1MXkt1CktQ%3D%3D
    • Lin SL, Kisseleva T, Brenner DA, Duffield JS (2008) Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173(6):1617–1627
    • (2008) Am J Pathol , vol.173 , Issue.6 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 20
    • 84882289111 scopus 로고    scopus 로고
    • Origin and function of myofibroblasts in kidney fibrosis
    • This study employed a number of genetic models to dissect the relative contributions of bone marrow, resident kidney fibroblasts, kidney pericytes, endothelial cells, and epithelial cells. The authors concluded that resident fibroblasts account for the majority of myofibroblasts, with significant contributions from bone marrow and much smaller contributions from endothelial or epithelial cells. They did not observe a pericyte origin for myofibroblasts
    • ∙∙ Lebleu VS, Taduri G, O’Connell J et al (2013) Origin and function of myofibroblasts in kidney fibrosis. Nat Med 19(8):1047–53. This study employed a number of genetic models to dissect the relative contributions of bone marrow, resident kidney fibroblasts, kidney pericytes, endothelial cells, and epithelial cells. The authors concluded that resident fibroblasts account for the majority of myofibroblasts, with significant contributions from bone marrow and much smaller contributions from endothelial or epithelial cells. They did not observe a pericyte origin for myofibroblasts
    • (2013) Nat Med , vol.19 , Issue.8 , pp. 1047-1053
    • Lebleu, V.S.1    Taduri, G.2    O’Connell, J.3
  • 21
    • 44449161800 scopus 로고    scopus 로고
    • Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat
    • PID: 18449560, COI: 1:CAS:528:DC%2BD1cXmtlWit70%3D
    • Picard N, Baum O, Vogetseder A et al (2008) Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat. Histochem Cell Biol 130(1):141–155
    • (2008) Histochem Cell Biol , vol.130 , Issue.1 , pp. 141-155
    • Picard, N.1    Baum, O.2    Vogetseder, A.3
  • 22
    • 79960099283 scopus 로고    scopus 로고
    • A pericyte origin of spinal cord scar tissue
    • These data reveal that pericytes are major players in scarring of the spinal cord after injury. The authors performed lineage tracing using Glast-CreER driver mice and demonstrated that Glast-expressing pericytes of the sppinal cord parenchyma expand, gain α-SMA, and become myofibroblasts after injury
    • ∙∙ Goritz C, Dias DO, Tomilin N et al (2011) A pericyte origin of spinal cord scar tissue. Science 333(6039):238–42. These data reveal that pericytes are major players in scarring of the spinal cord after injury. The authors performed lineage tracing using Glast-CreER driver mice and demonstrated that Glast-expressing pericytes of the sppinal cord parenchyma expand, gain α-SMA, and become myofibroblasts after injury
    • (2011) Science , vol.333 , Issue.6039 , pp. 238-242
    • Goritz, C.1    Dias, D.O.2    Tomilin, N.3
  • 23
    • 84867382214 scopus 로고    scopus 로고
    • Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy
    • PID: 23062987, COI: 1:CAS:528:DC%2BC38XhsFSls7zO
    • Humphreys BD (2012) Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy. Semin Nephrol 32(5):463–470
    • (2012) Semin Nephrol , vol.32 , Issue.5 , pp. 463-470
    • Humphreys, B.D.1
  • 24
    • 14044279905 scopus 로고    scopus 로고
    • Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development
    • PID: 15634693, COI: 1:CAS:528:DC%2BD2MXhvVeltbc%3D
    • Levinson RS, Batourina E, Choi C et al (2005) Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development 132(3):529–539
    • (2005) Development , vol.132 , Issue.3 , pp. 529-539
    • Levinson, R.S.1    Batourina, E.2    Choi, C.3
  • 25
    • 0029741093 scopus 로고    scopus 로고
    • Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2
    • PID: 8666231, COI: 1:CAS:528:DyaK28XjvVOhsbY%3D
    • Hatini V, Huh SO, Herzlinger D et al (1996) Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev 10(12):1467–1478
    • (1996) Genes Dev , vol.10 , Issue.12 , pp. 1467-1478
    • Hatini, V.1    Huh, S.O.2    Herzlinger, D.3
  • 26
    • 84857111725 scopus 로고    scopus 로고
    • The origin of interstitial myofibroblasts in chronic kidney disease
    • PID: 21311912
    • Grgic I, Duffield JS, Humphreys BD (2012) The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol 27(2):183–193
    • (2012) Pediatr Nephrol , vol.27 , Issue.2 , pp. 183-193
    • Grgic, I.1    Duffield, J.S.2    Humphreys, B.D.3
  • 27
    • 84864722077 scopus 로고    scopus 로고
    • Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury
    • This work demonstrates, using genetic fate mapping, that ADAM12+ and PDGFR-α+ pericytes are the major source of myofibroblasts in scarring of skeletal muscle and skin. Genetic ablation of ADAM12+ cells or knockdown of ADAM12 was able to ameliorate the severity of fibrosis
    • ∙∙ Dulauroy S, Di Carlo SE, Langa F et al (2012) Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury. Nat Med 18(8). This work demonstrates, using genetic fate mapping, that ADAM12+ and PDGFR-α+ pericytes are the major source of myofibroblasts in scarring of skeletal muscle and skin. Genetic ablation of ADAM12+ cells or knockdown of ADAM12 was able to ameliorate the severity of fibrosis
