메뉴 건너뛰기




Volumn 28, Issue 5, 2005, Pages 604-611

Effect of solubilizing and microemulsifying excipients in polyethylene glycol 6000 solid dispersion on enhanced dissolution and bioavailability of ketoconazole

Author keywords

Bioavailability; Crystal structure; Dissolution rate; Pharmaceutical excipients; Solid dispersion; Solubilizing and microemulsifying

Indexed keywords

EXCIPIENT; KETOCONAZOLE; MACROGOL DERIVATIVE;

EID: 23844542459     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977766     Document Type: Article
Times cited : (88)

References (20)
  • 1
    • 0027233973 scopus 로고
    • Structures formed by interactions in solid dispersions of the system polyethylene glycol-griseofulvin with charged and noncharged surfactants added
    • Alden, M., Tegenfeldt, J., and Saers, E. S., Structures formed by interactions in solid dispersions of the system polyethylene glycol-griseofulvin with charged and noncharged surfactants added. Int. J. Pharm., 94, 31-38 (1993).
    • (1993) Int. J. Pharm. , vol.94 , pp. 31-38
    • Alden, M.1    Tegenfeldt, J.2    Saers, E.S.3
  • 2
    • 0042634183 scopus 로고    scopus 로고
    • The use of solid self-emulsifying systems in the delivery of diclofenac
    • Attama, A. A., Nzekwe, I. T., Nnamani, P. O., Adikwu, M. Y., and Onugu, C. O., The use of solid self-emulsifying systems in the delivery of diclofenac. Int. J. Pharm., 262, 23-28 (2003).
    • (2003) Int. J. Pharm. , vol.262 , pp. 23-28
    • Attama, A.A.1    Nzekwe, I.T.2    Nnamani, P.O.3    Adikwu, M.Y.4    Onugu, C.O.5
  • 3
    • 0022548510 scopus 로고
    • Pharmacokinetics of ketoconazole administered intravenously to dogs and orally as ablet and solution to humans and dogs
    • Baxter, J. G., Brass, C., Schentag, J. J., and Slaughter, F. L., Pharmacokinetics of ketoconazole administered intravenously to dogs and orally as ablet and solution to humans and dogs. Pharm. Res., 75, 443-447 (1986).
    • (1986) Pharm. Res. , vol.75 , pp. 443-447
    • Baxter, J.G.1    Brass, C.2    Schentag, J.J.3    Slaughter, F.L.4
  • 4
    • 0030016875 scopus 로고    scopus 로고
    • Characterization of glyburide-polyethylene glycol solid dispersions
    • Betageri, G. V. and Makarla, K. R., Characterization of glyburide-polyethylene glycol solid dispersions. Drug Dev. Ind. Pharm., 22, 731-734 (1996).
    • (1996) Drug Dev. Ind. Pharm. , vol.22 , pp. 731-734
    • Betageri, G.V.1    Makarla, K.R.2
  • 5
    • 0033818432 scopus 로고    scopus 로고
    • Effect of short-medium-and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats
    • Caliph, S., Charman, W. N., and Porter, C. J. H., Effect of short-medium-and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J. Pharm. Sci., 89, 1073-1084 (2000).
    • (2000) J. Pharm. Sci. , vol.89 , pp. 1073-1084
    • Caliph, S.1    Charman, W.N.2    Porter, C.J.H.3
  • 6
    • 33750694494 scopus 로고    scopus 로고
    • Preparation and dissolution of PVP-based solid dispersion capsules containing solubilizers
    • Cao, Q.-R., Kim, T.-W., Choi, C.-Y., Kwon, K .A., and Lee, B.-J., Preparation and dissolution of PVP-based solid dispersion capsules containing solubilizers. J. Kor. Pharm. Sci., 33, 7-14 (2003).
    • (2003) J. Kor. Pharm. Sci. , vol.33 , pp. 7-14
    • Cao, Q.-R.1    Kim, T.-W.2    Choi, C.-Y.3    Kwon, K.A.4    Lee, B.-J.5
  • 7
    • 0015124656 scopus 로고
    • Pharmaceutical applications of solid dispersion system
    • Chiou, W. L. and Riegelman, S., Pharmaceutical applications of solid dispersion system. J. Pharm. Sci., 60, 1281-1302 (1971).
    • (1971) J. Pharm. Sci. , vol.60 , pp. 1281-1302
    • Chiou, W.L.1    Riegelman, S.2
  • 8
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    • Constantinides, P. P., Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm. Res., 12, 1561-1572 (1995).
    • (1995) Pharm. Res. , vol.12 , pp. 1561-1572
    • Constantinides, P.P.1
  • 9
    • 2442671307 scopus 로고    scopus 로고
    • Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo
    • Cornaire, G., Woodley, J., Hermann, P., Cloarec, A., Arellano, C., and Houin, G., Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. Int. J. Pharm., 278, 119-131 (2004).
    • (2004) Int. J. Pharm. , vol.278 , pp. 119-131
    • Cornaire, G.1    Woodley, J.2    Hermann, P.3    Cloarec, A.4    Arellano, C.5    Houin, G.6
  • 10
    • 0035964448 scopus 로고    scopus 로고
    • Dissolution properties and anticonvulsant activity of phenytoinpolyethylene glycol 6000 and polyvinylpyrrolidone K-30 solid dispersions
