Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility

Expert Opinion on Drug Delivery

Volumn 7, Issue 5, 2010, Pages 647-661

  Tran, Phuong Ha Lien ^a   Tran, Thao Truong Dinh ^a   Lee, Kyoung Ho ^a   Kim, Dong Jin ^a   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

Author keywords

Dissolution modulating mechanism; Microenvironmental pH modulation; Molecular interactions; PH modified solid dispersion; Structural behaviors; Weakly acidic or basic drugs

Indexed keywords

ARGININE; ASCORBIC ACID; BENTONITE; BICARBONATE; CALCIUM CARBONATE; CITRATE SODIUM; CITRIC ACID; CREMOPHOR; DIPOTASSIUM HYDROGEN PHOSPHATE; DISODIUM HYDROGEN PHOSPHATE; FUMARIC ACID; MACROGOL 6000; MAGNESIUM OXIDE; MALIC ACID; MEGLUMINE; POLOXAMER; POTASSIUM BICARBONATE; POTASSIUM HYDROXIDE; SODIUM CARBONATE; SODIUM HYDROXIDE; SUCCINIC ACID; TARTARIC ACID; DELAYED RELEASE FORMULATION; DRUG; EXCIPIENT;

ACIDITY; ALKALINITY; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG SOLUBILITY; PH; REVIEW; CHEMISTRY; DELAYED RELEASE FORMULATION; SOLUBILITY;

DELAYED-ACTION PREPARATIONS; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 77951485229     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425241003645910     Document Type: Review

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