Differential Effects of Agonists on Adenylyl Cyclase Superactivation Mediated by the κ Opioid Receptors: Adenylyl Cyclase Superactivation Is Independent of Agonist-Induced Phosphorylation, Desensitization, Internalization, and Down-Regulation

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 3, 2003, Pages 1127-1134

  Wang, Yulin ^a   Li, Jian Guo ^a   Huang, Peng ^a   Xu, Wei ^a   Liu Chen, Lee Yuan ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; ADENYLATE CYCLASE; DYNORPHIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR; LEVORPHANOL; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE;

ANIMAL CELL; ARTICLE; CALCIUM CONDUCTANCE; DESENSITIZATION; DIURESIS; DRUG EFFECT; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ADENYLATE CYCLASE; ANALGESICS, OPIOID; ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DYNORPHINS; ENZYME ACTIVATION; FORSKOLIN; HUMANS; LEVORPHANOL; PHOSPHORYLATION; RATS; RECEPTORS, OPIOID, KAPPA; SPECIES SPECIFICITY;

EID: 0345167178     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055814     Document Type: Article

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