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Volumn 32, Issue 5, 2012, Pages 463-470

Targeting Pericyte Differentiation as a Strategy to Modulate Kidney Fibrosis in Diabetic Nephropathy

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; IMATINIB; PLATELET DERIVED GROWTH FACTOR; PROTEIN INHIBITOR; SONIC HEDGEHOG PROTEIN; SONIC HEDGEHOG PROTEIN INHIBITOR; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84867382214     PISSN: 02709295     EISSN: 15584488     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2012.07.009     Document Type: Article
Times cited : (38)

References (81)
  • 1
    • 0014421532 scopus 로고
    • Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis
    • Risdon R.A., Sloper J.C., De Wardener H.E. Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 1968, 2:363-366.
    • (1968) Lancet , vol.2 , pp. 363-366
    • Risdon, R.A.1    Sloper, J.C.2    De Wardener, H.E.3
  • 2
    • 0026769228 scopus 로고
    • Tubulointerstitial changes as a major determinant in the progression of renal damage
    • Nath K.A. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 1992, 20:1-17.
    • (1992) Am J Kidney Dis , vol.20 , pp. 1-17
    • Nath, K.A.1
  • 3
    • 0036098930 scopus 로고    scopus 로고
    • An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients
    • Katz A., Caramori M.L., Sisson-Ross S., et al. An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients. Kidney Int 2002, 61:2058-2066.
    • (2002) Kidney Int , vol.61 , pp. 2058-2066
    • Katz, A.1    Caramori, M.L.2    Sisson-Ross, S.3
  • 4
    • 10544247316 scopus 로고    scopus 로고
    • Patterns of renal injury in NIDDM patients with microalbuminuria
    • Fioretto P., Mauer M., Brocco E., et al. Patterns of renal injury in NIDDM patients with microalbuminuria. Diabetologia 1996, 39:1569-1576.
    • (1996) Diabetologia , vol.39 , pp. 1569-1576
    • Fioretto, P.1    Mauer, M.2    Brocco, E.3
  • 6
    • 4043077114 scopus 로고    scopus 로고
    • Rarefaction of peritubular capillaries following ischemic acute renal failure: a potential factor predisposing to progressive nephropathy
    • Basile D.P. Rarefaction of peritubular capillaries following ischemic acute renal failure: a potential factor predisposing to progressive nephropathy. Curr Opin Nephrol Hypertens 2004, 13:1-7.
    • (2004) Curr Opin Nephrol Hypertens , vol.13 , pp. 1-7
    • Basile, D.P.1
  • 7
    • 0032499911 scopus 로고    scopus 로고
    • Reversal of lesions of diabetic nephropathy after pancreas transplantation
    • Fioretto P., Steffes M.W., Sutherland D.E., et al. Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 1998, 339:69-75.
    • (1998) N Engl J Med , vol.339 , pp. 69-75
    • Fioretto, P.1    Steffes, M.W.2    Sutherland, D.E.3
  • 8
    • 68849128539 scopus 로고    scopus 로고
    • Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche
    • Diaz-Flores L., Gutierrez R., Madrid J.F., et al. Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol 2009, 24:909-969.
    • (2009) Histol Histopathol , vol.24 , pp. 909-969
    • Diaz-Flores, L.1    Gutierrez, R.2    Madrid, J.F.3
  • 9
    • 0020965804 scopus 로고
    • Fibronectin in the microvasculature: localization in the pericyte-endothelial interstitium
    • Courtnoy P., Boyles J. Fibronectin in the microvasculature: localization in the pericyte-endothelial interstitium. J Ultrastruct Res 1983, 83:258-273.
    • (1983) J Ultrastruct Res , vol.83 , pp. 258-273
    • Courtnoy, P.1    Boyles, J.2
  • 10
    • 0000178087 scopus 로고
    • Memoire sur le developpement, la structure et les proprietes physiologiques des capillaries sanguins et lymphatiques
    • Rouget C. Memoire sur le developpement, la structure et les proprietes physiologiques des capillaries sanguins et lymphatiques. Arch Physiol Norm Pathol 1873, 5:603-663.
