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Volumn 5 MAY, Issue , 2014, Pages

Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia

Author keywords

Afterdepolarizations; Arrhythmias; CaMKII; Cardiovascular diseases; Ryanodine receptor

Indexed keywords

ANKYRIN; ANKYRIN B; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; RYANODINE RECEPTOR 2; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CHANNEL NAV1.5; UNCLASSIFIED DRUG;

EID: 84904659830     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2014.00110     Document Type: Review
Times cited : (15)

References (99)
  • 2
    • 84883016295 scopus 로고    scopus 로고
    • Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure
    • doi: 10.1161/CIRCEP.113.000400
    • Aiba, T., Barth, A. S., Hesketh, G. G., Hashambhoy, Y. L., Chakir, K., Tunin, R. S., et al. (2013). Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure. Circ. Arrhythm. Electrophysiol. 6, 546-554. doi: 10.1161/CIRCEP.113.000400
    • (2013) Circ. Arrhythm. Electrophysiol , vol.6 , pp. 546-554
    • Aiba, T.1    Barth, A.S.2    Hesketh, G.G.3    Hashambhoy, Y.L.4    Chakir, K.5    Tunin, R.S.6
  • 3
    • 63649086323 scopus 로고    scopus 로고
    • Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy
    • doi: 10.1161/CIRCULATIONAHA.108.794834
    • Aiba, T., Hesketh, G. G., Barth, A. S., Liu, T., Daya, S., Chakir, K., et al. (2009). Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation 119, 1220-1230. doi: 10.1161/CIRCULATIONAHA.108.794834
    • (2009) Circulation , vol.119 , pp. 1220-1230
    • Aiba, T.1    Hesketh, G.G.2    Barth, A.S.3    Liu, T.4    Daya, S.5    Chakir, K.6
  • 5
    • 84862001882 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites
    • doi: 10.1074/jbc.M111.322537
    • 2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J. Biol. Chem. 287, 19856-19869. doi: 10.1074/jbc.M111.322537
    • (2012) J. Biol. Chem , vol.287 , pp. 19856-19869
    • Ashpole, N.M.1    Herren, A.W.2    Ginsburg, K.S.3    Brogan, J.D.4    Johnson, D.E.5    Cummins, T.R.6
  • 6
    • 33745812011 scopus 로고    scopus 로고
    • CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
    • doi: 10.1172/JCI27438
    • Backs, J., Song, K., Bezprozvannaya, S., Chang, S., and Olson, E. N. (2006). CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J. Clin. Invest. 116, 1853-1864. doi: 10.1172/JCI27438
    • (2006) J. Clin. Invest , vol.116 , pp. 1853-1864
    • Backs, J.1    Song, K.2    Bezprozvannaya, S.3    Chang, S.4    Olson, E.N.5
  • 7
    • 41149167595 scopus 로고    scopus 로고
    • The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels
    • doi: 10.1073/pnas.0710501105
    • Barrett, C. F., and Tsien, R. W. (2008). The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels. Proc. Natl. Acad. Sci. U.S.A. 105, 2157-2162. doi: 10.1073/pnas.0710501105
    • (2008) Proc. Natl. Acad. Sci. U.S.A , vol.105 , pp. 2157-2162
    • Barrett, C.F.1    Tsien, R.W.2
  • 8
    • 79957481291 scopus 로고    scopus 로고
    • The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function
    • doi: 10.1093/cvr/cvr025
    • Belevych, A. E., Terentyev, D., Terentyeva, R., Nishijima, Y., Sridhar, A., Hamlin, R. L., et al. (2011). The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function. Cardiovasc. Res. 90, 493-502. doi: 10.1093/cvr/cvr025
    • (2011) Cardiovasc. Res , vol.90 , pp. 493-502
    • Belevych, A.E.1    Terentyev, D.2    Terentyeva, R.3    Nishijima, Y.4    Sridhar, A.5    Hamlin, R.L.6
  • 9
    • 84904700703 scopus 로고    scopus 로고
    • CaMKII-dependent responses to ischemia and reperfusion challenges in the heart
    • doi: 10.3389/fphar.2014.00096
    • Bell, J. R., Vila-Petroff, M., and Delbridge, L. M. D. (2014). CaMKII-dependent responses to ischemia and reperfusion challenges in the heart. Front. Pharmacol. 5:96. doi: 10.3389/fphar.2014.00096
    • (2014) Front. Pharmacol , vol.5 , pp. 96
    • Bell, J.R.1    Vila-Petroff, M.2    Delbridge, L.M.D.3
  • 10
    • 70349754717 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels
    • doi: 10.1097/FJC.0b013e3181a25078
    • Bers, D. M., and Grandi, E. (2009). Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels. J. Cardiovasc. Pharmacol. 54, 180-187. doi: 10.1097/FJC.0b013e3181a25078
    • (2009) J. Cardiovasc. Pharmacol , vol.54 , pp. 180-187
    • Bers, D.M.1    Grandi, E.2
  • 11
    • 84904626189 scopus 로고    scopus 로고
    • CaMKII Regulation of cardiac ryanodine receptors and inositol triphosphate receptors
    • doi: 10.3389/fphar.2014.00101
    • Camors, E., and Valdivia, H. H. (2014). CaMKII Regulation of cardiac ryanodine receptors and inositol triphosphate receptors. Front. Pharmacol. 5:101. doi: 10.3389/fphar.2014.00101
    • (2014) Front. Pharmacol , vol.5 , pp. 101
    • Camors, E.1    Valdivia, H.H.2
  • 12
    • 84860539444 scopus 로고    scopus 로고
    • Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity
    • doi: 10.1016/j.yjmcc.2012.02.010
    • Camors, E., Mohler, P. J., Bers, D. M., and Despa, S. (2012). Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity. J. Mol. Cell. Cardiol. 52, 1240-1248. doi: 10.1016/j.yjmcc.2012.02.010
    • (2012) J. Mol. Cell. Cardiol , vol.52 , pp. 1240-1248
    • Camors, E.1    Mohler, P.J.2    Bers, D.M.3    Despa, S.4
  • 13
    • 84859913343 scopus 로고    scopus 로고
    • Genetics of ion-channel disorders