    • Franco, M., Trapani, G., Latrofa, A., Tullio, C., Provenzano, M. R., Serra, M., Muggironi, M., Biggio, G., and Liso, G., Dissolution properties and anticonvulsant activity of phenytoinpolyethylene glycol 6000 and polyvinylpyrrolidone K-30 solid dispersions. Int. J. Pharm., 225, 63-73 (2001).
    • (2001) Int. J. Pharm. , vol.225 , pp. 63-73
    • Franco, M.1    Trapani, G.2    Latrofa, A.3    Tullio, C.4    Provenzano, M.R.5    Serra, M.6    Muggironi, M.7    Biggio, G.8    Liso, G.9
  • 12
    • 33750694831 scopus 로고    scopus 로고
    • Dissolution profiles of solid dispersions containing poorly water-soluble drugs and solubilizing compositions
    • Kim, T.-W., Choi, C.-Y., Cao, Q.-R., Kwon, K. A., and Lee, B.-J., Dissolution profiles of solid dispersions containing poorly water-soluble drugs and solubilizing compositions. J. Kor. Pharm. Sci., 32, 191-197 (2002).
    • (2002) J. Kor. Pharm. Sci. , vol.32 , pp. 191-197
    • Kim, T.-W.1    Choi, C.-Y.2    Cao, Q.-R.3    Kwon, K.A.4    Lee, B.-J.5
  • 13
    • 0027054357 scopus 로고
    • Structural properties of polyethylene glycol-polysorbate 80 mixture, a solid dispersion vehicle
    • Morris, K. R., Knipp, G. T., and Serajuddin, A. T. M., Structural properties of polyethylene glycol-polysorbate 80 mixture, a solid dispersion vehicle. J. Pharm. Sci., 81, 1185-1188 (1992).
    • (1992) J. Pharm. Sci. , vol.81 , pp. 1185-1188
    • Morris, K.R.1    Knipp, G.T.2    Serajuddin, A.T.M.3
  • 14
    • 0029847154 scopus 로고    scopus 로고
    • Properties of solid dispersions of naproxen in various polyethylene glycols
    • Mura, P., manderioli, A., Bramanti, G., and Ceccareli, L., Properties of solid dispersions of naproxen in various polyethylene glycols. Drug Dev. Ind. Pharm., 22, 909-916 (1996).
    • (1996) Drug Dev. Ind. Pharm. , vol.22 , pp. 909-916
    • Mura, P.1    Manderioli, A.2    Bramanti, G.3    Ceccareli, L.4
  • 15
    • 0031684568 scopus 로고    scopus 로고
    • Comparative dissolution studies for mefenamic acid-polyethylene glycol solid dispersion systems and tablets
    • Owusu-Ababio, G., Ebube, N. K., Reams, R., and Habib, M., Comparative dissolution studies for mefenamic acid-polyethylene glycol solid dispersion systems and tablets. Pharm. Dev. Technol., 3, 405-412 (1998).
    • (1998) Pharm. Dev. Technol. , vol.3 , pp. 405-412
    • Owusu-Ababio, G.1    Ebube, N.K.2    Reams, R.3    Habib, M.4
  • 16
    • 0035940057 scopus 로고    scopus 로고
    • Intestinal lymphatic drug transport: An update
    • Porter, C. J. H. and Charman, W. N., Intestinal lymphatic drug transport: an update. Adv. Drug Del. Rev., 50, 61-80 (2001).
    • (2001) Adv. Drug Del. Rev. , vol.50 , pp. 61-80
    • Porter, C.J.H.1    Charman, W.N.2
  • 17
    • 0032885450 scopus 로고    scopus 로고
    • Solid dispersion of poorly water-soluble drugs: Early promises, subsquent problems, and recent breakthroughs
    • Serajuddin, A. T. M., Solid dispersion of poorly water-soluble drugs: Early promises, subsquent problems, and recent breakthroughs. J. Pharm. Sci., 88, 1058-1066 (1999).
    • (1999) J. Pharm. Sci. , vol.88 , pp. 1058-1066
    • Serajuddin, A.T.M.1
  • 18
    • 0028956464 scopus 로고
    • Formulation studies of a poorly water-soluble drug in solid dispersions to improve bioavailability
    • Sheen, P. C., Khetarpal, V. K., Cariola, C. M., and Rowlings, C. E., Formulation studies of a poorly water-soluble drug in solid dispersions to improve bioavailability. Int. J. Pharm., 118, 221-227 (1995).
    • (1995) Int. J. Pharm. , vol.118 , pp. 221-227
    • Sheen, P.C.1    Khetarpal, V.K.2    Cariola, C.M.3    Rowlings, C.E.4
  • 19
    • 0037027850 scopus 로고    scopus 로고
    • Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions
    • Verheyen, S., Blaton, N., Kinget, R., and Mooter, G. V., Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions. Int. J. Pharm., 249, 45-58 (2002).
    • (2002) Int. J. Pharm. , vol.249 , pp. 45-58
    • Verheyen, S.1    Blaton, N.2    Kinget, R.3    Mooter, G.V.4
  • 20
    • 8644277940 scopus 로고    scopus 로고
    • Determination of P-glycoprotein inhibition by excipients and their combinations using an integrated high-throughput process
    • Wang, S.-W., Monagle, J., McNulty, C., Putnam, D., and Chen, H., Determination of P-glycoprotein inhibition by excipients and their combinations using an integrated high-throughput process. J. Pharm. Sci., 93, 2755-2767 (2004).
    • (2004) J. Pharm. Sci. , vol.93 , pp. 2755-2767
    • Wang, S.-W.1    Monagle, J.2    McNulty, C.3    Putnam, D.4    Chen, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.