Investigation of physicochemical factors affecting the stability of a pH-modulated solid dispersion and a tablet during storage

International Journal of Pharmaceutics

Volumn 414, Issue 1-2, 2011, Pages 48-55

  Tran, Phuong Ha Lien ^a   Tran, Thao Truong Dinh ^a   Park, Jun Bom ^a   Min, Dong Hun ^a   Choi, Han Gon ^b   Han, Hyo Kyung ^c   Rhee, Yun Seok ^d   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

^b Hanyang University   (South Korea)

^c Dongguk University   (South Korea)

^d Gyeongsang National University   (South Korea)

Author keywords

Alkalizer; Humidity; Microenvironmental pH; pH modulated solid dispersion; Stability test; Telmisartan; Temperature

Indexed keywords

MACROGOL 6000; MAGNESIUM OXIDE; SODIUM CHLORIDE; TELMISARTAN;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; FOURIER TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMIDITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTESTINE FLUID; MELTING POINT; MOLECULAR INTERACTION; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOLID; STOMACH JUICE; TABLET; TABLET FORMULATION; TEMPERATURE; X RAY POWDER DIFFRACTION;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BENZIMIDAZOLES; BENZOATES; CRYSTALLIZATION; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; HUMIDITY; MAGNESIUM OXIDE; PHYSICOCHEMICAL PROCESSES; POLYETHYLENE GLYCOLS; SOLUBILITY; SUSPENSIONS; TABLETS; TEMPERATURE;

EID: 79959744350     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.04.065     Document Type: Article

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