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Volumn 172, Issue 2, 2015, Pages 349-363

Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)

Author keywords

A118G; addiction; analgesia; dependence; pharmacogenomics; tolerance

Indexed keywords

MU OPIATE RECEPTOR; MU OPIATE RECEPTOR 1; UNCLASSIFIED DRUG;

EID: 84906824182     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12644     Document Type: Review
Times cited : (21)

References (114)
  • 1
    • 84872527828 scopus 로고    scopus 로고
    • Conformational ensemble view of G protein-coupled receptors and the effect of mutations and ligand binding
    • Abrol R, Kim SK, Bray JK, Trzaskowski B, Goddard WA 3rd, (2013). Conformational ensemble view of G protein-coupled receptors and the effect of mutations and ligand binding. Methods Enzymol 520: 31-48.
    • (2013) Methods Enzymol , vol.520 , pp. 31-48
    • Abrol, R.1    Kim, S.K.2    Bray, J.K.3    Trzaskowski, B.4    Goddard, W.A.5
  • 4
    • 78650926798 scopus 로고    scopus 로고
    • Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
    • Atwood BK, Lopez J, Wager-Miller J, Mackie K, Straiker A, (2012). Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis. BMC Genomics 12: 14.
    • (2012) BMC Genomics , vol.12 , pp. 14
    • Atwood, B.K.1    Lopez, J.2    Wager-Miller, J.3    Mackie, K.4    Straiker, A.5
  • 5
    • 0029810024 scopus 로고    scopus 로고
    • Chronic opioid treatment induces adenylyl cyclase v superactivation. Involvment of Gβγ
    • Avidor-Reiss T, Nevo I, Levy R, Pfeuffer T, Vogel Z, (1996). Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvment of Gβγ. J Biol Chem 271: 21309-21315.
    • (1996) J Biol Chem , vol.271 , pp. 21309-21315
    • Avidor-Reiss, T.1    Nevo, I.2    Levy, R.3    Pfeuffer, T.4    Vogel, Z.5
  • 6
    • 69249213486 scopus 로고    scopus 로고
    • Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons
    • Bailey CP, Oldfield S, Llorente J, Caunt CJ, Teschemacher AG, Roberts L, et al. (2009). Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons. Br J Pharmacol 158: 157-164.
    • (2009) Br J Pharmacol , vol.158 , pp. 157-164
    • Bailey, C.P.1    Oldfield, S.2    Llorente, J.3    Caunt, C.J.4    Teschemacher, A.G.5    Roberts, L.6
  • 7
    • 0035793631 scopus 로고    scopus 로고
    • A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling
    • Befort K, Filliol D, Decaillot FM, Gaveriaux-Ruff C, Hoehe MR, Kieffer BL, (2001). A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling. J Biol Chem 276: 3130-3137.
    • (2001) J Biol Chem , vol.276 , pp. 3130-3137
    • Befort, K.1    Filliol, D.2    Decaillot, F.M.3    Gaveriaux-Ruff, C.4    Hoehe, M.R.5    Kieffer, B.L.6
  • 10
    • 2042527666 scopus 로고    scopus 로고
    • Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization and resensitization of the human mu-opioid receptor
    • Beyer A, Koch T, Schroder H, Schulz S, Hollt V, (2004). Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization and resensitization of the human mu-opioid receptor. J Neurochem 89: 553-560.
    • (2004) J Neurochem , vol.89 , pp. 553-560
    • Beyer, A.1    Koch, T.2    Schroder, H.3    Schulz, S.4    Hollt, V.5
  • 11
    • 13144261678 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction
    • Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, et al. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 95: 9608-9613.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9608-9613
    • Bond, C.1    Laforge, K.S.2    Tian, M.3    Melia, D.4    Zhang, S.5    Borg, L.6
  • 12
    • 0037805628 scopus 로고    scopus 로고
    • Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors
    • Borgland SL, Connor M, Osborne PB, Furness JB, Christie MJ, (2003). Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors. J Biol Chem 278: 18776-18784.
    • (2003) J Biol Chem , vol.278 , pp. 18776-18784
    • Borgland, S.L.1    Connor, M.2    Osborne, P.B.3    Furness, J.B.4    Christie, M.J.5
  • 13
    • 0031590309 scopus 로고    scopus 로고
    • Agonist-induced signaling and trafficking of the μ-opioid receptor: Role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain
    • Capeyrou R, Riond J, Corbani M, Lepage JF, Bertin B, Emorine LJ, (1997). Agonist-induced signaling and trafficking of the μ-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain. FEBS Lett 415: 200-205.
    • (1997) FEBS Lett , vol.415 , pp. 200-205
    • Capeyrou, R.1    Riond, J.2    Corbani, M.3    Lepage, J.F.4    Bertin, B.5    Emorine, L.J.6
  • 14
    • 84885108045 scopus 로고    scopus 로고
    • Real-time characterisation of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action
    • Cawston EE, Redmond WJ, Breen C, Grimsey N, Connor M, Glass M, (2013). Real-time characterisation of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action. Br J Pharmacol 170: 893-907.
