Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

Kidney International

Volumn 82, Issue 2, 2012, Pages 172-183

  Grgic, Ivica ^a,b   Campanholle, Gabriela ^a   Bijol, Vanesa ^a   Wang, Chang ^a   Sabbisetti, Venkata S ^a   Ichimura, Takaharu ^a   Humphreys, Benjamin D ^a,c   Bonventre, Joseph V ^a,c,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

acute kidney injury; chronic kidney disease; nephron; proliferation; renal cell biology

Indexed keywords

CRE RECOMBINASE; DIPHTHERIA TOXIN; DIPHTHERIA TOXIN RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SIX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUSAL ATTRIBUTION; CELL COUNT; CELL DAMAGE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; FIBROGENESIS; FIBROSING ALVEOLITIS; GLOMERULOSCLEROSIS; KIDNEY TUBULE EPITHELIUM; KIDNEY TUBULE NECROSIS; MOUSE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

EID: 84863306899     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.20     Document Type: Article

References (29)

1. Thadhani R, Pascual M, Bonventre JV. Acute renal failure. N Engl J Med 1996; 334: 1448-1460.
2. Chertow GM, Burdick E, Honour M et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005; 16: 3365-3370.
3. Hsu CY. Where is the epidemic in kidney disease? J Am Soc Nephrol 2010; 21: 1607-1611.
4. Yang L, Besschetnova TY, Brooks CR et al. Epithelial cell cycle arrest in g2/m mediates kidney fibrosis after injury. Nat Med 2010; 16: 535-543, 531p following 143.
5. Okusa MD, Chertow GM, Portilla D. The nexus of acute kidney injury, chronic kidney disease, and World Kidney Day 2009. Clin J Am Soc Nephrol 2009; 4: 520-522.
6. Heyman SN, Lieberthal W, Rogiers P et al. Animal models of acute tubular necrosis. Curr Opin Crit Care 2002; 8: 526-534.
7. Saito M, Iwawaki T, Taya C et al. Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol 2001; 19: 746-750.
8. Kobayashi A, Valerius MT, Mugford JW et al. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008; 3: 169-181.
9. Buch T, Heppner FL, Tertilt C et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2005; 2: 419-426.
10. Han WK, Bonventre JV. Biologic markers for the early detection of acute kidney injury. Curr Opin Crit Care 2004; 10: 476-482.
11. Paragas N, Qiu A, Zhang Q et al. The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat Med 2011; 17: 216-222.
12. Humphreys BD, Valerius MT, Kobayashi A et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008; 2: 284-291.
13. Koesters R, Kaissling B, Lehir M et al. Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol 2010; 177: 632-643.
14. Bonventre JV, Zuk A. Ischemic acute renal failure: an inflammatory disease? Kidney Int 2004; 66: 480-485.
15. Jang HR, Rabb H. The innate immune response in ischemic acute kidney injury. Clin Immunol 2009; 130: 41-50.
16. Wu H, Chen G, Wyburn KR et al. TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 2007; 117: 2847-2859.
17. Leemans JC, Stokman G, Claessen N et al. Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005; 115: 2894-2903.
18. Wu H, Ma J, Wang P et al. HMGB1 contributes to kidney ischemia reperfusion injury. J Am Soc Nephrol 2010; 21: 1878-1890.
19. Venkatachalam MA, Griffin KA, Lan R et al. Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 2010; e-pub ahead of print 3 March 2012.
20. Suzuki T, Kimura M, Asano M et al. Role of atrophic tubules in development of interstitial fibrosis in microembolism-induced renal failure in rat. Am J Pathol 2001; 158: 75-85.
21. Kimura M, Asano M, Abe K et al. Role of atrophic changes in proximal tubular cells in the peritubular deposition of type IV collagen in a rat renal ablation model. Nephrol Dial Transplant 2005; 20: 1559-1565.
22. Lin SL, Kisseleva T, Brenner DA et al. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008; 173: 1617-1627.
23. Grgic I, Duffield JS, Humphreys BD. The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol 2012; 27: 183-193.
24. Humphreys BD, Lin SL, Kobayashi A et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010; 176: 85-97.
25. de Borst MH, Prakash J, Sandovici M et al. c-Jun NH2-terminal kinase is crucially involved in renal tubulo-interstitial inflammation. J Pharmacol Exp Ther 2009; 331: 896-905.
26. Lin SL, Chang FC, Schrimpf C et al. Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis. Am J Pathol 2011; 178: 911-923.
27. Matsui K, Kamijo-Ikemori A, Hara M et al. Clinical significance of tubular and podocyte biomarkers in acute kidney injury. Clin Exp Nephrol 2011; 15: 220-225.
28. Chevalier RL, Forbes MS. Generation and evolution of atubular glomeruli in the progression of renal disorders. J Am Soc Nephrol 2008; 19: 197-206.
29. Vaidya VS, Niewczas MA, Ficociello LH et al. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-beta- Dglucosaminidase. Kidney Int 2011; 79: 464-470.