Na v1.5-dependent persistent Na + influx activates CaMKII in rat ventricular myocytes and N 1325S mice

American Journal of Physiology - Cell Physiology

Volumn 301, Issue 3, 2011, Pages

  Yao, Lina ^a   Fan, Peidong ^a   Jiang, Zhan ^a   Viatchenko Karpinski, Serge ^a   Wu, Yuzhi ^a   Kornyeyev, Dmytro ^a   Hirakawa, Ryoko ^a   Budas, Grant R ^a   Rajamani, Sridharan ^a   Shryock, John C ^a   Belardinelli, Luiz ^a  

^a Department of Biology Gilead Sciences ^*  (United States)

Author keywords

Arrhythmia; Ca 2+ calmodulin dependent protein kinase II; Late Na + current; Phospholamban; Ryanodine receptor

Indexed keywords

AUTOCAMTIDE 2 RELATED INHIBITORY PEPTIDE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PEPTIDE; PHOSPHOLAMBAN; RANOLAZINE; RYANODINE RECEPTOR 2; SEA ANEMONE TOXIN; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.5; SODIUM ION; TETRODOTOXIN; UNCLASSIFIED DRUG; VERATRIDINE; ACETANILIDE DERIVATIVE; AUTOCAMPTIDE 2 RELATED INHIBITORY PEPTIDE II; AUTOCAMPTIDE-2-RELATED INHIBITORY PEPTIDE II; CALCIUM; CALCIUM BINDING PROTEIN; CASP3 PROTEIN, RAT; CASPASE 3; COELENTERATE VENOM; PIPERAZINE DERIVATIVE; RYANODINE RECEPTOR; SMALL INTERFERING RNA; SODIUM; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGER 1; SODIUM CHANNEL; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA; SODIUM-CALCIUM EXCHANGER 1; TOXIN II (ANEMONIA SULCATA);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CELL DEATH; CELL PROTECTION; COIMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; FEMALE; GAIN OF FUNCTION MUTATION; GENE SILENCING; HEART MUSCLE CELL; HEART MUSCLE PERFUSION; HEART VENTRICLE WALL; IMMUNOPRECIPITATION; INHIBITION KINETICS; MOUSE; MOUSE STRAIN; NEWBORN; NONHUMAN; PHARMACOLOGICAL BLOCKING; POLYMORPHIC VENTRICULAR TACHYCARDIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SODIUM CURRENT; SODIUM TRANSPORT; TRANSGENIC MOUSE; AMINO ACID SUBSTITUTION; ANIMAL; CALCIUM SIGNALING; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENETICS; HEART VENTRICLE; HEART VENTRICLE TACHYCARDIA; HUMAN; METABOLISM; PERFUSION; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; RABBIT; SPRAGUE DAWLEY RAT;

ANEMONE; MUS; MUS MUSCULUS; RATTUS;

ACETANILIDES; AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CASPASE 3; CELL DEATH; CELL SURVIVAL; CNIDARIAN VENOMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; GENE EXPRESSION; HEART VENTRICLES; HUMANS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PEPTIDES; PERFUSION; PHOSPHORYLATION; PIPERAZINES; PROTEIN BINDING; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SODIUM; SODIUM CHANNELS; SODIUM-CALCIUM EXCHANGER; TACHYCARDIA, VENTRICULAR; TETRODOTOXIN; VERATRIDINE;

EID: 80052254219     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00125.2011     Document Type: Article

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