    • (2013) Br J Pharmacol , vol.170 , pp. 893-907
    • Cawston, E.E.1    Redmond, W.J.2    Breen, C.3    Grimsey, N.4    Connor, M.5    Glass, M.6
  • 15
    • 1342265799 scopus 로고    scopus 로고
    • Distinct domains of the mu-opioid receptor control uncoupling and internalization
    • Celver J, Xu M, Jin W, Lowe J, Chavkin C, (2004). Distinct domains of the mu-opioid receptor control uncoupling and internalization. Mol Pharmacol 65: 528-537.
    • (2004) Mol Pharmacol , vol.65 , pp. 528-537
    • Celver, J.1    Xu, M.2    Jin, W.3    Lowe, J.4    Chavkin, C.5
  • 16
    • 0035895932 scopus 로고    scopus 로고
    • Threonin 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes
    • Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C, (2001). Threonin 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes. J Biol Chem 276: 4894-4900.
    • (2001) J Biol Chem , vol.276 , pp. 4894-4900
    • Celver, J.P.1    Lowe, J.2    Kovoor, A.3    Gurevich, V.V.4    Chavkin, C.5
  • 17
    • 0038814253 scopus 로고    scopus 로고
    • Ligand-selective activation of μ-opioid receptor: Demonstrated with deletion and single amino acid mutations of third intracellular loop domain
    • Chaipatikul V, Loh HH, Law PY, (2003). Ligand-selective activation of μ-opioid receptor: demonstrated with deletion and single amino acid mutations of third intracellular loop domain. J Pharmacol Exp Ther 305: 909-918.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 909-918
    • Chaipatikul, V.1    Loh, H.H.2    Law, P.Y.3
  • 18
    • 84897116629 scopus 로고    scopus 로고
    • Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists
    • et al. doi: 10.1007/s00018-013-1461-7.
    • Charfi I, Nagi K, Mnie-Filali O, Thibault D, Balboni G, Schiller PW, et al. (2013). Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists. Cell Mol Life Sci. doi: 10.1007/s00018-013-1461-7.
    • (2013) Cell Mol Life Sci
    • Charfi, I.1    Nagi, K.2    Mnie-Filali, O.3    Thibault, D.4    Balboni, G.5    Schiller, P.W.6
  • 19
    • 0034954517 scopus 로고    scopus 로고
    • Regulation of opioid receptor function by chronic agonist exposure: Constitutive activity and desensitization
    • Chavkin C, McLaughlin JP, Celver JP, (2001). Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization. Mol Pharmacol 60: 20-25.
    • (2001) Mol Pharmacol , vol.60 , pp. 20-25
    • Chavkin, C.1    McLaughlin, J.P.2    Celver, J.P.3
  • 20
    • 33751185359 scopus 로고    scopus 로고
    • Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: Differential effects of nonpeptide and peptide agonists
    • Chen Y, Chen C, Wang Y, Liu-Chen LY, (2006). Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists. J Pharmacol Exp Ther 319: 765-775.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 765-775
    • Chen, Y.1    Chen, C.2    Wang, Y.3    Liu-Chen, L.Y.4
  • 21
    • 77149154974 scopus 로고    scopus 로고
    • Phosphorylation of the μ-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy
    • Clayton CC, Bruchas MR, Lee ML, Chavkin C, (2010). Phosphorylation of the μ-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy. Mol Pharmacol 77: 339-347.
    • (2010) Mol Pharmacol , vol.77 , pp. 339-347
    • Clayton, C.C.1    Bruchas, M.R.2    Lee, M.L.3    Chavkin, C.4
  • 22
    • 0041318947 scopus 로고    scopus 로고
    • Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addiction
    • Comptom P, Geschwind DH, Alarcon M, (2003). Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addiction. Am J Med Genet B Neuropsychiatr Genet 121B: 76-82.
    • (2003) Am J Med Genet B Neuropsychiatr Genet , vol.121 B , pp. 76-82
    • Comptom, P.1    Geschwind, D.H.2    Alarcon, M.3
  • 24
    • 10044280635 scopus 로고    scopus 로고
    • Mu-opioid receptor desensitization: Is morphine different?
    • Connor M, Osborne PB, Christie MJ, (2004). Mu-opioid receptor desensitization: is morphine different? Br J Pharmacol 143: 685-696.
    • (2004) Br J Pharmacol , vol.143 , pp. 685-696
    • Connor, M.1    Osborne, P.B.2    Christie, M.J.3
  • 26
    • 30444442324 scopus 로고    scopus 로고
    • 75 years of opioid research: The exciting but vain quest for the Holy Grail
    • Corbett AD, Henderson G, McKnight AT, Paterson SJ, (2006). 75 years of opioid research: the exciting but vain quest for the Holy Grail. Br J Pharmacol 147 (Suppl. 1): S153-S162.
    • (2006) Br J Pharmacol , vol.147 , Issue.SUPPL. 1 , pp. S153-S162
    • Corbett, A.D.1    Henderson, G.2    McKnight, A.T.3    Paterson, S.J.4
  • 27
    • 84875469202 scopus 로고    scopus 로고
    • Recent developments in the study of opioid receptors
    • Cox B, (2013). Recent developments in the study of opioid receptors. Mol Pharmacol 83: 723-728.
    • (2013) Mol Pharmacol , vol.83 , pp. 723-728
    • Cox, B.1
  • 29
    • 84255187298 scopus 로고    scopus 로고
    • A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African American women
    • Crystal HA, Hamon S, Randesi M, Cook J, Anastos K, Lazar J, (2012). A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African American women. Addict Biol 17: 181-191.
