Wnt pathway regulation in chronic renal allograft damage

American Journal of Transplantation

Volumn 9, Issue 10, 2009, Pages 2223-2239

  Von Toerne, C ^a   Schmidt, C ^b   Adams, J ^b   Kiss, E ^b   Bedke, J ^b   Porubsky, S ^b   Gretz, N ^c   Lindenmeyer, M T ^d   Cohen, C D ^d   Grone H J ^b   Nelson, P J ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Chronic allograft dysfunction; Fibrosis; Rat kidney allotransplantation; Transcriptome

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; FIBRONECTIN; HERMES ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; LYMPHOID ENHANCER FACTOR 1; MATRILYSIN; PROTEIN KINASE C; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA; VIMENTIN; WNT PROTEIN; WNT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC ALLOGRAFT NEPHROPATHY; CONTROLLED STUDY; COURSE EVALUATION; GENE CONTROL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL POLARITY; FIBROSIS; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MODELS, ANIMAL; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED F344; RATS, INBRED LEW; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSPLANTATION, HOMOLOGOUS; WNT PROTEINS;

EID: 70349222997     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02762.x     Document Type: Article

References (57)

1. Chai Q, Krag S, Chai S, Ledet T, Wogensen L. Localisation and phenotypical characterisation of collagen-producing cells in TGF-beta 1-induced renal interstitial fibrosis. Histochem Cell Biol 2003 119 : 267 280.
2. Huang Y, Noble NA. PAI-1 as a target in kidney disease. Curr Drug Targets 2007 8 : 1007 1015.
3. Rockey DC, Chung JJ. Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility. J Clin Invest 1995 95 : 1199 1206.
4. Königshoff M, Balsara N, Pfaff E-M et al. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS ONE 2008 3 : e2142.
5. Staal FJ, Luis TC, Tiemessen MM. WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol 2008 8 : 581 593.
6. Endo Y, Wolf V, Muraiso K et al. Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem 2005 280 : 777 786.
7. Liang H, Coles AH, Zhu Z et al. Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J Exp Med 2007 204 : 3077 3084.
8. Bedke J, Kiss E, Schaefer L et al. Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage. Am J Transplant 2007 7 : 527 537.
9. Adams J, Kiss E, Arroyo ABV et al. 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. Am J Pathol 2005 167 : 285 298.
10. Lee S. An improved technique of renal transplantation in the rat. Surgery 1967 61 : 771 773.
11. Dennis G Jr., Sherman BT, Hosack DA et al. DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol 2003 4 : R60.
12. Hosack DA, Dennis G Jr., Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol 2003 4 : R70.
13. Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000 28 : 27 30.
14. Kanehisa M, Goto S, Hattori M et al. From genomics to chemical genomics: New developments in KEGG. Nucleic Acids Res 2006 34 : D354 D357.
15. Kanehisa M, Araki M, Goto S et al. KEGG for linking genomes to life and the environment. Nucleic Acids Res 2008 36 : D480 D484.
16. Grone H-J, Weber C, Weber KSC et al. Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: Blocking monocyte arrest and recruitment. FASEB J 1999 13 : 1371 1383.
17. Porter KA. The Kidneys: The Urinary Tract: Systemic Pathology. 3rd Ed. Philadelphia, PA : Saunders, 1992.
18. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002 110 : 341 350. doi : 10.1172/JCI200215518. (Pubitemid 34847966)
19. Rerolle JP, Hertig A, Nguyen G, Sraer JD, Rondeau EP. Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis. Kidney Int 2000 58 : 1841 1850.
20. Tyler JR, Robertson H, Booth TA, Burt AD, Kirby JA. Chronic allograft nephropathy: Intraepithelial signals generated by transforming growth factor-β and bone morphogenetic protein-7 Am J Transplant 2006 6 : 1367 1376. doi : 10.1111/j.1600-6143.2006.01339.x.
21. Zou J, Yaoita E, Watanabe Y et al. Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury. Virchows Arch 2006 448 : 485 492.
22. Zou J, Chang TH, Chang H et al. Time course of expression of intermediate filament protein vimentin, nestin and desmin in rat renal glomerular injury. Chin Med J (Engl) 2007 120 : 1203 1205.
23. Katoh Y, Katoh M. Comparative genomics on SFRP1 orthologs. Int J Oncol 2005 27 : 861 865.
24. Vlad A, Rohrs S, Klein-Hitpass L, Muller O. The first five years of the Wnt targetome. Cell Signal 2008 20 : 795 802.