    • doi: 10.1097/HCO.0b013e328352429d
    • Cerrone, M., Napolitano, C., and Priori, S. G. (2012). Genetics of ion-channel disorders. Curr. Opin. Cardiol. 27, 242-252. doi: 10.1097/HCO.0b013e328352429d
    • (2012) Curr. Opin. Cardiol , vol.27 , pp. 242-252
    • Cerrone, M.1    Napolitano, C.2    Priori, S.G.3
  • 14
    • 41649117160 scopus 로고    scopus 로고
    • Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization
    • doi: 10.1161/CIRCULATIONAHA.107.706291
    • Chakir, K., Daya, S. K., Tunin, R. S., Helm, R. H., Byrne, M. J., Dimaano, V. L., et al. (2008). Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization. Circulation 117, 1369-1377. doi: 10.1161/CIRCULATIONAHA.107.706291
    • (2008) Circulation , vol.117 , pp. 1369-1377
    • Chakir, K.1    Daya, S.K.2    Tunin, R.S.3    Helm, R.H.4    Byrne, M.J.5    Dimaano, V.L.6
  • 16
  • 17
    • 77953356086 scopus 로고    scopus 로고
    • Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II
    • doi: 10.1016/j.yjmcc.2010.03.013
    • Curran, J., Brown, K. H., Santiago, D. J., Pogwizd, S., Bers, D. M., and Shannon, T. R. (2010). Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J. Mol. Cell. Cardiol. 49, 25-32. doi: 10.1016/j.yjmcc.2010.03.013
    • (2010) J. Mol. Cell. Cardiol , vol.49 , pp. 25-32
    • Curran, J.1    Brown, K.H.2    Santiago, D.J.3    Pogwizd, S.4    Bers, D.M.5    Shannon, T.R.6
  • 18
    • 0028914969 scopus 로고
    • A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
    • doi: 10.1016/0092-8674(95)90358-5
    • Curran, M. E., Splawski, I., Timothy, K. W., Vincen, G. M., Green, E. D., and Keating, M. T. (1995). A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80, 795-803. doi: 10.1016/0092-8674(95)90358-5
    • (1995) Cell , vol.80 , pp. 795-803
    • Curran, M.E.1    Splawski, I.2    Timothy, K.W.3    Vincen, G.M.4    Green, E.D.5    Keating, M.T.6
  • 19
    • 84870440232 scopus 로고    scopus 로고
    • CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome
    • doi: 10.1016/j.hrthm.2012.08.026
    • DeGrande, S., Nixon, D., Koval, O., Curran, J. W., Wright, P., Wang, Q., et al. (2012). CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm 9, 2034-2041. doi: 10.1016/j.hrthm.2012.08.026
    • (2012) Heart Rhythm , vol.9 , pp. 2034-2041
    • DeGrande, S.1    Nixon, D.2    Koval, O.3    Curran, J.W.4    Wright, P.5    Wang, Q.6
  • 20
    • 84887454024 scopus 로고    scopus 로고
    • CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia
    • doi: 10.1038/cddis.2013.369
    • Di Pasquale, E., Lodola, F., Miragoli, M., Denegri, M., Avelino-Cruz, J. E., Buonocore, M., et al. (2013). CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia. Cell Death Dis. 4:e843. doi: 10.1038/cddis.2013.369
    • (2013) Cell Death Dis , vol.4
    • Di Pasquale, E.1    Lodola, F.2    Miragoli, M.3    Denegri, M.4    Avelino-Cruz, J.E.5    Buonocore, M.6
  • 21
    • 84889021419 scopus 로고    scopus 로고
    • Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8)
    • doi: 10.1016/j.yjmcc.2013.10.021
    • Drum, B. M., Dixon, R. E., Yuan, C., Cheng, E. P., and Santana, L. F. (2014). Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8). J. Mol. Cell. Cardiol. 66, 63-71. doi: 10.1016/j.yjmcc.2013.10.021
    • (2014) J. Mol. Cell. Cardiol , vol.66 , pp. 63-71
    • Drum, B.M.1    Dixon, R.E.2    Yuan, C.3    Cheng, E.P.4    Santana, L.F.5
  • 23
    • 0033781028 scopus 로고    scopus 로고
    • Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
    • doi: 10.1038/35004052
    • Dzhura, I., Wu, Y., Colbran, R. J., Balser, J. R., and Anderson, M. E. (2000). Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat. Cell Biol. 2, 173-177. doi: 10.1038/35004052
    • (2000) Nat. Cell Biol , vol.2 , pp. 173-177
    • Dzhura, I.1    Wu, Y.2    Colbran, R.J.3    Balser, J.R.4    Anderson, M.E.5
  • 24
    • 64249158777 scopus 로고    scopus 로고
    • Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes
    • doi: 10.1161/CIRCRESAHA.108.191007
    • El-Haou, S., Balse, E., Neyroud, N., Dilanian, G., Gavillet, B., Abriel, H., et al. (2009). Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. Circ. Res. 104, 758-769. doi: 10.1161/CIRCRESAHA.108.191007
    • (2009) Circ. Res , vol.104 , pp. 758-769
    • El-Haou, S.1    Balse, E.2    Neyroud, N.3    Dilanian, G.4    Gavillet, B.5    Abriel, H.6
  • 25
    • 84901062033 scopus 로고    scopus 로고
    • Mechanisms of CaMKII activation in the heart
    • doi: 10.3389/fphar.2014.00059
    • Erickson, J. R. (2014). Mechanisms of CaMKII activation in the heart. Front. Pharmacol. 5:59. doi: 10.3389/fphar.2014.00059
    • (2014) Front. Pharmacol , vol.5 , pp. 59
    • Erickson, J.R.1
  • 26
    • 33644870558 scopus 로고    scopus 로고
    • Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices
    • doi: 10.1073/pnas.0511322103
    • Erxleben, C., Liao, Y., Gentile, S., Chin, D., Gomez-Alegria, C., Mori, Y., et al. (2006). Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc. Natl. Acad. Sci. U.S.A. 103, 3932-3937. doi: 10.1073/pnas.0511322103
    • (2006) Proc. Natl. Acad. Sci. U.S.A , vol.103 , pp. 3932-3937
    • Erxleben, C.1    Liao, Y.2    Gentile, S.3    Chin, D.4    Gomez-Alegria, C.5    Mori, Y.6
  • 27
    • 84883206388 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology
    • doi: 10.1161/CIRCULATIONAHA.113.001746.