    • (2012) Nat Med , vol.18 , Issue.8
    • Dulauroy1    Di Carlo, S.2    Langa, S.E.F.3
  • 28
    • 81155131228 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis
    • PID: 21716259, COI: 1:CAS:528:DC%2BC3MXhsVylsL7L
    • Chen YT, Chang FC, Wu CF et al (2011) Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis. Kidney Int 80(11):1170–1181
    • (2011) Kidney Int , vol.80 , Issue.11 , pp. 1170-1181
    • Chen, Y.T.1    Chang, F.C.2    Wu, C.F.3
  • 29
    • 34547891908 scopus 로고    scopus 로고
    • NG2 proteoglycan increases mesangial cell proliferation and extracellular matrix production
    • PID: 17686464, COI: 1:CAS:528:DC%2BD2sXpt1Kgtb4%3D
    • Xiong J, Wang Y, Zhu Z et al (2007) NG2 proteoglycan increases mesangial cell proliferation and extracellular matrix production. Biochem Biophys Res Commun 361(4):960–967
    • (2007) Biochem Biophys Res Commun , vol.361 , Issue.4 , pp. 960-967
    • Xiong, J.1    Wang, Y.2    Zhu, Z.3
  • 30
    • 84864595831 scopus 로고    scopus 로고
    • The renal (myo-)fibroblast: a heterogeneous group of cells
    • PID: 22851626
    • Boor P, Floege J (2012) The renal (myo-)fibroblast: a heterogeneous group of cells. Nephrol Dial Transplant 27(8):3027–3036
    • (2012) Nephrol Dial Transplant , vol.27 , Issue.8 , pp. 3027-3036
    • Boor, P.1    Floege, J.2
  • 31
    • 84875975382 scopus 로고    scopus 로고
    • Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts
    • PID: 23229927, COI: 1:CAS:528:DC%2BC3sXlsV2qsrk%3D
    • Seikrit C, Henkel C, van Roeyen CR et al (2013) Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts. Nephrol Dial Transplant 28(4):889–900
    • (2013) Nephrol Dial Transplant , vol.28 , Issue.4 , pp. 889-900
    • Seikrit, C.1    Henkel, C.2    van Roeyen, C.R.3
  • 32
    • 79959743981 scopus 로고    scopus 로고
    • Pivotal role of pericytes in kidney fibrosis
    • PID: 21517936
    • Kida Y, Duffield JS (2011) Pivotal role of pericytes in kidney fibrosis. Clin Exp Pharmacol Physiol 38(7):467–473
    • (2011) Clin Exp Pharmacol Physiol , vol.38 , Issue.7 , pp. 467-473
    • Kida, Y.1    Duffield, J.S.2
  • 33
    • 84875748988 scopus 로고    scopus 로고
    • EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury
    • PID: 23492730, COI: 1:CAS:528:DC%2BC3sXmslWhu7w%3D
    • Kida Y, Ieronimakis N, Schrimpf C et al (2013) EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury. J Am Soc Nephrol 24(4):559–572
    • (2013) J Am Soc Nephrol , vol.24 , Issue.4 , pp. 559-572
    • Kida, Y.1    Ieronimakis, N.2    Schrimpf, C.3
  • 34
    • 4043077114 scopus 로고    scopus 로고
    • Rarefaction of peritubular capillaries following ischemic acute renal failure: a potential factor predisposing to progressive nephropathy
    • PID: 15090853
    • Basile DP (2004) Rarefaction of peritubular capillaries following ischemic acute renal failure: a potential factor predisposing to progressive nephropathy. Curr Opin Nephrol Hypertens 13(1):1–7
    • (2004) Curr Opin Nephrol Hypertens , vol.13 , Issue.1 , pp. 1-7
    • Basile, D.P.1
  • 35
    • 48649099815 scopus 로고    scopus 로고
    • The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease
    • PID: 18528327
    • Eardley KS, Kubal C, Zehnder D et al (2008) The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease. Kidney Int 74(4):495–504
    • (2008) Kidney Int , vol.74 , Issue.4 , pp. 495-504
    • Eardley, K.S.1    Kubal, C.2    Zehnder, D.3
  • 36
    • 0025634252 scopus 로고
    • Number of interstitial capillary cross-sections assessed by monoclonal antibodies: relation to interstitial damage
    • PID: 2128387, COI: 1:STN:280:DyaK3M3gsVaiuw%3D%3D
    • Seron D, Alexopoulos E, Raftery MJ et al (1990) Number of interstitial capillary cross-sections assessed by monoclonal antibodies: relation to interstitial damage. Nephrol Dial Transplant 5(10):889–893
    • (1990) Nephrol Dial Transplant , vol.5 , Issue.10 , pp. 889-893
    • Seron, D.1    Alexopoulos, E.2    Raftery, M.J.3
  • 37
    • 0034523928 scopus 로고    scopus 로고
    • Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endothelial growth factor
    • PID: 11150374, COI: 1:STN:280:DC%2BD3M%2FpsVGgsw%3D%3D
    • Choi YJ, Chakraborty S, Nguyen V et al (2000) Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endothelial growth factor. Hum Pathol 31(12):1491–1497
    • (2000) Hum Pathol , vol.31 , Issue.12 , pp. 1491-1497
    • Choi, Y.J.1    Chakraborty, S.2    Nguyen, V.3
  • 38
    • 84860645452 scopus 로고    scopus 로고
    • Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury
    • PID: 22383695, COI: 1:CAS:528:DC%2BC38Xns12isbg%3D
    • Schrimpf C, Xin C, Campanholle G et al (2012) Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury. J Am Soc Nephrol 23(5):868–883
    • (2012) J Am Soc Nephrol , vol.23 , Issue.5 , pp. 868-883
    • Schrimpf, C.1    Xin, C.2    Campanholle, G.3
  • 39
    • 79951816985 scopus 로고    scopus 로고
    • Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis
