Salt formation to improve drug solubility

Advanced Drug Delivery Reviews

Volumn 59, Issue 7, 2007, Pages 603-616

  Serajuddin, Abu T M ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Common ion effect; Counterion; Dissolution rate; Microenvironmental pH; pH solubility profile; Salt; Salt selection; Self association; solubility

Indexed keywords

ACIDITY; DISSOLUTION; PH EFFECTS; SALTS; SOLUBILITY;

COUNTERION; DISSOLUTION RATES; SALT FORMATION; SALT SELECTION; SELF ASSOCIATION;

DRUG PRODUCTS;

AVITRIPTAN; FLURBIPROFEN; HALOPERIDOL; ORGANIC SOLVENT; PHENYTOIN; SODIUM CHLORIDE;

ACIDITY; CHEMICAL STRUCTURE; DISSOLUTION; DRUG FORMULATION; DRUG SOLUBILITY; PH MEASUREMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SCREENING;

DOSAGE FORMS; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; PHARMACEUTICAL PREPARATIONS; SALTS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548032742     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2007.05.010     Document Type: Review

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