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Volumn 36, Issue 8, 2014, Pages 1581-1593

The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production

Author keywords

Autophagy; Endoplasmic reticulum; ER expansion; ER associated degradation; Oxidative stress; Recombinant protein production; Unfolded protein response

Indexed keywords

CELL MEMBRANES; MAMMALS; OXIDATIVE STRESS; PHYSIOLOGY; RECOMBINANT PROTEINS;

EID: 84903714956     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-014-1537-y     Document Type: Review
Times cited : (44)

References (106)
  • 2
    • 56249135270 scopus 로고    scopus 로고
    • Chaperonin chamber accelerates protein folding through passive action of preventing aggregation
    • Apetri AC, Horwich AL (2008) Chaperonin chamber accelerates protein folding through passive action of preventing aggregation. Proc Natl Acad Sci USA 105: 17351-17355.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17351-17355
    • Apetri, A.C.1    Horwich, A.L.2
  • 3
    • 84860468095 scopus 로고    scopus 로고
    • Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
    • Appenzeller-Herzog C, Hall MN (2012) Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol 22: 274-282.
    • (2012) Trends Cell Biol , vol.22 , pp. 274-282
    • Appenzeller-Herzog, C.1    Hall, M.N.2
  • 4
    • 50249084987 scopus 로고    scopus 로고
    • Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
    • Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffiths G, Ktistakis NT (2008) Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 182: 685-701.
    • (2008) J Cell Biol , vol.182 , pp. 685-701
    • Axe, E.L.1    Walker, S.A.2    Manifava, M.3    Chandra, P.4    Roderick, H.L.5    Habermann, A.6    Griffiths, G.7    Ktistakis, N.T.8
  • 5
    • 0037457338 scopus 로고    scopus 로고
    • Stability of protein production from recombinant mammalian cells
    • Barnes LM, Bentley CM, Dickson AJ (2003) Stability of protein production from recombinant mammalian cells. Biotechnol Bioeng 81: 631-639.
    • (2003) Biotechnol Bioeng , vol.81 , pp. 631-639
    • Barnes, L.M.1    Bentley, C.M.2    Dickson, A.J.3
  • 6
    • 33846894940 scopus 로고    scopus 로고
    • Molecular analysis of successful cell line selection in transfected GS-NS0 myeloma cells
    • Barnes LM, Bentley CM, Moy N, Dickson AJ (2007) Molecular analysis of successful cell line selection in transfected GS-NS0 myeloma cells. Biotechnol Bioeng 96: 337-348.
    • (2007) Biotechnol Bioeng , vol.96 , pp. 337-348
    • Barnes, L.M.1    Bentley, C.M.2    Moy, N.3    Dickson, A.J.4
  • 8
    • 77950461287 scopus 로고    scopus 로고
    • Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells
    • Becker E, Florin L, Pfizenmaier K, Kaufmann H (2009) Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells. J Biotechnol 146: 198-206.
    • (2009) J Biotechnol , vol.146 , pp. 198-206
    • Becker, E.1    Florin, L.2    Pfizenmaier, K.3    Kaufmann, H.4
  • 9
    • 79955520100 scopus 로고    scopus 로고
    • A CHOP-regulated microRNA controls rhodopsin expression
    • Behrman S, Acosta-Alvear D, Walter P (2011) A CHOP-regulated microRNA controls rhodopsin expression. J Cell Biol 192: 919-927.
    • (2011) J Cell Biol , vol.192 , pp. 919-927
    • Behrman, S.1    Acosta-Alvear, D.2    Walter, P.3
  • 10
    • 33845480131 scopus 로고    scopus 로고
    • Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response
    • Bernales S, McDonald KL, Walter P (2006) Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 4: 2311-2324.
    • (2006) PLoS Biol , vol.4 , pp. 2311-2324
    • Bernales, S.1    McDonald, K.L.2    Walter, P.3
  • 11
    • 79954423426 scopus 로고    scopus 로고
    • ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER
    • Bernasconi R, Molinari M (2011) ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER. Curr Opin Cell Biol 23: 176-183.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 176-183
    • Bernasconi, R.1    Molinari, M.2
  • 12
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    • Bertolotti A, Zhang YH, Hendershot LM, Harding HP, Ron D (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2: 326-332.