    • PID: 21281822, COI: 1:CAS:528:DC%2BC3MXjtVOltLk%3D
    • Lin SL, Chang FC, Schrimpf C et al (2011) Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis. Am J Pathol 178(2):911–923
    • (2011) Am J Pathol , vol.178 , Issue.2 , pp. 911-923
    • Lin, S.L.1    Chang, F.C.2    Schrimpf, C.3
  • 40
    • 34547688939 scopus 로고    scopus 로고
    • Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts
    • PID: 17594488
    • Pohlers D, Beyer A, Koczan D et al (2007) Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther 9(3):R59
    • (2007) Arthritis Res Ther , vol.9 , Issue.3 , pp. R59
    • Pohlers, D.1    Beyer, A.2    Koczan, D.3
  • 41
    • 0036895640 scopus 로고    scopus 로고
    • Cellular basis of diabetic nephropathy: II. The transforming growth factor-beta system and diabetic nephropathy lesions in type 1 diabetes
    • PID: 12453917, COI: 1:CAS:528:DC%2BD38Xptl2msr0%3D
    • Huang C, Kim Y, Caramori ML et al (2002) Cellular basis of diabetic nephropathy: II. The transforming growth factor-beta system and diabetic nephropathy lesions in type 1 diabetes. Diabetes 51(12):3577–3581
    • (2002) Diabetes , vol.51 , Issue.12 , pp. 3577-3581
    • Huang, C.1    Kim, Y.2    Caramori, M.L.3
  • 42
    • 84867818057 scopus 로고    scopus 로고
    • TGF-beta1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner
    • PID: 22771387, COI: 1:CAS:528:DC%2BC38Xhsleru7%2FI
    • Wygrecka M, Zakrzewicz D, Taborski B et al (2012) TGF-beta1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner. Am J Respir Cell Mol Biol 47(5):614–627
    • (2012) Am J Respir Cell Mol Biol , vol.47 , Issue.5 , pp. 614-627
    • Wygrecka, M.1    Zakrzewicz, D.2    Taborski, B.3
  • 43
    • 34047148354 scopus 로고    scopus 로고
    • The role of TGF-beta signaling in myocardial infarction and cardiac remodeling
    • PID: 17109837, COI: 1:CAS:528:DC%2BD2sXjvFehs7g%3D
    • Bujak M, Frangogiannis NG (2007) The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res 74(2):184–195
    • (2007) Cardiovasc Res , vol.74 , Issue.2 , pp. 184-195
    • Bujak, M.1    Frangogiannis, N.G.2
  • 44
    • 84863878959 scopus 로고    scopus 로고
    • Cross talk among TGF-beta signaling pathways, integrins, and the extracellular matrix
    • PID: 21900405
    • Munger JS, Sheppard D (2011) Cross talk among TGF-beta signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol 3(11):a005017
    • (2011) Cold Spring Harb Perspect Biol , vol.3 , Issue.11 , pp. a005017
    • Munger, J.S.1    Sheppard, D.2
  • 45
    • 33646164362 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulation of immune responses
    • PID: 16551245, COI: 1:CAS:528:DC%2BD28XkvFSqt7w%3D
    • Li MO, Wan YY, Sanjabi S et al (2006) Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24:99–146
    • (2006) Annu Rev Immunol , vol.24 , pp. 99-146
    • Li, M.O.1    Wan, Y.Y.2    Sanjabi, S.3
  • 46
    • 0022471924 scopus 로고
    • Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
    • PID: 2424019, COI: 1:CAS:528:DyaL28XksFGhtL0%3D
    • Roberts AB, Sporn MB, Assoian RK et al (1986) Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83(12):4167–4171
    • (1986) Proc Natl Acad Sci USA , vol.83 , Issue.12 , pp. 4167-4171
    • Roberts, A.B.1    Sporn, M.B.2    Assoian, R.K.3
  • 47
    • 0030800795 scopus 로고    scopus 로고
    • Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung
    • PID: 9259574, COI: 1:CAS:528:DyaK2sXlsFejurs%3D
    • Sime PJ, Xing Z, Graham FL et al (1997) Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 100(4):768–776
    • (1997) J Clin Invest , vol.100 , Issue.4 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3
  • 48
    • 0026059613 scopus 로고
    • Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor
    • PID: 1846448, COI: 1:CAS:528:DyaK3MXpsFOmsw%3D%3D
    • Dennis PA, Rifkin DB (1991) Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci USA 88(2):580–584
    • (1991) Proc Natl Acad Sci USA , vol.88 , Issue.2 , pp. 580-584
    • Dennis, P.A.1    Rifkin, D.B.2
  • 49
    • 3042838388 scopus 로고    scopus 로고
    • Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation
    • PID: 15307633
    • Hyytiainen M, Penttinen C, Keski-Oja J (2004) Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation. Crit Rev Clin Lab Sci 41(3):233–264
    • (2004) Crit Rev Clin Lab Sci , vol.41 , Issue.3 , pp. 233-264
    • Hyytiainen, M.1    Penttinen, C.2    Keski-Oja, J.3
  • 50
    • 72449194274 scopus 로고    scopus 로고
    • Biogenesis and function of fibrillin assemblies
    • PID: 19513754, COI: 1:CAS:528:DC%2BD1MXhsVymt77N
    • Ramirez F, Sakai LY (2010) Biogenesis and function of fibrillin assemblies. Cell Tissue Res 339(1):71–82
    • (2010) Cell Tissue Res , vol.339 , Issue.1 , pp. 71-82
    • Ramirez, F.1    Sakai, L.Y.2
  • 51
    • 84866742560 scopus 로고    scopus 로고
    • TGFbeta signalling in context
    • PID: 22992590, COI: 1:CAS:528:DC%2BC38XhtlKrs73I
    • Massague J (2012) TGFbeta signalling in context. Nat Rev Mol Cell Biol 13(10):616–630
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.10 , pp. 616-630
    • Massague, J.1
  • 52
    • 0028170226 scopus 로고