    • (1873) Arch Physiol Norm Pathol , vol.5 , pp. 603-663
    • Rouget, C.1
  • 12
    • 0025833035 scopus 로고
    • The three-dimensional cytoarchitecture of the interstitial tissue in the rat kidney
    • Takahashi-Iwanaga H. The three-dimensional cytoarchitecture of the interstitial tissue in the rat kidney. Cell Tissue Res 1991, 264:269-281.
    • (1991) Cell Tissue Res , vol.264 , pp. 269-281
    • Takahashi-Iwanaga, H.1
  • 13
    • 0029128719 scopus 로고
    • Pericyte-endothelial gap junctions in developing rat cerebral capillaries: a fine structural study
    • Fujimoto K. Pericyte-endothelial gap junctions in developing rat cerebral capillaries: a fine structural study. Anat Rec 1995, 242:562-565.
    • (1995) Anat Rec , vol.242 , pp. 562-565
    • Fujimoto, K.1
  • 14
    • 0029963991 scopus 로고    scopus 로고
    • Morphology of interstitial cells in the healthy kidney
    • Kaissling B., Hegyi I., Loffing J., et al. Morphology of interstitial cells in the healthy kidney. Anat Embryol (Berl) 1996, 193:303-318.
    • (1996) Anat Embryol (Berl) , vol.193 , pp. 303-318
    • Kaissling, B.1    Hegyi, I.2    Loffing, J.3
  • 15
    • 79551521517 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
    • Kriz W., Kaissling B., Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?. J Clin Invest 2011, 121:468-474.
    • (2011) J Clin Invest , vol.121 , pp. 468-474
    • Kriz, W.1    Kaissling, B.2    Le Hir, M.3
  • 16
    • 80053394522 scopus 로고    scopus 로고
    • Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice
    • Asada N., Takase M., Nakamura J., et al. Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest 2011, 121:3981-3990.
    • (2011) J Clin Invest , vol.121 , pp. 3981-3990
    • Asada, N.1    Takase, M.2    Nakamura, J.3
  • 17
    • 0030723250 scopus 로고    scopus 로고
    • Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla
    • Park F., Mattson D.L., Roberts L.A., et al. Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla. Am J Physiol 1997, 273:R1742-R1748.
    • (1997) Am J Physiol , vol.273
    • Park, F.1    Mattson, D.L.2    Roberts, L.A.3
  • 18
    • 0035002936 scopus 로고    scopus 로고
    • Pericyte regulation of renal medullary blood flow
    • Pallone T.L., Silldorff E.P. Pericyte regulation of renal medullary blood flow. Exp Nephrol 2001, 9:165-170.
    • (2001) Exp Nephrol , vol.9 , pp. 165-170
    • Pallone, T.L.1    Silldorff, E.P.2
  • 19
    • 50849139576 scopus 로고    scopus 로고
    • A perivascular origin for mesenchymal stem cells in multiple human organs
    • Crisan M., Yap S., Casteilla L., et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008, 3:301-313.
    • (2008) Cell Stem Cell , vol.3 , pp. 301-313
    • Crisan, M.1    Yap, S.2    Casteilla, L.3
  • 20
    • 79960099283 scopus 로고    scopus 로고
    • A pericyte origin of spinal cord scar tissue
    • Goritz C., Dias D.O., Tomilin N., et al. A pericyte origin of spinal cord scar tissue. Science 2011, 333:238-242.
    • (2011) Science , vol.333 , pp. 238-242
    • Goritz, C.1    Dias, D.O.2    Tomilin, N.3
  • 21
    • 0025778643 scopus 로고
    • Heterogeneity of microvascular pericytes for smooth muscle type alpha-actin
    • Nehls V., Drenckhahn D. Heterogeneity of microvascular pericytes for smooth muscle type alpha-actin. J Cell Biol 1991, 113:147-154.
    • (1991) J Cell Biol , vol.113 , pp. 147-154
    • Nehls, V.1    Drenckhahn, D.2
  • 22
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • Lin S.L., Kisseleva T., Brenner D.A., et al. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008, 173:1617-1627.