    • (2000) Nat Cell Biol , vol.2 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.H.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 15
    • 13544249755 scopus 로고    scopus 로고
    • Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line
    • Borth N, Mattanovich D, Kunert R, Katinger H (2005) Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line. Biotechnol Prog 21: 106-111.
    • (2005) Biotechnol Prog , vol.21 , pp. 106-111
    • Borth, N.1    Mattanovich, D.2    Kunert, R.3    Katinger, H.4
  • 16
    • 84855281405 scopus 로고    scopus 로고
    • UPR-Mediated Membrane Biogenesis in B Cells
    • Brewer JW, Jackowski S (2012) UPR-Mediated Membrane Biogenesis in B Cells. Biochem Res Int 738471.
    • (2012) Biochem Res Int , pp. 738471
    • Brewer, J.W.1    Jackowski, S.2
  • 18
    • 43549087339 scopus 로고    scopus 로고
    • Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities
    • Cali T, Galli C, Olivari S, Molinari M (2008) Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities. Biochem Biophys Res Commun 371: 405-410.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 405-410
    • Cali, T.1    Galli, C.2    Olivari, S.3    Molinari, M.4
  • 20
    • 84865245211 scopus 로고    scopus 로고
    • Unfolded protein response
    • Cao SS, Kaufman RJ (2012) Unfolded protein response. Curr Biol 22: R622-R626.
    • (2012) Curr Biol , vol.22
    • Cao, S.S.1    Kaufman, R.J.2
  • 22
    • 84858328465 scopus 로고    scopus 로고
    • Reticulophagy and ribophagy: regulated degradation of protein production factories
    • Cebollero E, Reggiori F, Kraft C (2012) Reticulophagy and ribophagy: regulated degradation of protein production factories. Int J Cell Biol 182834-182834.
    • (2012) Int J Cell Biol , pp. 182834
    • Cebollero, E.1    Reggiori, F.2    Kraft, C.3
  • 23
    • 80054026314 scopus 로고    scopus 로고
    • A review of the mammalian unfolded protein response
    • Chakrabarti A, Chen AW, Varner JD (2011) A review of the mammalian unfolded protein response. Biotechnol Bioeng 108: 2777-2793.
    • (2011) Biotechnol Bioeng , vol.108 , pp. 2777-2793
    • Chakrabarti, A.1    Chen, A.W.2    Varner, J.D.3
  • 24
    • 65349110331 scopus 로고    scopus 로고
    • Mining transcriptome data for function-trait relationship of hyper productivity of recombinant antibody
    • Charaniya S, Karypis G, Hu WS (2009) Mining transcriptome data for function-trait relationship of hyper productivity of recombinant antibody. Biotechnol Bioeng 102: 1654-1669.
    • (2009) Biotechnol Bioeng , vol.102 , pp. 1654-1669
    • Charaniya, S.1    Karypis, G.2    Hu, W.S.3
  • 26
    • 84883156157 scopus 로고    scopus 로고
    • UPR-inducible miRNAs contribute to stressful situations
    • Chitnis N, Pytel D, Diehl JA (2013) UPR-inducible miRNAs contribute to stressful situations. Trends Biochem Sci 38: 447-452.
    • (2013) Trends Biochem Sci , vol.38 , pp. 447-452
    • Chitnis, N.1    Pytel, D.2    Diehl, J.A.3
  • 27
    • 1442352043 scopus 로고    scopus 로고
    • Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells
    • Chung JY, Lim SW, Hong YJ, Hwang SO, Lee GM (2004) Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells. Biotechnol Bioeng 85: 539-546.
