The roles of acidifiers in solid dispersions and physical mixtures

International Journal of Pharmaceutics

Volumn 384, Issue 1-2, 2010, Pages 60-66

  Tran, Thao Truong Dinh ^a   Tran, Phuong Ha Lien ^a   Choi, Han Gon ^b   Han, Hyo Kyung ^c   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

^b Yeungnam University   (South Korea)

^c Chosun University   (South Korea)

Author keywords

Acidifier release; Drug crystallinity; Micro environmental pH; Physical mixture; Solid dispersion; Weakly basic poorly water soluble drug

Indexed keywords

CITRIC ACID; FUMARIC ACID; GLYCOLIC ACID; ISRADIPINE; MALIC ACID; POVIDONE;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SOLUBILITY; EVAPORATION; HYDROGEN BOND; INFRARED SPECTROSCOPY; INTESTINE FLUID; PH; PRIORITY JOURNAL; TABLET COMPRESSION; X RAY DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; CITRIC ACID; CRYSTALLIZATION; DOSAGE FORMS; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 70649111297     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.09.039     Document Type: Article

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