    • Fischer, T. H., Herting, J., Tirilomis, T., Renner, A., Neef, S., Toischer, K., et al. (2013a). Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology. Circulation 128, 970-981. doi: 10.1161/CIRCULATIONAHA.113.001746
    • (2013) Circulation , vol.128 , pp. 970-981
    • Fischer, T.H.1    Herting, J.2    Tirilomis, T.3    Renner, A.4    Neef, S.5    Toischer, K.6
  • 28
    • 84876326824 scopus 로고    scopus 로고
    • The Ca-calmodulin dependent kinase II: a promising target for future antiarrhythmic therapies
    • doi: 10.1016/j.yjmcc.2012.11.003
    • Fischer, T. H., Neef, S., and Maier, L. S. (2013b). The Ca-calmodulin dependent kinase II: a promising target for future antiarrhythmic therapies? J. Mol. Cell. Cardiol. 58, 182-187. doi: 10.1016/j.yjmcc.2012.11.003
    • (2013) J.Mol. Cell. Cardiol. , vol.58 , pp. 182-187
    • Fischer, T.H.1    Neef, S.2    Maier, L.S.3
  • 30
    • 84897943657 scopus 로고    scopus 로고
    • CaMKII-dependent regulation of cardiac Na+ homeostasis
    • doi: 10.3389/fphar.2014.00041
    • Grandi, E., and Herren, A. W. (2014). CaMKII-dependent regulation of cardiac Na+ homeostasis. Front. Pharmacol. 5:41. doi: 10.3389/fphar.2014.00041
    • (2014) Front. Pharmacol , vol.5 , pp. 41
    • Grandi, E.1    Herren, A.W.2
  • 31
    • 84895561196 scopus 로고    scopus 로고
    • CaMKIIdelta subtypes: localization and function
    • doi: 10.3389/fphar.2014.00015
    • Gray, C. B. B., and Heller Brown, J. (2014). CaMKIIdelta subtypes: localization and function. Front. Pharmacol. 5:15. doi: 10.3389/fphar.2014.00015
    • (2014) Front. Pharmacol , vol.5 , pp. 15
    • Gray, C.B.B.1    Heller Brown, J.2
  • 33
    • 33747431210 scopus 로고    scopus 로고
    • Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes
    • doi: 10.1161/01.RES.0000236756.06252.13
    • Guo, T., Zhang, T., Mestril, R., and Bers, D. M. (2006). Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ. Res. 99, 398-406. doi: 10.1161/01.RES.0000236756.06252.13
    • (2006) Circ. Res , vol.99 , pp. 398-406
    • Guo, T.1    Zhang, T.2    Mestril, R.3    Bers, D.M.4
  • 34
    • 77956191808 scopus 로고    scopus 로고
    • Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model
    • doi: 10.1016/j.yjmcc.2010.07.011
    • Hashambhoy, Y. L., Greenstein, J. L., and Winslow, R. L. (2010). Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model. J. Mol. Cell. Cardiol. 49, 617-624. doi: 10.1016/j.yjmcc.2010.07.011
    • (2010) J. Mol. Cell. Cardiol , vol.49 , pp. 617-624
    • Hashambhoy, Y.L.1    Greenstein, J.L.2    Winslow, R.L.3
  • 35
    • 84897941229 scopus 로고    scopus 로고
    • Calcium dysregulation in atrial fibrillation: the role of CaMKII
    • doi: 10.3389/fphar.2014.00030
    • Heijman, J., Voigt, N., Wehrens, X. H. T., and Dobrev, D. (2014). Calcium dysregulation in atrial fibrillation: the role of CaMKII. Front. Pharmacol. 5:30. doi: 10.3389/fphar.2014.00030
    • (2014) Front. Pharmacol , vol.5 , pp. 30
    • Heijman, J.1    Voigt, N.2    Wehrens, X.H.T.3    Dobrev, D.4
  • 36
    • 84881639229 scopus 로고    scopus 로고
    • Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias
    • doi: 10.1152/ajpheart.00306.2013
    • Herren, A. W., Bers, D. M., and Grandi, E. (2013). Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias. Am. J. Physiol. Heart Circ. Physiol. 305, H431-H445. doi: 10.1152/ajpheart.00306.2013
    • (2013) Am. J. Physiol. Heart Circ. Physiol , vol.305
    • Herren, A.W.1    Bers, D.M.2    Grandi, E.3
  • 37
    • 84891351174 scopus 로고    scopus 로고
    • Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides
    • doi: 10.1093/cvr/cvt233
    • Ho, H. T., Liu, B., Snyder, J. S., Lou, Q., Brundage, E. A., Velez-Cortes, F., et al. (2013). Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc. Res. 101, 165-174. doi: 10.1093/cvr/cvt233
    • (2013) Cardiovasc. Res , vol.101 , pp. 165-174
    • Ho, H.T.1    Liu, B.2    Snyder, J.S.3    Lou, Q.4    Brundage, E.A.5    Velez-Cortes, F.6
  • 38
    • 0033515617 scopus 로고    scopus 로고
    • Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium
    • doi: 10.1161/01.RES.84.6.713
    • Hoch, B., Meyer, R., Hetzer, R., Krause, E. G., and Karczewski, P. (1999). Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ. Res. 84, 713-721. doi: 10.1161/01.RES.84.6.713
    • (1999) Circ. Res , vol.84 , pp. 713-721
    • Hoch, B.1    Meyer, R.2    Hetzer, R.3    Krause, E.G.4    Karczewski, P.5
  • 40
    • 39449101787 scopus 로고    scopus 로고
    • Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure
    • doi: 10.1371/journal.pone.0000292