    • (2004) Biotechnol Bioeng , vol.85 , pp. 539-546
    • Chung, J.Y.1    Lim, S.W.2    Hong, Y.J.3    Hwang, S.O.4    Lee, G.M.5
  • 28
    • 0027324844 scopus 로고
    • Transcriptional induction of genes encoding Endoplasmic-Reticulum resident proteins requires a transmembrane protein-kinase
    • Cox JS, Shamu CE, Walter P (1993) Transcriptional induction of genes encoding Endoplasmic-Reticulum resident proteins requires a transmembrane protein-kinase. Cell 73: 1197-1206.
    • (1993) Cell , vol.73 , pp. 1197-1206
    • Cox, J.S.1    Shamu, C.E.2    Walter, P.3
  • 29
    • 0242712492 scopus 로고    scopus 로고
    • Endoplasmic reticulum signaling as a determinant of recombinant protein expression
    • Cudna RE, Dickson AJ (2003) Endoplasmic reticulum signaling as a determinant of recombinant protein expression. Biotechnol Bioeng 81: 56-65.
    • (2003) Biotechnol Bioeng , vol.81 , pp. 56-65
    • Cudna, R.E.1    Dickson, A.J.2
  • 31
    • 38049155818 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis
    • Deniaud A, El Dein OS, Maillier E, Poncet D, Kroemer G, Lemaire C, Brenner C (2008) Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 27: 285-299.
    • (2008) Oncogene , vol.27 , pp. 285-299
    • Deniaud, A.1    El Dein, O.S.2    Maillier, E.3    Poncet, D.4    Kroemer, G.5    Lemaire, C.6    Brenner, C.7
  • 32
    • 84889889353 scopus 로고    scopus 로고
    • Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy
    • Digaleh H, Kiaei M, Khodagholi F (2013) Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy. Cell Mol Life Sci 70: 4681-4694.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 4681-4694
    • Digaleh, H.1    Kiaei, M.2    Khodagholi, F.3
  • 34
    • 0024404910 scopus 로고
    • Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese-Hamster Ovary cells
    • Dorner AJ, Wasley LC, Kaufman RJ (1989) Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese-Hamster Ovary cells. J Biol Chem 264: 20602-20607.
    • (1989) J Biol Chem , vol.264 , pp. 20602-20607
    • Dorner, A.J.1    Wasley, L.C.2    Kaufman, R.J.3
  • 35
    • 79952581899 scopus 로고    scopus 로고
    • Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of Chinese Hamster Ovary cells
    • Dreesen IAJ, Fussenegger M (2011) Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of Chinese Hamster Ovary cells. Biotechnol Bioeng 108: 853-866.
    • (2011) Biotechnol Bioeng , vol.108 , pp. 853-866
    • Dreesen, I.A.J.1    Fussenegger, M.2
  • 38
    • 79954417748 scopus 로고    scopus 로고
    • Disulfide bonds in ER protein folding and homeostasis
    • Feige MJ, Hendershot LM (2011) Disulfide bonds in ER protein folding and homeostasis. Curr Opin Cell Biol 23: 167-175.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 167-175
    • Feige, M.J.1    Hendershot, L.M.2
  • 39
    • 70349777048 scopus 로고    scopus 로고
    • Regulation of apoptosis by the unfolded protein response
    • Fribley A, Zhang K, Kaufman RJ (2009) Regulation of apoptosis by the unfolded protein response. Meth Mol Biol 559: 191-204.
    • (2009) Meth Mol Biol , vol.559 , pp. 191-204
    • Fribley, A.1    Zhang, K.2    Kaufman, R.J.3
  • 40
    • 84863872630 scopus 로고    scopus 로고
    • MiRNAs-pathway engineering of CHO cell factories that avoids translational burdening
    • Hackl M, Borth N, Grillari J (2012) MiRNAs-pathway engineering of CHO cell factories that avoids translational burdening. Trends Biotechnol 30: 405-406.
    • (2012) Trends Biotechnol , vol.30 , pp. 405-406
    • Hackl, M.1    Borth, N.2    Grillari, J.3
  • 42
    • 77951518297 scopus 로고    scopus 로고
    • Hyperosmotic stress induces autophagy and apoptosis in recombinant Chinese hamster ovary cell culture
    • Han YK, Kim YG, Kim JY, Lee GM (2010) Hyperosmotic stress induces autophagy and apoptosis in recombinant Chinese hamster ovary cell culture. Biotechnol Bioeng 105: 1187-1192.