    • (2012) Addict Biol , vol.17 , pp. 181-191
    • Crystal, H.A.1    Hamon, S.2    Randesi, M.3    Cook, J.4    Anastos, K.5    Lazar, J.6
  • 30
    • 74049120335 scopus 로고    scopus 로고
    • Incidence, reversal and prevention of opioid-induced respiratory depression
    • Dahan A, Aarts L, Smith TW, (2010). Incidence, reversal and prevention of opioid-induced respiratory depression. Anesthesiology 112: 226-238.
    • (2010) Anesthesiology , vol.112 , pp. 226-238
    • Dahan, A.1    Aarts, L.2    Smith, T.W.3
  • 31
    • 84857476249 scopus 로고    scopus 로고
    • Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons
    • Dang VC, Christie MJ, (2012). Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons. Br J Pharmacol 165: 1704-1716.
    • (2012) Br J Pharmacol , vol.165 , pp. 1704-1716
    • Dang, V.C.1    Christie, M.J.2
  • 32
    • 72849146368 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction
    • Deb I, Chakraborty J, Gangopadhyay PK, Choudhury SR, Das S, (2010). Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction. J Neurochem 112: 486-496.
    • (2010) J Neurochem , vol.112 , pp. 486-496
    • Deb, I.1    Chakraborty, J.2    Gangopadhyay, P.K.3    Choudhury, S.R.4    Das, S.5
  • 33
    • 84857394758 scopus 로고    scopus 로고
    • Facing up to the prescription opioid crisis
    • Dhalla IA, Persaud N, Juurlink DN, (2011). Facing up to the prescription opioid crisis. BMJ 343: d5142.
    • (2011) BMJ , vol.343 , pp. d5142
    • Dhalla, I.A.1    Persaud, N.2    Juurlink, D.N.3
  • 34
    • 83355160649 scopus 로고    scopus 로고
    • Elucidation of mu-opioid gene structure: How genetics can help predict therapeutic response to opioids
    • Diatchenko L, Robinson JE, Maixner W, (2011). Elucidation of mu-opioid gene structure: how genetics can help predict therapeutic response to opioids. Eur J Pain Suppl 5: 433-448.
    • (2011) Eur J Pain Suppl , vol.5 , pp. 433-448
    • Diatchenko, L.1    Robinson, J.E.2    Maixner, W.3
  • 35
    • 80051615294 scopus 로고    scopus 로고
    • Agonist-selective patterns of mu-opioid receptor phosphorylation revealed by phosphosite-specific antibodies
    • Doll C, Konietzko J, Poll F, Koch T, Hollt V, Schulz S, (2011). Agonist-selective patterns of mu-opioid receptor phosphorylation revealed by phosphosite-specific antibodies. Br J Pharmacol 164: 298-307.
    • (2011) Br J Pharmacol , vol.164 , pp. 298-307
    • Doll, C.1    Konietzko, J.2    Poll, F.3    Koch, T.4    Hollt, V.5    Schulz, S.6
  • 36
    • 84867802836 scopus 로고    scopus 로고
    • Deciphering μ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells
    • Doll C, Poll F, Peuker K, Loktev A, Gluck L, Schulz S, (2012). Deciphering μ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells. Br J Pharmacol 167: 1259-1270.
    • (2012) Br J Pharmacol , vol.167 , pp. 1259-1270
    • Doll, C.1    Poll, F.2    Peuker, K.3    Loktev, A.4    Gluck, L.5    Schulz, S.6
  • 37
    • 0035918284 scopus 로고    scopus 로고
    • Phosphorylation of Ser363, Thr370 and Ser375 residues within the carboxyl tail differentially regulates μ-opioid receptor internalization
    • El Kouhen R, Burd AL, Erickson-Herbrandson LJ, Chang CY, Law PY, Loh HH, (2001). Phosphorylation of Ser363, Thr370 and Ser375 residues within the carboxyl tail differentially regulates μ-opioid receptor internalization. J Biol Chem 276: 12774-12780.
    • (2001) J Biol Chem , vol.276 , pp. 12774-12780
    • El Kouhen, R.1    Burd, A.L.2    Erickson-Herbrandson, L.J.3    Chang, C.Y.4    Law, P.Y.5    Loh, H.H.6
  • 38
    • 77958124076 scopus 로고    scopus 로고
    • The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs
    • Fortin JP, Ci L, Schroeder J, Goldstein C, Montefusco MC, Peter I, et al. (2010). The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs. Mol Pharmacol 78: 837-845.
    • (2010) Mol Pharmacol , vol.78 , pp. 837-845
    • Fortin, J.P.1    Ci, L.2    Schroeder, J.3    Goldstein, C.4    Montefusco, M.C.5    Peter, I.6
  • 39
    • 0031566047 scopus 로고    scopus 로고
    • Selective interactions of mu-opioid receptors with Pertussis toxin-sensitive G proteins: Involvement of the third intracellular loop and the c-terminal tail in coupling
    • Georgoussi Z, Merkouris M, Mullaney I, Megaritis G, Carr C, Zioudrou C, et al. (1997). Selective interactions of mu-opioid receptors with Pertussis toxin-sensitive G proteins: involvement of the third intracellular loop and the c-terminal tail in coupling. Biochim Biophys Acta 1359: 263-274.