    • Hullin, R., Matthes, J., von Vietinghoff, S., Bodi, I., Rubio, M., D'Souza, K., et al. (2007). Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure. PLoS ONE 2:e292. doi: 10.1371/journal.pone.0000292
    • (2007) PLoS ONE , vol.2
    • Hullin, R.1    Matthes, J.2    von Vietinghoff, S.3    Bodi, I.4    Rubio, M.5    D'Souza, K.6
  • 41
    • 77957838101 scopus 로고    scopus 로고
    • A ß(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice
    • doi: 10.1172/JCI43621
    • Hund, T. J., Koval, O. M., Li, J., Wright, P. J., Qian, L., Snyder, J. S., et al. (2010). A ß(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J. Clin. Invest. 120, 3508-3519. doi: 10.1172/JCI43621
    • (2010) J. Clin. Invest , vol.120 , pp. 3508-3519
    • Hund, T.J.1    Koval, O.M.2    Li, J.3    Wright, P.J.4    Qian, L.5    Snyder, J.S.6
  • 42
    • 84904681715 scopus 로고    scopus 로고
    • CaMKII and stress mix it up in mitochondria
    • doi: 10.3389/fphar.2014.00067
    • Joiner, M.-L. A., and Koval, O. M. (2014). CaMKII and stress mix it up in mitochondria. Front. Pharmacol. 5:67. doi: 10.3389/fphar.2014.00067
    • (2014) Front. Pharmacol , vol.5 , pp. 67
    • Joiner, M.-L.A.1    Koval, O.M.2
  • 44
    • 0032897465 scopus 로고    scopus 로고
    • Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts
    • doi: 10.1016/S0008-6363(98)00296-X
    • Kirchhefer, U., Schmitz, W., Scholz, H., and Neumann, J. (1999). Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts. Cardiovasc. Res. 42, 254-261. doi: 10.1016/S0008-6363(98)00296-X
    • (1999) Cardiovasc. Res , vol.42 , pp. 254-261
    • Kirchhefer, U.1    Schmitz, W.2    Scholz, H.3    Neumann, J.4
  • 45
    • 77950419553 scopus 로고    scopus 로고
    • CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations
    • doi: 10.1073/pnas.0913760107
    • Koval, O. M., Guan, X., Wu, Y., Joiner, M. L., Gao, Z., Chen, B., et al. (2010). CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proc. Natl. Acad. Sci. U.S.A. 107, 4996-5000. doi: 10.1073/pnas.0913760107
    • (2010) Proc. Natl. Acad. Sci. U.S.A , vol.107 , pp. 4996-5000
    • Koval, O.M.1    Guan, X.2    Wu, Y.3    Joiner, M.L.4    Gao, Z.5    Chen, B.6
  • 46
    • 84867777430 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease
    • doi: 10.1161/CIRCULATIONAHA.112.105320
    • Koval, O. M., Snyder, J. S., Wolf, R. M., Pavlovicz, R. E., Glynn, P., Curran, J., et al. (2012). C2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease. Circulation 126, 2084-2094. doi: 10.1161/CIRCULATIONAHA.112.105320
    • (2012) Circulation , vol.126 , pp. 2084-2094
    • Koval, O.M.1    Snyder, J.S.2    Wolf, R.M.3    Pavlovicz, R.E.4    Glynn, P.5    Curran, J.6
  • 47
    • 33750915091 scopus 로고    scopus 로고
    • Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents
    • doi: 10.1161/01.RES.0000249369.71709.5c
    • Li, J., Marionneau, C., Zhang, R., Shah, V., Hell, J. W., Nerbonne, J. M., et al. (2006). Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents. Circ. Res. 99, 1092-1099. doi: 10.1161/01.RES.0000249369.71709.5c
    • (2006) Circ. Res , vol.99 , pp. 1092-1099
    • Li, J.1    Marionneau, C.2    Zhang, R.3    Shah, V.4    Hell, J.W.5    Nerbonne, J.M.6
  • 48
    • 78650819612 scopus 로고    scopus 로고
    • Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia
    • doi: 10.1016/j.yjmcc.2010.10.001
    • Liu, N., Ruan, Y., Denegri, M., Bachetti, T., Li, Y., Colombi, B., et al. (2011). Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia. J. Mol. Cell. Cardiol. 50, 214-222. doi: 10.1016/j.yjmcc.2010.10.001
    • (2011) J. Mol. Cell. Cardiol , vol.50 , pp. 214-222
    • Liu, N.1    Ruan, Y.2    Denegri, M.3    Bachetti, T.4    Li, Y.5    Colombi, B.6
  • 49
    • 80052740644 scopus 로고    scopus 로고
    • CaMKIIdB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart
    • doi: 10.1371/journal.pone.0024724
    • Lu, Y. M., Huang, J., Shioda, N., Fukunaga, K., Shirasaki, Y., Li, X. M., et al. (2011). CaMKIIdB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart. PLoS ONE 6:e24724. doi: 10.1371/journal.pone.0024724
    • (2011) PLoS ONE , vol.6
    • Lu, Y.M.1    Huang, J.2    Shioda, N.3    Fukunaga, K.4    Shirasaki, Y.5    Li, X.M.6
  • 50
    • 84901847600 scopus 로고    scopus 로고
    • CaMKII oxidative activation and the pathogenesis of cardiac disease
    • doi: 10.1016/j.yjmcc.2014.02.004 [Epub ahead of print].
    • Luczak, E. D., and Anderson, M. E. (2014). CaMKII oxidative activation and the pathogenesis of cardiac disease. J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2014.02.004 [Epub ahead of print].