    • (2010) Biotechnol Bioeng , vol.105 , pp. 1187-1192
    • Han, Y.K.1    Kim, Y.G.2    Kim, J.Y.3    Lee, G.M.4
  • 44
    • 84891040487 scopus 로고    scopus 로고
    • Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression
    • Haredy AM, Nishizawa A, Honda K, Ohya T, Ohtake H, Omasa T (2013) Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression. Cytotechnology 65: 993-1002.
    • (2013) Cytotechnology , vol.65 , pp. 993-1002
    • Haredy, A.M.1    Nishizawa, A.2    Honda, K.3    Ohya, T.4    Ohtake, H.5    Omasa, T.6
  • 46
    • 33745893809 scopus 로고    scopus 로고
    • Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
    • Hollien J, Weissman JS (2006) Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 313: 104-107.
    • (2006) Science , vol.313 , pp. 104-107
    • Hollien, J.1    Weissman, J.S.2
  • 48
    • 84881617305 scopus 로고    scopus 로고
    • Chinese Hamster Ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell
    • Hu Z, Guo D, Yip SSM, Zhan D, Misaghi S, Joly JC, Snedecor BR, Shen AY (2013) Chinese Hamster Ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell. Biotechnol Prog 29: 980-985.
    • (2013) Biotechnol Prog , vol.29 , pp. 980-985
    • Hu, Z.1    Guo, D.2    Yip, S.S.M.3    Zhan, D.4    Misaghi, S.5    Joly, J.C.6    Snedecor, B.R.7    Shen, A.Y.8
  • 49
    • 38049056162 scopus 로고    scopus 로고
    • Autophagy and apoptosis in Chinese hamster ovary cell culture
    • Hwang SO, Lee GM (2008a) Autophagy and apoptosis in Chinese hamster ovary cell culture. Autophagy 4: 70-72.
    • (2008) Autophagy , vol.4 , pp. 70-72
    • Hwang, S.O.1    Lee, G.M.2
  • 50
    • 38449096145 scopus 로고    scopus 로고
    • Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture
    • Hwang SO, Lee GM (2008b) Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture. Biotechnol Bioeng 99: 678-685.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 678-685
    • Hwang, S.O.1    Lee, G.M.2
  • 51
    • 0013899589 scopus 로고
    • Ultrastructure of fatty liver induced by prolonged ethanol ingestion
    • Iseri OA, Lieber CS, Gottlieb LS (1966) Ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am J Path 48: 535-555.
    • (1966) Am J Path , vol.48 , pp. 535-555
    • Iseri, O.A.1    Lieber, C.S.2    Gottlieb, L.S.3
  • 53
    • 54249169966 scopus 로고    scopus 로고
    • Engineering of chaperone systems and of the unfolded protein response
    • Khan SU, Schroder M (2008) Engineering of chaperone systems and of the unfolded protein response. Cytotechnology 57: 207-231.
    • (2008) Cytotechnology , vol.57 , pp. 207-231
    • Khan, S.U.1    Schroder, M.2
  • 54
    • 84856389498 scopus 로고    scopus 로고
    • CHO cells in biotechnology for production of recombinant proteins: current state and further potential
    • Kim JY, Kim YG, Lee GM (2012) CHO cells in biotechnology for production of recombinant proteins: current state and further potential. App Microbiol Biotechnol 93: 917-930.
    • (2012) App Microbiol Biotechnol , vol.93 , pp. 917-930
    • Kim, J.Y.1    Kim, Y.G.2    Lee, G.M.3
  • 55
    • 84885594052 scopus 로고    scopus 로고
    • Autophagy and its implication in Chinese Hamster Ovary cell culture
    • Kim YJ, Baek E, Lee JS, Lee GM (2013) Autophagy and its implication in Chinese Hamster Ovary cell culture. Biotechnol Lett 35: 1753-1763.
