Roles of MgO release from polyethylene glycol 6000-based solid dispersions on microenvironmental pH, enhanced dissolution and reduced gastrointestinal damage of telmisartan

Archives of Pharmacal Research

Volumn 34, Issue 5, 2011, Pages 747-755

  Phuong, Ha Lien Tran ^a   Tran, Thao Truong Dinh ^a   Lee, Seung Aeon ^a   Nho, Vo Hong ^b   Chi, Sang Cheol ^b   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Enhanced drug dissolution; Microenvironmental pH; Reduced intestinal damages; Release rate of MgO; Solid dispersions

Indexed keywords

MACROGOL 6000; MAGNESIUM OXIDE; TELMISARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DISPERSION; DRUG FORMULATION; DRUG SOLUBILITY; INTESTINE FLUID; INTESTINE INJURY; MALE; MOLECULAR INTERACTION; NONHUMAN; RAT; SOLID DISPERSION; STOMACH JUICE; TABLET; TABLET HARDNESS;

ANIMALS; BENZIMIDAZOLES; BENZOATES; DRUG CARRIERS; DRUG COMPOUNDING; GASTRIC JUICE; GASTRIC MUCOSA; GASTROENTERITIS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL MUCOSA; INTESTINAL SECRETIONS; IRRITANTS; KINETICS; MAGNESIUM OXIDE; PHARMACEUTIC AIDS; POLYETHYLENE GLYCOLS; RATS; SOLUBILITY; SURFACE PROPERTIES; TABLETS;

EID: 79960251436     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0508-2     Document Type: Article

References (13)

1. W. L. Chiou S. Riegelman 1971 Pharmaceutical applications of solid dispersion systems J. Pharm. Sci. 60 1281 1302 4935981 10.1002/jps.2600600902 1:STN:280:DyaE3M3otFersQ%3D%3D
2. D. Q. Craig 2002 The mechanisms of drug release from solid dispersions in water-soluble polymers Int. J. Pharm. 231 131 144 11755266 10.1016/S0378- 5173(01)00891-2 1:CAS:528:DC%2BD3MXptlaitL0%3D (Pubitemid 34033673)
3. J. L. Ford 1986 The current status of solid dispersions Pharm. Acta Helv. 61 69 88 3520598 1:CAS:528:DyaL28XhvFaqtb4%3D (Pubitemid 16134014)
4. M. Y. Heo Z. Z. Piao T. W. Kim Q. R. Cao A. Kim B. -J. Lee 2005 Effect of solubilizing and microemulsifying excipients in polyethylene glycol 6000 solid dispersion on enhanced dissolution and bioavailability of ketoconazole Arch. Pharm. Res. 28 604 611 15974450 10.1007/BF02977766 1:CAS:528: DC%2BD2MXltVamtbw%3D (Pubitemid 44698739)
5. T. Kai Y. Akiyama S. Nomura M. Sato 1996 Oral absorption improvement of poorly soluble drug using solid dispersion technique Chem. Pharm. Bull. 44 568 571 8882454 1:CAS:528:DyaK28XhvFSjurk%3D (Pubitemid 26103123)
6. R. W. Lengeling F. A. Mitros J. A. Brennan K. S. Schulze 2003 Ulcerative ileitis encountered at ileo-colonoscopy: likely role of nonsteroidal agents Clin. Gastroenterol. Hepatol. 1 160 169 15017486 10.1016/S1542-3565(03)70031-7 1:CAS:528:DC%2BD3sXlsVeltL0%3D (Pubitemid 37248065)
7. C. Leuner J. Dressman 2000 Improving drug solubility for oral delivery using solid dispersions Eur. J. Pharm. Biopharm. 50 47 60 10840192 10.1016/S0939-6411(00)00076-X 1:CAS:528:DC%2BD3cXjslyju7c%3D (Pubitemid 30326688)
8. V. Pillay R. Fassihi 1999 Electrolyte-induced compositional heterogeneity: a novel approach for rate-controlled oral drug delivery J. Pharm. Sci. 88 1140 1148 10564062 10.1021/js9901054 1:CAS:528:DyaK1MXmsVKntr8%3D (Pubitemid 29526299)
9. T. Riis A. Bauer-Brandl T. Wagner H. Kranz 2007 pHindependent drug release of an extremely poorly soluble weakly acidic drug from multiparticulate extended release formulations Eur. J. Pharm. Biopharm. 65 78 84 16919924 10.1016/j.ejpb.2006.07.001 1:CAS:528:DC%2BD28Xht1KlsL%2FF (Pubitemid 44827687)
10. S. Siepe B. Lueckel A. Kramer A. Ries R. Gurny 2006 Strategies for the design of hydrophilic matrix tablets with controlled microenvironmental pH Int. J. Pharm. 316 14 20 16551495 10.1016/j.ijpharm.2006.02.021 1:CAS:528: DC%2BD28XkvVWrsb4%3D (Pubitemid 44226313)
11. A. Streubel J. Siepmann A. Dashevsky R. Bodmeier 2000 pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets J. Control. Release 67 101 110 10773333 10.1016/S0168-3659(00)00200-5 1:CAS:528:DC%2BD3cXisV2nt7w%3D (Pubitemid 30201685)
12. P. H. L. Tran H. T. T. Tran B.-J. Lee 2008 Modulation of microenvironmental pH and crystallinity of ionizable telmisartan using alkalizers in solid dispersions for controlled release J. Control. Release 129 59 65 18501462 10.1016/j.jconrel.2008.04.001 1:CAS:528:DC%2BD1cXmvVGjtL0%3D
13. T. T.-D. Tran P. H.-L. Tran B.-J. Lee 2009 Dissolutionmodulating mechanism of alkalizers and polymers in nanoemulsifying solid dispersion containing ionizable and poorly water-soluble drug Eur. J. Pharm. Biopharm. 72 83 90 19141319 10.1016/j.ejpb.2008.12.009 1:CAS:528:DC%2BD1MXjvVOqtLo%3D