    • (2014) J. Mol. Cell. Cardiol
    • Luczak, E.D.1    Anderson, M.E.2
  • 51
    • 84874607556 scopus 로고    scopus 로고
    • Diabetes increases mortality after myocardial infarction by oxidizing CaMKII
    • doi: 10.1172/JCI65268
    • Luo, M., Guan, X., Luczak, E. D., Lang, D., Kutschke, W., Gao, Z., et al. (2013). Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J. Clin. Invest. 123, 1262-1274. doi: 10.1172/JCI65268
    • (2013) J. Clin. Invest , vol.123 , pp. 1262-1274
    • Luo, M.1    Guan, X.2    Luczak, E.D.3    Lang, D.4    Kutschke, W.5    Gao, Z.6
  • 53
    • 74149093364 scopus 로고    scopus 로고
    • beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes
    • doi: 10.1016/j.yjmcc.2009.11.007
    • Mani, S. K., Egan, E. A., Addy, B. K., Grimm, M., Kasiganesan, H., Thiyagarajan, T., et al. (2010). beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J. Mol. Cell. Cardiol. 48, 342-351. doi: 10.1016/j.yjmcc.2009.11.007
    • (2010) J. Mol. Cell. Cardiol , vol.48 , pp. 342-351
    • Mani, S.K.1    Egan, E.A.2    Addy, B.K.3    Grimm, M.4    Kasiganesan, H.5    Thiyagarajan, T.6
  • 54
    • 0028842251 scopus 로고
    • A new form of long QT syndrome associated with syndactyly
    • doi: 10.1016/0735-1097(94)00318-K
    • Marks, M. L., Whisler, S. L., Clericuzio, C., and Keating, M. (1995). A new form of long QT syndrome associated with syndactyly. J. Am. Coll. Cardiol. 25, 59-64. doi: 10.1016/0735-1097(94)00318-K
    • (1995) J. Am. Coll. Cardiol , vol.25 , pp. 59-64
    • Marks, M.L.1    Whisler, S.L.2    Clericuzio, C.3    Keating, M.4
  • 55
    • 0242464931 scopus 로고    scopus 로고
    • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
    • doi: 10.1038/nature01335
    • Mohler, P. J., Schott, J.-J., Gramolini, A. O., Dilly, K. W., Guatimosim, S., duBell, W. H., et al. (2003). Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature 421, 634-639. doi: 10.1038/nature01335
    • (2003) Nature , vol.421 , pp. 634-639
    • Mohler, P.J.1    Schott, J.-J.2    Gramolini, A.O.3    Dilly, K.W.4    Guatimosim, S.5    duBell, W.H.6
  • 57
    • 84896031762 scopus 로고    scopus 로고
    • A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII
    • doi: 10.1113/jphysiol.2013.266676
    • Morotti, S., Edwards, A. G., McCulloch, A. D., Bers, D. M., and Grandi, E. (2014). A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. J. Physiol. doi: 10.1113/jphysiol.2013.266676
    • (2014) J. Physiol
    • Morotti, S.1    Edwards, A.G.2    McCulloch, A.D.3    Bers, D.M.4    Grandi, E.5
  • 58
    • 84895513413 scopus 로고    scopus 로고
    • CaMKII regulation of cardiac K channels
    • doi: 10.3389/fphar.2014.00020
    • Mustroph, J., Maier, L. S., and Wagner, S. (2014). CaMKII regulation of cardiac K channels. Front. Pharmacol. 5:20. doi: 10.3389/fphar.2014.00020
    • (2014) Front. Pharmacol , vol.5 , pp. 20
    • Mustroph, J.1    Maier, L.S.2    Wagner, S.3
  • 59
    • 84860120316 scopus 로고    scopus 로고
    • Sudden cardiac death and genetic ion channelopathies: long QT, Brugada, short QT, catecholaminergic polymorphic ventricular tachycardia, and idiopathic ventricular fibrillation
    • doi: 10.1161/CIRCULATIONAHA.111.055947
    • Napolitano, C., Bloise, R., Monteforte, N., and Priori, S. G. (2012). Sudden cardiac death and genetic ion channelopathies: long QT, Brugada, short QT, catecholaminergic polymorphic ventricular tachycardia, and idiopathic ventricular fibrillation. Circulation 125, 2027-2034. doi: 10.1161/CIRCULATIONAHA.111.055947
    • (2012) Circulation , vol.125 , pp. 2027-2034
    • Napolitano, C.1    Bloise, R.2    Monteforte, N.3    Priori, S.G.4
  • 60
    • 50949115126 scopus 로고    scopus 로고
    • Atrial remodeling and atrial fibrillation: mechanisms and implications
    • doi: 10.1161/CIRCEP.107.754564
    • Nattel, S., Burstein, B., and Dobrev, D. (2008). Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ. Arrhythm. Electrophysiol. 1, 62-73. doi: 10.1161/CIRCEP.107.754564
    • (2008) Circ. Arrhythm. Electrophysiol , vol.1 , pp. 62-73
    • Nattel, S.1    Burstein, B.2    Dobrev, D.3
  • 61
    • 2342566988 scopus 로고    scopus 로고
    • Studying cardiac arrhythmias in the mouse-a reasonable model for probing mechanisms
    • doi: 10.1016/j.tcm.2003.12.006
    • Nerbonne, J. M. (2004). Studying cardiac arrhythmias in the mouse-a reasonable model for probing mechanisms? Trends Cardiovasc. Med. 14, 83-93. doi: 10.1016/j.tcm.2003.12.006
    • (2004) Trends Cardiovasc. Med , vol.14 , pp. 83-93
    • Nerbonne, J.M.1
  • 62
    • 84895560919 scopus 로고    scopus 로고
    • Modeling CaMKII in cardiac physiology: from molecule to tissue
    • doi: 10.3389/fphar.2014.00009
    • Onal, B., Unudurthi, S. D., and Hund, T. J. (2014). Modeling CaMKII in cardiac physiology: from molecule to tissue. Front. Pharmacol. 5:9. doi: 10.3389/fphar.2014.00009
    • (2014) Front. Pharmacol , vol.5 , pp. 9
    • Onal, B.1    Unudurthi, S.D.2    Hund, T.J.3
  • 63
    • 0037357819 scopus 로고    scopus 로고
    • Mutation analysis in congenital Long QT Syndrome-a case with missense mutations in KCNQ1 and SCN5A
    • doi: 10.1089/109065703321560958
    • Paulussen, A., Matthijs, G., Gewillig, M., Verhasselt, P., Cohen, N., and Aerssens, J. (2003). Mutation analysis in congenital Long QT Syndrome-a case with missense mutations in KCNQ1 and SCN5A. Genet. Test. 7, 57-61. doi: 10.1089/109065703321560958
    • (2003) Genet. Test , vol.7 , pp. 57-61
    • Paulussen, A.1    Matthijs, G.2    Gewillig, M.3    Verhasselt, P.4    Cohen, N.5    Aerssens, J.6
