Dissolution-modulating mechanism of alkalizers and polymers in a nanoemulsifying solid dispersion containing ionizable and poorly water-soluble drug

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 1, 2009, Pages 83-90

  Tran, Thao Truong Dinh ^a   Tran, Phuong Ha Lien ^a   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

Author keywords

Alkalizers; Crystalline structure; Dissolution modulating mechanism; Microenvironmental pH; Nanoemulsifying solid dispersion; Spring like precipitation

Indexed keywords

ACECLOFENAC; ALKALI; ARGININE; BENTONITE; BICARBONATE; CALCIUM CARBONATE; CREMOPHOR; GELUCIRE; GELUCIRE 44 14; MACROGOL 6000; MAGNESIUM OXIDE; MEGLUMINE; POLOXAMER; POLYMER; POTASSIUM DIHYDROGEN PHOSPHATE; SODIUM CARBONATE; SODIUM DIHYDROGEN PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED DRUG RELEASE; CRYSTAL STRUCTURE; DRUG SOLUBILITY; MELTING POINT; MOLECULAR INTERACTION; NANOEMULSION; PH; PRECIPITATION; SIMULATION; STOMACH JUICE; SURFACE PROPERTY;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG DELIVERY SYSTEMS; EMULSIONS; HYDROGEN-ION CONCENTRATION; IONS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; POLOXAMER; SOLUBILITY; TEMPERATURE; WATER; X-RAY DIFFRACTION;

EID: 62949131342     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.12.009     Document Type: Article

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