Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists

Cellular and Molecular Life Sciences

Volumn 71, Issue 8, 2014, Pages 1529-1546

  Charfi, Iness ^a,b   Nagi, Karim ^a,b   Mnie Filali, Ouissame ^a,b   Thibault, Dominic ^b   Balboni, Gianfranco ^c   Schiller, Peter W ^b,d   Trudeau, Louis Eric ^b   Pineyro, Graciela ^a,b  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Analgesic tolerance; Biased agonism; Functional selectivity; Operational model; Trafficking

Indexed keywords

4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; CYCLIC AMP; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MORPHINE; POLYPEPTIDE; TIPP PEPTIDE; UFP 512; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; RAT; RECEPTOR BINDING ASSAY;

ANALYSIS OF VARIANCE; BENZAMIDES; BENZIMIDAZOLES; BLOTTING, WESTERN; CHRONIC PAIN; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ENKEPHALIN, D-PENICILLAMINE (2,5)-; FLUORESCENT ANTIBODY TECHNIQUE; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; LIGANDS; NEURONS; OLIGOPEPTIDES; PIPERAZINES; RECEPTORS, OPIOID, DELTA;

EID: 84897116629     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1461-7     Document Type: Article

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