    • Mechanism of activation of the TGF-beta receptor
    • PID: 8047140, COI: 1:CAS:528:DyaK2cXlt1Kju78%3D
    • Wrana JL, Attisano L, Wieser R et al (1994) Mechanism of activation of the TGF-beta receptor. Nature 370(6488):341–347
    • (1994) Nature , vol.370 , Issue.6488 , pp. 341-347
    • Wrana, J.L.1    Attisano, L.2    Wieser, R.3
  • 53
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • PID: 12809600, COI: 1:CAS:528:DC%2BD3sXkvVekt7o%3D
    • Shi Y, Massague J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113(6):685–700
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 54
    • 34548329486 scopus 로고    scopus 로고
    • Differentiation plasticity regulated by TGF-beta family proteins in development and disease
    • PID: 17762890, COI: 1:CAS:528:DC%2BD2sXpslGju7k%3D
    • Derynck R, Akhurst RJ (2007) Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol 9(9):1000–1004
    • (2007) Nat Cell Biol , vol.9 , Issue.9 , pp. 1000-1004
    • Derynck, R.1    Akhurst, R.J.2
  • 55
    • 79956011495 scopus 로고    scopus 로고
    • A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis
    • PID: 21368745, COI: 1:CAS:528:DC%2BC3MXmtVOqs74%3D
    • Trachtman H, Fervenza FC, Gipson DS et al (2011) A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney Int 79(11):1236–1243
    • (2011) Kidney Int , vol.79 , Issue.11 , pp. 1236-1243
    • Trachtman, H.1    Fervenza, F.C.2    Gipson, D.S.3
  • 56
    • 79551599216 scopus 로고    scopus 로고
    • The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential
    • PID: 20980457, COI: 1:CAS:528:DC%2BC3MXisVOmu7g%3D
    • Chen HY, Huang XR, Wang W et al (2011) The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 60(2):590–601
    • (2011) Diabetes , vol.60 , Issue.2 , pp. 590-601
    • Chen, H.Y.1    Huang, X.R.2    Wang, W.3
  • 57
    • 79960364782 scopus 로고    scopus 로고
    • Exploring anti-TGF-beta therapies in cancer and fibrosis
    • PID: 21718111, COI: 1:CAS:528:DC%2BC3MXoslOit7o%3D
    • Hawinkels LJ, Ten Dijke P (2011) Exploring anti-TGF-beta therapies in cancer and fibrosis. Growth Factors 29(4):140–152
    • (2011) Growth Factors , vol.29 , Issue.4 , pp. 140-152
    • Hawinkels, L.J.1    Ten Dijke, P.2
  • 58
    • 84859334535 scopus 로고    scopus 로고
    • Pirfenidone treatment of idiopathic pulmonary fibrosis
    • PID: 22333982, COI: 1:CAS:528:DC%2BC38Xot1egur8%3D
    • Azuma A (2012) Pirfenidone treatment of idiopathic pulmonary fibrosis. Ther Adv Respir Dis 6(2):107–114
    • (2012) Ther Adv Respir Dis , vol.6 , Issue.2 , pp. 107-114
    • Azuma, A.1
  • 59
    • 0037302348 scopus 로고    scopus 로고
    • TGF-beta signal transduction and mesangial cell fibrogenesis
    • PID: 12529270, COI: 1:CAS:528:DC%2BD3sXhtlOqtLo%3D
    • Schnaper HW, Hayashida T, Hubchak SC, Poncelet AC (2003) TGF-beta signal transduction and mesangial cell fibrogenesis. Am J Physiol Renal Physiol 284(2):F243–F252
    • (2003) Am J Physiol Renal Physiol , vol.284 , Issue.2 , pp. F243-F252
    • Schnaper, H.W.1    Hayashida, T.2    Hubchak, S.C.3    Poncelet, A.C.4
  • 60
    • 80052754775 scopus 로고    scopus 로고
    • Diverse roles of TGF-beta/Smads in renal fibrosis and inflammation
    • PID: 21927575, COI: 1:CAS:528:DC%2BC3MXht1Onu77I
    • Lan HY (2011) Diverse roles of TGF-beta/Smads in renal fibrosis and inflammation. Int J Biol Sci 7(7):1056–1067
    • (2011) Int J Biol Sci , vol.7 , Issue.7 , pp. 1056-1067
    • Lan, H.Y.1
  • 61
    • 0037498439 scopus 로고    scopus 로고
    • Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    • PID: 12761254, COI: 1:CAS:528:DC%2BD3sXjslanuro%3D
    • Lan HY, Mu W, Tomita N et al (2003) Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 14(6):1535–1548
    • (2003) J Am Soc Nephrol , vol.14 , Issue.6 , pp. 1535-1548
    • Lan, H.Y.1    Mu, W.2    Tomita, N.3
  • 62
    • 27144458232 scopus 로고    scopus 로고
    • Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis
    • PID: 16117784, COI: 1:CAS:528:DC%2BD2MXhtVersbjE
    • Santiago B, Gutierrez-Canas I, Dotor J et al (2005) Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis. J Investig Dermatol 125(3):450–455
    • (2005) J Investig Dermatol , vol.125 , Issue.3 , pp. 450-455
    • Santiago, B.1    Gutierrez-Canas, I.2    Dotor, J.3
  • 63
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFbeta signalling pathway in disease
    • PID: 23000686, COI: 1:CAS:528:DC%2BC38XhtlyltbjM
    • Akhurst RJ, Hata A (2012) Targeting the TGFbeta signalling pathway in disease. Nat Rev Drug Discov 11(10):790–811
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.10 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 64
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling and disease
    • PID: 22682243, COI: 1:CAS:528:DC%2BC38XosVaktrg%3D
    • Clevers H, Nusse R (2012) Wnt/beta-catenin signaling and disease. Cell 149(6):1192–1205
    • (2012) Cell , vol.149 , Issue.6 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 65
    • 0030978351 scopus 로고    scopus 로고
    • beta-Catenin is a target for the ubiquitin-proteasome pathway