  • 64
    • 84895517603 scopus 로고    scopus 로고
    • CaMKII inhibitors: from research tools to therapeutic agents
    • doi: 10.3389/fphar.2014.00021
    • Pellicena, P., and Schulman, H. (2014). CaMKII inhibitors: from research tools to therapeutic agents. Front. Pharmacol. 5:21. doi: 10.3389/fphar.2014.00021
    • (2014) Front. Pharmacol , vol.5 , pp. 21
    • Pellicena, P.1    Schulman, H.2
  • 65
    • 0036645605 scopus 로고    scopus 로고
    • Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia
    • doi: 10.1161/01.CIR.0000020013.73106.D8
    • Priori, S. G., Napolitano, C., Memmi, M., Colombi, B., Drago, F., Gasparini, M., et al. (2002). Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation 106, 69-74. doi: 10.1161/01.CIR.0000020013.73106.D8
    • (2002) Circulation , vol.106 , pp. 69-74
    • Priori, S.G.1    Napolitano, C.2    Memmi, M.3    Colombi, B.4    Drago, F.5    Gasparini, M.6
  • 66
    • 84885795044 scopus 로고    scopus 로고
    • Oxidized Ca2+/calmodulin-dependent protein kinase II triggers atrial fibrillation
    • doi: 10.1161/CIRCULATIONAHA.113.003313
    • Purohit, A., Rokita, A. G., Guan, X., Chen, B., Koval, O. M., Voigt, N., et al. (2013). Oxidized Ca2+/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation 128, 1748-1757. doi: 10.1161/CIRCULATIONAHA.113.003313
    • (2013) Circulation , vol.128 , pp. 1748-1757
    • Purohit, A.1    Rokita, A.G.2    Guan, X.3    Chen, B.4    Koval, O.M.5    Voigt, N.6
  • 67
    • 84861591191 scopus 로고    scopus 로고
    • Role of RyR2 phosphorylation at S2814 during heart failure progression
    • doi: 10.1161/CIRCRESAHA.112.268094
    • Respress, J. L., van Oort, R. J., Li, N., Rolim, N., Dixit, S. S., deAlmeida, A., et al. (2012). Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ. Res. 110, 1474-1483. doi: 10.1161/CIRCRESAHA.112.268094
    • (2012) Circ. Res , vol.110 , pp. 1474-1483
    • Respress, J.L.1    van Oort, R.J.2    Li, N.3    Rolim, N.4    Dixit, S.S.5    deAlmeida, A.6
  • 68
    • 79957832166 scopus 로고    scopus 로고
    • Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation
    • doi: 10.1113/jphysiol.2010.201400
    • Ronkainen, J. J., Hänninen, S. L., Korhonen, T., Koivumäki, J. T., Skoumal, R., Rautio, S., et al. (2011). Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation. J. Physiol. 589, 2669-2686. doi: 10.1113/jphysiol.2010.201400
    • (2011) J. Physiol , vol.589 , pp. 2669-2686
    • Ronkainen, J.J.1    Hänninen, S.L.2    Korhonen, T.3    Koivumäki, J.T.4    Skoumal, R.5    Rautio, S.6
  • 69
    • 74249087588 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure
    • doi: 10.1161/CIRCHEARTFAILURE.109.865279
    • Sag, C. M., Wadsack, D. P., Khabbazzadeh, S., Abesser, M., Grefe, C., Neumann, K., et al. (2009). Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ. Heart Fail. 2, 664-675. doi: 10.1161/CIRCHEARTFAILURE.109.865279
    • (2009) Circ. Heart Fail , vol.2 , pp. 664-675
    • Sag, C.M.1    Wadsack, D.P.2    Khabbazzadeh, S.3    Abesser, M.4    Grefe, C.5    Neumann, K.6
  • 71
    • 80055115759 scopus 로고    scopus 로고
    • Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias
    • doi: 10.1016/j.yjmcc.2011.08.010
    • Said, M., Becerra, R., Valverde, C. A., Kaetzel, M. A., Dedman, J. R., Mundiña-Weilenmann, C., et al. (2011). Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias. J. Mol. Cell. Cardiol. 51, 936-944. doi: 10.1016/j.yjmcc.2011.08.010
    • (2011) J. Mol. Cell. Cardiol , vol.51 , pp. 936-944
    • Said, M.1    Becerra, R.2    Valverde, C.A.3    Kaetzel, M.A.4    Dedman, J.R.5    Mundiña-Weilenmann, C.6
  • 72
    • 0032497272 scopus 로고    scopus 로고
    • Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle
    • doi: 10.1161/01.CIR.98.10.969
    • Schröder, F., Handrock, R., Beuckelmann, D. J., Hirt, S., Hullin, R., Priebe, L., et al. (1998). Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle. Circulation 98, 969-976. doi: 10.1161/01.CIR.98.10.969
    • (1998) Circulation , vol.98 , pp. 969-976
    • Schröder, F.1    Handrock, R.2    Beuckelmann, D.J.3    Hirt, S.4    Hullin, R.5    Priebe, L.6
  • 73
    • 20444426877 scopus 로고    scopus 로고
    • Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations
    • doi: 10.1073/pnas.0502506102
    • Splawski, I., Timothy, K. W., Decher, N., Kumar, P., Sachse, F. B., Beggs, A. H., et al. (2005). Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proc. Natl. Acad. Sci. U.S.A. 102, 8089-8096. doi: 10.1073/pnas.0502506102
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , pp. 8089-8096
    • Splawski, I.1    Timothy, K.W.2    Decher, N.3    Kumar, P.4    Sachse, F.B.5    Beggs, A.H.6
  • 74
    • 5344223383 scopus 로고    scopus 로고
    • Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    • doi: 10.1016/j.cell.2004.09.011
    • Splawski, I., Timothy, K. W., Sharpe, L. M., Decher, N., Kumar, P., Bloise, R., et al. (2004). Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 119, 19-31. doi: 10.1016/j.cell.2004.09.011
    • (2004) Cell , vol.119 , pp. 19-31
    • Splawski, I.1    Timothy, K.W.2    Sharpe, L.M.3    Decher, N.4    Kumar, P.5    Bloise, R.6
  • 75
    • 84862296973 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias
    • doi: 10.1161/CIRCRESAHA.111.243956
    • Swaminathan, P. D., Purohit, A., Hund, T. J., and Anderson, M. E. (2012). Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ. Res. 110, 1661-1677. doi: 10.1161/CIRCRESAHA.111.243956
    • (2012) Circ. Res , vol.110 , pp. 1661-1677