    • (2013) Biotechnol Lett , vol.35 , pp. 1753-1763
    • Kim, Y.J.1    Baek, E.2    Lee, J.S.3    Lee, G.M.4
  • 56
    • 84897408960 scopus 로고    scopus 로고
    • Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese hamster ovary cells
    • Klanert G, Jadhav V, Chanoumidou K, Grillari J, Borth N, Hackl M (2013) Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese hamster ovary cells. Biotechnol J 9: 538-544.
    • (2013) Biotechnol J , vol.9 , pp. 538-544
    • Klanert, G.1    Jadhav, V.2    Chanoumidou, K.3    Grillari, J.4    Borth, N.5    Hackl, M.6
  • 57
    • 84865356675 scopus 로고    scopus 로고
    • Development of a novel ER stress based selection system for the isolation of highly productive clones
    • Kober L, Zehe C, Bode J (2012) Development of a novel ER stress based selection system for the isolation of highly productive clones. Biotechnol Bioeng 109: 2599-2611.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 2599-2611
    • Kober, L.1    Zehe, C.2    Bode, J.3
  • 58
    • 43049138051 scopus 로고    scopus 로고
    • Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease
    • Kraft C, Deplazes A, Sohrmann M, Peter M (2008) Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nat Cell Biol 10: 602-610.
    • (2008) Nat Cell Biol , vol.10 , pp. 602-610
    • Kraft, C.1    Deplazes, A.2    Sohrmann, M.3    Peter, M.4
  • 59
    • 37549030190 scopus 로고    scopus 로고
    • Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells
    • Ku SC, Ng DT, Yap MG, Chao SH (2008) Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells. Biotechnol Bioeng 99: 155-164.
    • (2008) Biotechnol Bioeng , vol.99 , pp. 155-164
    • Ku, S.C.1    Ng, D.T.2    Yap, M.G.3    Chao, S.H.4
  • 60
    • 77950950835 scopus 로고    scopus 로고
    • Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells
    • Ku SC, Toh PC, Lee YY, Chusainow J, Yap MG, Chao SH (2009) Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells. Biotechnol Prog 26: 517-526.
    • (2009) Biotechnol Prog , vol.26 , pp. 517-526
    • Ku, S.C.1    Toh, P.C.2    Lee, Y.Y.3    Chusainow, J.4    Yap, M.G.5    Chao, S.H.6
  • 61
    • 84880575033 scopus 로고    scopus 로고
    • The role of phospholipids in the biological activity and structure of the endoplasmic reticulum
    • Lagace TA, Ridgway ND (2013) The role of phospholipids in the biological activity and structure of the endoplasmic reticulum. Biochim Biophys Acta 1833: 2499-2510.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 2499-2510
    • Lagace, T.A.1    Ridgway, N.D.2
  • 62
    • 29244448729 scopus 로고    scopus 로고
    • XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
    • Lee AH, Chu GC, Iwakoshi NN, Glimcher LH (2005) XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J 24: 4368-4380.
    • (2005) EMBO J , vol.24 , pp. 4368-4380
    • Lee, A.H.1    Chu, G.C.2    Iwakoshi, N.N.3    Glimcher, L.H.4
  • 63
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Lee AH, Scapa EF, Cohen DE, Glimcher LH (2008) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496.
    • (2008) Science , vol.320 , pp. 1492-1496
    • Lee, A.H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 64
    • 12944308330 scopus 로고    scopus 로고
    • Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
    • Levine B (2005) Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 120: 159-162.
    • (2005) Cell , vol.120 , pp. 159-162
    • Levine, B.1
  • 65
    • 70349905357 scopus 로고    scopus 로고
    • Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis
    • Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I (2009) Role of ERO1-alpha-mediated stimulation of inositol 1, 4, 5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol 186: 783-792.
    • (2009) J Cell Biol , vol.186 , pp. 783-792
    • Li, G.1    Mongillo, M.2    Chin, K.T.3    Harding, H.4    Ron, D.5    Marks, A.R.6    Tabas, I.7
  • 66
    • 7544222395 scopus 로고    scopus 로고
    • The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role
    • Lieber CS (2004) The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. Drug Metab Rev 36: 511-529.