    • (1997) Biochim Biophys Acta , vol.1359 , pp. 263-274
    • Georgoussi, Z.1    Merkouris, M.2    Mullaney, I.3    Megaritis, G.4    Carr, C.5    Zioudrou, C.6
  • 40
    • 84862177656 scopus 로고    scopus 로고
    • Successful prediction of the intra- and extracellular loops of four G-protein coupled receptors
    • Goldfeld DA, Zhu K, Beuming T, Friesner RA, (2011). Successful prediction of the intra- and extracellular loops of four G-protein coupled receptors. Proc Natl Acad Sci USA 109: 9665-9671.
    • (2011) Proc Natl Acad Sci USA , vol.109 , pp. 9665-9671
    • Goldfeld, D.A.1    Zhu, K.2    Beuming, T.3    Friesner, R.A.4
  • 41
    • 80053276069 scopus 로고    scopus 로고
    • Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A mu-opioid receptor knock-in mice
    • Grecksch G, Just S, Pierstorff C, Imhof AK, Gluck L, Doll C, et al. (2011). Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A mu-opioid receptor knock-in mice. J Neurosci 31: 13890-13896.
    • (2011) J Neurosci , vol.31 , pp. 13890-13896
    • Grecksch, G.1    Just, S.2    Pierstorff, C.3    Imhof, A.K.4    Gluck, L.5    Doll, C.6
  • 42
    • 0034703870 scopus 로고    scopus 로고
    • Sequence variability and candidate gene analysis in complex disease: Association of mu opioid receptor gene variation with substance dependence
    • Hoehe MR, Kopke K, Wendel B, Rohde K, Flachmeier C, Kidd KK, et al. (2000). Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. Hum Mol Genet 9: 2895-2908.
    • (2000) Hum Mol Genet , vol.9 , pp. 2895-2908
    • Hoehe, M.R.1    Kopke, K.2    Wendel, B.3    Rohde, K.4    Flachmeier, C.5    Kidd, K.K.6
  • 43
    • 84055223534 scopus 로고    scopus 로고
    • A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability
    • Huang P, Chen C, Mague SD, Blendy JA, Liu-Chen LY, (2012). A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. Biochem J 441: 379-386.
    • (2012) Biochem J , vol.441 , pp. 379-386
    • Huang, P.1    Chen, C.2    Mague, S.D.3    Blendy, J.A.4    Liu-Chen, L.Y.5
  • 44
  • 45
    • 33746265800 scopus 로고    scopus 로고
    • Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells
    • Johnson EA, Oldfield S, Braksator E, Gonzalez-Cuello A, Couch D, Hall KJ, (2006). Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells. Mol Pharmacol 70: 676-685.
    • (2006) Mol Pharmacol , vol.70 , pp. 676-685
    • Johnson, E.A.1    Oldfield, S.2    Braksator, E.3    Gonzalez-Cuello, A.4    Couch, D.5    Hall, K.J.6
  • 46
    • 0031874288 scopus 로고    scopus 로고
    • Molecular mechanisms of opioid receptor signal transduction
    • Jordan B, Devi LA, (1998). Molecular mechanisms of opioid receptor signal transduction. Br J Anaesth 81: 12-19.
    • (1998) Br J Anaesth , vol.81 , pp. 12-19
    • Jordan, B.1    Devi, L.A.2
  • 47
    • 38049065992 scopus 로고    scopus 로고
    • A118G polymorphism in mu opioid receptor gene (oprm1): Association with opiate addiction in subjects of Indian origin
    • Kapur S, Sharad S, Singh RA, Gupta AK, (2007). A118G polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin. J Integr Neurosci 6: 511-522.
    • (2007) J Integr Neurosci , vol.6 , pp. 511-522
    • Kapur, S.1    Sharad, S.2    Singh, R.A.3    Gupta, A.K.4
  • 49
    • 40349114499 scopus 로고    scopus 로고
    • Agonist-selective mechanisms of GPCR desensitization
    • Kelly E, Bailey CP, Henderson G, (2008). Agonist-selective mechanisms of GPCR desensitization. Br J Pharmacol 153 (Suppl. 1): S379-S388.
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 1 , pp. S379-S388
    • Kelly, E.1    Bailey, C.P.2    Henderson, G.3
  • 50
    • 84880311864 scopus 로고    scopus 로고
    • Efficacy and ligand bias at the μ-opioid receptor
    • Kelly E, (2013). Efficacy and ligand bias at the μ-opioid receptor. Br J Pharmacol 169: 1430-1446.
    • (2013) Br J Pharmacol , vol.169 , pp. 1430-1446
    • Kelly, E.1
  • 51
    • 0036463901 scopus 로고    scopus 로고
    • Efficacy at G-protein-coupled receptors
    • Kenakin T, (2002). Efficacy at G-protein-coupled receptors. Nat Rev Drug Discov 1: 103-110.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 103-110
    • Kenakin, T.1
  • 52
    • 84875227396 scopus 로고    scopus 로고
    • Signalling bias in new drug discovery: Detection, quantification and therapeutic impact
    • Kenakin T, Christopoulos A, (2013). Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nat Rev Drug Discov 12: 205-216.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 205-216
    • Kenakin, T.1    Christopoulos, A.2
  • 53
    • 77952354490 scopus 로고    scopus 로고
    • Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
    • Kenakin T, Miller LJ, (2010). Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev 62: 265-304.