    • PID: 9233789, COI: 1:CAS:528:DyaK2sXkslShsbk%3D
    • Aberle H, Bauer A, Stappert J et al (1997) beta-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16(13):3797–3804
    • (1997) EMBO J , vol.16 , Issue.13 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3
  • 66
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
    • PID: 11336703, COI: 1:CAS:528:DC%2BD3MXjsVentL0%3D
    • Mao J, Wang J, Liu B et al (2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell 7(4):801–809
    • (2001) Mol Cell , vol.7 , Issue.4 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3
  • 67
    • 84861972831 scopus 로고    scopus 로고
    • Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex
    • PID: 22682247, COI: 1:CAS:528:DC%2BC38XosVaktr0%3D
    • Li VS, Ng SS, Boersema PJ et al (2012) Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex. Cell 149(6):1245–1256
    • (2012) Cell , vol.149 , Issue.6 , pp. 1245-1256
    • Li, V.S.1    Ng, S.S.2    Boersema, P.J.3
  • 68
    • 33644679351 scopus 로고    scopus 로고
    • Wnt signaling induces epithelial differentiation during cutaneous wound healing
    • PID: 16426441
    • Fathke C, Wilson L, Shah K et al (2006) Wnt signaling induces epithelial differentiation during cutaneous wound healing. BMC Cell Biol 7:4
    • (2006) BMC Cell Biol , vol.7 , pp. 4
    • Fathke, C.1    Wilson, L.2    Shah, K.3
  • 69
    • 0037076354 scopus 로고    scopus 로고
    • beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds
    • PID: 11983872, COI: 1:CAS:528:DC%2BD38XjvFCqsLY%3D
    • Cheon SS, Cheah AY, Turley S et al (2002) beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci USA 99(10):6973–6978
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.10 , pp. 6973-6978
    • Cheon, S.S.1    Cheah, A.Y.2    Turley, S.3
  • 70
    • 78449254335 scopus 로고    scopus 로고
    • A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway
    • PID: 20810909, COI: 1:CAS:528:DC%2BC3cXhsFSgu7vM
    • Trensz F, Haroun S, Cloutier A et al (2010) A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway. Am J Physiol Cell Physiol 299(5):C939–C947
    • (2010) Am J Physiol Cell Physiol , vol.299 , Issue.5 , pp. C939-C947
    • Trensz, F.1    Haroun, S.2    Cloutier, A.3
  • 71
    • 79953677802 scopus 로고    scopus 로고
    • Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension
    • PID: 21360508, COI: 1:CAS:528:DC%2BC3MXksFWrs7s%3D
    • Hsu E, Shi H, Jordan RM et al (2011) Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension. Arthritis Rheum 63(3):783–794
    • (2011) Arthritis Rheum , vol.63 , Issue.3 , pp. 783-794
    • Hsu, E.1    Shi, H.2    Jordan, R.M.3
  • 72
    • 0036714307 scopus 로고    scopus 로고
    • Secreted frizzled-related proteins: searching for relationships and patterns
    • PID: 12210517, COI: 1:CAS:528:DC%2BD38XnsFSjs7c%3D
    • Jones SE, Jomary C (2002) Secreted frizzled-related proteins: searching for relationships and patterns. BioEssays 24(9):811–820
    • (2002) BioEssays , vol.24 , Issue.9 , pp. 811-820
    • Jones, S.E.1    Jomary, C.2
  • 73
    • 33846036984 scopus 로고    scopus 로고
    • ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription
    • PID: 16787331, COI: 1:CAS:528:DC%2BD2MXovFSjtLk%3D
    • Eguchi M, Nguyen C, Lee SC, Kahn M (2005) ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. Med Chem 1(5):467–472
    • (2005) Med Chem , vol.1 , Issue.5 , pp. 467-472
    • Eguchi, M.1    Nguyen, C.2    Lee, S.C.3    Kahn, M.4
  • 74
    • 77956288500 scopus 로고    scopus 로고
    • Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
    • PID: 20660310
    • Henderson WR Jr, Chi EY, Ye X et al (2010) Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA 107(32):14309–14314
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.32 , pp. 14309-14314
    • Henderson, W.R.1    Chi, E.Y.2    Ye, X.3
  • 75
    • 78649747488 scopus 로고    scopus 로고
    • Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling
    • PID: 21170416, COI: 1:CAS:528:DC%2BC3cXhsFaqu7bF
    • Saraswati S, Alfaro MP, Thorne CA et al (2010) Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLoS ONE 5(11):e15521
    • (2010) PLoS ONE , vol.5 , Issue.11
    • Saraswati, S.1    Alfaro, M.P.2    Thorne, C.A.3
  • 76
    • 2442642567 scopus 로고    scopus 로고
    • Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4
    • PID: 15149334, COI: 1:CAS:528:DC%2BD2cXltFKgsbc%3D
    • Surendran K, Simon TC, Liapis H, McGuire JK (2004) Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4. Kidney Int 65(6):2212–2222
    • (2004) Kidney Int , vol.65 , Issue.6 , pp. 2212-2222
    • Surendran, K.1    Simon, T.C.2    Liapis, H.3    McGuire, J.K.4
  • 77
    • 65249134946 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling promotes renal interstitial fibrosis
    • PID: 19297557, COI: 1:CAS:528:DC%2BD1MXltFOqu70%3D
    • He W, Dai C, Li Y et al (2009) Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 20(4):765–776
    • (2009) J Am Soc Nephrol , vol.20 , Issue.4 , pp. 765-776
    • He, W.1    Dai, C.2    Li, Y.3
  • 78
    • 84884306401 scopus 로고    scopus 로고