    • (2004) Drug Metab Rev , vol.36 , pp. 511-529
    • Lieber, C.S.1
  • 67
    • 77954683888 scopus 로고    scopus 로고
    • Engineering mammalian cells in bioprocessing-current achievements and future perspectives
    • Lim Y, Wong NS, Lee YY, Ku SC, Wong DC, Yap MG (2010) Engineering mammalian cells in bioprocessing-current achievements and future perspectives. Biotechnol Appl Biochem 55: 175-189.
    • (2010) Biotechnol Appl Biochem , vol.55 , pp. 175-189
    • Lim, Y.1    Wong, N.S.2    Lee, Y.Y.3    Ku, S.C.4    Wong, D.C.5    Yap, M.G.6
  • 68
    • 80051788173 scopus 로고    scopus 로고
    • Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER
    • Lynes EM, Simmen T (2011) Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER. Biochim Biophys Acta 1813: 1893-1905.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1893-1905
    • Lynes, E.M.1    Simmen, T.2
  • 70
    • 78650031117 scopus 로고    scopus 로고
    • Oxidative Protein folding in the secretory pathway and redox signaling across compartments and cells
    • Margittai E, Sitia R (2011) Oxidative Protein folding in the secretory pathway and redox signaling across compartments and cells. Traffic 12: 1-8.
    • (2011) Traffic , vol.12 , pp. 1-8
    • Margittai, E.1    Sitia, R.2
  • 71
    • 33746032588 scopus 로고    scopus 로고
    • ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies
    • Mattioli L, Anelli T, Fagioli C, Tacchetti C, Sitia R, Valetti C (2006) ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies. J Cell Sci 119: 2532-2541.
    • (2006) J Cell Sci , vol.119 , pp. 2532-2541
    • Mattioli, L.1    Anelli, T.2    Fagioli, C.3    Tacchetti, C.4    Sitia, R.5    Valetti, C.6
  • 72
    • 84879155370 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling: the microRNA connection
    • Maurel M, Chevet E (2013) Endoplasmic reticulum stress signaling: the microRNA connection. Am J Physiol Cell Physiol 304: C1117-C1126.
    • (2013) Am J Physiol Cell Physiol , vol.304
    • Maurel, M.1    Chevet, E.2
  • 73
    • 44949158950 scopus 로고    scopus 로고
    • Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells
    • Mohan C, Kim YG, Koo J, Lee GM (2008) Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells. Biotechnol J 3: 624-630.
    • (2008) Biotechnol J , vol.3 , pp. 624-630
    • Mohan, C.1    Kim, Y.G.2    Koo, J.3    Lee, G.M.4
  • 74
    • 84870166429 scopus 로고    scopus 로고
    • The unfolded protein response in secretory cell function
    • Moore KA, Hollien J (2012) The unfolded protein response in secretory cell function. Annu Rev Genet 46: 165-183.
    • (2012) Annu Rev Genet , vol.46 , pp. 165-183
    • Moore, K.A.1    Hollien, J.2
  • 75
    • 0027305620 scopus 로고
    • A transmembrane protein with a cdc2 +/cdc28-related kinase-activity is required for signaling from the ER to the nucleus
    • Mori K, Ma WZ, Gething MJ, Sambrook J (1993) A transmembrane protein with a cdc2 +/cdc28-related kinase-activity is required for signaling from the ER to the nucleus. Cell 74: 743-756.
    • (1993) Cell , vol.74 , pp. 743-756
    • Mori, K.1    Ma, W.Z.2    Gething, M.J.3    Sambrook, J.4
  • 76
    • 84874560748 scopus 로고    scopus 로고
    • Metabolism and metabolic burden by alpha(1)-antitrypsin production in human AGE1.HN cells
    • Niklas J, Priesnitz C, Rose T, Sandig V, Heinzle E (2013) Metabolism and metabolic burden by alpha(1)-antitrypsin production in human AGE1. HN cells. Metab Eng 16: 103-114.