    • (2010) Pharmacol Rev , vol.62 , pp. 265-304
    • Kenakin, T.1    Miller, L.J.2
  • 55
    • 84892775419 scopus 로고    scopus 로고
    • A real time, fluorescence-based assay for measuring μ-opioid receptor modulation of adenylyl cyclase activity in Chinese hamster ovary cells
    • Knapman A, Abogadie F, McIntrye P, Connor M, (2014). A real time, fluorescence-based assay for measuring μ-opioid receptor modulation of adenylyl cyclase activity in Chinese hamster ovary cells. J Biomol Screen, 19: 223-231.
    • (2014) J Biomol Screen , vol.19 , pp. 223-231
    • Knapman, A.1    Abogadie, F.2    McIntrye, P.3    Connor, M.4
  • 56
    • 38349103412 scopus 로고    scopus 로고
    • Role of receptor internalization in opioid tolerance and dependence
    • Koch T, Hollt V, (2008). Role of receptor internalization in opioid tolerance and dependence. Pharmacol Ther 117: 199-206.
    • (2008) Pharmacol Ther , vol.117 , pp. 199-206
    • Koch, T.1    Hollt, V.2
  • 57
    • 0033944519 scopus 로고    scopus 로고
    • Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling
    • Koch T, Kroslak T, Averbeck M, Mayer P, Schroder H, Raulf E, et al. (2000). Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling. Mol Pharmacol 58: 328-334.
    • (2000) Mol Pharmacol , vol.58 , pp. 328-334
    • Koch, T.1    Kroslak, T.2    Averbeck, M.3    Mayer, P.4    Schroder, H.5    Raulf, E.6
  • 58
    • 14144253824 scopus 로고    scopus 로고
    • Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments
    • Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA, (2005). Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol Rev 57: 1-26.
    • (2005) Pharmacol Rev , vol.57 , pp. 1-26
    • Kreek, M.J.1    Bart, G.2    Lilly, C.3    Laforge, K.S.4    Nielsen, D.A.5
  • 59
    • 34548653719 scopus 로고    scopus 로고
    • The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor
    • Kroslak T, LaForge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ, (2007). The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem 103: 77-87.
    • (2007) J Neurochem , vol.103 , pp. 77-87
    • Kroslak, T.1    Laforge, K.S.2    Gianotti, R.J.3    Ho, A.4    Nielsen, D.A.5    Kreek, M.J.6
  • 60
    • 0034723054 scopus 로고    scopus 로고
    • Opioid receptor and peptide gene polymorphisms: Potential implications for addictions
    • LaForge KS, Yuferov V, Kreek MJ, (2000). Opioid receptor and peptide gene polymorphisms: potential implications for addictions. Eur J Pharmacol 410: 249-268.
    • (2000) Eur J Pharmacol , vol.410 , pp. 249-268
    • Laforge, K.S.1    Yuferov, V.2    Kreek, M.J.3
  • 61
    • 0034128416 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of opioid receptor signaling
    • Law PY, Wong YH, Loh HH, (2000). Molecular mechanisms and regulation of opioid receptor signaling. Annu Rev Pharmacol Toxicol 40: 389-430.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 389-430
    • Law, P.Y.1    Wong, Y.H.2    Loh, H.H.3
  • 62
    • 0032563291 scopus 로고    scopus 로고
    • G protein couple receptors III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
    • Lefkowitz RJ, (1998). G protein couple receptors III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J Biol Chem 273: 18677-18680.
    • (1998) J Biol Chem , vol.273 , pp. 18677-18680
    • Lefkowitz, R.J.1
  • 63
    • 0035834092 scopus 로고    scopus 로고
    • Constitutive activation of the mu-opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression
    • Li J, Huang P, Chen C, de Riel JK, Weinstein H, Liu-Chen LY, (2001). Constitutive activation of the mu-opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. Biochemistry 40: 12039-12050.
    • (2001) Biochemistry , vol.40 , pp. 12039-12050
    • Li, J.1    Huang, P.2    Chen, C.3    De Riel, J.K.4    Weinstein, H.5    Liu-Chen, L.Y.6
  • 64
    • 84864302826 scopus 로고    scopus 로고
    • A118G mu opioid receptor polymorphism increases inhibitory effects on CaV2.2 channels
    • Lopez Soto EJ, Raingo J, (2012). A118G mu opioid receptor polymorphism increases inhibitory effects on CaV2.2 channels. Neurosci Lett 523: 190-194.
    • (2012) Neurosci Lett , vol.523 , pp. 190-194
    • Lopez Soto, E.J.1    Raingo, J.2
  • 65
    • 13244298667 scopus 로고    scopus 로고
    • Are μ-opioid receptor polymorphisms important for clinical opioid therapy?
    • Lotsch J, Geisslinger G, (2005). Are μ-opioid receptor polymorphisms important for clinical opioid therapy? Trends Mol Med 11: 82-89.