    • Wnt4/beta-catenin signaling in medullary kidney myofibroblasts
    • EPub ahead of print
    • Dirocco DP, Kobayashi A, Taketo MM et al (2013) Wnt4/beta-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol [EPub ahead of print]
    • (2013) J am Soc Nephrol
    • Dirocco, D.P.1    Kobayashi, A.2    Taketo, M.M.3
  • 79
    • 80052335469 scopus 로고    scopus 로고
    • Targeted inhibition of beta-catenin/CBP signaling ameliorates renal interstitial fibrosis
    • PID: 21816937, COI: 1:CAS:528:DC%2BC3MXht1GktLzM
    • Hao S, He W, Li Y et al (2011) Targeted inhibition of beta-catenin/CBP signaling ameliorates renal interstitial fibrosis. J Am Soc Nephrol 22(9):1642–1653
    • (2011) J Am Soc Nephrol , vol.22 , Issue.9 , pp. 1642-1653
    • Hao, S.1    He, W.2    Li, Y.3
  • 80
    • 84872867267 scopus 로고    scopus 로고
    • LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1
    • PID: 23302695, COI: 1:CAS:528:DC%2BC3sXhvFKku7w%3D
    • Ren S, Johnson BG, Kida Y et al (2013) LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci USA 110(4):1440–1445
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.4 , pp. 1440-1445
    • Ren, S.1    Johnson, B.G.2    Kida, Y.3
  • 81
    • 70349222997 scopus 로고    scopus 로고
    • Wnt pathway regulation in chronic renal allograft damage
    • von Toerne C, Schmidt C, Adams J et al (2009) Wnt pathway regulation in chronic renal allograft damage. Am J Transplant 9(10):2223–2239
    • (2009) Am J Transplant , vol.9 , Issue.10 , pp. 2223-2239
    • von Toerne, C.1    Schmidt, C.2    Adams, J.3
  • 82
    • 84860229922 scopus 로고    scopus 로고
    • The platelet-derived growth factor system in renal disease: an emerging role of endogenous inhibitors
    • PID: 21872965
    • van Roeyen CR, Ostendorf T, Floege J (2012) The platelet-derived growth factor system in renal disease: an emerging role of endogenous inhibitors. Eur J Cell Biol 91(6–7):542–551
    • (2012) Eur J Cell Biol , vol.91 , Issue.6-7 , pp. 542-551
    • van Roeyen, C.R.1    Ostendorf, T.2    Floege, J.3
  • 83
    • 84863980883 scopus 로고    scopus 로고
    • The PDGF family in renal fibrosis
    • PID: 21597969
    • Ostendorf T, Eitner F, Floege J (2012) The PDGF family in renal fibrosis. Pediatr Nephrol 27(7):1041–1050
    • (2012) Pediatr Nephrol , vol.27 , Issue.7 , pp. 1041-1050
    • Ostendorf, T.1    Eitner, F.2    Floege, J.3
  • 84
    • 84879080578 scopus 로고    scopus 로고
    • Molecular targets for treatment of kidney fibrosis
    • COI: 1:CAS:528:DC%2BC3sXntlSjtrc%3D
    • Chuang PY, Menon MC, He JC (2013) Molecular targets for treatment of kidney fibrosis. J Mol Med (Berl) 91(5):549–559
    • (2013) J Mol Med (Berl) , vol.91 , Issue.5 , pp. 549-559
    • Chuang, P.Y.1    Menon, M.C.2    He, J.C.3
  • 85
    • 39049115240 scopus 로고    scopus 로고
    • PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis
    • PID: 18184860, COI: 1:CAS:528:DC%2BD1cXivFKqtrY%3D
    • Eitner F, Bucher E, van Roeyen C et al (2008) PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis. J Am Soc Nephrol 19(2):281–289
    • (2008) J Am Soc Nephrol , vol.19 , Issue.2 , pp. 281-289
    • Eitner, F.1    Bucher, E.2    van Roeyen, C.3
  • 86
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • PID: 6776413, COI: 1:STN:280:DyaL3M%2Flt1ersQ%3D%3D
    • Nusslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287(5785):795–801
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 87
    • 84879414522 scopus 로고    scopus 로고
    • The mechanisms of Hedgehog signalling and its roles in development and disease
    • COI: 1:CAS:528:DC%2BC3sXosVeqtrk%3D
    • Briscoe J, Therond PP (2013) The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 14(7):418–431
    • (2013) Nat Rev Mol Cell Biol , vol.14 , Issue.7 , pp. 418-431
    • Briscoe, J.1    Therond, P.P.2
  • 88
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • PID: 18754008, COI: 1:CAS:528:DC%2BD1cXhtFams7fP
    • Yauch RL, Gould SE, Scales SJ et al (2008) A paracrine requirement for hedgehog signalling in cancer. Nature 455(7211):406–410
    • (2008) Nature , vol.455 , Issue.7211 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 89
    • 78651426961 scopus 로고    scopus 로고
    • The role of Hedgehog signaling in fibrogenic liver repair
    • PID: 21056686, COI: 1:CAS:528:DC%2BC3MXmsVKktA%3D%3D
    • Choi SS, Omenetti A, Syn WK, Diehl AM (2011) The role of Hedgehog signaling in fibrogenic liver repair. Int J Biochem Cell Biol 43(2):238–244
    • (2011) Int J Biochem Cell Biol , vol.43 , Issue.2 , pp. 238-244
    • Choi, S.S.1    Omenetti, A.2    Syn, W.K.3    Diehl, A.M.4
  • 90
    • 0037385280 scopus 로고    scopus 로고
    • Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes
    • PID: 12635140, COI: 1:CAS:528:DC%2BD3sXlt1Sgtbo%3D
    • Stewart GA, Hoyne GF, Ahmad SA et al (2003) Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. J Pathol 199(4):488–495
    • (2003) J Pathol , vol.199 , Issue.4 , pp. 488-495
    • Stewart, G.A.1    Hoyne, G.F.2    Ahmad, S.A.3
  • 91
    • 84877111846 scopus 로고    scopus 로고
    • Sonic Hedgehog signaling in pulmonary fibrosis: a spiky issue?
