Conformational ensemble view of G protein-coupled receptors and the effect of mutations and ligand binding

Methods in Enzymology

Volumn 520, Issue , 2013, Pages 31-48

  Abrol, Ravinder ^a   Kim, Soo Kyung ^a   Bray, Jenelle K ^b   Trzaskowski, Bartosz ^c   Goddard III, William A ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WARSAW   (Poland)

Author keywords

Conformational energy landscape; Functional selectivity; GPCRs; Keywords; Mutagenesis; Protein structure prediction; Seven transmembrane receptors

Indexed keywords

ADENOSINE A3 RECEPTOR; CHEMOKINE RECEPTOR CCR5; G PROTEIN COUPLED RECEPTOR;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; GENE MUTATION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84872527828     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-391861-1.00002-2     Document Type: Chapter

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