    • (2005) Trends Mol Med , vol.11 , pp. 82-89
    • Lotsch, J.1    Geisslinger, G.2
  • 66
    • 77952420724 scopus 로고    scopus 로고
    • OPRM1 SNP (A118G): Involvement in disease development, treatment response, and animal models
    • Mague SD, Blendy JA, (2010). OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models. Drug Alcohol Depend 108: 172-182.
    • (2010) Drug Alcohol Depend , vol.108 , pp. 172-182
    • Mague, S.D.1    Blendy, J.A.2
  • 68
    • 80055014810 scopus 로고    scopus 로고
    • Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca2+ channels in humanized mouse sensory neurons
    • Mahmoud S, Thorsell A, Sommer WH, Heilig M, Holgate JK, Bartlett SE, et al. (2011). Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca2+ channels in humanized mouse sensory neurons. Anesthesiology 115: 1054-1062.
    • (2011) Anesthesiology , vol.115 , pp. 1054-1062
    • Mahmoud, S.1    Thorsell, A.2    Sommer, W.H.3    Heilig, M.4    Holgate, J.K.5    Bartlett, S.E.6
  • 70
    • 33846926501 scopus 로고    scopus 로고
    • Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human μ opioid receptors (hMORs) containing the the A118G single-nucleotide polymorphism
    • Margas W, Zubkoff I, Schuler HG, Janicki PK, Ruiz-Velasco V, (2007). Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human μ opioid receptors (hMORs) containing the the A118G single-nucleotide polymorphism. J Neurophysiol 97: 1058-1067.
    • (2007) J Neurophysiol , vol.97 , pp. 1058-1067
    • Margas, W.1    Zubkoff, I.2    Schuler, H.G.3    Janicki, P.K.4    Ruiz-Velasco, V.5
  • 71
    • 0035983601 scopus 로고    scopus 로고
    • Agonists activate Gi1α or Gi2α fused to the human mu opioid receptor differently
    • Massotte D, Brillet K, Kieffer BL, Milligan G, (2002). Agonists activate Gi1α or Gi2α fused to the human mu opioid receptor differently. J Neurochem 81: 1372-1382.
    • (2002) J Neurochem , vol.81 , pp. 1372-1382
    • Massotte, D.1    Brillet, K.2    Kieffer, B.L.3    Milligan, G.4
  • 72
    • 0029852678 scopus 로고    scopus 로고
    • Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene
    • Matthes HWD, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, et al. (1996). Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene. Nature 383: 819-823.
    • (1996) Nature , vol.383 , pp. 819-823
    • Matthes, H.W.D.1    Maldonado, R.2    Simonin, F.3    Valverde, O.4    Slowe, S.5    Kitchen, I.6
  • 73
    • 18844411043 scopus 로고    scopus 로고
    • STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor
    • Mazarakou G, Georgoussi Z, (2005). STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor. J Neurochem 93: 918-931.
    • (2005) J Neurochem , vol.93 , pp. 918-931
    • Mazarakou, G.1    Georgoussi, Z.2
  • 75
    • 0029955446 scopus 로고    scopus 로고
    • Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides
    • Merkouris M, Dragatsis I, Megaritis G, Konidakis G, Zioudrou C, Milligan G, et al. (1996). Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides. Mol Pharmacol 50: 985-993.
    • (1996) Mol Pharmacol , vol.50 , pp. 985-993
    • Merkouris, M.1    Dragatsis, I.2    Megaritis, G.3    Konidakis, G.4    Zioudrou, C.5    Milligan, G.6
  • 77
    • 25144518583 scopus 로고    scopus 로고
    • Prevalence of opioid adverse events in chronic non-malignant pain: Systematic review of randomized trials of oral opioids
    • Moore RA, McQuay HJ, (2005). Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomized trials of oral opioids. Arthritis Res Ther 7: R1046-R1051.
    • (2005) Arthritis Res Ther , vol.7 , pp. R1046-R1051
    • Moore, R.A.1    McQuay, H.J.2
  • 78
    • 84877892328 scopus 로고    scopus 로고
    • Consequences of the 118A > G polymorphism in the OPRM1 gene: Translation from bench to bedside?
    • Mura E, Govoni S, Racchi M, Carossa V, Ranzani GN, Allegri M, et al. (2013). Consequences of the 118A > G polymorphism in the OPRM1 gene: translation from bench to bedside? J Pain Res 6: 331-353.
    • (2013) J Pain Res , vol.6 , pp. 331-353
    • Mura, E.1    Govoni, S.2    Racchi, M.3    Carossa, V.4    Ranzani, G.N.5    Allegri, M.6
  • 80
    • 65249146144 scopus 로고    scopus 로고
    • A common human μ-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain
    • Oertel BG, Kettner M, Scholich K, Renne C, Roskam B, Geisslinger G, et al. (2009). A common human μ-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain. J Biol Chem 284: 6530-6535.
    • (2009) J Biol Chem , vol.284 , pp. 6530-6535
    • Oertel, B.G.1    Kettner, M.2    Scholich, K.3    Renne, C.4    Roskam, B.5    Geisslinger, G.6
  • 82
    • 84876675044 scopus 로고    scopus 로고
    • Mu opioids and their receptors: Evolution of a concept
    • Pasternak GW, Pan YX, (2013). Mu opioids and their receptors: evolution of a concept. Pharmacol Rev 65: 1257-1317.
