Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched I is present in circulating T lymphocytes

Journal of Pathology

Volumn 199, Issue 4, 2003, Pages 488-495

  Stewart, Gareth A ^a   Hoyne, Gerard F ^a   Ahmad, Sharon A ^a,b   Jarman, Elizabeth ^a   Wallace, William A H ^a,b   Harrison, David J ^a,b   Haslett, Christopher ^a   Lamb, Jonathan R ^a   Howie, Sarah E M ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Developmental genes; Inflammation; Interstitial lung disease; Pulmonary fibrosis; Sonic hedgehog; TGF 1

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MESSENGER RNA; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRANCHING MORPHOGENESIS; BRONCHIECTASIS; CASE REPORT; CELL COMMUNICATION; CELL PROLIFERATION; CLINICAL OBSERVATION; CONTROLLED STUDY; EPITHELIUM CELL; EXPERIMENTAL MODEL; FIBROSING ALVEOLITIS; GOBLET CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INTERSTITIAL LUNG DISEASE; LUNG ALVEOLUS; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG DEVELOPMENT; LUNG FIBROSIS; MEDICAL DOCUMENTATION; MONONUCLEAR CELL; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION;

ANIMALS; ANTIGENS, DERMATOPHAGOIDES; BRONCHIECTASIS; CHRONIC DISEASE; FEMALE; HEDGEHOG PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PNEUMONIA; PULMONARY FIBROSIS; RECEPTORS, CELL SURFACE; RESPIRATORY HYPERSENSITIVITY; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 0037385280     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1295     Document Type: Review

References (53)