    • (2008) Am J Pathol , vol.173 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3
  • 23
    • 0027744498 scopus 로고
    • Microvascular pericytes express platelet-derived growth factor-beta receptors in human healing wounds and colorectal adenocarcinoma
    • Sundberg C., Ljungstrom M., Lindmark G., et al. Microvascular pericytes express platelet-derived growth factor-beta receptors in human healing wounds and colorectal adenocarcinoma. Am J Pathol 1993, 143:1377-1388.
    • (1993) Am J Pathol , vol.143 , pp. 1377-1388
    • Sundberg, C.1    Ljungstrom, M.2    Lindmark, G.3
  • 24
    • 31644441212 scopus 로고    scopus 로고
    • The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 2-tumours and tumour-like lesions
    • Eyden B. The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 2-tumours and tumour-like lesions. J Submicrosc Cytol Pathol 2005, 37:231-296.
    • (2005) J Submicrosc Cytol Pathol , vol.37 , pp. 231-296
    • Eyden, B.1
  • 25
    • 0029816341 scopus 로고    scopus 로고
    • The cellular derivation and the life span of the myofibroblast
    • Gabbiani G. The cellular derivation and the life span of the myofibroblast. Pathol Res Pract 1996, 192:708-711.
    • (1996) Pathol Res Pract , vol.192 , pp. 708-711
    • Gabbiani, G.1
  • 26
    • 28444434653 scopus 로고    scopus 로고
    • Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis
    • Rajkumar V.S., Howell K., Csiszar K., et al. Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis. Arthritis Res Ther 2005, 7:R1113-R1123.
    • (2005) Arthritis Res Ther , vol.7
    • Rajkumar, V.S.1    Howell, K.2    Csiszar, K.3
  • 27
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M., Neilson E.G. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009, 119:1429-1437.
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 28
    • 73949096744 scopus 로고    scopus 로고
    • Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    • Humphreys B.D., Lin S.L., Kobayashi A., et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010, 176:85-97.
    • (2010) Am J Pathol , vol.176 , pp. 85-97
    • Humphreys, B.D.1    Lin, S.L.2    Kobayashi, A.3
  • 29
    • 84857111725 scopus 로고    scopus 로고
    • The origin of interstitial myofibroblasts in chronic kidney disease
    • Grgic I., Duffield J.S., Humphreys B.D. The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol 2012, 27:183-193.
    • (2012) Pediatr Nephrol , vol.27 , pp. 183-193
    • Grgic, I.1    Duffield, J.S.2    Humphreys, B.D.3
  • 30
    • 55249103431 scopus 로고    scopus 로고
    • Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    • Zeisberg E.M., Potenta S.E., Sugimoto H., et al. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008, 19:2282-2287.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2282-2287
    • Zeisberg, E.M.1    Potenta, S.E.2    Sugimoto, H.3
  • 31
    • 84855511323 scopus 로고    scopus 로고
    • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
    • Rock J.R., Barkauskas C.E., Cronce M.J., et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A 2011, 108:E1475-E1483.
    • (2011) Proc Natl Acad Sci U S A , vol.108
    • Rock, J.R.1    Barkauskas, C.E.2    Cronce, M.J.3
  • 32
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: paradigms and principles
    • Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001, 15:3059-3087.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 33
    • 77952165223 scopus 로고    scopus 로고
    • Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract
    • Mao J., Kim B.M., Rajurkar M., et al. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development 2010, 137:1721-1729.
    • (2010) Development , vol.137 , pp. 1721-1729
    • Mao, J.1    Kim, B.M.2    Rajurkar, M.3
  • 34
    • 0036860686 scopus 로고    scopus 로고
    • Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney
    • Yu J., Carroll T.J., McMahon A.P. Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 2002, 129:5301-5312.
    • (2002) Development , vol.129 , pp. 5301-5312
    • Yu, J.1    Carroll, T.J.2    McMahon, A.P.3
  • 35
    • 80052295886 scopus 로고    scopus 로고
    • Control of mammalian kidney development by the Hedgehog signaling pathway
    • Cain J.E., Rosenblum N.D. Control of mammalian kidney development by the Hedgehog signaling pathway. Pediatr Nephrol 2011, 26:1365-1371.