    • (2013) Pharmacol Rev , vol.65 , pp. 1257-1317
    • Pasternak, G.W.1    Pan, Y.X.2
  • 83
    • 0037007201 scopus 로고    scopus 로고
    • Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation
    • Petäjä-Repo UE, Hogue M, Bhalla S, Laperrière A, Morello JP, Bouvier M, (2002). Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation. EMBO J 21: 1628-1637.
    • (2002) EMBO J , vol.21 , pp. 1628-1637
    • Petäjä-Repo, U.E.1    Hogue, M.2    Bhalla, S.3    Laperrière, A.4    Morello, J.P.5    Bouvier, M.6
  • 84
    • 33845311870 scopus 로고    scopus 로고
    • Ligand-specific receptor states: Implications for opiate receptor signaling and regulation
    • Pineyro G, Archer-Lahlou E, (2007). Ligand-specific receptor states: implications for opiate receptor signaling and regulation. Cell Signal 19: 8-19.
    • (2007) Cell Signal , vol.19 , pp. 8-19
    • Pineyro, G.1    Archer-Lahlou, E.2
  • 88
  • 91
    • 0006169580 scopus 로고
    • Morphine receptors as regulators of adenylate cyclase activity
    • Sharma SK, Nirenberg M, Klee WA, (1975). Morphine receptors as regulators of adenylate cyclase activity. Proc Natl Acad Sci USA 72: 590-594.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 590-594
    • Sharma, S.K.1    Nirenberg, M.2    Klee, W.A.3
  • 92
    • 0036548042 scopus 로고    scopus 로고
    • Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin
    • Shi J, Hui L, Xu Y, Wang F, Huang W, Hu G, (2002). Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. Hum Mutat 19: 459-460.
    • (2002) Hum Mutat , vol.19 , pp. 459-460
    • Shi, J.1    Hui, L.2    Xu, Y.3    Wang, F.4    Huang, W.5    Hu, G.6
  • 94
    • 46049118417 scopus 로고    scopus 로고
    • Variable response to opioid treatment: Any genetic predictors in sight?
    • Skorpen F, Laugsand EA, (2008). Variable response to opioid treatment: any genetic predictors in sight? Palliat Med 22: 310-327.
    • (2008) Palliat Med , vol.22 , pp. 310-327
    • Skorpen, F.1    Laugsand, E.A.2
  • 95
    • 0038637894 scopus 로고    scopus 로고
    • Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations
    • Tan EC, Tan CH, Karupathivan U, Yap EP, (2003). Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport 14: 569-572.
    • (2003) Neuroreport , vol.14 , pp. 569-572
    • Tan, E.C.1    Tan, C.H.2    Karupathivan, U.3    Yap, E.P.4
  • 97
    • 84890783779 scopus 로고    scopus 로고
    • Endocytic profiles of δ-opioid receptor ligands determine the duration of rapid but not sustained cAMP responses
    • Tudashki HB, Robertson DN, Schiller PW, Pineyro G, (2014). Endocytic profiles of δ-opioid receptor ligands determine the duration of rapid but not sustained cAMP responses. Mol Pharmacol 85: 148-161.
    • (2014) Mol Pharmacol , vol.85 , pp. 148-161
    • Tudashki, H.B.1    Robertson, D.N.2    Schiller, P.W.3    Pineyro, G.4
  • 98
    • 0035341402 scopus 로고    scopus 로고
    • Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia
    • Ueda H, Inoue M, Matsumoto T, (2001). Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia. J Neurosci 21: 2967-2973.
    • (2001) J Neurosci , vol.21 , pp. 2967-2973
    • Ueda, H.1    Inoue, M.2    Matsumoto, T.3
  • 99
    • 0033529255 scopus 로고    scopus 로고
    • The mu opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses
    • Uhl GR, Sora I, Wang Z, (1999). The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Proc Natl Acad Sci USA 96: 7752-7755.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7752-7755
    • Uhl, G.R.1    Sora, I.2    Wang, Z.3
  • 100
    • 7244253015 scopus 로고    scopus 로고
    • Pharmacologic rescue of conformationally-defective proteins: Implications for the treatment of human disease
    • Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM, (2004). Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease. Traffic 5: 821-837.
    • (2004) Traffic , vol.5 , pp. 821-837
    • Ulloa-Aguirre, A.1    Janovick, J.A.2    Brothers, S.P.3    Conn, P.M.4
  • 101
    • 0034883021 scopus 로고    scopus 로고
    • Differences in conformational properties of the second intracellular loop (IL2) in 5HT(2C) receptors modified by RNA editing can account for G protein coupling efficiency
    • Visiers I, Hassan SA, Weinstein H, (2001). Differences in conformational properties of the second intracellular loop (IL2) in 5HT(2C) receptors modified by RNA editing can account for G protein coupling efficiency. Protein Eng 14: 409-414.
    • (2001) Protein Eng , vol.14 , pp. 409-414
    • Visiers, I.1    Hassan, S.A.2    Weinstein, H.3
  • 102
    • 70350620288 scopus 로고    scopus 로고
    • Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment
    • Walter C, Lotsch J, (2009). Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment. Pain 146: 270-275.
