Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion

International Journal of Pharmaceutics

Volumn 439, Issue 1-2, 2012, Pages 145-156

  Kalivoda, Adela ^a,b   Fischbach, Matthias ^a   Kleinebudde, Peter ^b  

^a Merck Serono GmbH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Dissolution; Hot melt extrusion; Oral drug delivery; Oxeglitazar; Polymeric drug carrier; Solid dispersion; Solubility

Indexed keywords

COPOLYMER; COPOVIDONE; DRUG CARRIER; HYDROXYPROPYLMETHYLCELLULOSE; OXEGLITAZAR; POLYVINYL CAPROLACTAM POLYVINYL ACETATE POLYETHYLENE GLYCOL COPOLYMER; UNCLASSIFIED DRUG;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STORAGE; PRIORITY JOURNAL; X RAY DIFFRACTION;

BENZOXEPINS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG COMPOUNDING; HOT TEMPERATURE; POLYMERS; SOLUBILITY; X-RAY DIFFRACTION;

EID: 84868233981     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.10.013     Document Type: Article

References (33)

1. Technical Information Soluplus, 2010. Available online: http://www.pharma-ingredients.basf.com/Statements/Technical%20Informations/EN/ Pharma%20Solutions/03-090801e-Soluplus.pdf (2012.05.06.).
2. H. Afrasiabi Garekani, F. Sadeghi, and A. Ghazi Increasing the aqueous solubility of acetaminophen in the presence of polyvinylpyrrolidone and investigation of the mechanisms involved Drug Dev. Ind. Pharm. 29 2003 173 179
3. G.L. Amidon, H. Lennernäs, V.P. Shah, and J.R. Crison A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability Pharm. Res. 12 1995 413 420
4. E. Badens, V. Majerik, G. Horváth, z. Szokonya, L.s. Bosc, N. Teillaud, and E.G.r. Charbit Comparison of solid dispersions produced by supercritical antisolvent and spray-freezing technologies Int. J. Pharm. 377 2009 25 34
5. T. Bee, and M. Rahman Using polymer technology to enhance bioavailability Pharm. Technol. 34 2010 s37 s42
6. J. Breitenbach Melt extrusion: from process to drug delivery technology Eur. J. Pharm. Biopharm. 54 2002 107 117
7. W.L. Chiou, and S. Riegelman Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin J. Pharm. Sci. 58 1969 1505 1510
8. W.L. Chiou, and S. Riegelman Pharmaceutical applications of solid dispersion systems J. Pharm. Sci. 60 1971 1281 1302
9. K. Coppens, M. Hall, V. He, P. Larsen, B. Koblinski, M. Read, and U. Shrestha Excipient blends in hot melt extrusion 2006 Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists San Antonio, TX, USA 2006
10. M.M. Crowley, F. Zhang, M.A. Repka, S. Thumma, S.B. Upadhye, S.K. Battu, J.W. McGinity, and C. Martin Pharmaceutical applications of hot-melt extrusion: part I Drug Dev. Ind. Pharm. 33 2007 909 926
11. D. Djuric, and K. Kolter Bioavailability enhancement of fenofibrate and itraconazole by forming solid solutions with an innovative amphiphilic copolymer PBP World Meeting Malta, Valletta 2010
12. M.A. El-Egakey, M. Soliva, and P. Speiser Hot extruded dosage forms Pharm. Acta Helv. 46 1971 31 52
13. R. Fissoune, N. Pellet, L. Chaabane, F. Contard, D. Guerrier, and A. Briguet Evaluation of adipose tissue distribution in obese fa/fa Zucker rats by in vivo MR imaging: effects of peroxisome proliferator-activated receptor agonists MAGMA 17 2004 229 235
14. J.L. Ford The current status of solid dispersions Pharm. Acta Helv. 61 1986 69 88
