Structural basis for μ-opioid receptor binding and activation

Structure

Volumn 19, Issue 11, 2011, Pages 1683-1690

  Serohijos, Adrian W R ^a,c,d   Yin, Shuangye ^a   Ding, Feng ^a   Gauthier, Josee ^b   Gibson, Dustin G ^b   Maixner, William ^b   Dokholyan, Nikolay V ^a,b   Diatchenko, Luda ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c University of North Carolina at Chapel Hill   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPRENORPHINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; MU OPIATE RECEPTOR; NALMEFENE; NALOXONE; OPIATE RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG; ZINC 16940005; ZINC 17130997; ZINC 22065588; ZINC 22129845;

ARTICLE; BINDING SITE; CELL STRAIN HEK293; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR LIBRARY; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BINDING; SIMULATION; SITE DIRECTED MUTAGENESIS; VALIDITY;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CATTLE; CYCLIC AMP; DATABASES, FACTUAL; DECAPODIFORMES; DIPRENORPHINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MORPHINE; MUTAGENESIS, SITE-DIRECTED; NALTREXONE; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; SMALL MOLECULE LIBRARIES;

EID: 80855156721     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.08.003     Document Type: Article

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