    • Swaminathan, P.D.1    Purohit, A.2    Hund, T.J.3    Anderson, M.E.4
  • 76
    • 79961015131 scopus 로고    scopus 로고
    • Oxidized CaMKII causes cardiac sinus node dysfunction in mice
    • doi: 10.1172/JCI57833
    • Swaminathan, P. D., Purohit, A., Soni, S., Voigt, N., Singh, M. V., Glukhov, A. V., et al. (2011). Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J. Clin. Invest. 121, 3277-3288. doi: 10.1172/JCI57833
    • (2011) J. Clin. Invest , vol.121 , pp. 3277-3288
    • Swaminathan, P.D.1    Purohit, A.2    Soni, S.3    Voigt, N.4    Singh, M.V.5    Glukhov, A.V.6
  • 77
    • 0032725076 scopus 로고    scopus 로고
    • Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes
    • doi: 10.1161/01.RES.85.9.810
    • Tessier, S., Karczewski, P., Krause, E. G., Pansard, Y., Acar, C., Lang-Lazdunski, M., et al. (1999). Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes. Circ. Res. 85, 810-819. doi: 10.1161/01.RES.85.9.810
    • (1999) Circ. Res , vol.85 , pp. 810-819
    • Tessier, S.1    Karczewski, P.2    Krause, E.G.3    Pansard, Y.4    Acar, C.5    Lang-Lazdunski, M.6
  • 78
    • 77953837444 scopus 로고    scopus 로고
    • Epidemiologic, molecular, and functional evidence suggest A572D-SCN5A should not be considered an independent LQT3-susceptibility mutation
    • doi: 10.1016/j.hrthm.2010.04.014
    • Tester, D. J., Valdivia, C., Harris-Kerr, C., Alders, M., Salisbury, B. A., Wilde, A. A., et al. (2010). Epidemiologic, molecular, and functional evidence suggest A572D-SCN5A should not be considered an independent LQT3-susceptibility mutation. Heart Rhythm 7, 912-919. doi: 10.1016/j.hrthm.2010.04.014
    • (2010) Heart Rhythm , vol.7 , pp. 912-919
    • Tester, D.J.1    Valdivia, C.2    Harris-Kerr, C.3    Alders, M.4    Salisbury, B.A.5    Wilde, A.A.6
  • 79
    • 17144415220 scopus 로고    scopus 로고
    • Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing
    • doi: 10.1016/j.hrthm.2005.01.020
    • Tester, D. J., Will, M. L., Haglund, C. M., and Ackerman, M. J. (2005). Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Heart Rhythm 2, 507-517. doi: 10.1016/j.hrthm.2005.01.020
    • (2005) Heart Rhythm , vol.2 , pp. 507-517
    • Tester, D.J.1    Will, M.L.2    Haglund, C.M.3    Ackerman, M.J.4
  • 80
    • 57749181755 scopus 로고    scopus 로고
    • Proarrhythmic defects in Timothy syndrome require calmodulin kinase II
    • doi: 10.1161/CIRCULATIONAHA.108.788067
    • Thiel, W. H., Chen, B., Hund, T. J., Koval, O. M., Purohit, A., Song, L. S., et al. (2008). Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. Circulation 118, 2225-2234. doi: 10.1161/CIRCULATIONAHA.108.788067
    • (2008) Circulation , vol.118 , pp. 2225-2234
    • Thiel, W.H.1    Chen, B.2    Hund, T.J.3    Koval, O.M.4    Purohit, A.5    Song, L.S.6
  • 81
    • 84880328248 scopus 로고    scopus 로고
    • Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease
    • doi: 10.1016/j.yjmcc.2013.03.021
    • Toischer, K., Hartmann, N., Wagner, S., Fischer, T. H., Herting, J., Danner, B. C., et al. (2013). Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. J. Mol. Cell. Cardiol. 61, 111-122. doi: 10.1016/j.yjmcc.2013.03.021
    • (2013) J. Mol. Cell. Cardiol , vol.61 , pp. 111-122
    • Toischer, K.1    Hartmann, N.2    Wagner, S.3    Fischer, T.H.4    Herting, J.5    Danner, B.C.6
  • 82
    • 0032979720 scopus 로고    scopus 로고
    • Electrophysiological remodeling in hypertrophy and heart failure
    • doi: 10.1016/S0008-6363(99)00017-6
    • Tomaselli, G. F., and Marbán, E. (1999). Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc. Res. 42, 270-283. doi: 10.1016/S0008-6363(99)00017-6
    • (1999) Cardiovasc. Res , vol.42 , pp. 270-283
    • Tomaselli, G.F.1    Marbán, E.2
  • 83
    • 14744290314 scopus 로고    scopus 로고
    • Increased late sodium current in myocytes from a canine heart failure model and from failing human heart
    • doi: 10.1016/j.yjmcc.2004.12.012
    • Valdivia, C. R., Chu, W. W., Pu, J., Foell, J. D., Haworth, R. A., Wolff, M. R., et al. (2005). Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J. Mol. Cell. Cardiol. 38, 475-483. doi: 10.1016/j.yjmcc.2004.12.012
    • (2005) J. Mol. Cell. Cardiol , vol.38 , pp. 475-483
    • Valdivia, C.R.1    Chu, W.W.2    Pu, J.3    Foell, J.D.4    Haworth, R.A.5    Wolff, M.R.6
  • 84
    • 78650701435 scopus 로고    scopus 로고
    • Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure
    • doi: 10.1161/CIRCULATIONAHA.110.982298
    • van Oort, R. J., McCauley, M. D., Dixit, S. S., Pereira, L., Yang, Y., Respress, J. L., et al. (2010). Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation 122, 2669-2679. doi: 10.1161/CIRCULATIONAHA.110.982298
    • (2010) Circulation , vol.122 , pp. 2669-2679
    • van Oort, R.J.1    McCauley, M.D.2    Dixit, S.S.3    Pereira, L.4    Yang, Y.5    Respress, J.L.6
  • 85
    • 84860338741 scopus 로고    scopus 로고
    • 2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation
    • doi: 10.1161/CIRCULATIONAHA.111.067306
    • 2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation 125, 2059-2070. doi: 10.1161/CIRCULATIONAHA.111.067306
    • (2012) Circulation , vol.125 , pp. 2059-2070
    • Voigt, N.1    Li, N.2    Wang, Q.3    Wang, W.4    Trafford, A.W.5    Abu-Taha, I.6
  • 86
    • 33845284849 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
    • doi: 10.1172/JCI26620
    • Wagner, S., Dybkova, N., Rasenack, E. C., Jacobshagen, C., Fabritz, L., Kirchhof, P., et al. (2006). Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J. Clin. Invest. 116, 3127-3138. doi: 10.1172/JCI26620