    • (2009) Pain , vol.146 , pp. 270-275
    • Walter, C.1    Lotsch, J.2
  • 103
    • 0033618426 scopus 로고    scopus 로고
    • Calmodulin binding to G protein coupling domain of opioid receptors
    • Wang D, Sadee W, Quillan JM, (1999). Calmodulin binding to G protein coupling domain of opioid receptors. J Biol Chem 274: 22081-22088.
    • (1999) J Biol Chem , vol.274 , pp. 22081-22088
    • Wang, D.1    Sadee, W.2    Quillan, J.M.3
  • 104
    • 0035860745 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the human μ opioid receptor gene alter basal G protein coupling and calmodulin binding
    • Wang D, Quillan JM, Winans K, Lucas JL, Sadee W, (2001). Single nucleotide polymorphisms in the human μ opioid receptor gene alter basal G protein coupling and calmodulin binding. J Biol Chem 276: 34624-34630.
    • (2001) J Biol Chem , vol.276 , pp. 34624-34630
    • Wang, D.1    Quillan, J.M.2    Winans, K.3    Lucas, J.L.4    Sadee, W.5
  • 105
    • 0033048623 scopus 로고    scopus 로고
    • A conserved arginine in the distal third intracellular loop of the mu-opioid receptor is required for G protein activation
    • Wang HL, (1999). A conserved arginine in the distal third intracellular loop of the mu-opioid receptor is required for G protein activation. J Neurochem 72: 1307-1314.
    • (1999) J Neurochem , vol.72 , pp. 1307-1314
    • Wang, H.L.1
  • 106
    • 0345167178 scopus 로고    scopus 로고
    • Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: Adenylyl cylcase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation
    • Wang Y, Li JG, Huang P, Xu W, Liu-Chen LY, (2003). Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cylcase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation. J Pharmacol Exp Ther 307: 1127-1134.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 1127-1134
    • Wang, Y.1    Li, J.G.2    Huang, P.3    Xu, W.4    Liu-Chen, L.Y.5
  • 107
    • 84862829325 scopus 로고    scopus 로고
    • Reduced expression of the μ-opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G
    • Wang YJ, Huang P, Ung A, Blendy JA, Liu-Chen LY, (2012). Reduced expression of the μ-opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G. Neuroscience 205: 178-184.
    • (2012) Neuroscience , vol.205 , pp. 178-184
    • Wang, Y.J.1    Huang, P.2    Ung, A.3    Blendy, J.A.4    Liu-Chen, L.Y.5
  • 108
    • 0033179904 scopus 로고    scopus 로고
    • Functional dissociation of mu opioid receptor signaling and endocytosis: Implications for the biology of opiate tolerance and addiction
    • Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M, (1999). Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 23: 737-746.
    • (1999) Neuron , vol.23 , pp. 737-746
    • Whistler, J.L.1    Chuang, H.H.2    Chu, P.3    Jan, L.Y.4    Von Zastrow, M.5
  • 109
    • 84874290339 scopus 로고    scopus 로고
    • Regulation of μ-opioid receptors: Desensitization, phosphorylation, internalization, and tolerance
    • Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, et al. (2013). Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev 65: 223-254.
    • (2013) Pharmacol Rev , vol.65 , pp. 223-254
    • Williams, J.T.1    Ingram, S.L.2    Henderson, G.3    Chavkin, C.4    Von Zastrow, M.5    Schulz, S.6
  • 110
    • 84888786434 scopus 로고    scopus 로고
    • S49G and R389G polymorphisms of the β-adrenergic receptor influence signaling via the cAMP-PKA and ERK pathways
    • Zhang F, Steinberg SF, (2013). S49G and R389G polymorphisms of the β-adrenergic receptor influence signaling via the cAMP-PKA and ERK pathways. Physiol Genomics 45: 1186-1192.
    • (2013) Physiol Genomics , vol.45 , pp. 1186-1192
    • Zhang, F.1    Steinberg, S.F.2
  • 111
    • 84888877100 scopus 로고    scopus 로고
    • A novel noncanonical signaling pathway for the μ-opioid receptor
    • Zhang L, Loh HH, Law PY, (2013). A novel noncanonical signaling pathway for the μ-opioid receptor. Mol Pharmacol 84: 844-853.
    • (2013) Mol Pharmacol , vol.84 , pp. 844-853
    • Zhang, L.1    Loh, H.H.2    Law, P.Y.3
  • 112
    • 25444491710 scopus 로고    scopus 로고
    • Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    • Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W, (2005). Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 280: 32618-32624.
    • (2005) J Biol Chem , vol.280 , pp. 32618-32624
    • Zhang, Y.1    Wang, D.2    Johnson, A.D.3    Papp, A.C.4    Sadee, W.5
  • 113
    • 84877131934 scopus 로고    scopus 로고
    • The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain
    • Zheng C, Chen L, Chen X, He X, Yang J, Shi Y, et al. (2013). The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain. PLoS ONE 8: e63262.
    • (2013) PLoS ONE , vol.8 , pp. e63262
    • Zheng, C.1    Chen, L.2    Chen, X.3    He, X.4    Yang, J.5    Shi, Y.6
  • 114
    • 77949721283 scopus 로고    scopus 로고
    • Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications
    • Zheng H, Loh HH, Law PY, (2010). Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications. IUBMB Life 62: 112-119.
    • (2010) IUBMB Life , vol.62 , pp. 112-119
    • Zheng, H.1    Loh, H.H.2    Law, P.Y.3


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