25. Luo J, Chen J, Deng ZL et al. Wnt signaling and human diseases: What are the therapeutic implications? Lab Invest 2007 87 : 97 103.
26. Pishvaian MJ, Byers SW. Biomarkers of WNT signaling. Cancer Biomark 2007 3 : 263 274.
27. Katoh M. WNT signaling in stem cell biology and regenerative medicine. Curr Drug Targets 2008 9 : 565 570.
28. Djamali A, Reese S, Yracheta J, Oberley T, Hullett D, Becker B. Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathy. Am J Transplant 2005 5 : 500 509. doi : 10.1111/j.1600-6143.2004. 00713.x. (Pubitemid 40313341)
29. Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: New insights in signaling, development, and disease. J Cell Biol 2006 172 : 973 981. 10.1083/jcb.200601018.
30. Rossini M, Cheunsuchon B, Donnert E et al. Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease. 2005 68 : 2621 2628.
31. Le Hir M, Kaissling B. Antibodies against macrophages that overlap in specificity with fibroblasts. Kidney Int 2005 68 : author reply 2400 2401.
32. Lin S-L, Kisseleva T, Brenner DA, Duffield JS. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008 173 : 1617 1627. 10.2353/ajpath.2008. 080433.
33. Shihab FS, Tanner AM, Shao Y, Weffer MI. Expression of TGF-beta 1 and matrix proteins is elevated in rats with chronic rejection. Kidney Int 1996 50 : 1904 1913.
34. Fan JM, Ng YY, Hill PA et al. Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int 1999 56 : 1455 1467.
35. Zeisberg M. Bone morphogenic protein-7 and the kidney: Current concepts and open questions. Nephrol Dial Transplant 2006 21 : 568 573. 10.1093/ndt/gfk010. (Pubitemid 43372898)
36. Ducy P, Karsenty G. The family of bone morphogenetic proteins. Kidney Int 2000 57 : 2207 2214.
37. Kirikoshi H, Sekihara H, Katoh M. WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. Biochem Biophys Res Commun 2001 283 : 798 805.
38. Nishizuka M, Koyanagi A, Osada S, Imagawa M. Wnt4 and Wnt5a promote adipocyte differentiation. FEBS Lett 2008 582 : 3201 3205.
39. Iglesias DM, Hueber PA, Chu L et al. Canonical WNT signaling during kidney development. Am J Physiol Renal Physiol 2007 293 : F494 F500.
40. Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP. A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 2009 136 : 161 171.
41. Lobov IB, Rao S, Carroll TJ et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 2005 437 : 417 421.
42. Smith K, Bui TD, Poulsom R, Kaklamanis L, Williams G, Harris AL. Up-regulation of macrophage Wnt gene expression in adenoma-carcinoma progression of human colorectal cancer. Br J Cancer 1999 81 : 496 502.
43. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006 127 : 469 480.
44. He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009 20 : 765 776.
45. Speyer CL, Neff TA, Warner RL et al. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol 2003 163 : 2319 2328.
46. Miyamoto S, Nakamura M, Yano K et al. Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-II via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix. Cancer Sci 2007 98 : 685 691.
47. Cohen CD, Lindenmeyer MT, Eichinger F et al. Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis. PLoS ONE 2008 3 : e2937.
48. Decleves AE, Caron N, Nonclercq D et al. Dynamics of hyaluronan, CD44, and inflammatory cells in the rat kidney after ischemia/reperfusion injury. Int J Mol Med 2006 18 : 83 94.
49. Rouschop KM, Sewnath ME, Claessen N et al. CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy. J Am Soc Nephrol 2004 15 : 674 686.
50. Acharya PS, Majumdar S, Jacob M et al. Fibroblast migration is mediated by CD44-dependent TGF beta activation. J Cell Sci 2008 121 (Pt 9 1393 1402.
51. Lim SK, Hoffmann FM. Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-β signaling. Proc Natl Acad Sci 2006 103 : 18580 18585. 10.1073pnas.0604773103.
52. Cerezo A, Kalthoff H, Schuermann M, Schafer B, Boukamp P. Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT. J Cell Sci 2002 115 : 1305 1312.
53. Medyouf H, Ghysdael J. The calcineurin/NFAT signaling pathway: A novel therapeutic target in leukemia and solid tumors. Cell Cycle 2008 7 : 297 303.
54. Bourajjaj M, Armand AS, da Costa Martins PA et al. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem 2008 283 : 22295 22303.
55. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001 29 : e45.
56. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987 162 : 156 159.
57. Schmid H, Cohen CD, Henger A, Irrgang S, Schlondorff D, Kretzler M. Validation of endogenous controls for gene expression analysis in microdissected human renal biopsies. 2003 64 : 356 360.