1. Warburton D, Wuenschell C, Flores D, Anderson K. Commitment and differentiation of lung cell lineages. Biochem Cell Biol 1998; 76: 971-995.
2. Warburton D, Schwarz M, Tefft D, Flores-Delgado G, Anderson KD, Cardoso WV. The molecular basis of lung morphogenesis. Mech Dev 2000; 92: 55-81.
3. Hogan BL, Grindley J, Bellusci S, Dunn NR, Emoto H, Itoh N. Branching morphogenesis of the lung: new models for a classical problem. Cold Spring Harbor Symp Quant Biol 1997; 62: 249-256.
4. Hogan BL, Yingling JM. Epithelial/mesenchymal interactions and branching morphogenesis of the lung. Curr Opin Genet Dev 1998; 8: 481-486.
5. Kasper M, Haroske G. Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis. Histol Histopathol 1996; 11: 463-483.
6. Kuhn C, Boldt J, King TEJ, Crouch E, Vartio T, McDonald JA. An immunohistochemical study of architectural remodeling and connective tissue synthesis in pulmonary fibrosis. Am Rev Respir Dis 1989; 140: 1693-1703.
7. Reiser KM, Last JA. Early cellular events in pulmonary fibrosis. Exp Lung Res 1986; 10: 331-355.
8. Lympany PA, Dubois RM. Interstitial lung disease: basic mechanisms and genetic predisposition. Monaldi Arch Chest Dis 1997; 52: 33-36.
9. Turner-Warwick M. Interstitial lung disease of unknown etiology. Chest 1991; 100: 232-233.
10. Tuder RM. A pathologist's approach to interstitial lung disease. Curr Opin Pulm Med 1996; 2: 357-363.
11. Crystal RG, Bitterman PB, Rennard SI, Hance AJ, Keogh BA. Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract. N Engl J Med 1984; 310: 235-244.
12. Ryu JH, Colby TV, Hartman TE, Vassallo R. Smoking-related interstitial lung diseases: a concise review. Eur Respir J 2001; 17: 122-132.
13. Nicholson AG, Colby TV, du Bois R, Hansell DM, Wells AU. The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med 2000; 162: 2213-2217.
14. Wallace WA, Howie SE, Krajewski AS, Lamb D. The immunological architecture of B-lymphocyte aggregates in cryptogenic fibrosing alveolitis. J Pathol 1996; 173: 323-329.
15. Fireman E, Vardinon N, Burke M, et al. Predictive value of response to treatment of T-lymphocyte subpopulations in idiopathic pulmonary fibrosis. Eur Respir J 1998; 11: 706-711.
16. Wallace WA, Ramage EA, Lamb D, Howie SE. A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA). Clin Exp Immunol 1995; 101: 436-441.
17. Wallace WA, Roberts SN, Caldwell H, et al. Circulating antibodies to lung protein(s) in patients with cryptogenic fibrosing alveolitis. Thorax 1994; 49: 218-222.
18. Wallace WA, Schofield JA, Lamb D, Howie SE. Localisation of a pulmonary autoantigen in cryptogenic fibrosing alveolitis. Thorax 1994; 49: 1139-1145.
19. Serra R, Pelton RW, Moses HL. TGF beta 1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures. Development 1994; 120: 2153-2161.
20. Zhao J, Bu D, Lee M, Slavkin HC, Hall FL, Warburton D. Abrogation of transforming growth factor-beta type II receptor stimulates embryonic mouse lung branching morphogenesis in culture. Dev Biol 1996; 180: 242-257.
21. Heine UI, Munoz EF, Flanders KC, Roberts AB, Sporn MB. Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 1990; 109: 29-36.
22. Corrin B, Butcher D, McAnulty BJ, et al. Immunohistochemical localization of transforming growth factor-beta 1 in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and other lung disorders. Histopathology 1994; 24: 145-150.
23. Khalil N, O'Connor RN, Flanders KC, Unruh H. TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am J Respir Cell Mol Biol 1996; 14: 131-138.
24. Young SL, Chang LY, Erickson HP. Tenascin-C in rat lung: distribution, ontogeny and role in branching morphogenesis. Dev Biol 1994; 161: 615-625.
25. Wallace WA, Howie SE, Lamb D, Salter DM. Tenascin immunoreactivity in cryptogenic fibrosing alveolitis. J Pathol 1995; 175: 415-420.
26. Roman J, Little CW, McDonald JA. Potential role of RGD-binding integrins in mammalian lung branching morphogenesis. Development 1991; 112: 551-558.
27. Barquin N, Chou P, Ramos C, Montano M, Pardo A, Selman M. Increased expression of intercellular adhesion molecule 1, CD11/CD18 cell surface adhesion glycoproteins and alpha 4 beta 1 integrin in a rat model of chronic interstitial lung fibrosis. Pathobiology 1996; 64: 187-192.
28. Levine D, Rockey DC, Milner TA, Breuss JM, Fallon JT, Schnapp LM. Expression of the integrin alpha 8 beta 1 during pulmonary and hepatic fibrosis. Am J Pathol 2000; 156: 1927-1935.
29. Wahl SM, Orenstein JM, Chen W. TGF-beta influences the life and death decisions of T lymphocytes. Cytokine Growth Factor Rev 2000; 11: 71-79.
30. 3H]-thymidine incorporation in CD3 epsilon mAb- and CD28 mAb-activated splenocytes and thymocytes. Immunopharmacology 2000; 48: 101-115.
31. Pepicelli CV, Lewis PM, McMahon AP. Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol 1998; 8: 1083-1086.
32. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nature Immunol 2001; 2: 172-180.
33. Bellusci S, Furuta Y, Rush MG, Henderson R, Winnier G, Hogan BL. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 1997; 124: 53-63.
34. Outram SV, Varas A, Pepicelli CV, Crompton T. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity 2000; 13: 187-197.
35. Fan H, Khavari PA. Sonic hedgehog opposes epithelial cell cycle arrest. J Cell Biol 1999; 147: 71-76.
36. Motoyama J, Liu J, Mo R, Ding Q, Post M, Hui CC. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus [see comments]. Nature Genet 1998; 20: 54-57.
37. Barnes EA, Kong M, Ollendorff V, Donoghue DJ. Patched 1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J 2001; 20: 2214-2223.
38. Gauldie J, Sime PJ, Xing Z, Marr B, Tremblay GM. Transforming growth factor-beta gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis. Curr Top Pathol 1999; 93: 35-45.
39. Roberts SN, Howie SE, Wallace WA, et al. A novel model for human interstitial lung disease: hapten-driven lung fibrosis in rodents. J Pathol 1995; 176: 309-318.
40. Derynck R, Jarrett JA, Chen EY, Goeddel DV. The murine transforming growth factor-beta precursor. J Biol Chem 1986; 261: 4377-4379.
41. Hammerschmidt M, Brook A, McMahon AP. The world according to hedgehog. Trends Genet 1997; 13: 14-21.
42. Parisi MJ, Lin H. The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human. Cell Res 1998; 8: 15-21.
43. Fan H, Oro AE, Scott MP, Khavari PA. Induction of basal cell carcinoma features in transgenic human skin expressing Sonic hedgehog. Nature Med 1997; 3: 788-792.
44. Tojo M, Mori T, Kiyosawa H, et al. Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma. Pathol Int 1999; 49: 687-694.
45. Xie J, Murone M, Luoh SM, et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998; 391: 90-92.
46. Oro AE, Higgins KM, Hu Z, Bonifas JM, Epstein EH, Scott MP. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 1997; 276: 817-821.
47. Levanat S, Paveliç B, Crniç I, Oreskoviç S, Manojloviç S. Involvement of PTCH gene in various noninflammatory cysts. J Mol Med 2000; 78: 140-146.
48. Pola R, Ling LE, Silver M, et al. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nature Med 2001; 7: 706-711.
49. Cerwenka A, Swain SL. TGF-beta1: immunosuppressant and viability factor for T lymphocytes. Microbes Infect 1999; 1: 1291-1296.
50. Letterio JJ. Murine models define the role of TGF-beta as a master regulator of immune cell function. Cytokine Growth Factor Rev 11: 81-87.
51. Detmer K, Walker AN, Jenkins TM, Steele TA, Dannawi H. Erythroid differentiation in vitro is blocked by cyclopamine, an inhibitor of hedgehog signaling. Blood Cells Mol Dis 2000; 26: 360-372.
52. Zhao J, Sime PJ, Bringas PJ, Gauldie J, Warburton D. Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis. Am J Physiol 1999; 277: L412 -L422.
53. Zhao J, Sime PJ, Bringas PJ, Gauldie J, Warburton D. Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA. Mech Dev 1998; 72: 89-100.