Development of solid lipid nanoparticles for enhanced solubility of poorly soluble drugs

Journal of Biomedical Nanotechnology

Volumn 6, Issue 6, 2010, Pages 634-640

  Potta, Sriharsha Gupta ^a   Minemi, Sriharsha ^a   Nukala, Ravi Kumar ^a   Peinado, Chairmane ^b   Lamprou, Dimitrios A ^c   Urquhart, Andrew ^c   Douroumis, D ^a  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

^b UNIVERSITÉ DE ROUEN   (France)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Cyclosporine; Cytotoxicity; High pressure homogenization; Solid lipid nanoparticles

Indexed keywords

CACO-2 CELLS; CYCLOSPORINE; DRUG DISSOLUTION; DRUG SOLUBILITY; HIGH PRESSURE HOMOGENIZATION; LIPID COMPOSITION; LIPID CORES; METASTABLE FORM; POORLY SOLUBLE DRUGS; PROCESSING TEMPERATURE; SOLID CORE; SOLID LIPID NANOPARTICLES; SOLVENT FREE;

ATOMIC FORCE MICROSCOPY; ATOMIC SPECTROSCOPY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG PRODUCTS; HOMOGENIZATION METHOD; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PROCESSING; SOLUBILITY; STEARIC ACID; X RAY DIFFRACTION;

NANOPARTICLES;

CYCLOSPORIN A; LAURIC ACID DERIVATIVE; SOLID LIPID NANOPARTICLE; STEARIC ACID; TRILAURIN; TRIPALMITIN; UNCLASSIFIED DRUG; CYCLOSPORIN; DERMATOLOGICAL AGENT; LIPID; NANOPARTICLE;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MANUFACTURE; DRUG RELEASE; DRUG SOLUBILITY; FREEZE DRYING; HUMAN; HUMAN CELL; LIPID COMPOSITION; PARTICLE SIZE; ATOMIC FORCE MICROSCOPY; CELL SURVIVAL; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFECT; MICROCAPSULE; SOLUBILITY;

CACO-2 CELLS; CALORIMETRY, DIFFERENTIAL SCANNING; CAPSULES; CELL SURVIVAL; CYCLOSPORINE; DERMATOLOGIC AGENTS; HUMANS; LIPIDS; MICROSCOPY, ATOMIC FORCE; NANOPARTICLES; SOLUBILITY;

EID: 79953009485     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2010.1169     Document Type: Article

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