Dissolution-enhancing mechanism of alkalizers in poloxamer-based solid dispersions and physical mixtures containing poorly water-soluble valsartan

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 7, 2011, Pages 844-850

  Ha, Nam Sung ^a   Tran, Thao Truong Dinh ^a   Tran, Phuong Ha Lien ^a   Park, Jun Bom ^a   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

Author keywords

Alkalizer; Drug dissolution; Microenvironmental pH; Solid dispersion; Structural change; Valsartan

Indexed keywords

ARGININE; CARBONYL DERIVATIVE; MAGNESIUM OXIDE; MEGLUMINE; POLOXAMER; SODIUM CARBONATE; VALSARTAN;

ARTICLE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MICROENVIRONMENT; MOLECULAR INTERACTION; SOLID DISPERSION; STOMACH JUICE; STOMACH PH; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CARBONATES; CHEMISTRY, PHARMACEUTICAL; ELECTRODES; HYDROGEN-ION CONCENTRATION; POLOXAMER; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TETRAZOLES; VALINE; WATER; X-RAY DIFFRACTION;

EID: 79959793974     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.844     Document Type: Article

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