Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 73, Issue 1, 2009, Pages 154-161

  Srinarong, P ^a   Faber, J H ^a   Visser, M R ^a   Hinrichs, W L J ^a   Frijlink, H W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Fenofibrate; Freeze drying; Hydroxypropyl cyclodextrin; Inulin; Mannitol; Polyethylene glycol (PEG); Polyvinylpyrrolidone (PVP); Solid dispersions; Superdisintegrants

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CROSPOVIDONE; DRUG CARRIER; FENOFIBRATE; INULIN; MACROGOL; MANNITOL; POVIDONE; STARCH GLYCOLATE SODIUM;

ARTICLE; CONTROLLED STUDY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; HYDROPHILICITY; LIPOPHILICITY; PHYSICAL CHEMISTRY; TABLET DISINTEGRATION; TABLET FORMULATION;

CHEMISTRY, PHARMACEUTICAL; INULIN; PROCETOFEN; SOLUBILITY; TABLETS; X-RAY DIFFRACTION;

EID: 68349157666     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.05.006     Document Type: Article

References (19)

1. Arias M.J., Gines J.M., Moyano J.R., and Rabasco A.M. The application of solid dispersion technique with D-mannitol to the improvement in oral absorption of triamterene. J. Drug Target 2 (1994) 45-51
2. Zerrouk N., Chemtob C., Arnaud P., Toscani S., and Dugue J. In vitro and in vivo evaluation of carbamazepine-PEG 6000 solid dispersions. Int. J. Pharm. 225 (2001) 49-62
3. Palmieri G.F., Cantalamessa F., Di Martino P., Nasuti C., and Martelli S. Lonidamine solid dispersions: in vitro and in vivo evaluation. Drug Dev. Ind. Pharm. 28 (2002) 1241-1250
4. Lee S., Nam K., Kim M.S., Jun S.W., Park J.S., Woo J.S., and Hwang S.J. Preparation and characterization of solid dispersions of itraconazole by using aerosol solvent extraction system for improvement in drug solubility and bioavailability. Arch. Pharm. Res. 28 (2005) 866-874
5. Yonemochi E., Ueno Y., Ohmae T., Oguchi T., Nakajima S., and Yamamoto K. Evaluation of amorphous ursodeoxycholic acid by thermal methods. Pharm. Res. 14 (1997) 798-803
6. Yonemochi E., Kitahara S., Maeda S., Yamamura S., Oguchi T., and Yamamoto K. Physicochemical properties of amorphous clarithromycin obtained by grinding and spray drying. Eur. J. Pharm. Sci. 7 (1999) 331-338
7. Mura P., Cirri M., Faucci M.T., Gines-Dorado J.M., and Bettinetti G.P. Investigation of the effects of grinding and co-grinding on physicochemical properties of glisentide. J. Pharm. Biomed. Anal. 30 (2002) 227-237
8. Dai W.G., Dong L.C., and Song Y.Q. Nanosizing of a drug/carrageenan complex to increase solubility and dissolution rate. Int. J. Pharm. 342 (2007) 201-207
9. Kubo H., and Mizobe M. Improvement of dissolution rate and oral bioavailability of a sparingly water-soluble drug, (+/-)-5-[[2-(2-naphthalenylmethyl)-5-benzoxazolyl]-methyl]- 2, 4-thiazolidinedione, in co-ground mixture with D-mannitol. Biol. Pharm. Bull. 20 (1997) 460-463
10. Purvis T., Vaughn J.M., Rogers T.L., Chen X., Overhoff K.A., Sinswat P., Hu J., McConville J.T., Johnston K.P., and Williams R.O. 3rd, Cryogenic liquids, nanoparticles, and microencapsulation. Int. J. Pharm. 324 (2006) 43-50
11. Kawashima Y., Saito M., and Takenaka H. Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray-drying technique. J. Pharm. Pharmacol. 27 (1975) 1-5
12. Chow A.H.L., Hsia C.K., Gordon J.D., Young J.W.M., and Vargha-Butler E.I. Assessment of wettability and its relationship to the intrinsic dissolution rate of doped phenytoin crystals. Int. J. Pharm. 126 (1995) 21-28
13. van Drooge D.J., Hinrichs W.L., and Frijlink H.W. Anomalous dissolution behaviour of tablets prepared from sugar glass-based solid dispersions. J. Control. Release 97 (2004) 441-452
14. de Waard H., Hinrichs W.L., Visser M.R., Bologna C., and Frijlink H.W. Unexpected differences in dissolution behavior of tablets prepared from solid dispersions with a surfactant physically mixed or incorporated. Int. J. Pharm. 349 (2008) 66-73
15. Van Drooge D.J., Hinrichs W.L., and Frijlink H.W. Incorporation of lipophilic drugs in sugar glasses by lyophilization using a mixture of water and tertiary butyl alcohol as solvent. J. Pharm. Sci. 93 (2004) 713-725
16. 2. Pharm. Res. 15 (1998) 889-896
17. Heinz A., Gordon K.C., McGoverin C.M., Rades T., and Strachan C.J. Understanding the solid-state forms of fenofibrate - a spectroscopic and computational study. Eur. J. Pharm. Biopharm. 71 (2009) 100-108
18. Quadir A., and Kolter K. A comparative study of current superdisintegrants. Pharm. Technol. 30 (2006) s38-s42
19. Dordunoo S.K., Ford J.L., and Rubinstein M.H. Physical stability of solid dispersions containing triamterene or temazepam in polyethylene glycols. J. Pharm. Pharmacol. 49 (1997) 390-396