SR-targeted CaMKII inhibition improves SR Ca2+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC

Journal of Molecular and Cellular Cardiology

Volumn 50, Issue 1, 2011, Pages 230-238

  Huke, Sabine ^a   DeSantiago, Jaime ^b   Kaetzel, Marcia A ^c   Mishra, Shikha ^d   Brown, Joan H ^d   Dedman, John R ^c   Bers, Donald M ^e  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ca2+ sparks; Ca2+ Calmodulin dependent kinase; Diastolic Ca2+ leak; Excitation contraction coupling; Heart failure; Transgenic mice

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II DELTA C; CALCIUM ION; PHOSPHOLAMBAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL PERMEABILIZATION; CONTROLLED STUDY; ENZYME INHIBITION; HEART FUNCTION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART RIGHT VENTRICLE FAILURE; HEART VENTRICLE REMODELING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; ECHOCARDIOGRAPHY; HEART VENTRICLES; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PHOSPHORYLATION; SARCOPLASMIC RETICULUM;

MUS; MUS MUSCULUS;

EID: 78650841818     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.10.014     Document Type: Article

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