    • PID: 23316071
    • Mailleux AA, Moshai EF, Crestani B (2013) Sonic Hedgehog signaling in pulmonary fibrosis: a spiky issue? Am J Physiol Lung Cell Mol Physiol 304(6):L391–L393
    • (2013) Am J Physiol Lung Cell Mol Physiol , vol.304 , Issue.6 , pp. L391-L393
    • Mailleux, A.A.1    Moshai, E.F.2    Crestani, B.3
  • 92
    • 84859015834 scopus 로고    scopus 로고
    • Hedgehog-Gli pathway activation during kidney fibrosis
    • PID: 22342522, COI: 1:CAS:528:DC%2BC38XmsFCisro%3D
    • Fabian SL, Penchev RR, St-Jacques B et al (2012) Hedgehog-Gli pathway activation during kidney fibrosis. Am J Pathol 180(4):1441–1453
    • (2012) Am J Pathol , vol.180 , Issue.4 , pp. 1441-1453
    • Fabian, S.L.1    Penchev, R.R.2    St-Jacques, B.3
  • 93
    • 84860633548 scopus 로고    scopus 로고
    • Sonic hedgehog signaling mediates epithelial–mesenchymal communication and promotes renal fibrosis
    • PID: 22302193, COI: 1:CAS:528:DC%2BC38Xns12isL0%3D
    • Ding H, Zhou D, Hao S et al (2012) Sonic hedgehog signaling mediates epithelial–mesenchymal communication and promotes renal fibrosis. J Am Soc Nephrol 23(5):801–813
    • (2012) J Am Soc Nephrol , vol.23 , Issue.5 , pp. 801-813
    • Ding, H.1    Zhou, D.2    Hao, S.3
  • 94
    • 84865270456 scopus 로고    scopus 로고
    • The utility of hedgehog signaling pathway inhibition for cancer
    • PID: 22851551, COI: 1:CAS:528:DC%2BC38XhsFygu7nF
    • Sahebjam S, Siu LL, Razak AA (2012) The utility of hedgehog signaling pathway inhibition for cancer. Oncologist 17(8):1090–1099
    • (2012) Oncologist , vol.17 , Issue.8 , pp. 1090-1099
    • Sahebjam, S.1    Siu, L.L.2    Razak, A.A.3
  • 95
    • 64849094028 scopus 로고    scopus 로고
    • Hedgehog signalling: emerging evidence for non-canonical pathways
    • PID: 19399989, COI: 1:CAS:528:DC%2BD1MXltFelu7g%3D
    • Jenkins D (2009) Hedgehog signalling: emerging evidence for non-canonical pathways. Cell Signal 21(7):1023–1034
    • (2009) Cell Signal , vol.21 , Issue.7 , pp. 1023-1034
    • Jenkins, D.1
  • 96
    • 84871191878 scopus 로고    scopus 로고
    • Medical options to fight mortality in end-stage renal disease: A review of the literature
    • This review summarizes treatment strategies that have undergone randomized controlled clinical trials (RCTs) in ESRD patients with mortality reduction as a pre-specified study endpoint. Survival improvement in ESRD patients has been demonstrated only in telmisartan, candesartan, and carvedilol
    • ∙ Kramann R, Floege J, Ketteler M et al (2012) Medical options to fight mortality in end-stage renal disease: a review of the literature. Nephrol Dial Transplant 27(12):4298–307. This review summarizes treatment strategies that have undergone randomized controlled clinical trials (RCTs) in ESRD patients with mortality reduction as a pre-specified study endpoint. Survival improvement in ESRD patients has been demonstrated only in telmisartan, candesartan, and carvedilol
    • (2012) Nephrol Dial Transplant , vol.27 , Issue.12 , pp. 4298-4307
    • Kramann, R.1    Floege, J.2    Ketteler, M.3
  • 97
    • 33845501641 scopus 로고    scopus 로고
    • Antihypertensive therapy in the presence of proteinuria
    • PID: 17185142, COI: 1:CAS:528:DC%2BD2sXhsFSjsLo%3D
    • Sarafidis PA, Khosla N, Bakris GL (2007) Antihypertensive therapy in the presence of proteinuria. Am J Kidney Dis 49(1):12–26
    • (2007) Am J Kidney Dis , vol.49 , Issue.1 , pp. 12-26
    • Sarafidis, P.A.1    Khosla, N.2    Bakris, G.L.3
  • 98
    • 15844368318 scopus 로고    scopus 로고
    • Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting-Enzyme Inhibition in Progressive Renal Insufficiency Study Group
    • PID: 8596594, COI: 1:CAS:528:DyaK28XislKmsbg%3D
    • Maschio G, Alberti D, Janin G et al (1996) Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting-Enzyme Inhibition in Progressive Renal Insufficiency Study Group. N Engl J Med 334(15):939–945
    • (1996) N Engl J Med , vol.334 , Issue.15 , pp. 939-945
    • Maschio, G.1    Alberti, D.2    Janin, G.3
  • 99
    • 0030604561 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia) (1997) Lancet 349(9069):1857–1863
    • (1997) Lancet , vol.349 , Issue.9069 , pp. 1857-1863
  • 100
    • 0032906385 scopus 로고    scopus 로고
    • In chronic nephropathies prolonged ACE inhibition can induce remission: dynamics of time-dependent changes in GFR. Investigators of the GISEN Group. Gruppo Italiano Studi Epidemiologici in Nefrologia
    • PID: 10232685, COI: 1:CAS:528:DyaK1MXivF2hsbc%3D
    • Ruggenenti P, Perna A, Benini R et al (1999) In chronic nephropathies prolonged ACE inhibition can induce remission: dynamics of time-dependent changes in GFR. Investigators of the GISEN Group. Gruppo Italiano Studi Epidemiologici in Nefrologia. J Am Soc Nephrol 10(5):997–1006
    • (1999) J Am Soc Nephrol , vol.10 , Issue.5 , pp. 997-1006
    • Ruggenenti, P.1    Perna, A.2    Benini, R.3
  • 101
    • 32444440002 scopus 로고    scopus 로고
    • ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease
    • PID: 16395266, COI: 1:CAS:528:DC%2BD28XivFOmsLc%3D
    • Remuzzi A, Gagliardini E, Sangalli F et al (2006) ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease. Kidney Int 69(7):1124–1130
    • (2006) Kidney Int , vol.69 , Issue.7 , pp. 1124-1130
    • Remuzzi, A.1    Gagliardini, E.2    Sangalli, F.3
  • 102
    • 79955763790 scopus 로고    scopus 로고
    • Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARgamma, and HO-1
    • PID: 21289052, COI: 1:CAS:528:DC%2BC3MXms1WrtrY%3D
    • Wu QQ, Wang Y, Senitko M et al (2011) Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARgamma, and HO-1. Am J Physiol Renal Physiol 300(5):F1180–F1192
    • (2011) Am J Physiol Renal Physiol , vol.300 , Issue.5 , pp. F1180-F1192
    • Wu, Q.Q.1    Wang, Y.2    Senitko, M.3
  • 103
    • 79954582442 scopus 로고    scopus 로고
    • Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD
    • PID: 21508635, COI: 1:CAS:528:DC%2BC3MXmtFyls7w%3D
    • Pergola PE, Krauth M, Huff JW et al (2011) Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD. Am J Nephrol 33(5):469–476
    • (2011) Am J Nephrol , vol.33 , Issue.5 , pp. 469-476
    • Pergola, P.E.1    Krauth, M.2    Huff, J.W.3
  • 104
    • 79960855656 scopus 로고    scopus 로고
    • Bardoxolone methyl and kidney function in CKD with type 2 diabetes
    • This study highlights the favorable results from a preliminary study of bardoxolone methyl on kidney function. It is important to note that, when bardoxolone methyl was tested in larger phase 3 trials, the positive effects of this trial vanished. An example of the necessity to understand a biological outcome in the context of a disease
    • ∙∙ Pergola PE, Raskin P, Toto RD et al (2011) Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med 365(4):327–36. This study highlights the favorable results from a preliminary study of bardoxolone methyl on kidney function. It is important to note that, when bardoxolone methyl was tested in larger phase 3 trials, the positive effects of this trial vanished. An example of the necessity to understand a biological outcome in the context of a disease
    • (2011) N Engl J Med , vol.365 , Issue.4 , pp. 327-336
    • Pergola, P.E.1    Raskin, P.2    Toto, R.D.3
  • 106
    • 84861122379 scopus 로고    scopus 로고
    • Endothelin receptor antagonists: a place in the management of essential hypertension?