15. A.H. Goldberg, M. Gibaldi, and J.L. Kanig Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures. I. Theoretical considerations and discussion of the literature J. Pharm. Sci. 54 1965 1145 1148
16. X. He Integration of physical, chemical, mechanical, and biopharmaceutical properties in solid oral dosage form development Q. Yihong, C. Yisheng, G.Z.Z. Geoff, L. Lirong, W.R. Porter, Developing Solid Oral Dosage Forms 2009 Academic Press San Diego 407 441
17. ICH ICH harmonised tripartite guideline, stability testing of new drug substances and products Q1A(R2) International Conference on Harmonisation 2003
18. S. Janssens, H.N. de Armas, C.J. Roberts, and G. Van den Mooter Characterization of ternary solid dispersions of itraconazole, PEG 6000, and HPMC 2910 E5 J. Pharm. Sci. 97 2008 2110 2120
19. K. Kolter, M. Karl, S. Nalawade, and N. Rottmann Hot-Melt Extrusion with BASF Pharma Polymers: Extrusion Compendium first ed. 2010 BASF SE Ludwigshafen
20. A. Kalivoda, M. Fischbach, and P. Kleinebudde Application of mixtures of polymeric carriers for dissolution enhancement of fenofibrate using hot-melt extrusion Int. J. Pharm. 429 2012 58 68
21. C. Leuner, and J. Dressman Improving drug solubility for oral delivery using solid dispersions Eur. J. Pharm. Biopharm. 50 2000 47 60
22. T. Loftsson, H. Fririksdóttir, and T.K. Gumundsdóttir The effect of water-soluble polymers on aqueous solubility of drugs Int. J. Pharm. 127 1996 293 296
23. Majerik, F.V.; 2006. Improvement of bioavailability of LM4156 using supercritical and cryogenic technologies. Dissertation. University of Veszprém and University of Aix-Marseille III.
24. V. Majerik, G. Charbit, E. Badens, G. Horváth, L. Szokonya, N. Bosc, and E. Teillaud Bioavailability enhancement of an active substance by supercritical antisolvent precipitation J. Supercrit. Fluids 40 2007 101 110
25. V. Majerik, G. Horváth, G. Charbit, E. Badens, L. Szokonya, N. Bosc, and E. Teillaud Solid dispersions of oxeglitazar in PVP K17 and Poloxamer 407 by supercritical antisolvent and co-evaporation methods Hung. J. Ind. Chem. 34 2006 41 49
26. E.J. Munson Analytical techniques in solid-state characterization Q. Yihong, C. Yisheng, G.Z.Z. Geoff, L. Lirong, W.R. Porter, Developing Solid Oral Dosage Forms 2009 Academic Press San Diego 61 74
27. K. Nollenberger, A. Gryczke, C. Meier, J. Dressman, M. Schmidt, and S. Brühne Pair distribution function X-ray analysis explains dissolution characteristics of felodipine melt extrusion products J. Pharm. Sci. 98 2009 1476 1486
28. K. Nollenberger, A. Gryczke, M. Takayuki, and I. Tatsuya Using polymers to enhance solubility of poorly soluble drugs Pharm. Technol. 2009 s20 s25
29. S. Prodduturi, K. Urman, J. Otaigbe, and M. Repka Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends AAPS PharmSciTech 8 2007 E152 E161
30. M.A. Repka, S.K. Battu, S.B. Upadhye, S. Thumma, M.M. Crowley, F. Zhang, C. Martin, and J.W. McGinity Pharmaceutical applications of hot-melt extrusion: part II Drug Dev. Ind. Pharm. 33 2007 1043 1057
31. M.A. Repka, S. Majumdar, S. Kumar Battu, R. Srirangam, and S.B. Upadhye Applications of hot-melt extrusion for drug delivery Expert Opin. Drug Deliv. 5 2008 1357 1376
32. K. Sekiguchi, and N. Obi Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man Chem. Pharm. Bull. (Tokyo) 9 1961 866 872
33. A.T.M. Serajuddin Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs J. Pharm. Sci. 88 1999 1058 1066