    • (2011) Pediatr Nephrol , vol.26 , pp. 1365-1371
    • Cain, J.E.1    Rosenblum, N.D.2
  • 36
    • 33244463281 scopus 로고    scopus 로고
    • GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
    • Hu M.C., Mo R., Bhella S., et al. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 2006, 133:569-578.
    • (2006) Development , vol.133 , pp. 569-578
    • Hu, M.C.1    Mo, R.2    Bhella, S.3
  • 37
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki H., Nishizaki Y., Hui C., et al. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999, 126:3915-3924.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3
  • 38
    • 63149124772 scopus 로고    scopus 로고
    • Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
    • Tian H., Callahan C.A., DuPree K.J., et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A 2009, 106:4254-4259.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4254-4259
    • Tian, H.1    Callahan, C.A.2    DuPree, K.J.3
  • 39
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch R.L., Gould S.E., Scales S.J., et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008, 455:406-410.
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 40
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive K.P., Jacobetz M.A., Davidson C.J., et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009, 324:1457-1461.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 41
    • 79953746223 scopus 로고    scopus 로고
    • Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
    • Shin K., Lee J., Guo N., et al. Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature 2011, 472:110-114.
    • (2011) Nature , vol.472 , pp. 110-114
    • Shin, K.1    Lee, J.2    Guo, N.3
  • 42
    • 55849135600 scopus 로고    scopus 로고
    • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
    • Omenetti A., Porrello A., Jung Y., et al. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 2008, 118:3331-3342.
    • (2008) J Clin Invest , vol.118 , pp. 3331-3342
    • Omenetti, A.1    Porrello, A.2    Jung, Y.3
  • 43
    • 78751479915 scopus 로고    scopus 로고
    • Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
    • Syn W.K., Choi S.S., Liaskou E., et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology 2011, 53:106-115.
    • (2011) Hepatology , vol.53 , pp. 106-115
    • Syn, W.K.1    Choi, S.S.2    Liaskou, E.3
  • 44
    • 72749094687 scopus 로고    scopus 로고
    • Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis
    • Choi S.S., Omenetti A., Witek R.P., et al. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol 2009, 297:G1093-G1106.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297
    • Choi, S.S.1    Omenetti, A.2    Witek, R.P.3
  • 45
    • 0037385280 scopus 로고    scopus 로고
    • Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes
    • Stewart G.A., Hoyne G.F., Ahmad S.A., et al. Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. J Pathol 2003, 199:488-495.
    • (2003) J Pathol , vol.199 , pp. 488-495
    • Stewart, G.A.1    Hoyne, G.F.2    Ahmad, S.A.3
  • 46
    • 84859015834 scopus 로고    scopus 로고
    • Hedgehog-Gli pathway activation during kidney fibrosis
    • Fabian S.L., Penchev R.R., St-Jacques B., et al. Hedgehog-Gli pathway activation during kidney fibrosis. Am J Pathol 2012, 180:1441-1453.
    • (2012) Am J Pathol , vol.180 , pp. 1441-1453
    • Fabian, S.L.1    Penchev, R.R.2    St-Jacques, B.3
  • 47
    • 67650723106 scopus 로고    scopus 로고
    • Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
    • Tremblay M.R., Lescarbeau A., Grogan M.J., et al. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926). J Med Chem 2009, 52:4400-4418.
    • (2009) J Med Chem , vol.52 , pp. 4400-4418
    • Tremblay, M.R.1    Lescarbeau, A.2    Grogan, M.J.3
  • 48
    • 0037407935 scopus 로고    scopus 로고
    • Overview: combating diabetic nephropathy
    • Ziyadeh F.N., Sharma K. Overview: combating diabetic nephropathy. J Am Soc Nephrol 2003, 14:1355-1357.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1355-1357
    • Ziyadeh, F.N.1    Sharma, K.2
  • 49
    • 34147159558 scopus 로고    scopus 로고
    • Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment
    • Zhu Y., Usui H.K., Sharma K. Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment. Semin Nephrol 2007, 27:153-160.
