Microenvironmental pH-modified solid dispersions to enhance the dissolution and bioavailability of poorly water-soluble weakly basic GT0918, a developing anti-prostate cancer drug: Preparation, characterization and evaluation in vivo

International Journal of Pharmaceutics

Volumn 475, Issue 1-2, 2014, Pages 97-109

  Yang, Meiyan ^a   He, Shaolong ^a,b   Fan, Yunzhou ^c   Wang, Yuli ^a   Ge, Zhenzhong ^d   Shan, Li ^a   Gong, Wei ^a   Huang, Xiaoli ^a,b   Tong, Youzhi ^e   Gao, Chunsheng ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^d HENAN UNIVERSITY   (China)

^e Suzhou Kintor Pharmaceutics Inc   (China)

Author keywords

Acidifier; Bioavailability; Microenvironmental pH; Poorly water soluble drug; Solid dispersion

Indexed keywords

ANTINEOPLASTIC AGENT; CINNAMIC ACID; CITRIC ACID; FUMARIC ACID; GT 0918; POVIDONE; SOLVENT; SUCCINIC ACID; UNCLASSIFIED DRUG; CINNAMIC ACID DERIVATIVE; EXCIPIENT; FUMARIC ACID DERIVATIVE; GT0918; IMIDAZOLE DERIVATIVE; NEW DRUG; NITRILE; OXAZOLE DERIVATIVE; SUSPENSION; TABLET; THIOHYDANTOIN DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; ELIMINATION HALF-LIFE; ELIMINATION RATE CONSTANT; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PH; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; POWDER X RAY DIFFRACTION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SINGLE DRUG DOSE; SOLID STATE; TABLET; X RAY DIFFRACTION; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DOG; DRUG FORMULATION; INBRED STRAIN; MALE; PROSTATIC NEOPLASMS; RANDOMIZATION; SOLUBILITY; SUSPENSION; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; BEAGLE; CONTROLLED STUDY; DRUG DESIGN; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; HYDROGEN BOND; PROSTATE CANCER; X RAY POWDER DIFFRACTION;

ANIMALS; ANIMALS, INBRED STRAINS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CINNAMATES; CITRIC ACID; DOGS; DRUG COMPOUNDING; DRUGS, INVESTIGATIONAL; EXCIPIENTS; FUMARATES; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; MALE; NITRILES; OXAZOLES; POVIDONE; PROSTATIC NEOPLASMS; RANDOM ALLOCATION; SOLUBILITY; SUCCINIC ACID; SUSPENSIONS; TABLETS; THIOHYDANTOINS;

EID: 84906857080     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.08.047     Document Type: Article

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