    • (2006) J. Clin. Invest , vol.116 , pp. 3127-3138
    • Wagner, S.1    Dybkova, N.2    Rasenack, E.C.3    Jacobshagen, C.4    Fabritz, L.5    Kirchhof, P.6
  • 87
    • 70349471243 scopus 로고    scopus 로고
    • Ca/calmodulin kinase II differentially modulates potassium currents
    • doi: 10.1161/CIRCEP.108.842799
    • Wagner, S., Hacker, E., Grandi, E., Weber, S. L., Dybkova, N., Sossalla, S., et al. (2009). Ca/calmodulin kinase II differentially modulates potassium currents. Circ. Arrhythm. Electrophysiol. 2, 285-294. doi: 10.1161/CIRCEP.108.842799
    • (2009) Circ. Arrhythm. Electrophysiol , vol.2 , pp. 285-294
    • Wagner, S.1    Hacker, E.2    Grandi, E.3    Weber, S.L.4    Dybkova, N.5    Sossalla, S.6
  • 88
    • 80054943333 scopus 로고    scopus 로고
    • Mechanism underlying catecholaminergic polymorphic ventricular tachycardia and approaches to therapy
    • doi: 10.1016/j.jelectrocard.2011.07.025
    • Watanabe, H., and Knollmann, B. C. (2011). Mechanism underlying catecholaminergic polymorphic ventricular tachycardia and approaches to therapy. J. Electrocardiol. 44, 650-655. doi: 10.1016/j.jelectrocard.2011.07.025
    • (2011) J. Electrocardiol , vol.44 , pp. 650-655
    • Watanabe, H.1    Knollmann, B.C.2
  • 89
    • 3042763171 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor
    • doi: 10.1161/01.RES.0000125626.33738.E2
    • 2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ. Res. 94, e61-e70. doi: 10.1161/01.RES.0000125626.33738.E2
    • (2004) Circ. Res , vol.94
    • Wehrens, X.H.1    Lehnart, S.E.2    Reiken, S.R.3    Marks, A.R.4
  • 90
    • 0025772161 scopus 로고
    • Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity
    • Witcher, D. R., Kovacs, R. J., Schulman, H., Cefali, D. C., and Jones, L. R. (1991). Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity. J. Biol. Chem. 266, 11144-11152.
    • (1991) J. Biol. Chem. , vol.266 , pp. 11144-11152
    • Witcher, D.R.1    Kovacs, R.J.2    Schulman, H.3    Cefali, D.C.4    Jones, L.R.5
  • 91
    • 84897952396 scopus 로고    scopus 로고
    • CaMKII in sinoatrial node physiology and dysfunction
    • doi: 10.3389/fphar.2014.00048
    • Wu, Y., and Anderson, M. E. (2014). CaMKII in sinoatrial node physiology and dysfunction. Front. Pharmacol. 5:48. doi: 10.3389/fphar.2014.00048
    • (2014) Front. Pharmacol , vol.5 , pp. 48
    • Wu, Y.1    Anderson, M.E.2
  • 93
    • 84901014984 scopus 로고    scopus 로고
    • Numerical modeling calcium and CaMKII effects in the SA node
    • doi: 10.3389/fphar.2014.00058
    • Yaniv, Y., and Maltsev, V. A. (2014). Numerical modeling calcium and CaMKII effects in the SA node. Front. Pharmacol. 5:58. doi: 10.3389/fphar.2014.00058
    • (2014) Front. Pharmacol , vol.5 , pp. 58
    • Yaniv, Y.1    Maltsev, V.A.2
  • 94
    • 80052254219 scopus 로고    scopus 로고
    • Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice
    • doi: 10.1152/ajpcell.00125.2011
    • Yao, L., Fan, P., Jiang, Z., Viatchenko-Karpinski, S., Wu, Y., Kornyeyev, D., et al. (2011). Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice. Am. J. Physiol. Cell Physiol. 301, C577-C586. doi: 10.1152/ajpcell.00125.2011
    • (2011) Am. J. Physiol. Cell Physiol , vol.301
    • Yao, L.1    Fan, P.2    Jiang, Z.3    Viatchenko-Karpinski, S.4    Wu, Y.5    Kornyeyev, D.6
  • 95
    • 59649098928 scopus 로고    scopus 로고
    • The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation
    • doi: 10.1113/jphysiol.2008.161737
    • Yarotskyy, V., Gao, G., Peterson, B. Z., and Elmslie, K. S. (2009). The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation. J. Physiol. 587, 551-565. doi: 10.1113/jphysiol.2008.161737
    • (2009) J. Physiol , vol.587 , pp. 551-565
    • Yarotskyy, V.1    Gao, G.2    Peterson, B.Z.3    Elmslie, K.S.4
  • 96
    • 79952438377 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
    • doi: 10.1038/nature09855
    • Yazawa, M., Hsueh, B., Jia, X., Pasca, A. M., Bernstein, J. A., Hallmayer, J., et al. (2011). Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 471, 230-234. doi: 10.1038/nature09855
    • (2011) Nature , vol.471 , pp. 230-234
    • Yazawa, M.1    Hsueh, B.2    Jia, X.3    Pasca, A.M.4    Bernstein, J.A.5    Hallmayer, J.6
  • 97
    • 2342597764 scopus 로고    scopus 로고
    • LQT4 gene: the "missing" ankyrin
    • doi: 10.1124/mi.3.3.131
    • Yong, S., Tian, X., and Wang, Q. (2003). LQT4 gene: the "missing" ankyrin. Mol. Interv. 3, 131-136. doi: 10.1124/mi.3.3.131
    • (2003) Mol. Interv , vol.3 , pp. 131-136
    • Yong, S.1    Tian, X.2    Wang, Q.3
  • 98
    • 0027966195 scopus 로고
    • Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase
    • Yuan, W., and Bers, D. M. (1994). Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase. Am. J. Physiol. 267, H982-H993.
    • (1994) Am. J. Physiol. , vol.267
    • Yuan, W.1    Bers, D.M.2
  • 99
    • 0038643573 scopus 로고    scopus 로고
    • The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
    • doi: 10.1161/01.RES.0000069686.31472.C5
    • Zhang, T., Maier, L. S., Dalton, N. D., Miyamoto, S., Ross, J., Bers, D. M., et al. (2003). The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ. Res. 92, 912-919. doi: 10.1161/01.RES.0000069686.31472.C5
    • (2003) Circ. Res , vol.92 , pp. 912-919
    • Zhang, T.1    Maier, L.S.2    Dalton, N.D.3    Miyamoto, S.4    Ross, J.5    Bers, D.M.6


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