    • (2007) Semin Nephrol , vol.27 , pp. 153-160
    • Zhu, Y.1    Usui, H.K.2    Sharma, K.3
  • 50
    • 0027479442 scopus 로고
    • Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy
    • Yamamoto T., Nakamura T., Noble N.A., et al. Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci U S A 1993, 90:1814-1818.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 1814-1818
    • Yamamoto, T.1    Nakamura, T.2    Noble, N.A.3
  • 51
    • 0034761986 scopus 로고    scopus 로고
    • Pathogenesis of diabetic nephropathy: focus on transforming growth factor-beta and connective tissue growth factor
    • Sakharova O.V., Taal M.W., Brenner B.M. Pathogenesis of diabetic nephropathy: focus on transforming growth factor-beta and connective tissue growth factor. Curr Opin Nephrol Hypertens 2001, 10:727-738.
    • (2001) Curr Opin Nephrol Hypertens , vol.10 , pp. 727-738
    • Sakharova, O.V.1    Taal, M.W.2    Brenner, B.M.3
  • 52
    • 0029953788 scopus 로고    scopus 로고
    • Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease
    • Kopp J.B., Factor V.M., Mozes M., et al. Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. Lab Invest 1996, 74:991-1003.
    • (1996) Lab Invest , vol.74 , pp. 991-1003
    • Kopp, J.B.1    Factor, V.M.2    Mozes, M.3
  • 53
    • 0033667322 scopus 로고    scopus 로고
    • Renal fibrosis in mice treated with human recombinant transforming growth factor-beta2
    • Ledbetter S., Kurtzberg L., Doyle S., et al. Renal fibrosis in mice treated with human recombinant transforming growth factor-beta2. Kidney Int 2000, 58:2367-2376.
    • (2000) Kidney Int , vol.58 , pp. 2367-2376
    • Ledbetter, S.1    Kurtzberg, L.2    Doyle, S.3
  • 54
    • 0025277164 scopus 로고
    • Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1
    • Border W.A., Okuda S., Languino L.R., et al. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1. Nature 1990, 346:371-374.
    • (1990) Nature , vol.346 , pp. 371-374
    • Border, W.A.1    Okuda, S.2    Languino, L.R.3
  • 55
    • 0034783503 scopus 로고    scopus 로고
    • Effects of anti-TGF-beta type II receptor antibody on experimental glomerulonephritis
    • Kasuga H., Ito Y., Sakamoto S., et al. Effects of anti-TGF-beta type II receptor antibody on experimental glomerulonephritis. Kidney Int 2001, 60:1745-1755.
    • (2001) Kidney Int , vol.60 , pp. 1745-1755
    • Kasuga, H.1    Ito, Y.2    Sakamoto, S.3
  • 56
    • 0028324267 scopus 로고
    • Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules
    • Zimmerman B.J., Holt J.W., Paulson J.C., et al. Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules. Am J Physiol 1994, 266:H847-H853.
    • (1994) Am J Physiol , vol.266
    • Zimmerman, B.J.1    Holt, J.W.2    Paulson, J.C.3
  • 57
    • 0346727324 scopus 로고    scopus 로고
    • Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • Sato M., Muragaki Y., Saika S., et al. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003, 112:1486-1494.
    • (2003) J Clin Invest , vol.112 , pp. 1486-1494
    • Sato, M.1    Muragaki, Y.2    Saika, S.3
  • 58
    • 3242797424 scopus 로고    scopus 로고
    • Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction
    • Inazaki K., Kanamaru Y., Kojima Y., et al. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 2004, 66:597-604.
    • (2004) Kidney Int , vol.66 , pp. 597-604
    • Inazaki, K.1    Kanamaru, Y.2    Kojima, Y.3
  • 59
    • 33748031093 scopus 로고    scopus 로고
    • Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease
    • Burns W.C., Twigg S.M., Forbes J.M., et al. Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease. J Am Soc Nephrol 2006, 17:2484-2494.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2484-2494
    • Burns, W.C.1    Twigg, S.M.2    Forbes, J.M.3
  • 60
    • 70350545853 scopus 로고    scopus 로고
    • TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy
    • Hills C.E., Squires P.E. TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy. Am J Nephrol 2010, 31:68-74.