    • (2013) Metab Eng , vol.16 , pp. 103-114
    • Niklas, J.1    Priesnitz, C.2    Rose, T.3    Sandig, V.4    Heinzle, E.5
  • 77
    • 84878854474 scopus 로고    scopus 로고
    • Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells
    • Nishimiya D, Mano T, Miyadai K, Yoshida H, Takahashi T (2013) Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells. Appl Microbiol Biotechnol 97: 2531-2539.
    • (2013) Appl Microbiol Biotechnol , vol.97 , pp. 2531-2539
    • Nishimiya, D.1    Mano, T.2    Miyadai, K.3    Yoshida, H.4    Takahashi, T.5
  • 78
    • 70350236472 scopus 로고    scopus 로고
    • Coordination of lipid metabolism in membrane biogenesis
    • Nohturfft A, Zhang SC (2009) Coordination of lipid metabolism in membrane biogenesis. Annu Rev Cell Dev Biol 25: 539-566.
    • (2009) Annu Rev Cell Dev Biol , vol.25 , pp. 539-566
    • Nohturfft, A.1    Zhang, S.C.2
  • 79
    • 0344586053 scopus 로고    scopus 로고
    • Genetic heterogeneity of stably transfected cell lines revealed by expression profiling with oligonucleotide microarrays
    • Oh MK, Scoles DR, Haipek C, Strand AD, Gutmann DH, Olson JM, Pulst SM (2003) Genetic heterogeneity of stably transfected cell lines revealed by expression profiling with oligonucleotide microarrays. J Cell Biochem 90: 1068-1078.
    • (2003) J Cell Biochem , vol.90 , pp. 1068-1078
    • Oh, M.K.1    Scoles, D.R.2    Haipek, C.3    Strand, A.D.4    Gutmann, D.H.5    Olson, J.M.6    Pulst, S.M.7
  • 80
    • 78649682788 scopus 로고    scopus 로고
    • Membrane delivery to the yeast autophagosome from the Golgi-Endosomal system
    • Ohashi Y, Munro S (2010) Membrane delivery to the yeast autophagosome from the Golgi-Endosomal system. Mol Biol Cell 21: 3998-4008.
    • (2010) Mol Biol Cell , vol.21 , pp. 3998-4008
    • Ohashi, Y.1    Munro, S.2
  • 83
    • 77955131007 scopus 로고    scopus 로고
    • Plasma membrane contributes to the formation of pre-autophagosomal structures
    • Ravikumar B, Moreau K, Jahreiss L, Puri C, Rubinsztein DC (2010) Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol 12: 747-758.
    • (2010) Nat Cell Biol , vol.12 , pp. 747-758
    • Ravikumar, B.1    Moreau, K.2    Jahreiss, L.3    Puri, C.4    Rubinsztein, D.C.5
  • 85
    • 84897586906 scopus 로고    scopus 로고
    • CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors
    • Sanchez N, Kelly P, Gallagher C, Lao NT, Clarke C, Clynes M, Barron N (2013) CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors. Biotechnol J 9: 396-404.
    • (2013) Biotechnol J , vol.9 , pp. 396-404
    • Sanchez, N.1    Kelly, P.2    Gallagher, C.3    Lao, N.T.4    Clarke, C.5    Clynes, M.6    Barron, N.7
  • 88
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • Schroder M, Kaufman RJ (2005) ER stress and the unfolded protein response. Mutat Res 569: 29-63.
    • (2005) Mutat Res , vol.569 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 89
    • 73349106233 scopus 로고    scopus 로고
    • Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response
    • Schuck S, Prinz WA, Thorn KS, Voss C, Walter P (2009) Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biol 187: 525-536.