    • PID: 22311858, COI: 1:CAS:528:DC%2BC38XnsFGns74%3D
    • Burnier M, Forni V (2012) Endothelin receptor antagonists: a place in the management of essential hypertension? Nephrol Dial Transplant 27(3):865–868
    • (2012) Nephrol Dial Transplant , vol.27 , Issue.3 , pp. 865-868
    • Burnier, M.1    Forni, V.2
  • 107
    • 77949877308 scopus 로고    scopus 로고
    • Avosentan for overt diabetic nephropathy
    • This study tested the endothelin receptor antagonis avosentan in patients with diabetic nephropathy. Previous studies have shown that blocking the endothelin pathway, particularly ETA receptors, could produce powerful anti-hypertensive effects that were beneficial in preclinical and clinical models of nephropathy. This clinical study used a dose of avosentan that was higher than previous studies indicated as safe, and resulted in trial discontinuation due to increased severe adverse effects and death in the experimental arms compared to the control arms. Deeper understanding of the biology of the endothelin pathway in the context of chronic kidney disease is warranted
    • ∙ Mann JF, Green D, Jamerson K et al (2010) Avosentan for overt diabetic nephropathy. J Am Soc Nephrol 21(3):527–35. This study tested the endothelin receptor antagonis avosentan in patients with diabetic nephropathy. Previous studies have shown that blocking the endothelin pathway, particularly ETA receptors, could produce powerful anti-hypertensive effects that were beneficial in preclinical and clinical models of nephropathy. This clinical study used a dose of avosentan that was higher than previous studies indicated as safe, and resulted in trial discontinuation due to increased severe adverse effects and death in the experimental arms compared to the control arms. Deeper understanding of the biology of the endothelin pathway in the context of chronic kidney disease is warranted
    • (2010) J am Soc Nephrol , vol.21 , Issue.3 , pp. 527-535
    • Mann, J.F.1    Green, D.2    Jamerson, K.3
  • 108
    • 84881152296 scopus 로고    scopus 로고
    • Endothelin antagonists for diabetic and non-diabetic chronic kidney disease
    • Kohan DE, Pollock DM (2012) Endothelin antagonists for diabetic and non-diabetic chronic kidney disease. Br J Clin Pharmacol. doi:10.1111/bcp.12064
    • (2012) Br J Clin Pharmacol
    • Kohan, D.E.1    Pollock, D.M.2
  • 109
    • 78649835509 scopus 로고    scopus 로고
    • Targeting BAFF in autoimmunity
    • PID: 20970975, COI: 1:CAS:528:DC%2BC3cXhsFaqsrvF
    • Davidson A (2010) Targeting BAFF in autoimmunity. Curr Opin Immunol 22(6):732–739
    • (2010) Curr Opin Immunol , vol.22 , Issue.6 , pp. 732-739
    • Davidson, A.1
  • 110
    • 84858699217 scopus 로고    scopus 로고
    • BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus
    • PID: 22231653, COI: 1:CAS:528:DC%2BC38XktV2murY%3D
    • Vincent FB, Morand EF, Mackay F (2012) BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus. Immunol Cell Biol 90(3):293–303
    • (2012) Immunol Cell Biol , vol.90 , Issue.3 , pp. 293-303
    • Vincent, F.B.1    Morand, E.F.2    Mackay, F.3
  • 111
    • 84864849342 scopus 로고    scopus 로고
    • Biologic differences between various inhibitors of the BLyS/BAFF pathway: should we expect differences between belimumab and other inhibitors in development?
    • PID: 22547203, COI: 1:CAS:528:DC%2BC38XpvFCjtbY%3D
    • Stohl W (2012) Biologic differences between various inhibitors of the BLyS/BAFF pathway: should we expect differences between belimumab and other inhibitors in development? Curr Rheumatol Rep 14(4):303–309
    • (2012) Curr Rheumatol Rep , vol.14 , Issue.4 , pp. 303-309
    • Stohl, W.1
  • 112
    • 80053429073 scopus 로고    scopus 로고
    • Mice overexpressing BAFF develop a commensal flora-dependent IgA-associated nephropathy
    • PID: 21881212, COI: 1:CAS:528:DC%2BC3MXht12ht7nL
    • McCarthy DD, Kujawa J, Wilson C et al (2011) Mice overexpressing BAFF develop a commensal flora-dependent IgA-associated nephropathy. J Clin Investig 121(10):3991–4002
    • (2011) J Clin Investig , vol.121 , Issue.10 , pp. 3991-4002
    • McCarthy, D.D.1    Kujawa, J.2    Wilson, C.3
  • 113
    • 84880087242 scopus 로고    scopus 로고
    • Serum BAFF is elevated in patients with IgA nephropathy and associated with clinical and histopathological features
    • PID: 23042433
    • Xin G, Shi W, Xu LX et al (2012) Serum BAFF is elevated in patients with IgA nephropathy and associated with clinical and histopathological features. J Nephrol 26(4):683–690
    • (2012) J Nephrol , vol.26 , Issue.4 , pp. 683-690
    • Xin, G.1    Shi, W.2    Xu, L.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.