    • (2010) Am J Nephrol , vol.31 , pp. 68-74
    • Hills, C.E.1    Squires, P.E.2
  • 61
    • 78049449123 scopus 로고    scopus 로고
    • Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
    • Bielesz B., Sirin Y., Si H., et al. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 2010, 120:4040-4054.
    • (2010) J Clin Invest , vol.120 , pp. 4040-4054
    • Bielesz, B.1    Sirin, Y.2    Si, H.3
  • 62
    • 79959754392 scopus 로고    scopus 로고
    • Exploring the origin of the cells responsible for regeneration and fibrosis in the kidneys [abstract]
    • Endo T., Okuda T., Nakamura J., et al. Exploring the origin of the cells responsible for regeneration and fibrosis in the kidneys [abstract]. J Am Soc Nephrol 2010, 21:36A.
    • (2010) J Am Soc Nephrol , vol.21
    • Endo, T.1    Okuda, T.2    Nakamura, J.3
  • 63
    • 77957252460 scopus 로고    scopus 로고
    • Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells
    • Koesters R., Kaissling B., Lehir M., et al. Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol 2010, 177:632-643.
    • (2010) Am J Pathol , vol.177 , pp. 632-643
    • Koesters, R.1    Kaissling, B.2    Lehir, M.3
  • 64
    • 0344844508 scopus 로고    scopus 로고
    • Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop
    • Fraser D., Brunskill N., Ito T., et al. Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop. Am J Pathol 2003, 163:2565-2574.
    • (2003) Am J Pathol , vol.163 , pp. 2565-2574
    • Fraser, D.1    Brunskill, N.2    Ito, T.3
  • 65
    • 34147106793 scopus 로고    scopus 로고
    • ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells
    • Zhang M., Fraser D., Phillips A. ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells. Am J Pathol 2006, 169:1282-1293.
    • (2006) Am J Pathol , vol.169 , pp. 1282-1293
    • Zhang, M.1    Fraser, D.2    Phillips, A.3
  • 66
    • 77952174830 scopus 로고    scopus 로고
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    • 1p following 143
    • Yang L., Besschetnova T.Y., Brooks C.R., et al. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 2010, 16:535-543. 1p following 143.
    • (2010) Nat Med , vol.16 , pp. 535-543
    • Yang, L.1    Besschetnova, T.Y.2    Brooks, C.R.3
  • 67
    • 77951224948 scopus 로고    scopus 로고
    • Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?
    • Van Geest R.J., Klaassen I., Vogels I.M., et al. Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?. Invest Ophthalmol Vis Sci 2010, 51:1857-1865.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 1857-1865
    • Van Geest, R.J.1    Klaassen, I.2    Vogels, I.M.3
  • 68
    • 0035136844 scopus 로고    scopus 로고
    • TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)
    • Strutz F., Zeisberg M., Renziehausen A., et al. TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). Kidney Int 2001, 59:579-592.
    • (2001) Kidney Int , vol.59 , pp. 579-592
    • Strutz, F.1    Zeisberg, M.2    Renziehausen, A.3
  • 69
    • 0034112481 scopus 로고    scopus 로고
    • Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation
    • Strutz F., Zeisberg M., Hemmerlein B., et al. Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation. Kidney Int 2000, 57:1521-1538.
    • (2000) Kidney Int , vol.57 , pp. 1521-1538
    • Strutz, F.1    Zeisberg, M.2    Hemmerlein, B.3
  • 70
    • 66449136561 scopus 로고    scopus 로고
    • Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts
    • Vasko R., Koziolek M., Ikehata M., et al. Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts. Am J Physiol 2009, 296:F1452-F1463.