    • (2009) J Cell Biol , vol.187 , pp. 525-536
    • Schuck, S.1    Prinz, W.A.2    Thorn, K.S.3    Voss, C.4    Walter, P.5
  • 92
    • 77954956306 scopus 로고    scopus 로고
    • Lipidomics: coming to grips with lipid diversity
    • Shevchenko A, Simons K (2010) Lipidomics: coming to grips with lipid diversity. Nat Rev Mol Cell Biol 11: 593-598.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 593-598
    • Shevchenko, A.1    Simons, K.2
  • 93
    • 5444222234 scopus 로고    scopus 로고
    • XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
    • Sriburi R, Jackowski S, Mori K, Brewer JW (2004) XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol 167: 35-41.
    • (2004) J Cell Biol , vol.167 , pp. 35-41
    • Sriburi, R.1    Jackowski, S.2    Mori, K.3    Brewer, J.W.4
  • 94
    • 34147172715 scopus 로고    scopus 로고
    • Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1 (S)-induced endoplasmic reticulum biogenesis
    • Sriburi R, Bommiasamy H, Buldak GL, Robbins GR, Frank M, Jackowski S, Brewer JW (2007) Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1 (S)-induced endoplasmic reticulum biogenesis. J Biol Chem 282: 7024-7034.
    • (2007) J Biol Chem , vol.282 , pp. 7024-7034
    • Sriburi, R.1    Bommiasamy, H.2    Buldak, G.L.3    Robbins, G.R.4    Frank, M.5    Jackowski, S.6    Brewer, J.W.7
  • 95
    • 77953028045 scopus 로고    scopus 로고
    • Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell
    • Stolz A, Wolf DH (2010) Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell. Biochim Biophys Acta 1803: 694-705.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 694-705
    • Stolz, A.1    Wolf, D.H.2
  • 96
    • 84864502516 scopus 로고    scopus 로고
    • Russell body inducing threshold depends on the variable domain sequences of individual human IgG clones and the cellular protein homeostasis
    • Stoops J, Byrd S, Hasegawa H (2012) Russell body inducing threshold depends on the variable domain sequences of individual human IgG clones and the cellular protein homeostasis. Biochim Biophys Acta 1823: 1643-1657.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 1643-1657
    • Stoops, J.1    Byrd, S.2    Hasegawa, H.3
  • 98
    • 33646078130 scopus 로고    scopus 로고
    • Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells
    • Tigges M, Fussenegger M (2006) Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells. Metab Eng 8: 264-272.
    • (2006) Metab Eng , vol.8 , pp. 264-272
    • Tigges, M.1    Fussenegger, M.2
  • 101
    • 77956690413 scopus 로고    scopus 로고
    • Biopharmaceutical benchmarks 2010
    • Walsh G (2010) Biopharmaceutical benchmarks 2010. Nat Biotechnol 28: 917-924.
    • (2010) Nat Biotechnol , vol.28 , pp. 917-924
    • Walsh, G.1
  • 102
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: from stress pathway to homeostatic regulation
    • Walter P, Ron D (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081-1086.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 103
    • 79952319773 scopus 로고    scopus 로고
    • Mitochondria removal by autophagy
    • Wang K, Klionsky DJ (2011) Mitochondria removal by autophagy. Autophagy 7: 297-300.
    • (2011) Autophagy , vol.7 , pp. 297-300
    • Wang, K.1    Klionsky, D.J.2
  • 105
    • 58149214612 scopus 로고    scopus 로고
    • Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells
    • Yee JC, Gerdtzen ZP, Hu WS (2009) Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells. Biotechnol Bioeng 102: 246-263.
    • (2009) Biotechnol Bioeng , vol.102 , pp. 246-263
    • Yee, J.C.1    Gerdtzen, Z.P.2    Hu, W.S.3
  • 106
    • 0034918705 scopus 로고    scopus 로고
    • Effect of antioxidants on the apoptosis of CHO cells and production of tissue plasminogen activator in suspension culture
    • Yun ZY, Takagi M, Yoshida T (2001) Effect of antioxidants on the apoptosis of CHO cells and production of tissue plasminogen activator in suspension culture. J Biosci Bioeng 91: 581-585.
    • (2001) J Biosci Bioeng , vol.91 , pp. 581-585
    • Yun, Z.Y.1    Takagi, M.2    Yoshida, T.3


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