    • (2009) Am J Physiol , vol.296
    • Vasko, R.1    Koziolek, M.2    Ikehata, M.3
  • 71
    • 38149107161 scopus 로고    scopus 로고
    • A new look at platelet-derived growth factor in renal disease
    • Floege J., Eitner F., Alpers C.E. A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol 2008, 19:12-23.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 12-23
    • Floege, J.1    Eitner, F.2    Alpers, C.E.3
  • 72
    • 20544477176 scopus 로고    scopus 로고
    • Imatinib attenuates diabetic nephropathy in apolipoprotein E-knockout mice
    • Lassila M., Jandeleit-Dahm K., Seah K.K., et al. Imatinib attenuates diabetic nephropathy in apolipoprotein E-knockout mice. J Am Soc Nephrol 2005, 16:363-373.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 363-373
    • Lassila, M.1    Jandeleit-Dahm, K.2    Seah, K.K.3
  • 73
    • 81155131228 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis
    • Chen Y.T., Chang F.C., Wu C.F., et al. Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis. Kidney Int 2011, 80:1170-1181.
    • (2011) Kidney Int , vol.80 , pp. 1170-1181
    • Chen, Y.T.1    Chang, F.C.2    Wu, C.F.3
  • 74
    • 9444299108 scopus 로고    scopus 로고
    • CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin
    • Chen Y., Abraham D.J., Shi-Wen X., et al. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell 2004, 15:5635-5646.
    • (2004) Mol Biol Cell , vol.15 , pp. 5635-5646
    • Chen, Y.1    Abraham, D.J.2    Shi-Wen, X.3
  • 75
    • 40949119494 scopus 로고    scopus 로고
    • Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability
    • Abraham S., Kogata N., Fassler R., et al. Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability. Circ Res 2008, 102:562-570.
    • (2008) Circ Res , vol.102 , pp. 562-570
    • Abraham, S.1    Kogata, N.2    Fassler, R.3
  • 76
    • 13444250205 scopus 로고    scopus 로고
    • Imbalance of growth factor signalling in diabetic kidney disease: is connective tissue growth factor (CTGF, CCN2) the perfect intervention point?
    • van Nieuwenhoven F.A., Jensen L.J., Flyvbjerg A., et al. Imbalance of growth factor signalling in diabetic kidney disease: is connective tissue growth factor (CTGF, CCN2) the perfect intervention point?. Nephrol Dial Transplant 2005, 20:6-10.
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 6-10
    • van Nieuwenhoven, F.A.1    Jensen, L.J.2    Flyvbjerg, A.3
  • 77
    • 33644875787 scopus 로고    scopus 로고
    • Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy
    • Nguyen T.Q., Tarnow L., Andersen S., et al. Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy. Diabetes Care 2006, 29:83-88.
    • (2006) Diabetes Care , vol.29 , pp. 83-88
    • Nguyen, T.Q.1    Tarnow, L.2    Andersen, S.3
  • 78
    • 48649102468 scopus 로고    scopus 로고
    • Plasma connective tissue growth factor is an independent predictor of end-stage renal disease and mortality in type 1 diabetic nephropathy
    • Nguyen T.Q., Tarnow L., Jorsal A., et al. Plasma connective tissue growth factor is an independent predictor of end-stage renal disease and mortality in type 1 diabetic nephropathy. Diabetes Care 2008, 31:1177-1182.
    • (2008) Diabetes Care , vol.31 , pp. 1177-1182
    • Nguyen, T.Q.1    Tarnow, L.2    Jorsal, A.3
  • 79
    • 67650069660 scopus 로고    scopus 로고
    • Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen
    • Ponticos M., Holmes A.M., Shi-wen X., et al. Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum 2009, 60:2142-2155.
    • (2009) Arthritis Rheum , vol.60 , pp. 2142-2155
    • Ponticos, M.1    Holmes, A.M.2    Shi-wen, X.3
  • 80
    • 78650798178 scopus 로고    scopus 로고
    • CCN2 is required for bleomycin-induced skin fibrosis in mice
    • Liu S., Shi-wen X., Abraham D.J., et al. CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum 2011, 63:239-246.
    • (2011) Arthritis Rheum , vol.63 , pp. 239-246
    • Liu, S.1    Shi-wen, X.2    Abraham, D.J.3
  • 81
    • 77955743198 scopus 로고    scopus 로고
    • Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria
    • Adler S.G., Schwartz S., Williams M.E., et al. Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria. Clin J Am Soc Nephrol 2010, 5:1420-1428.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 1420-1428
    • Adler, S.G.1    Schwartz, S.2    Williams, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.